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| 1 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 2 | Multi-scale HPC system for multi-scale discrete simulation—Development and application of a supercomputer with 1 Petaflops peak performance in single precision显示文摘A supercomputer with 1.0 Petaflops peak performance in single precision,designed and established by Institute of Process Engineering,Chinese Academy of Sciences,is introduced in this brief communication.A designing philosophy utilizing the similarity between hardware,software and the problems to be solved is embodied,based on the multi-scale method and discrete simulation approaches developed at Institute of Process Engineering(IPE)and implemented in a graphic processing unit(GPU)-based hybrid computing mode.The preliminary applications of this machine in areas of multi-phase flow,molecular dynamics and so on are reported,demonstrating the supercomputer as a paradigm of green computation in new architecture. | Feiguo Chen Wei Ge Li Guo Xianfeng He Bo Li Jinghai Li Xipeng Li Xiaowei Wang Xiaolong Yuan | 2009 | Particuology2009，7，4： | 19 |
| 3 | Quasi-real-time simulation of rotating drum using discrete element method with parallel GPU computing显示文摘Real-time simulation of industrial equipment is a huge challenge nowadays. The high performance and fine-grained parallel computing provided by graphics processing units (GPUs) bring us closer to our goals. In this article, an industrial-scale rotating drum is simulated using simplified discrete element method (DEM) without consideration of the tangential components of contact force and particle rotation. A single GPU is used first to simulate a small model system with about 8000 particles in realtime, and the simulation is then scaled up to industrial scale using more than 200 GPUs in a 1D domain-decomposition parallelization mode. The overall speed is about 1/11 of the real-time. Optimization of the communication part of the parallel GPU codes can speed up the simulation further, indicating that such real-time simulations have not only methodological but also industrial implications in the near future. | Ji Xu Huabiao Oi Xiaojian Fang Liqiang Lu Wei Ge Xiaowei Wang Ming xu Feiguo Chen xianfeng He Jinghai Li | 2011 | Particuology2011，9，4： | 16 |
| 4 | Sedimentary fill history of the Huicheng Basin in the West Qinling Mountains and associated constraints on Mesozoic intracontinental tectonic evolution显示文摘The Qinling Orogenic Belt is divided commonly by the Fengxian-Taibai strike-slip shear zone and the Huicheng Basin into the East and West Qinling mountains,which show significant geological differences after the Indosinian orogeny.The Fengxian-Taibai fault zone and the Meso-Cenozoic Huicheng Basin,situated at the boundary of the East and West Qinling,provide a natural laboratory for tectonic analysis and sedimentological study of intracontinental tectonic evolution of the Qinling Orogenic Belt.In order to explain the dynamic development of the Huicheng Basin and elucidate its post-orogenic tectonic evolution at the junction of the East and West Qinling,we studied the geometry and kinematics of fault zones between the blocks of West Qinling,as well as the sedimentary fill history of the Huicheng Basin.First,we found that after the collisional orogeny in the Late Triassic,post-orogenic extensional collapse occurred in the Early and Middle Jurassic within the Qinling Orogenic Belt,resulting in a series of rift basins.Second,in the Late Jurassic and Early Cretaceous,a NE-SW compressive stress field caused large-scale sinistral strike-slip faults in the Qinling Orogenic Belt,causing intracontinental escape tectonics at the junction of the East and West Qinling,including eastward finite escape of the East Qinling micro-plate and southwest lateral escape of the Bikou Terrane.Meanwhile,the strike-slip-related Early Cretaceous sedimentary basin was formed with a right-order echelon arrangement in sinistral shear zones along the southern margin of the Huicheng fault.Overall during the Mesozoic,the Huicheng Basin and surrounding areas experienced four tectonic evolutionary stages,including extensional rift basin development in the Early and Middle Jurassic,intense compressive uplift in the Late Jurassic,formation of a strike-slip extensional basin in the Early Cretaceous,and compressive uplift in the Late Cretaceous. | LI Wei DONG YunPeng GUO AnLin LIU XiaoMing LIU YiQun ZHA XianFeng ZHANG KuaiLe | 2013 | Science China Earth Sciences2013，56，10： | 7 |
