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| 1 | Characteristics of and strategies for patients with severe burn-blast combined injury显示文摘背景严重灼伤强风联合了损害是对为它的高死亡的医疗队的大挑战。这研究的目的是阐明损害并且到现在的临床的特征我们有严重灼伤强风的五个病人联合了的如此的 cases.Methods 的治疗上的临床的经验损害进入我们在 2005 年 6 月 7 日 77 个小时损害以后的医院。灼伤程度从 80% ~ 97%(89.6% 鞪? 亘吗?? | CHAI Jia-ke SHENG Zhi-yong LU Jiang-yang WEN Zhong-guang YANG Hong-ming JIA Xiao-ming LI Li-gen CAO Wei-hong HAO Dai-feng SHEN Chuan-an TUO Xiao-ye LIANG Li-ming WANG Shu-jun | 2007 | Chinese Medical Journal2007，，20： | 17 |
| 2 | Treatment strategies for mass burn casualties显示文摘因为很多严重受伤的病人在一短时间以内被送,背景集体灼伤伤亡总是是对一个医疗队的大挑战。通常,高死亡正在逼近。从牺牲品的成功的治疗获得的经验可能在在武装 conflict.Methods 指导集体伤亡的照顾是有用的在单个批的 35 个灼伤牺牲品,坐飞机不停地被转移并且从一个远省的高速公路,被承认 48 个小时损害以后。所有病人与吝啬的年龄是男性的(22.4 ? 蟠 ?( | CHAI Jia-ke SHENG Zhi-yong YANG Hong-ming HAO Dai-feng SHEN Chuan-an JIA Xiao-ming LI Feng JING Sa LI Li-gen SONG Hui-feng JIA Chi-yu TUO Xiao-ye SUN Tian-jun HU Quan | 2009 | Chinese Medical Journal2009，，5： | 10 |
| 3 | Effects of Salinity on Embryonic Development, Survival, and Growth of Crassostrea hongkongensis显示文摘This study examined the effects of salinity on embryonic development, survival, and growth of the Hong Kong oyster Crassostrea hongkongensis. The embryos, larvae, and juveniles of C. hongkongensis were held in artificial seawater at three different salinities(low, 15; medium, 23; and high, 30) to determine the optimum hatchery and nursery conditions for mass production of the seeds. Results showed that the percentage production of straight-hinged larvae from fertilized eggs was significantly lower at the high salinity than at the low- and medium-salinities(P < 0.05). The survival rates of larvae and juveniles differed significantly among the three salinity trials, with the highest survival rate observed at the low salinity(P < 0.05). The shell height of larvae was significantly larger at the low salinity than at the high and medium salinities from days 9 to 15(P < 0.05), whereas that of juveniles was significantly larger at the low salinity than at the high and medium salinities on day 70(P < 0.05). These results indicate that the larvae and juveniles of C. hongkongensis are tolerant to a wide range of salinities(15 to 30), but show better growth and survival at relatively low salinities. Thus, it is recommended to use relatively low salinities in hatchery and nursery systems for improved yields of C. hongkongensis. | HUO Zhongming WANG Zhaoping LIANG Jian ZHANG Yuehuan SHEN Jianping YAO Tuo SU Jiaqi YU Ruihai | 2014 | Journal of Ocean University of China2014，13，4： | 6 |
| 4 | Immunomodulatory effects of Caulerpa racemosa var peltata polysaccharide and its selenizing product on T lymphocytes and NK cells in mice显示文摘A polysaccharide, CrvpPS, was isolated from Caulerpa racemosa var peltata. It was reacted with nano-selenium in distilled water containing ascorbic acid (Vit C) to form a stable CrvpPS-nano-Se complex. The immunomodulatory effects of CrvpPS and CrvpPS-nano-Se on T lymphocytes subgroups and NK cells in mice were investigated. After intragastric administration for 10 days separately, both CrvpPS and CrvpPS-nano-Se showed significant stimulatory functions to thymus gland of mice. Moreover, the CrvpPS-nano-Se induced the percentage of CD3+, CD3+CD4+, NK cells and the CD4+/CD8+ value to increase significantly (P<0.05) when analyzed by flow cytometry, which is better than the CrvpPS, sucrose-nano-Se, and even the positive drug levamisole. | SHEN WeiZai WANG Hui GUO GuoQing TUO JingJing | 2008 | Science China(Life Sciences)2008，51，9： | 6 |
| 5 | Combination of ablative fractional carbon dioxide laser and platelet-rich plasma treatment to improve hypertrophic scars:a retrospective clinical observational study显示文摘Background:Hypertrophic scars are one of the main complications that affect the quality of life of patients after burns.Many methods have been shown to be effective in the treatment of hypertrophic scars,such as ablative fractional CO_(2) laser(AFCL)and platelet-rich plasma(PRP).However,there are few studies on the effect of the combined application of these measures.The purpose of this study was to explore the therapeutic effect of AFCL combined with PRP on hypertrophic