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| 1 | Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells显示文摘 | Zhikun Li Haifeng Wan Guihai Feng Leyun Wang Zhengquan He YukaiWang Xiu-Jie Wang Wei Li Qi Zhou Baoyang Hu | 2016 | Cell Research2016，26，1： | 15 |
| 2 | Features of Tight Sandstone Reservoir and Origin of Tightness:An Example from Chang-7 Member,Triassic Yanchang Formation in Chenghao Area,Ordos Basin显示文摘1 Introduction Permeability of Member-6,Member-7,and Member-8,Triassic Yangchang Formation in Ordos Basin is lower than 1?0-3μm2,so sandstone in those formations are typical tight reservoir(Zhao et al.,2012a,2012b;Yang et al.,2013).Because of the maximum flooding event of Late Triassic during deposition of Chang-7 Member,the lacustrine basin had a wide range of deposition area | ER Chuang ZHAO Jingzhou BAI Yubin WU Weitao ZHANG Jie WEI Zhikun | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 4 |
| 3 | Synergistic engineering of CRISPR-Cas nucleases enables robust mammalian genome editing显示文摘The naturally occurring prokaryotic CRISPR-Cas systems provide valuable resources for the development of new genome-editing tools.However,the majority of prokaryotic Cas nucleases exhibit poor editing efficiency in mammalian cells,which significantly limits their utility.Here,we have developed a method termed Improving Editing Activity by Synergistic Engineering(MIDAS).This method exerts a synergistic effect to improve mammalian genome-editing efficiency of a wide range of CRISPR-Cas systems by enhancing the interactions of Cas nuclease with the protospacer adjacent motif(PAM)and the single-stranded DNA(ssDNA)substrate in the catalytic pocket simultaneously.MIDAS robustly and significantly increased the gene-editing efficiency of Cas12i,Cas12b,and CasX in human cells.Notably,a Cas12i variant,Cas12iMax,exhibited robust activity with a very broad PAM range(NTNN,NNTN,NAAN,and NCAN)and higher efficiency than the current widely used Cas nucleases.A high-fidelity version of Cas12iMax(Cas12iHiFi)has been further engineered to minimize off-target effects.Our work provides an expandable and efficacious method for engineering Cas nucleases for robust mammalian genome editing. | Yangcan Chen Yanping Hu Xinge Wang Shengqiu Luo Ning Yang Yi Chen Zhikun Li Qi Zhou Wei Li | 2022 | The Innovation2022，3，4： | 3 |
| 4 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 5 | The advance in obtaining fault slip rate of strike slip fault-A review显示文摘Slip rate along the major active fault is an important parameter in the quantitative study of active tectonics.It is the average rate of fault slip during a certain period of time,reflecting the rate of strain energy accumulation on the fault zone.It cannot only be directly applied to evaluate the activity of the fault,the probabilistic seismic hazard analysis,but also important basic data for the study of geodynamics.However,due to the nonstandardized process of obtaining fault slip rates for a given strike-slip fault,the results could be diverse based on various methods by different researchers.In this review,we analyzed the main advances in the approaches to obtain fault slip rate.We found that there are four main sources affecting the final results of slip rate:the displacement along the fault,the dating of the corresponding displacement,the fitting of the displacement and corresponding dating results,and paleoslip analysis.The main advances in obtaining fault slip rates are based on improving the reli-ability of the above four main factors.To obtain a more reasonable and reliable slip rate for a given fault,it is necessary to select a suitable method according to the specific situation. | Jinrui Liu Zhikun Ren Wei Min Guanghao Ha Jinghao Lei | 2021 | Earthquake Research Advances2021，1，4： | 2 |
| 6 | Surfactants Mediated Synthesis of Highly Crystalline Thin Films of Imine-Linked Covalent Organic Frameworks on Water Surface显示文摘Imine-linked covalent organic frameworks(COFs)have attracted extensive attention due to designable structures,tunable properties,and excellent thermal and chemical stability.They were typically obtained as insoluble and unprocessable powders,which seriously limits their full promise.Progress has been made in the synthesis of thin films of imine-linked COFs by interfacial synthesis.However,the synthesis of highly crystalline,self-supporting thin films of COFs remains challenging.Here,we employed a surfactants-mediated method to synthesize such films at an air-water interface,showed the films could be transferred onto arbitrary substrates on demand,and demonstrated the generality of the methodology with two different COFs.We found that the length of hydrophobic segments of surfactants played a key role in determination of the crystallinity and single crystalline domain size of the films.This work provides a feasible strategy to generate highly crystalline thin films of COFs. | Zhaowei Ou Zihao Liang Xin Dong Fanglin Tan Li Gong Pei Zhao Honglei Wang Wei Liu Zhikun Zheng | 2021 | Chinese Journal of Chemistry2021，39，12： | 2 |