| 5 | Efficient parallel implementation of the lattice Boltzmann method on large clusters of graphic processing units显示文摘Many-core processors, such as graphic processing units (GPUs), are promising platforms for intrinsic parallel algorithms such as the lattice Boltzmann method (LBM). Although tremendous speedup has been obtained on a single GPU compared with mainstream CPUs, the performance of the LBM for multiple GPUs has not been studied extensively and systematically. In this article, we carry out LBM simulation on a GPU cluster with many nodes, each having multiple Fermi GPUs. Asynchronous execution with CUDA stream functions, OpenMP and non-blocking MPI communication are incorporated to improve efficiency. The algorithm is tested for two-dimensional Couette flow and the results are in good agreement with the analytical solution. For both the oneand two-dimensional decomposition of space, the algorithm performs well as most of the communication time is hidden. Direct numerical simulation of a two-dimensional gas-solid suspension containing more than one million solid particles and one billion gas lattice cells demonstrates the potential of this algorithm in large-scale engineering applications. The algorithm can be directly extended to the three-dimensional decomposition of space and other modeling methods including explicit grid-based methods. | XIONG QinGang LI Bo XU Ji FANG XiaoJian WANG XiaoWei WANG LiMin HE XianFeng GE Wei | 2012 | Chinese Science Bulletin2012，57，7： | 6 |
| 6 | Far-field super-resolution imaging by nonlinearly excited evanescent waves显示文摘Abbe’s resolution limit,one of the best-known physical limitations,poses a great challenge for any wave system in imaging,wave transport,and dynamics.Originally formulated in linear optics,the Abbe limit can be broken using nonlinear optical interactions.We extend the Abbe theory into a nonlinear regime and experimentally demonstrate a far-field,label-free,and scan-free super-resolution imaging technique based on nonlinear four-wave mixing to retrieve near-field scattered evanescent waves,achieving a sub-wavelength resolution ofλ∕5.6.This method paves the way for numerous new applications in biomedical imaging,semiconductor metrology,and photolithography. | Zhihao Zhou Wei Liu Jiajing He Lei Chen Xin Luo Dongyi Shen Jianjun Cao Yaping Dan Xianfeng Chen Wenjie Wan | 2021 | Advanced Photonics2021，3，2： | 6 |
| 7 | Application of the Mole-8.5 supercomputer:Probing the whole influenza virion at the atomic level显示文摘Discrete computer simulations are quite helpful in understanding dynamic structures in complex systems.Recently,using the Mole-8.5 supercomputer and molecular dynamics simulations as a'computational microscope',we simulated the dynamic structure of a whole H1N1 influenza virion in solution for the first time at the atomic level.In total,300 million atoms in a periodic cube with an edge length of 148.5 nm were simulated.Using 288 low level hybrids with 1728 C2050 GPUs and a software package developed specifically for the hardware,the simulation executed 770 ps/d with an integration time step of 1 fs,and analyzed the dynamic structure.With the tremendous computational power of GPUs,efficient software packages for various hardware designs,and consistent physical models,more challenging applications will be carried out in the near future. | XU Ji WANG XiaoWei HE XianFeng REN Ying GE Wei LI JingHai | 2011 | Chinese Science Bulletin2011，56，20： | 5 |