burn scars.Methods:A retrospective clinical observation study was conducted on 50 patients with hypertrophic burn scars.The AFCL+PRP group included 31 patients who received AFCL combined with PRP treatment;the AFCL group included 19 patients who received AFCL treatment only.The University of North Carolina 4P Scar Scale(UNC4P)and the Vancouver Scar Scale(VSS)scores that were collected before each treatment were used as indicators of the effectiveness of the previous treatment.The scores recorded at the second,fourth and seventh months were analysed.Results:The demographic data of the 2 groups were not significantly different.Before treatment,therewas no difference in the UNC4P and VSS scores between the 2 groups.Therewas a significant decline in the UNC4P and VSS total scores over 6 months in both groups(p<0.05)and scores in the 2 groups were comparable after 3 and 6 months(p<0.05).UNC4P scores in the AFCL+PRP group decreased from a mean of 8.26 to 2.61(p<0.05)with a concomitant drop in VSS scores from a mean of 11.74 to 6.06(p<0.01).In the AFCL group UNC4P and VSS scores decreased from 7.68 to 4.63(p<0.05)and from 10.89 to 8.16(p<0.05),respectively.The sub-items of these 2 assessments were analysed and the results suggest that AFCL combined with PRP can comprehensively improve scarring.Conclusions:This study shows that PRP is an effective adjunct for AFCL in the treatment of hypertrophic burn scars and that the combination of PRP and AFCL proved to be more useful than AFCL alone.This combination may be a new and effective clinical practice for the treatment of scars.However,larger and higher-level clinical studies are still needed to determine its efficacy and possible mechanisms. | Zhanzhan Dai Xiaozhen Lou Tuo Shen Yu Sun Yongqiang Xiao Xingfeng Zheng Xuexin Wang Yu Peng Yukun Guo Yibin Guo Jiannan Wen He Fang Bing Ma Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 4 |
| 6 | The effect of pmpR on the type Ⅲ secretion system in Pseudomonas aeruginosa显示文摘The type III secretion system(T3SS) plays important roles in Pseudomonas aeruginosa pathogenicity.Previously,we reported that the uncharacterized protein PmpR could regulate pqsR,an important regulator in the quorum-sensing system,by directly binding to its promoter region.As the T3SS is controlled by the quorum-sensing system,here,we investigated the relationship between PmpR and the T3SS.Our data showed that expression of the T3SS genes exoS,exoY,exoT,and exsD was dramatically increased in a pmpR-deletion mutant compared with that in the wild-type P.aeruginosa strain PAO1.Data from DNA mobility assays indicated that PmpR affects the T3SS indirectly.It is unlikely that PmpR controls the T3SS via the Pseudomonas quinolone signal(PQS) because the PQS negatively regulates the T3SS,while pmpR negatively regulates the PQS.The effect of PmpR on the T3SS seems to be independent of the PQS;further investigation is required to uncover the underlying regulatory pathways. | LIANG HaiHua KONG WeiNa SHEN Tuo DUAN JiaLi DUAN KangMin | 2012 | Chinese Science Bulletin2012，57，19： | 4 |
| 7 | Stable Lithium-Carbon Composite Enabled by Dual-Salt Additives显示文摘Lithium metal is regarded as the ultimate negative electrode material for secondary batteries due to its high energy density.However,it suffers from poor cycling stability because of its high reactivity with liquid electrolytes.Therefore,continuous efforts have been put into improving the cycling Coulombic efficiency(CE)to extend the lifespan of the lithium metal negative electrode.Herein,we report that using dual-salt additives of LiPF_(6) and LiNO_(3) in an ether solvent-based electrolyte can significantly improve the cycling stability and rate capability of a Li-carbon(Li-CNT)composite.As a result,an average cycling CE as high as 99.30% was obtained for the Li-CNT at a current density of 2.5 mA cm^(-2) and an negative electrode to positive electrode capacity(N/P)ratio of 2.The cycling stability and rate capability enhancement of the Li-CNT negative electrode could be attributed to the formation of a better solid electrolyte interphase layer that contains both inorganic components and organic polyether.The former component mainly originates from the decomposition of the LiNO_(3) additive,while the latter comes from the LiPF_(6)-induced ring-opening polymerization of the ether solvent.This novel surface chemistry significantly improves the CE of Li negative electrode,revealing its importance for the practical application of lithium metal batteries. | Lei Zheng Feng Guo Tuo Kang Yingzhu Fan Wei Gu Yayun Mao Ya Liu Rong Huang Zhiyun Li Yanbin Shen Wei Lu Liwei Chen | 2021 | Nano-Micro Letters2021，13，7： | 3 |