| 7 | A New Family of Galeaspids(Jawless Stem-Gnathostomata) from the Early Silurian of Chongqing, Southwestern China显示文摘A new genus and species of agnathan Eugaleaspidiformes(Galeaspida), Yongdongaspis littoralis gen. et sp. nov., is described from the Llandovery(lower Silurian) Huixingshao Formation at Yongdong Town, Xiushan County, Chongqing, southwestern China. This new Telychian taxon morphologically exhibits some transitional states between Sinogaleaspidae and a cluster of higher eugaleaspidiforms containing Tridensaspidae, Eugaleaspidae, Yunnanogaleaspis, and Nochelaspis, which we term here as the ’eugaleaspid cluster’. Phylogenetic analysis of an extended character matrix of Galeaspida reveals Yongdongaspis, on which Yongdongaspidae fam. nov. is erected, as the sister taxon of this ’eugaleaspid cluster’, supported by two synapomorphies, the presence of one median transverse canal, and two lateral transverse canals leaving from the infraorbital canal. As the first fish described from the Llandovery Huixingshao Formation in Chongqing, Yongdongaspis provides new fossil evidence for the subdivision and correlation of the Upper Red Beds in South China. | CHEN Yang GAI Zhikun LI Qiang WANG Jianhua PENG Lijian WEI Guangbiao ZHU Min | 2022 | Acta Geologica Sinica(English Edition)2022，96，2： | 2 |
| 8 | Current advances in haploid stem cells显示文摘Diploidy is the typical genomic mode in all mammals.Haploid stem cells are artificial cell lines experimentally derived in vitro in the form of different types of stem cells,which combine the characteristics of haploidy with a broad developmental potential and open the possibility to uncover biological mysteries at a genomic scale.To date,a multitude of haploid stem cell types from mouse,rat,monkey and humans have been derived,as more are in development.They have been applied in high-throughput genetic screens and mammalian assisted reproduction.Here,we review the generation,unique properties and broad applications of these remarkable cells. | Tongtong Cui Zhikun Li Qi Zhou Wei Li | 2020 | Protein & Cell2020，11，1： | 1 |
| 9 | Synthesis of a Highly Crystalline Amide-Linked Covalent Organic Framework显示文摘The dilemma for the synthesis of covalent organic frameworks(COFs)is crystallinity and stability.Herein,we present the synthesis of a single-crystalline amide-linked COF,and demonstrate its excellent chemical as well as thermal stabilities.This study will inspire the synthesis of a wide spectrum of highly crystalline and stable COFs,promote their structure-property investigations and boost their applications in selective gas adsorption,storage and separation. | Yuyao Li Zhipeng Zhou Yuexian Hong Xin Dong Yonghang Yang Zihao Liang Junliang Sun Xudong Chen Wei Liu Zhikun Zheng | 2023 | Chinese Journal of Chemistry2023，41，4： | 1 |
| 10 | 显示文摘 | Wei Feng Li Guieun Zhang Zhikun | 2005 | Mater Res Bull2005，40，： | 1 |
| 11 | Absorption spectra of 4f electron transitions of the neodymium and erbium complexes with benzoyl - indan - 1,3 - dione and cetyltrimethyl- ammonium bromide and its analytical application显示文摘 | NaiXing Wang ZhiKun Si Wei Jiang | 1997 | Spectroehimica Acta Part A1997，53，1997： | 1 |
| 12 | In-situ biotransformation of nitric oxide by functionalized surfaces of cardiovascular stents显示文摘Cardiovascular diseases(CVDs)are among the leading causes of mortality and morbidity worldwide.Nitric oxide(NO)is a signalling molecule that plays a vital role in protecting and regulating cardiovascular function and homeostasis.Despite several successful outcomes of exogenous supplementation of NO for cardiovascular disease therapy,a great challenge lies in controlled and long-term delivery due to the short half-life and instability of NO.Recently,increasing attention has been paid to the in situ conversion of endogenous NO donors catalysed by functional surfaces.Based on bioinspired and biomimicking strategies,a series of surface functionalization methods for cardiovascular stents has been successfully developed.By further combining NO catalysis with other biofunctionalities,improved endothelium healing and long-term patency can be anticipated. | Meng Qian Qi Liu Yan Wei Zhikun Guo Qiang Zhao | 2021 | Bioactive Materials2021，6，5： | 1 |
