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| 1 | Environmental and Psycho-social Factors Related to Prostate Cancer Risk in the Chinese Population:a Case-control Study显示文摘Objective To study the risk environmental and psycho-social factors associated to prostate cancer(PCa) in Chinese population. Methods 250 PCa patients and 500 controls were enrolled in this case-control study. Information was collected and logistic regression analysis was used to estimate the odds ratios(OR) and 95% confidence intervals(95% CI) for relationship between lifestyle, eating habits and psycho-social factors with PCa risk. Results Green vegetables and green tea were associated with a decreased risk of PCa(OR=0.39, 95% CI: 0.28-0.53; OR=0.59, 95% CI: 0.40-0.87, respectively). Family history of PCa(OR=7.16, 95% CI: 2.01-25.49), history of prostate diseases(OR=2.28, 95% CI: 1.53-3.41), alcohol consumption(OR=1.97, 95% CI: 1.33-2.90), red meat consumption(OR=1.74, 95% CI: 1.20-2.52), barbecued(OR=2.29, 95% CI: 1.11-4.73) or fried(OR=2.35, 95% CI: 1.24-4.43) foods were related with increased PCa risk. Negative psycho-social factors including occupational setbacks(OR=1.61, 95% CI: 1.00-2.59), marital separation(OR=1.94, 95% CI: 1.29-2.91), self-contained suffering(OR=2.37, 95% CI: 1.58-3.55), and high sensitivity to the personal comments(OR=1.73, 95% CI: 1.18-2.54) were related to PCa. Conclusion Regular consumption of green vegetables and green tea may suggest protective effects on PCa. Alcohol consumption, red meat consumption and barbecued or fried foods were associated with PCa. Negative psycho-social factors may also play a role in the incidence of PCa in Chinese population. | LI Mei Ling LIN Ji HOU Jian Guo XU Lei CUI Xin Gang XU Xing Xing YU Yong Wei HAN Xue WANG Guo Min GUO Jian Ming XU Dan Feng THOMPSON Timothy C CAO Guang Wen ZHANG Hong Wei | 2014 | Biomedical and Environmental Sciences2014，27，9： | 5 |
| 2 | National Park vegetation mapping using multitemporal Landsat 7 data and a decision tree classifier显示文摘 | Eric C. Brown de Colstoun Michael H. Story Craig Thompson Kathy Commisso Timothy G. Smith James R. Irons | 2003 | Remote Sensing of Environment2003，，3： | 2 |
| 3 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 4 | High Levels of Phosphorylated Form of Akt-1 in Prostate Cancer and Non-Neoplastic Prostate Tissues Are Strong Predictors of Biochemical Recurrence显示文摘 | Gustavo Ayala Timothy Thompson Guang Yang | 2004 | Clinical Cancer Research2004，10，： | 1 |
| 5 | Association between Endothelial Dysfunction and Acute Brain Dysfunction during Critical Illness显示文摘 | Christopher G. Hughes Alessandro Morandi Timothy D. Girard Bernhard Riedel Jennifer L. Thompson Ayumi K. Shintani Brenda T. Pun E. Wesley Ely Pratik P. Pandharipande | 2013 | Anesthesiology2013，，3： | 1 |
| 6 | Endoscopic ultrasound is highly accurate and directs management in patients with neuroendocrine tumors of the pancreas显示文摘 | Michelle A Anderson Steven Carpenter Norman W Thompson Timothy T Nostrant Grace H Elta James M Scheiman | 2000 | The American Journal of Gastroenterology2000，，9： | 1 |
| 7 | The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: The VISIONS cohort magnetic resonance imaging study*显示文摘 | Max L. Gunther Alessandro Morandi Erin Krauskopf Pratik Pandharipande Timothy D. Girard James C. Jackson Jennifer Thompson Ayumi K. Shintani Sunil Geevarghese Russell R. Miller Angelo Canonico Kristen Merkle Christopher J. Cannistraci Baxter P. Rogers J. | 2012 | Critical Care Medicine2012，，7： | 1 |
| 8 | Delirium as a predictor of long-term cognitive impairment in survivors of critical illness显示文摘 | Timothy D. Girard James C. Jackson Pratik P. Pandharipande Brenda T. Pun Jennifer L. Thompson Ayumi K. Shintani Sharon M. Gordon Angelo E. Canonico Robert S. Dittus Gordon R. Bernard E. Wesley Ely | 2010 | Critical Care Medicine2010，，7： | 1 |
