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| 1 | FAM83D inhibits autophagy and promotes proliferation and invasion of ovarian cancer cells via PI3K/AKT/mTOR pathway显示文摘Ovarian cancer is one of the most lethal malignant tumors in women.The family with sequence similarity 83,member D(FAM83D)plays an important role in several cancers,but its function and underlying mechanism in ovarian cancer remain unknown.To investigate the role of FAM83D in ovarian cancer,the expression of FAM83D was determined by immunohistochemistry in tissue microarray slide.Cellular proliferation and invasion were detected by 5-Ethynyl-2′-deoxyuridine assays and transwell invasion assays.The correlations between FAM83D and autophagy were detected by western blot analysis and confocal microscopy.Western blot analysis was used to identify the protein expression of FAM83D,phosphoinositide 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR)and Sequestosome 1(P62).Tumorigenesis in nude mice was used to explore the function of FAM83D in vivo.We found high expression level of FAM83D in ovarian cancer tissues as compared to the normal ovarian tissues.Knockdown of FAM83D in SKOV3 cells enhanced autophagy and inhibited the proliferation and invasion in vitro,whereas ectopic expression of FAM83D in A2780 cells exerted an opposite effect.Mechanistically,overexpression of FAM83D activated the PI3K/AKT/mTOR pathway,and Torin1 could suppress FAM83D-induced cell proliferation and invasion.In vivo,overexpression FAM83D promoted tumor growth.Overall,FAM83D promoted ovarian cancer cell invasion and proliferation,while inhibited autophagy via the PI3K/AKT/mTOR signaling pathway.Our results suggest that FAM83D may be a candidate oncogene in ovarian cancer,which provides a fresh perspective of FAM83D in ovarian cancer. | Hongtao Zhu Shuai Diao Vincent Lim Lina Hu Jianguo Hu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 11 |
| 2 | 血栓弹力图在产后出血中的临床应用显示文摘产后出血是导致产妇死亡的主要原因之一,迅速和合适的管理是改善结局的基础。血栓弹力图是一种能对凝血和纤溶过程进行全面及动态评估的方法,其用图表的形式反应了凝血过程中所有成分的相互作用。近年来有研究表明血栓弹力图相比传统实验室检测方法更利于产后出血的全面评估及指导治疗决策的制定。该研究简要综述了血栓弹力图的检测方法及其在产后出血中的临床应用。 | 杨倩 Vincent Lim 董晓静 | 2015 | 中外医疗2015，34，15： | 8 |
| 3 | 心理咨询在不孕女性中的运用显示文摘目前不孕症发病率呈上升趋势,随着对疾病的进一步认识,心理健康在不孕患者诊治中有着不可忽视的作用。精神心理因素不仅影响患者的生活质量和身体健康状况,还可能影响不孕症妇女辅助生殖治疗的疗效。心理咨询在不孕女性中运用的有效性及其意义存在一定争议。本文对于接受辅助生殖助孕的不孕女性进行心理咨询后对妊娠结局及心理健康情况的影响进行综述。 | 钟晓翠 董晓静 Vincent Lim 刘丽 | 2017 | 重庆医科大学学报2017，42，4： | 6 |
| 4 | 泛素E3连接酶MARCH5对子宫颈癌细胞增殖、侵袭和迁移的影响显示文摘目的 探讨泛素E3连接酶膜相关锌指蛋白5 (membrane-associated RING-CH 5,MARCH5)在子宫颈癌组织中的表达、功能以及潜在机制。方法 用免疫组织化学检测泛素E3连接酶MARCH5在宫颈癌组织中的表达,EdU、Transwell实验和划痕实验检测沉默泛素E3连接酶MARCH5后,宫颈癌细胞增殖、侵袭和迁移能力变化情况,Western blot检测宫颈癌HeLa细胞株沉默MARCH5基因后Drp1、Bax、MARCH5、PGAM的表达情况。使用Mito Tracker Green标记线粒体,然后使用免疫荧光检测MARCH5与线粒体的共定位。结果 在宫颈癌组织中MARCH5的表达明显较正常宫颈组织高,且MARCH5的表达与宫颈癌的分级有关(P 〈0. 01),与年龄和分期无关(P〉 0. 05)。沉默MARCH5后,HeLa细胞的增殖、侵袭和迁移能力降低(P 〈0. 05)。沉默MARCH5后,Drp1表达下调,PGAM5和Bax表达上调(P 〈0. 05)。结论 MARCH5在宫颈癌组织中表达上调,是宫颈癌候选癌基因,也是宫颈癌治疗的一个潜在靶点。 | 刁帅 胡丽娜 朱宏涛 Vincent Lim 胡建国 | 2018 | 第三军医大学学报2018，40，22： | 3 |