| 8 | Concurrent optimization of structural topology and infill properties with a CBF-based level set method显示文摘In this paper,a parametric level-set-based topology optimization framework is proposed to concurrently optimize the structural topology at the macroscale and the effective infill properties at the micro/meso scale.The concurrent optimization is achieved by a computational framework combining a new parametric level set approach with mathematical programming.Within the proposed framework,both the structural boundary evolution and the effective infill property optimization can be driven by mathematical programming,which is more advantageous compared with the conventional partial differential equatiodriven level set approach.Moreover,the proposed approach will be more efficient in handling nonlinear problems with multiple constraints.Instead of using radial basis functions(RBF),in this paper,we propose to construct a new type of cardinal basis functions(CBF)for the level set function parameterization.The proposed CBF parameterization ensures an explicit impose of the lower and upper bounds of the design variables.This overcomes the intrinsic disadvantage of the conventional RBF-based parametric level set method,where the lower and upper bounds of the design variables oftentimes have to be set by trial and error;A variational distance regularization method is utilized in this research to regularize the level set function to be a desired distanceregularized shape.With the distance information embedded in the level set model,the wrapping boundary layer and the interior infill region can be naturally defined.The isotropic infill achieved via the mesoscale topology optimization is conformally fit into the wrapping boundary layer using the shape-preserving conformal mapping method,which leads to a hierarchical physical structure with optimized overall topology and effective infill properties.The proposed method is expected to provide a timely solution to the increasing demand for multiscale and multifunctional structure design. | Long JIANG Yang GUO Shikui CHEN Peng WEI Na LEI Xianfeng David GU | 2019 | Frontiers of Mechanical Engineering2019，14，2： | 3 |
| 9 | Rapid growth of well-aligned carbon nanotube arrays显示文摘 | Xianfeng Zhang Anyuan Cao Bingqing Wei Yanhui Li Jinquan Wei Cailu Xu Dehai Wu | 2002 | Chemical Physics Letters2002，，3： | 2 |
| 10 | Highly sensitive integrated flexible tactile sensors with piezoresistive Ge2Sb2Te5 thin films显示文摘Flexible tactile sensor has been extensively investigated as a key component for emerging electronics applications such as robotics,wearable devices,computer hardware,and security systems.Tactile sensors based on various one-dimensional materials have been widely explored.However,precise control of the direction and distribution of these nanomaterials remains a great challenge,and it has been difficult to scale down the device.Here,we introduce highly sensitive integrated flexible tactile sensors based on uniform phase-change Ge_(2)Sb_(2)Te_(5)(GST)thin films that can scale device size down,at least,to micrometer range.Significant piezoresistive effect has been observed in GST-based sensors,showing a giant gauge factor of 338.A proof of concept 5×5 sensor array functioning as a touch panel has been demonstrated.Also,the flexible GST tactile sensor has been utilized for monitoring of radial artery pulse.In addition to the well-known tunable electrical and optical properties,the piezoresistive GST films provide a versatile platform for the integration of sensing,recording,and displaying functions. | Zhiguang Wang Cunzheng Dong Xinjun Wang Menghui Li Tianxiang Nan Xianfeng Liang Huaihao Chen Yuyi Wei Haomiao Zhou Mohsen Zaeimbashi Syd Cash Nian-Xiang Sun | 2018 | npj Flexible Electronics2018，2，1： | 2 |