| 8 | A polyimide cathode with superior stability and rate capability for lithium-ion batteries显示文摘Organic-based electrode materials for lithium-ion batteries (LIBs) are promising due to their high theoretical capacity,structure versatility and environmental benignity.However,the poor intrinsic electric conductivity of most polymers results in slow reaction kinetics and hinders their application as electrode materials for LIBs.A binder-free self-supporting organic electrode with excellent redox kinetics is herein demonstrated via in situ polymerization of a uniform thin polyimide (PI) layer on a porous and highly conductive carbonized nanofiber (CNF) framework.The PI active material in the porous PI@CNF film has large physical contact area with both the CNF and the electrolyte thus obtains superior electronic and ionic conduction.As a result,the PI@CNF cathode exhibits a discharge capacity of 170 mAh·g^-1 at 1 C (175 mA·g^-1),remarkable rate-performance (70.5% of 0.5 C capacity can be obtained at a 100 C discharge rate),and superior cycling stability with 81.3% capacity retention after 1,000 cycles at 1 C.Last but not least,a four-electron transfer redox process of the PI polymer was realized for the first time thanks to the excellent redox kinetics of the PI@CNF electrode,showing a discharge capacity exceeding 300 mAh·g^-1 at a current of 175 mA·g^-1. | Jianghui Zhao Tuo Kang Yanli Chu Peng Chen Feng Jin Yanbin Shen Liwei Chen | 2019 | Nano Research2019，12，6： | 3 |
| 9 | Long-term variations of X-ray pulse profiles for the Crab pulsar:data analysis and modeling显示文摘The pulse profiles of the Crab pulsar(as well as some other pulsars)vary with time.They can lead to a major source of intrinsic timing noise,which lacks a detailed physical model.The phase separation?between the first left peak(P1)and the second right peak(P2)is a key parameter that shows the variations of pulse profiles for the Crab pulsar.It was found that the evolution of?has a tendency with increasing rates of 0.82?±0.25?,0.80?±0.54?,and 0.77?±0.28?per century for the 2-6,6-15,and15-60 ke V bands,respectively.Furthermore,the flux ratios(P2/P1)of X-ray pulse profiles in the three bands were calculated,and the derived flux ratios were consistent with the radio and X-ray measurements of the Insight-HXMT.In addition to discovering the physical origin of the pulse changes,the high-SNR X-ray pulse profiles were simulated in the annular gap model,and two model parameters(e.g.,the maximum emission heights of the two peaks)were observed to slightly affect the variations of peak separation.We fitted the long-term variations of emission heights of the two peaks and discovered that the emission heights showed increasing tendencies with time.Variations of these emission heights induced a characteristic period derivative,and a complete formula for both the magnetic dipole radiation and wind-particle-induced variations of the moment of inertia was used for the pulsar’s spin-down to obtain the variation rate˙αof the magnetic inclination angle,which was-1.60?per century.Intrinsic timing noise is observed to be mainly induced by the variations of pulse profiles,which might correlate with a characteristic spin period derivative arising from the fluctuations of the emission regions.This work will lay a foundation for understanding the origin of intrinsic timing noise and making high-precision timing models in the future. | LunHua Shang YuanJie Du XiangQun Cui ShiJun Dang JiGuang Lu JunTao Bai QiJun Zhi YouLi Tuo LinLi Yan LiangWei Huang XinYuan Zhang XiaoMin Bei QingQing Lin GuoJun Qiao Hua Shen RiHong Zhu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 2 |