| 9 | One-bottle self-etching adhesives applied to dentine air-abraded using bioactive glasses containing polyacrylicacid: An in vitro microtensile bond strength and confocal microscopy study显示文摘 | Salvatore Sauro Timothy F Watson Ian Thompson | 2012 | J Dent Res2012，40，： | 1 |
| 10 | 临床限局性前列腺癌显示文摘前列腺癌是英国男性最常见的癌症。2002年有32000例男性诊断为前列腺癌,超过10000例死于该病。随着血前列腺特异性抗原(PSA)检测的开展,前列腺癌的发病率也在升高,但疾病相关的死亡率在下降。本综述提供了该病的危险因素、预防、检测、自然病程和治疗上的证据,重点探讨临床限局性前列腺癌,以指导全科医生的临床工作。 | Timothy J Wilt Ian M Thompson 郝秀原(译) | 2007 | 英国医学杂志中文版2007，10，2： | 1 |
| 11 | Brazilian Foreign Policy in the Cardoso Era:The Search for Autonomy through Integration显示文摘 | Tullo Vigevani Marcelo Fernandes de Oliveira Timothy Thompson | | 0，，05： | 1 |
| 12 | Loss of caveolin‐1 in prostate cancer stroma correlates with reduced relapse‐free survival and is functionally relevant to tumour progression显示文摘 | Gustavo Ayala Matteo Morello Anna Frolov Sungyong You Rile Li Fabiana Rosati Gianluca Bartolucci Giovanna Danza Rosalyn M Adam Timothy C Thompson Michael P Lisanti Michael R Freeman Dolores Di Vizio | 2013 | Pathol2013，，1： | 1 |
| 13 | Serial Cardiac Magnetic Resonance Imaging of Injected Mesenchymal Stem Cells显示文摘 | Jonathan M. Hill Alexander J. Dick Venkatesh K. Raman Richard B. Thompson Zu-Xi Yu K. Allison Hinds Breno S.S. Pessanha Michael A. Guttman Timothy R. Varney Bradley J. Martin Cynthia E. Dunbar Elliot R. McVeigh Robert J. Lederman | 2003 | Circulation: Journal of the American Heart Association2003，，8： | 1 |
| 14 | Temporal Patterns of Postoperative Complications显示文摘 | Thompson B Timothy Baxter | 2003 | Arch Surg2003，138，： | 1 |
| 15 | Hepatitis B Virus Combo Mutations Improve the Prediction and Active Prophylaxis of Hepatocellular Carcinoma: A Clinic-Based Cohort Study显示文摘 | Jianhua Yin Junxue Wang Rui Pu Haiguang Xin Zixiong Li Xue Han Yibo Ding Yan Du Wenbin Liu Yang Deng Xiaowei Ji Ming Wu Min Yu Hongwei Zhang Hongyang Wang Timothy C. Thompson Wu Ni Guangwen Cao | 2015 | Cancer Prevention Research2015，，： | 1 |
| 16 | Connecting supplier and DoD blockchains for transparent part tracking显示文摘Blockchains have been around for more than ten years,and since 2015,a plethora of systems have been launched to target more flexible use cases.More recently,several enterprise blockchain systems,such as Consensys Quorum and Hyperledger Fabric,have been launched to make blockchain simpler to apply in complex organizational configurations.In this paper,we identify a specific Department of Defense use case,extrapolate requirements,and perform a thorough assessment of the different layers of the blockchain stack to identify the existing state of the art and undertake a gap analysis of the technology for this context.We describe a platform that meets many of these challenges and show how we architected,designed,and implemented a solution for this use case for deployment at NAVAIR.This solution connects transactions from two separate blockchain systems,Consensys Quorum and Hyperledger Fabric,by using a graph-based approach that preserves privacy while enabling full transparency across the military and supplier networks. | Francis Asuncion Adam Brinckman Dwayne Cole Jeffrey Curtis Matt Davis Timothy Dunlevy Calvin Farmer Andrew Harrison Daniel P.Johnson Joshua Joyce Chris Klubertanz Jonathan Lane John Martin Jarek Nabrzyski Joel Neidig Deysi Olivares Gregory Robinson Gabriel Rodriguez Chris Root Karen Rowand Al Salour Jeff Score David Scott Ian Taylor Chandler Thompson Huy Truong Xiqun Wang Dale Warren | 2021 | Blockchain(Research and Applications)2021，2，3： | 1 |