| 11 | 多西他赛联合同步放疗治疗晚期鼻咽癌的临床研究(英文)显示文摘Objective:The aim of this study was to study the short-term curative effects and adverse reactions of docetaxel(DOC) in concurrent chemoradiotherapy compared to DDP plus 5-Fu(DF) combined with concurrent radiotherapy in patients with advanced nasopharyngeal carcinoma.Methods:Thirty-three patients in the experimental group(DOC group) were given DOC 25 mg/m 2 ivgtt,d1,7 times,concurrent radiotherapy was performed from d1.Thirty-three patients in the control group(DF group) were given cisplatin 25 mg/m 2 ivgtt d1–3 and 5-Fu 550 mg/m 2 iv,d1–5,3 weeks a cycle,2 cycles,and concurrent radiotherapy was performed from d1.Six MV X-ray and 9 MeV electronic line for external irradiation were adopted in concurrent radiotherapy.Results:The response rates of DOC group and DF group were 90.9% and 93.9%,the rates of neutropenia were 45.45% and 67.74%,and the rates of oral mucositis were 60.61% and 90.32%.Conclusion:The difference of shortterm curative effects between DOC group and DF group was not statistically significant in patients with advanced nasopharyngeal carcinoma.The rates of adverse reactions were lower in DOC group.DOC combined with concurrent radiotherapy could be a new choice for patients with advanced nasopharyngeal carcinoma. | Wei Luo Wei Ge Yongfa Zheng Xianfeng Pan Jing Song Huilin Xu Pingpo Ming | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，12： | 2 |
| 12 | Involvement of levels of Toll like receptor-4 in monocytes, CD4+ T-lymphocyte subsets, and cytokines in patients with immune thrombocytopenic purpura显示文摘 | Hongyun Liu Xianfeng Ouyang Yiqing Li Hua Zeng Xiuju Wang Shuangfeng Xie Danian Nie Jie Xiao Jing Wei Yudan Wu Songmei Yin Liping Ma | 2013 | Thrombosis Research2013，，： | 2 |
| 13 | A novel (W-Al)-C-Co composite cemented carbide prepared by mechanical alloying and hot-pressing sintering显示文摘 | QIAO Zhuhui MA Xianfeng ZHAO Wei | 2008 | International Journal of Refractory Metals and Hard Materials2008，26，3： | 1 |
| 14 | A practical method of modeling and simulation for drill fluting显示文摘 | ZHANG Wei WANG Xianfeng HE Fenghao | | 0，，06： | 1 |
| 15 | A practical method of modelling and simulation for drill fluting显示文摘 | ZHANG Wei WANG Xianfeng HE Fengbao | 2006 | International Journal of Machine Tools and Manufacture2006，46，6： | 1 |
| 16 | MicroRNA‐103a inhibits gastric cancer cell proliferation, migration and invasion by targeting c‐Myb显示文摘 | Jinlong Liang Xianfeng Liu Hongpeng Xue Bing Qiu Bin Wei Kan Sun | 2015 | Cell Prolif2015，，1： | 1 |
| 17 | Nonlinear thermal emission and visible thermometry显示文摘The control of thermal emission is of great importance for emerging applications in energy conversion and thermometric sensing.Usually,thermal emission at ambient temperature is limited to the midto far-infrared,according to the linear theory of Planck’s law.We experimentally demonstrate a broadband nonlinear thermal emission in the visible-NIR spectrum within a quadradic nonlinear medium,which emits visible thermal radiation through a pump-driven nonlinear upconversion from its mid-IR components even at room temperature,unlike its linear counterpart which requires ultrahigh temperature.The broadband emission is enabled by the crucial random quasi-phase-matching condition in our nonlinear nanocrystal powders.Moreover,nonlinear thermal emission also permits visible thermometry using traditional optical cameras instead of thermal ones.This scheme paves the way to understand thermal radiation dynamics with nonlinearity in many fields,such as nonlinear heat transfer and nonlinear thermodynamics. | Zhihao Zhou Wei Liu Hengzhe Yan Xianfeng Chen Wenjie Wan | 2022 | Advanced Photonics2022，4，4： | 1 |
| 18 | High Temperature Crystallization of Free‐Standing Anatase TiO2 Nanotube Membranes for High Efficiency Dye‐Sensitized Solar Cells显示文摘 | Jia Lin Min Guo Cho Tung Yip Wei Lu Guoge Zhang Xiaolin Liu Limin Zhou Xianfeng Chen Haitao Huang | 2013 | Mater2013，，47： | 1 |
| 19 | First human-caused extinction of a cetacean species?显示文摘 | Turvey Samuel T Pitman Robert L Taylor Barbara L Barlow Jay Akamatsu Tomonari Barrett Leigh A Zhao Xiujiang Reeves Randall R Stewart Brent S Wang Kexiong Wei Zhuo Zhang Xianfeng Pusser L.T Richlen Michael Brandon John R Wang Ding | 2007 | Biology Letters2007，，5： | 1 |
| 20 | Transforming Growth Factor (TGF)-β-Induced MicroRNA-216a Promotes Acute Pancreatitis Via Akt and TGF-β Pathway in Mice显示文摘 | Jian Zhang Xianfeng Ning Wei Cui Meisheng Bi Dianliang Zhang Jianli Zhang | 2015 | Digestive Diseases and Sciences2015，，1： | 1 |
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