| 10 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 11 | An efficient papaya leaf distortion mosaic potyvirus vector for virus-induced gene silencing in papaya显示文摘Papaya(Carica papaya L.)is regarded as an excellent model for genomic studies of tropical trees because of its short generation time and its small genome that has been sequenced.However,functional genomic studies in papaya depend on laborious genetic transformations because no rapid tools exist for this species.Here,we developed a highly efficient virus-induced gene silencing(VIGS)vector for use in papaya by modifying an artificially attenuated infectious clone of papaya leaf distortion mosaic virus(PLDMV;genus:Potyvirus),PLDMV-E,into a stable Nimble Cloning(NC)-based PLDMV vector,pPLDMV-NC,in Escherichia coli.The target fragments for gene silencing can easily be cloned into pPLDMV-NC without multiple digestion and ligation steps.Using this PLDMV VIGS system,we silenced and characterized five endogenous genes in papaya,including two common VIGS marker genes,namely,phytoene desaturase,Mg-chelatase H subunit,putative GIBBERELLIN(GA)-INSENSITIVE DWARF1A and 1B encoding GA receptors;and the cytochrome P450 gene CYP83B1,which encodes a key enzyme involved in benzylglucosinolate biosynthesis.The results demonstrate that our newly developed PLDMV VIGS vector is a rapid and convenient tool for functional genomic studies in papaya. | Decai Tuo Pu Yan Guangyuan Zhao Hongguang Cui Guopeng Zhu Yang Liu Xiukun Yang He Wang Xiaoying Li Wentao Shen Peng Zhou | 2021 | Horticulture Research2021，8，1： | 2 |
| 12 | Early activated hepatic stellate cell-derived molecules reverse acute hepatic injury显示文摘AIM: To test whether hepatic stellate cells(HSCs) at different activation stages play different roles in acetaminophen(APAP)-induced acute liver injury(ALI).METHODS: HSCs were isolated from mouse liver and cultured in vitro.Morphological changes of initiation HSCs [HSCs(5d)] and perpetuation HSCs [HSCs(p3)] were observed by immunofluorescence and transmission electron microscopy.The protective effects of HSCderived molecules, cell lysates and HSC-conditioned medium(HSC-CM) were tested in vivo by survival and histopathological analyses.Liver injury was determined by measuring aminotransferase levels in the serum and by histologic examination of tissue sections under a light microscope.Additionally, to determine the molecular mediators of the observed protective effects of initiation HSCs, we examined HSC-CM using a highdensity protein array.RESULTS: HSCs(5d) and HSCs(p3) had different morphological and phenotypic traits.HSCs(5d) presented a star-shaped appearance with expressing α-SMA at non-uniform levels between cells.However, HSCs(p3) evolved into myofibroblast-like cells without lipid droplets and expressed a uniform and higher level of α-SMA.HSC-CM(5d), but not HSC-CM(p3), provided a significant survival benefit and showed a dramatic reduction of hepatocellular necrosis and panlobular leukocyte infiltrates in mice exposed to APAP.However, this protective effect was abrogated at higher cell masses, indicating a therapeutic window of effectiveness.Furthermore, the protein array screenrevealed that HSC-CM(5d) was composed of many chemokines and growth factors that correlated with inflammatory inhibition and therapeutic activity.When compared with HSC-CM(p3), higher levels of monocyte chemoattractant protein-1, macrophage inflammatory protein-1γ, hepatocyte growth factor, interleukin-10, and matrix metalloproteinase-2, but lower levels of stem cell factor and Fas-Ligand were observed in HSCCM(5d).CONCLUSION: These data indicated that initiation HSCs and perpetuation HSCs were different in morphology and protein expression, and provided the first experimental evidence of the potential medical value of initiation HSC-derived molecules in the treatment of ALI. | Wen-Ju Chang Lu-Jun Song Tuo Yi Kun-Tang Shen Hong-Shan Wang Xiao-Dong Gao Min Li Jian-Min Xu Wei-Xin Niu Xin-Yu Qin | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 13 | Highly stable lithium anode enabled by self-assembled monolayer of dihexadecanoalkyl phosphate显示文摘Li has been considered as the ultimate anode material for high energy density secondary Li batteries.However,its practical application has been limited due to its low Coulombic efficiency(CE)and the formation