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| 1 | Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I显示文摘 | Michaela Ulrike Gack Randy Allen Albrecht Tomohiko Urano Kyung-Soo Inn I-Chueh Huang Elena Carnero Michael Farzan Satoshi Inoue Jae Ung Jung Adolfo García-Sastre | 2009 | Cell Host & Microbe2009，，5： | 2 |
| 2 | Mucosal necrosis of the small intestine in myopathy,encephalopathy,lactic acidosis,and stroke-like episodes syndrome显示文摘This report presents a case of massive mucosal necrosis of the small intestine in a patient with mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes(MELAS),which particularly affects the brain,nervous system and muscles.A 45-year-old Japanese female,with an established diagnosis of MELAS,presented with vomiting.Computed tomography showed portomesenteric venous gas and pneumatosis intestinalis.She underwent a resection of the small intestine.A microscopic study showed necrosis of the mucosa and vacuolar degeneration of smooth muscle cells in the arterial wall.Immunohistochemistry showed anti-mitochondrial antibody to be highly expressed in the crypts adjacent the necrotic mucosa.The microscopic and immunohistochemical findings suggested the presence of a large number of abnormal mitochondria in MELAS to be closely linked to mucosal necrosis of the small intestine. | Keita Fukuyama Yasuhide Ishikawa Tetsuro Ogino Hidenobu Inoue Ryoya Yamaoka Tetsuro Hirose Tomohiko Nishihira | 2012 | World Journal of Gastroenterology2012，18，41： | 2 |
| 3 | Gastric rupture with necrosis following acute gastric dilatation: report of a case显示文摘 | Takehiro Mishima Norihiro Kohara Yoshitsugu Tajima Junpei Maeda Keiji Inoue Tsuyoshi Ohno Amane Kitasato Takehito Watanabe Junji Irie Tomohiko Adachi Tamotsu Kuroki Susumu Eguchi Takashi Kanematsu | 2012 | Surgery Today2012，，10： | 1 |
| 4 | Efp as a new molecular target for breast cancer therapy显示文摘 | Kuniko Horie Tomohiko Urano Satoshi Inoue | 2003 | Anti-Cancer Drugs2003，，： | 1 |
| 5 | Simultaneous removal of COS and H2S from coke oven gas at low temperature by use of an iron oxide显示文摘 | Kouichi Mitra Kazuhiro Mae Tomohiko Inoue | 1992 | Ind Eng Chem Res1992，31，1： | 1 |
| 6 | The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures显示文摘 | Masataka Shiraki Tomohiko Urano Tatsuhiko Kuroda Mitsuru Saito Shiro Tanaka Mariko Miyao-Koshizuka Satoshi Inoue | 2008 | Journal of Bone and Mineral Metabolism2008，，6： | 1 |
| 7 | FOXP1 is an androgen-responsive transcription factor that negatively regulates androgen receptor signaling in prostate cancer cells显示文摘 | Kenichi Takayama Kuniko Horie-Inoue Kazuhiro Ikeda Tomohiko Urano Kayoko Murakami Yoshihide Hayashizaki Yasuyoshi Ouchi Satoshi Inoue | 2008 | Biochemical and Biophysical Research Communications2008，，2： | 1 |
| 8 | Comparison of Long-Term Functional Results of Colonic J-Pouch and Straight Anastomosis After Low Anterior Resection for Rectal Cancer: A Five-Year Follow-Up显示文摘 | Jin-ichi Hida M.D. Takehito Yoshifuji M.D. Tadao Tokoro M.D. Kiyohiko Inoue M.D. Tomohiko Matsuzaki M.D. Kiyotaka Okuno M.D. Hitoshi Shiozaki M.D. Masayuki Yasutomi M.D | 2004 | Diseases of the Colon & Rectum2004，，10： | 1 |
| 9 | Comparison of Long-Term Functional Results of Colonic J-Pouch and Straight Anastomosis After Low Anterior Resection for Rectal Cancer: A Five-Year Follow-Up显示文摘 | Jin-ichi Hida M.D. Takehito Yoshifuji M.D. Tadao Tokoro M.D. Kiyohiko Inoue M.D. Tomohiko Matsuzaki M.D. Kiyotaka Okuno M.D. Hitoshi Shiozaki M.D. Masayuki Yasutomi M.D | 2004 | Diseases of the Colon & Rectum2004，，10： | 1 |
| 10 | Field-deployable rapid multiple biosensing system for detection of chemical and biological warfare agents显示文摘The threat of biological and chemical terror acts remains a growing worldwide concern.There is therefore a need to develop appropriate technology for the detection of chemical and biological warfare agents,with early identification intended for use by first responders.Here,we disclose the developed autonomous air sampling and detection system for evaluation of the presence of chemical and biological warfare agents that can be harmful to the population.The current device utilizes the designed mist generator-assisted air collection system(338 l min^(−1))and biosensing chip technologies,such as electrochemical measurement,Au nanoparticle-based localized surface plasmon resonance,and rapid microfluidic chip PCR for detection of minute concentrations lower than the mean lethal dose(LD_(50))of nerve gases(sarin and VX),toxic proteins(BTX/A/Hc and ricin),and pathogens(anthrax simulant).An operation time of only 5–15 min is needed for the collection and detection;sample preparation is already integrated into the system without the need for direct human intervention.In addition to the system’s sensitivity and ease of use,its portability makes it highly beneficial for first responders,which could aid in immediate risk assessment and mitigation of on-site events. | Masato Saito Natsuko Uchida Shunsuke Furutani Mizuho Murahashi Wilfred Espulgar Naoki Nagatani Hidenori Nagai Yuki Inoue Tomohiko Ikeuchi Satoshi Kondo Hirotaka Uzawa Yasuo Seto Eiichi Tamiya | 2018 | Microsystems & Nanoengineering2018，4，1： | 1 |
| 11 | Review of novel therapeutic medicines targeting androgen signaling in castration-resistant prostate cancer显示文摘Prostate cancer is the most common male malignant neoplasm.Androgens and the androgen receptor(AR)play a key role in the onset and progression of prostate cancer.The expression of the AR is still preserved in the majority of patients with castration-resistant prostate cancer(CRPC).CRPC is considered to be induced by the following mechanisms:(1)sustained AR activation by enhancing intracellular conversion of adrenal androgens to dehydrotestosterone via a de novo route;(2)AR hypersensitivity;(3)promiscuous activation of AR signaling;and(4)outlaw pathways.Recent advances in the treatment of CRPC include novel medicinestargeting AR signaling pathways.In addition,functional molecular studies have shown that some of the ARregulated genes and AR coregulators are prognostic markers and potential therapeutic targets for prostate cancer,particularly in the castration-resistant state.Therefore,identification of the AR signaling pathways responsible for establishment of CRPC is critical for developing new strategies for the treatment of CRPC. | Daisuke Obinata Kyoko Fujiwara Kenya Yamaguchi Ken-ichi Takayama Tomohiko Urano Hiroki Nagase Satoshi Inoue Satoru Takahashi Noboru Fukuda | 2014 | World Journal of Clinical Urology2014，3，3： | 0 |
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