| 17 | Uncovering genetic and metabolite markers associated with resistance against anthracnose fruit rot in northern highbush blueberry显示文摘Anthracnose fruit rot(AFR),caused by the fungal pathogen Colletotrichum fioriniae,is among the most destructive and widespread fruit disease of blueberry,impacting both yield and overall fruit quality.Blueberry cultivars have highly variable resistance against AFR.To date,this pathogen is largely controlled by applying various fungicides;thus,a more cost-effective and environmentally conscious solution for AFR is needed.Here we report three quantitative trait loci associated with AFR resistance in northern highbush blueberry(Vaccinium corymbosum).Candidate genes within these genomic regions are associated with the biosynthesis of flavonoids(e.g.anthocyanins)and resistance against pathogens.Furthermore,we examined gene expression changes in fruits following inoculation with Colletotrichum in a resistant cultivar,which revealed an enrichment of significantly differentially expressed genes associated with certain specialized metabolic pathways(e.g.flavonol biosynthesis)and pathogen resistance.Using non-targeted metabolite profiling,we identified a flavonol glycoside with properties consistent with a quercetin rhamnoside as a compound exhibiting significant abundance differences among the most resistant and susceptible individuals from the genetic mapping population.Further analysis revealed that this compound exhibits significant abundance differences among the most resistant and susceptible individuals when analyzed as two groups.However,individuals within each group displayed considerable overlapping variation in this compound,suggesting that its abundance may only be partially associated with resistance against C.fioriniae.These findings should serve as a powerful resource that will enable breeding programs to more easily develop new cultivars with superior resistance to AFR and as the basis of future research studies. | MacKenzie Jacobs Samantha Thompson Adrian E.Platts Melanie J.A.Body Alexys Kelsey Amanda Saad Patrick Abeli Scott J.Teresi Anthony Schilmiller Randolph Beaudry Mitchell J.Feldmann Steven J.Knapp Guo-qing Song Timothy Miles Patrick P.Edger | 2023 | Horticulture Research2023，10，10： | 0 |
| 18 | Roles of a metastasis-associated molecule, RTVP-1, in cancer immunosurveillance显示文摘Objective: To elucidate distinct functions of a recently identified cancer metastasis-associated molecule, related to testes-specific, vespid, and pathogenesis protein-1 (RTVP-1) in the mammalian immune system. Methods: Immunohistochemical assays and functional analysis on the immune system were performed on RTVP-/- mice and RTVP-1+/+ mice. Protein-protein interaction (PPI) was used to predict the functions of RTVP-1. Results: Abnormal lymphocyte growth kinetics and reduced numbers of CD8+ T cells were revealed in lymph nodes of RTVP-1-/- mice. Expression of phenotypic markers of maturation in bone marrow-derived dendritic cells (DC) was impaired in RTVP-1-/- DC following antigenic stimulation in vitro and RTVP-1-/- DC failed to provide normal CD4+ T cell stimulatory activities in vivo. RTVP-1-/- mice failed to generate normal CTL or antibody responses in vivo after vaccination. In vivo tumor challenge experiments using a mouse cancer cell line demonstrated that the growth rate of subcutaneous tumors in RTVP-1-/- mice was significantly increased and CD8+ T cell infiltration significantly reduced compared to RTVP-1+/+ mice. PPI showed that RTVP-1 protein closely interacted with molecules associated with immune response and cancer metastasis. Conclusion: RTVP-1 might function as a tumor metastasis suppressor and immunosurveillance molecule in cancer. | Sun Junwen Chang Wenjun Yang Guang Hou Jianguo Ma Liye Zhang Hongwei Tan Xiaojie He Xiang Timothy C. Thompson Cao Guangwen | 2008 | Journal of Medical Colleges of PLA(China)2008，23，4： | 0 |
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