of lithium dendrites.Recently,we have developed a microspherical Li-carbon nanotube(Li-CNT)composite material passivated with octadecylphosphonic acid(OPA)self-assembled monolayer(SAM)exhibiting suppressed lithium dendrite formation and improved environmental/electrochemical stability.In this work,we demonstrated the significantly enhanced passivation effects of a SAM using dihexadecanoalkyl phosphate(DHP),a molecule that is comprised of double hydrophobic alkyl chains and forms a denser SAM on surfaces with large curvature.As a result,the DHP SAM delivers superior environmental and electrochemical stability to the OPA passivated Li-CNT material.In specific,the DHP passivated Li-CNT composite(DHP-Li-CNT)delivers a high CE of 99.25%under a 33.3%depth of discharge(DOD)at 1 C,when it is paired with a LiFePO4 cathode.The evolution of the SAM during cycling and the effects of DOD and current density on the CE of the DHP-Li-CNT anode have also been investigated.The improved SAM passivation constitutes an important step in achieving the goal of practically applicable Li anodes. | Lei Zheng Feng Guo Tuo Kang Jin Yang Ya Liu Wei Gu Yanfei Zhao Hongzhen Lin Yanbin Shen Wei Lu Liwei Chen | 2020 | Nano Research2020，13，5： | 1 |
| 14 | Dietary fat intake and liver cancer risk: A prospective cohort study in Chinese women显示文摘Objective:This study aimed to determine whether dietary fat intake increased liver cancer risk in Chinese women from a prospective population-based cohort.Methods:A total of 72,704 Chinese women were followed up from the time of baseline recruitment(1996–2000)to the end of 2016.Dietary fat intake was calculated using a validated food frequency questionnaire.The Cox regression model was used to assess the hazard ratio(HR)and 95%confidence intervals(CI)for dietary fat intake and liver cancer risk.Results:We identified 252 incident liver cancer cases out of 1,267,845 person-years during the overall follow-up time.Null associations,neither in quartiles nor per standard deviation(SD)increment,were detected between liver cancer risk and dietary total fat,fat subtypes and subtype ratios,and food sources.The HR(95%CI)of the 1-SD increment was 1.03(0.90–1.17)for total fat,1.06(0.93–1.20)for saturated fat,1.06(0.93–1.21)for monounsaturated fat,and 1.00(0.89–1.13)for polyunsaturated fat.Similar null associations were observed in stratification analyses according to body mass index and menopausal status.Conclusions:In our prospective cohort study,no significant association was observed in Chinese women between dietary fat and liver cancer risk,and in stratification and sensitivity analyses. | Xiaowei Ji Jing Wang Zhuoying Li Qiuming Shen Jiayi Tuo Jinghao Bi Yuting Tan Honglan Li Yongbing Xiang | 2022 | Cancer Biology & Medicine2022，19，3： | 1 |
| 15 | Multiple Data Sources Reveal a New Asian Leaf Litter Toad of Leptobrachella Smith, 1925 (Anura, Megophryidae) from Southwestern China显示文摘A new species of Leptobrachella is described from Sichuan Province and Chongqing Municipality,China.Molecular phylogenetic analyses based on mitochondrial and nuclear gene sequences indicated that the new species is genetically divergent from its congeners.It could be identified from its congeners by a combination of followings characters:body size of male 29.1-34.1 mm(n=14),female 34.1-34.9 mm(n=4);dorsal skin rough with large tubercles in size of humeral glands,without conical spines;fringes on toes narrow;ventral body basically floral white with deep grey pigments all over;dorsal body deep greyish brown with smoky black markings;iris gold above,gradually silver bellow;tibia-tarsal articulation reaches the level of the middle of the eye when leg being stretched forward;the main call type with dominant frequency4.08 ± 0.16 kHz(14.1-14.9℃),call duration 170.35± 15.19ms,the number of pulses for the first note in a call 3.50±0.89,and the number of pulses for the second note in a call 5.08±0.77. | Shengchao SHI Tuo SHEN Xin WANG Jianping JIANG Bin WANG | 2023 | Asian Herpetological Research2023，14，1： | 1 |