| 13 | Aqueous Synthesis of Covalent Organic Frameworks as Photocatalysts for Hydrogen Peroxide Production显示文摘Covalent organic frameworks(COFs)are crystalline porous polymers with designable structures and properties.Their crystallization typically relies on trialand-error experimentation involving harsh conditions,including organic solvents,presenting significant obstacles for rational design and large-scale production.Herein,we present a liquid crystal-directed synthesis methodology and its implementation for up to gram-scale production of highly crystalline COFs in water and air.It is compatible with monomers of different structures,shape,size,length of side chains,and electron-donating,electron-accepting,and heterocyclic substitutions near reactive sites.Seventeen types of donor-acceptor two-dimensional COFs including four types of new ones and a three-dimensional COF with a yield of up to 94%were demonstrated,showing great generality of the method.The as-synthesized donor-acceptor COFs are organic semiconductors and contain macropores besides intrinsic mesopores which make them attractive catalysts.The production of H_(2)O_(2)under visible light in water was studied and the structure-property relationships were revealed.The production rate reached 4347μmol h^(−1)gcat^(−1),which is about 467%better than that of the benchmark photocatalyst g-C_(3)N_(4).This study will inspire the mild synthesis and scale-up of a wide spectrum of COFs and organic semiconductors as efficient catalysts,promote their structure-property investigation,and boost their applications. | Fanglin Tan Yuanyuan Zheng Zhipeng Zhou Honglei Wang Xin Dong Jing Yang Zhaowei Ou Haoyuan Qi Wei Liu Zhikun Zheng Xudong Chen | 2022 | CCS Chemistry2022，4，12： | 1 |
| 14 | A new appronch to suppress spillover instability in structural vibration control显示文摘 | Liu Wei Hou Zhikun | 2004 | Strueturnl Control nnd Health Monitoring2004，，： | 1 |
| 15 | Synthesis of Thin Film of a Three-Dimensional Covalent Organic Framework as Anti-counterfeiting Label显示文摘Film plays a key role in the sustainable development of our society.Freestanding thin films of two-dimensional covalent organic frameworks(coFs)have been produced by interface,spin coating,microwave-assisted synthesis,and screen printing methods and are applied in nanofitration,molecular separation,photochemical sensing,anion transport,heat conduction,and proton conduction.On the other hand,the synthesis of their three-dimensional(3D)analogues and subsequent integration in devices remains challenging.Herein,self-supporting thin films of a three-dimensionai COF with tunable thickness was created by a stearic acid mediated synthesis methodology on water surface at room temperature in air.The film could be transferred onto arbitrary substrate,and when supported on indium tin oxide glass,it exhibited irreversible electrochromism.The optical feature made it act as a one-time anti-counterfeiting label in an electrochemical device.This work will inspire the synthesis of thin films of 3D COFs as well as other 3D materials,and boost their property and application exploration. | Xin Dong Jing Yang Honglei Wang Pei Zhao Fanglin Tan Zhipeng Zhou Zhaowei Ou Li Gong Wei Liu Xudong Chen Zhikun Zheng | 2022 | Chinese Journal of Chemistry2022，40，10： | 1 |
| 16 | When immunotherapy meets liver transplantation for hepatocellular carcinoma: A bumpy but promising road显示文摘Liver transplantation(LT)is a highly curative therapy for patients with hepatocellular carcinoma(HCC).However,due to the shortage of donor livers and rapid progression of HCC,a majority of patients are dropped out from the waitlist.Recently,immunotherapy has shown great promise in the treatment of advanced HCC.However,the use of immunotherapy is limited in LT mainly due to the potentially increasing risk of graft rejection.One of the main challenges for researchers is the protection of donor graft from an immunotherapy-boosted immune response mounted by the host.Besides,the safety,availability,and costs of immunotherapy are other challenges that need to be addressed.Here,we reviewed the literature involving patients who received immunotherapy prior to transplant to avoid waitlist dropouts and following transplantation to prevent the progression of tumor recurrence and metastasis.Statistically,the incidence of rejection was 25.0%pre-transplant and 18.5%post-transplant.Based on the review of these clinical studies,we can conclude that conducting clinical trials on the safety and efficacy of currently available immunotherapy drugs and identifying novel immunotherapy targets through extensive research may be promising for patients who do not meet the selection criteria for LT and who experience post-transplant recurrence.To date,the clinical experience on the use of immunotherapy before or after LT comes from individual case studies.Although some of the reported results are promising,they are not sufficient to support the standardized use of immunotherapy in clinical practice. | Yufeng Gu Shengjun Xu Zhengxin Wang Jiayin Yang Shusen Zheng Qiang Wei Zhikun Liu Xiao Xu | 2023 | Chinese Journal of Cancer Research2023，35，2： | 0 |