| 5 | 婴儿过敏性疾病早期预防的研究进展显示文摘随着社会经济的发展、饮食结构的改变及环境因素、遗传因素等的影响,在全球范围内婴儿期过敏性疾病的发病率越来越高,严重影响婴幼儿的生活质量,危害其健康[1]。近20年来,据WHO统计,过敏性疾病已跃居全球疾病的第6位,其发病率仍呈逐年上升趋势,全球约30%的2岁以下儿童患有或曾发生过湿疹[2]。在婴幼儿期,过敏性疾病对其生活造成严重影响,表现为反复的皮肤损害(如湿疹)、瘙痒、呼吸系统症状(如哮喘、鼻炎、流涕等)、胃肠道症状(如腹泻、便秘、便血等)及睡眠障碍等。 | 李霞 Vincent Lim 董晓静 | 2015 | 现代医药卫生2015，31，16： | 2 |
| 6 | FRP-confined concrete in circular sections: Review and assessment of stress–strain models显示文摘 | Togay Ozbakkaloglu Jian C. Lim Thomas Vincent | 2012 | Engineering Structures2012，，： | 1 |
| 7 | EGFL7 Is Expressed in Bone Microenvironment and Promotes Angiogenesis via ERK, STAT3, and Integrin Signaling Cascades显示文摘 | Shek Man Chim Vincent Kuek Siu To Chow Bay Sie Lim Jennifer Tickner Jinmin Zhao Rosa Chung Yu‐Wen Su Ge Zhang Wendy Erber Cory J. Xian Vicki Rosen Jiake Xu | 2015 | Physiol2015，，1： | 1 |
| 8 | FRP-confined concrete in circular sections: Review and assessment of stress–strain models显示文摘 | Togay Ozbakkaloglu Jian C. Lim Thomas Vincent | 2012 | Engineering Structures2012，，： | 1 |
| 9 | In vivo optical imaging in arthritis: an enlightening future 显示文摘 | Compels LL Lim NH Vincent T | 2010 | Rheumatology2010，49，8： | 1 |
| 10 | Prevalence of Dengue Maculopathy in Patients Hospitalized for Dengue Fever显示文摘 | Daniel Hsien-Wen Su Kristine Bacsal Soon-Phaik Chee John Vincent Policarpio Flores Wee-Kiak Lim Bobby Ching-Li Cheng Aliza Hee-Eng Jap | 2007 | Ophthalmology2007，，9： | 1 |
| 11 | Properties of a vector soliton laser passively mode-locked by a fiber-based semiconductor saturable absorber operating in transmission显示文摘 | Chunmei Ouyang Honghai Wang Ping Shum Songnian Fu Jia Haur Wong Kan Wu Desmond Rodney Chin Siong Lim Vincent Kwok Huei Wong Kenneth Eng Kian Lee | 2010 | Optics Communications2010，，2： | 1 |
| 12 | The use of PET in assessing tumor response after neoadjuvant chemoradiation for rectal cancer显示文摘 | Daisy Mak Daryl Lim Joon Michael Chao Morikatsu Wada Michael Lim Joon Andrew See Malcolm Feigen Patricia Jenkins Angelina Mercuri Joanne McNamara Aurora Poon Vincent Khoo | 2010 | Radiotherapy and Oncology2010，，2： | 1 |
| 13 | FRP-confined concrete in circular sections: Review and assessment of stress-strain models 显示文摘 | Ozbakkaloglu T Lim J C Vincent T | 2013 | Eng Strnct2013，49，： | 1 |
| 14 | The effect of comorbidity and age on hospital mortality and length of stay in patients with sepsis显示文摘 | Yong Yang Kok Soong Yang Yin Maw Hsann Vincent Lim Biauw Chi Ong | 2010 | Journal of Critical Care2010，，： | 1 |
| 15 | FRP-confined concrete in circular sections: review and assessment of stress-strain models 显示文摘 | OZBAKKALOGLU T LIM J C VINCENT T | 2013 | Engineering Structures2013，49，： | 1 |
| 16 | CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors显示文摘 | Wei Mo Jian Chen Amish Patel Liang Zhang Vincent Chau Yanjiao Li Woosung Cho Kyun Lim Jing Xu Alexander J. Lazar Chad J. Creighton Svetlana Bolshakov Renée M. McKay Dina Lev Lu Q. Le Luis F. Parada | 2013 | Cell2013，，： | 1 |
| 17 | 办公室的午后时光Media Arts Lab上海办公室显示文摘在静安区胶州路武定路路口有一座上世纪的红色砖瓦老建筑,在茂密的梧桐树掩映下愈显其独特的老上海风情.本案就位于这栋老建筑的4楼.作为Apple唯一的广告合作公司,Media Arts Lab(以下简称Mal)对于办公空间设计的要求,跟Ap-ple产品的精神一样:“我要做得更好.” | lim chan(设计/摄影) 小麦(整理) Yummy Yu Cecilia Jiang Danny Deng Steven Wang Vincent Xie 无 | 2016 | 室内设计与装修2016，0，7： | 0 |
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