| 16 | The histone methyltransferase SUVR2 promotes DSB repair via chromatin remodeling and liquidliquid phase separation显示文摘Maintaining genomic integrity and stability is particularly important for stem cells,which are at the top of the cell lineage origin.Here,we discovered that the plant-specific histone methyltransferase SUVR2 maintains the genome integrity of the root tip stem cells through chromatin remodeling and liquid-liquid phase separation(LLPS)when facing DNA double-strand breaks(DSBs).The histone methyltransferase SUVR2(MtSUVR2)has histone methyltransferase activity and catalyzes the conversion of histone H3 lysine 9 monomethylation(H3K9me1)to H3K9me2/3 in vitro and in Medicago truncatula.Under DNA damage,the proportion of heterochromatin decreased and the level of DSB damage marker y-H2AX increased in suvr2 mutants,indicating that MtSUVR2 promotes the compaction of the chromatin structure through H3K9 methylation modification to protect DNA from damage.Interestingly,MtSUVR2 was induced by DSBs to phase separate and form droplets to localize at the damage sites,and this was confirmed by immunofluorescence and fluorescence recovery after photobleaching experiments.The IDR1 and lowcomplexity domain regions of MtSUVR2 determined its phase separation in the nucleus,whereas the IDR2 region determined the interaction with the homologous recombinase MtRAD51.Furthermore,we found that MtSUVR2 drove the phase separation of MtRAD51 to form'DNA repair bodies,'which could enhance the stability of MtRAD51 proteins to facilitate error-free homologous recombination repair of stem cells.Taken together,our study reveals that chromatin remodeling-associated proteins participate in DNA repair through LLPS. | Qianwen Liu Peng Liu Tuo Ji Lihua Zheng Chen Shen Shasha Ran Jinling Liu Yafei Zhao Yiding Niu Tao Wang Jiangli Dong | 2022 | Molecular Plant2022，15，7： | 1 |
| 17 | Detection of Papaya leaf distortion mosaic virus by 'reverse-transcription loop-mediated isothermal amplification显示文摘 | Shen W Tuo D Yan P | 2014 | Janmal of Virological Methods2014，195，： | 1 |
| 18 | Reverse transcription loop- mediated isothermal amplification assay for rapid detection of Papaya ringspot virus显示文摘 | W Shen D Tuo P Yah Y | 2014 | Journal of Virological Methods2014，204，： | 1 |
| 19 | Global pattern and trend of liver cancer survival: a systematic review of population-based studies显示文摘Aim:To describe the global pattern and trend of liver cancer survival,using data from the population-based studies or cancer registration.Methods:By searching CNKI,Wanfang Data,PubMed,Web of Science,EMBASE and SEER.All population-based survival studies of liver cancer from 1 January 2000 to 30 April 2020 were collected and evaluated by patient gender,time period,and country.The overall or age-standardized five-year relative survival rate was used to describe the pattern and changes in liver cancer survival over the past decades.Results:Globally,the highest age-standardized five-year relative survival rate was observed in Italy(18.0%,2005-2007)and the highest overall five-year relative survival rate was observed in Korea(34.6%,2012-2016),when compared to other countries.The most remarkable increase in overall five-year relative survival rate can be seen in Korea(from 10.7%during 1993-1995 to 34.6%during 2012-2016).In general,worldwide,the five-year relative survival rate of younger patients with liver cancer was higher than old people.For most countries,the five-year relative survival rate of liver cancer was slightly higher in women than in men.In China,the overall five-year relative survival rate of liver cancer in Taiwan was higher than that in other areas,while Cixian of Hebei and Qidong of Jiangsu were lower.Conclusion:Over the past decades,the survival rates of liver cancer have gradually improved,but great variations are also observed globally.Worldwide,younger patients with liver cancer have experienced a better prognosis.Gender disparity in liver cancer survival was not obvious. | Yu-Fei Jiang Zhuo-Ying Li Xiao-Wei Ji Qiu-Ming Shen Jia-Yi Tuo Hui-Yun Yuan Yong-Bing Xiang | 2020 | Hepatoma Research2020，6，8： | 1 |
| 20 | Exacerbationof retinal degeneration and choroidal neovascularization bysubretinal injection of Matrigel in CCL2/MCP-1-deficient mice 显示文摘 | Shen D Wen R Tuo J Bojanowski CM Chan CC | 2006 | Ophthal Res2006，38，： | 1 |
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