| 17 | Efficacy and safety of anlotinib as an adjuvant therapy in hepatocellular carcinoma patients with a high risk of postoperative recurrence显示文摘Objective:Hepatocellular carcinoma(HCC)has a high rate of postoperative recurrence and lacks an effective treatment to prevent recurrence.This study aims to investigate the efficacy and safety of anlotinib in postoperative adjuvant therapy for HCC patients with high-risk recurrence factors.Methods:For this multicenter,retrospective study,we recruited 63 HCC patients who received either anlotinib(n=27)or transcatheter arterial chemoembolization(TACE)(n=36)from six research centers in China between March 2019 and October 2020.The primary endpoint was disease-free survival(DFS)and the secondary endpoints were overall survival(OS)and safety.Results:In this study,the median follow-up time was 25.9 and 26.8 months in the anlotinib and TACE groups,respectively.There was no significant difference in the median DFS between the anlotinib[26.8 months,95%confidence interval(95%CI):6.8-NE]and TACE groups(20.6 months,95%CI:8.4-NE).The 12-month OS rates in the anlotinib and TACE groups were 96.3%and 97.2%,respectively.In the anlotinib group,19 of 27patients(70.4%)experienced treatment-emergent adverse events,with the most common events(≥10%)being hypertension(22.2%)and decreased platelet count(22.2%).Conclusions:The results indicate that anlotinib,as a new,orally administered tyrosine kinase inhibitor,has the same efficacy as TACE,and side effects can be well controlled. | Jianguo Wang Xiaonan Xiang Zhixiong Shi Hui Zhang Quanbao Zhang Zhikun Liu Guangjie Zhao Chuanxing Wu Qiang Wei Lin Zhong Zhengxin Wang Guoyue Lv Shusen Zheng Xiao Xu | 2023 | Chinese Journal of Cancer Research2023，35，4： | 0 |
| 18 | Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells显示文摘Epigenetic reprogramming of somatic cells into induced pluripotent stem cells(i PSCs)by overexpression of defined factors holds great promise for disease modeling and regenerative medicine(Takahashi and Yamanaka,2006;Robinton and Daley,2012).However,the stochastic reprogramming process often results in variable pluripotency levels of i PSC lines as measured by their in vivo developmental potential, | Zhikun Li Libin Wang Yukai Wang Lei Liu Liu Wang Wei Li Qi Zhou | 2015 | Journal of Genetics and Genomics2015，42，3： | 0 |
| 19 | Solvent sieving separators implement dual electrolyte for highvoltage lithium-metal batteries显示文摘Lithium-metal batteries(LMBs)based on high-voltage cathodes would deliver high specific energy density to meet the demand of future energy storage.However,developing liquid electrolytes with wide electrochemical window for high-energy LMBs is intrinsically challenging.Herein,we demonstrate metal-organic framework-functionalized separators(PE@MOF)with solvent sieving capability that implement dual electrolyte for LMBs.The capability of PE@MOF separator to block the diffusion of liquid electrolytes has been investigated.The PE@MOF separator notably suppresses solvents shuttling,enabling the independent optimization of cathode-electrolyte and anode-electrolyte interfaces.By adapting commercial carbonate and ether electrolytes on cathode and anode sides,respectively,robust cathode-electrolyte interphase(CEI)and solid electrolyte interface(SEI)have been built on both electrodes.The lifespan of LiCoO_(2)(LCO)|Li full cell has been notably extended when using dual electrolyte and the solvent-sieving PE@MOF separator.This work demonstrates a new strategy to separately optimize the local environments at electrodes and to develop high-energy LMBs using low-cost and commercially available electrolytes. | Yan Liu Qianqian Liu Youran Hong Yifei Xu Zerui Chen Wei Zhao Zhikun Hu Jiangwei Wang Hao Bin Wu | 2023 | Nano Research2023，16，4： | 0 |
| 20 | Characterization of 24 microsatellite markers in Primula chungensis(Primulaceae),a distylous-homostylous species,using MiSeq sequencing显示文摘Primula chungensis is a species with considerable floral and mating-system variation,including distylous(outcrossing),homostylous(selfing) and mixed populations that contain both outcrossing and selfing forms.We isolated 24 microsatellite markers from P.chungensis using Illumina Mi Seq sequencing.Polymorphism and genetic diversity were then measured based on a sample of 24 individuals from a natural population in southern Tibet.All loci were polymorphic with the number of alleles per locus ranging from 2 to 4.The observed and expected heterozygosity ranged from 0 to 1 and 0.219 to 0.708,respectively.The microsatellite markers we have identified will serve as valuable tools for the investigation of the population genetic structure and phylogeography of P.chungensis and will inform models of the evolutionary history of mating systems in the species. | Wei Zhou Haidong Li Zhikun Wu Spencer C.H.Barrett Dezhu Li Hong Wang | 2016 | 植物分类与资源学报2016，38，2： | 0 |
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