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| 1 | Effects of gaps on regeneration of woody plants: a meta-analysis显示文摘Forest gaps, openings in the canopy caused by death of one or more trees, have a profound effect on forest regeneration and drive the forest growth cycle. It is therefore necessary to understand the effects of forest gaps on regeneration for modern forest management. In order to provide a quantitative assessment of the effects of forest gaps on regeneration of woody plants, we conducted this review of gap effects on woody plant regeneration on the basis of 527 observations from 42 individual papers, and reported the results of these data in a meta-analysis. Overall, densities of regenerated woody plants were significantly greater(359%) in forest gaps than on the closed-canopy forest floor. The regeneration density in gaps of plantation forests was significantly greater(P < 0.05) than that of natural forest because the regeneration in gaps of plantation forests was improved by both gap effects and experimental measures. Similarly, in comparison to natural gaps, regeneration was better enhanced in artificial gaps. Regeneration density exhibited a significantly positive correlation with gap size, but a negative correlation with gap age because the gap size decreased with increasing gap age. Shade tolerance of woody plants affected regeneration density in gaps and understory. Average regeneration density of shade-tolerant species exhibited a significantly positive response to gaps but densities remained lower in total than those of intermediate and shade-intolerant species. Gap effects on regeneration decreased in response to increasing temperature and precipitation because of the limiting effects of lower temperature and moisture on woody plant regeneration. In summary, forest gaps enhance woody plant regeneration, and the effects of gaps varied by forest type, gap characteristics, environmental factors and plant traits. The results of this meta-analysis are useful for better understanding the effects and roles of gaps on forest regeneration and forest management. | Jiaojun Zhu Deliang Lu Weidong Zhang | 2014 | Journal of Forestry Research2014，25，3： | 15 |
| 2 | Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer显示文摘The q24 band of chromosome 8(8q24)is frequently amplified in human cancers including breast cancer,and several SNPs(single nucleotide polymorphisms)at 8q24,including rs13281615,have been identified for their association with cancer risks.These SNPs are in a'gene desert'region,and their functions in cancer development remain to be illustrated,although several of the SNPs appear to influence the genes in the'desert'in a long-range manner,including the v-myc avian myelocytomatosis viral oncogene homolog(MYC)and the nonprotein coding plasmacytoma variant translocation 1(PVT1),both of which have been implicated in human cancers.In the current study,we examined rs13281615 for its potential role in breast cancer using normal and cancer tissues from 121 Chinese women with breast cancer.In addition to confirming the association of the GG genotype of rs13281615 with breast cancer risk,we found that germline GG genotype was significantly associated with estrogen receptor(ER)positivity,higher tumor grade and higher proliferation index.We also found frequent somatic mutations(22/121 or 18.2%)of this SNP in breast cancer.Interestingly,the majority of the mutations(17/22 or 77%)involved a G/A change,resulting in a decrease in the number of cancers with the GG risk genotype and subsequent loss of GG association with higher tumor grade and proliferation index in cancers.Furthermore,PVT1 expression was increased in cancers,and the increase was associated with the GG genotype of rs13281615.These results suggest that the GG genotype of SNP rs13281615 plays a role in breast cancer likely by influencing PVT1 expression,and that during oncogenesis,'protective'mutations could occur. | Zhiqian Zhang Zhengmao Zhu Baotong Zhang Weidong Li Xin Li Xiao Wu Lijuan Wang Liya Fu Li Fu Jin-Tang Dong | 2014 | Journal of Genetics and Genomics2014，41，4： | 12 |
| 3 | The Mechanism of Cortico-Striato-Thalamo-Cortical Neurocircuitry in Response Inhibition and Emotional Responding in Attention Deficit Hyperactivity Disorder with Comorbid Disruptive Behavior Disorder显示文摘The neurocircuitries that constitute the corticostriato-thalamo-cortical(CSTC) circuit provide a framework for bridging gaps between neuroscience and executive function in attention deficit hyperactivity disorder(ADHD), but it has been difficult to identify the mechanisms for regulating emotional problems from the understanding of ADHD comorbidity with disruptive behavior disorders(DBD). Research based on 'cool'' and 'hot''executive functional theory and the dual pathway models,which are thought of as applied response inhibition and delay aversion, respectively, within the neuropsychological view of ADHD, has shed light on emotional responding before and after decontextualized stimuli, while CSTC circuit-related domains have been suggested to explain the different emotional symptoms of ADHD with or without comorbid DBD. This review discusses the role of abnormal connections in each CSTC circuit, especially in the emotion circuit, which may be responsible for targeted executive dysfunction at the neuroscience level. Thus, the two major domains – abstract thinking(cool) and emotional trait(hot) – trigger the mechanism of onset of ADHD. | Yuncheng Zhu Xixi Jiang Weidong Ji | 2018 | Neuroscience Bulletin2018，34，3： | 12 |
| 4 | Clinical development of CAR T cell therapy in China:2020 update显示文摘Chimeric antigen receptor(CAR)T-cell therapy has achieved significant success in the treatment of hematological malignancies.In recent years,fast-growing CAR T clinical trials have actively explored their potential application scenarios.According to the data from the clinicaltrials.gov website,China became the country with the most registered CAR T trials in September 2017.As of June 30,2020,the number of registered CAR T trials in China has reached 357.In addition,as many as 150 other CAR T trials have been registered on ChiCTR.Although CAR T therapy is flourishing in China,there are still some problems that cannot be ignored.In this review,we aim to systematically summarize the clinical practice of CAR T-cell therapy in China.This review will provide an informative reference for colleagues in the field,and a better understanding of the history and current situation will help us more reasonably conduct research and promote cooperation. | Jianshu Wei Yelei Guo Yao Wang Zhiqiang Wu Jian Bo Bin Zhang Jun Zhu Weidong Han | 2021 | Cellular & Molecular Immunology2021，18，4： | 11 |
| 5 | In-plane corrugated cosine honeycomb for 1D morphing skin and its application on variable camber wing显示文摘A novel 0-Poisson's ratio cosine honeycomb support structure of flexible skin is proposed. Mechanical model of the structure is analyzed with the energy method, finite element method (FEM) and experiments have been performed to validate the theoretical model. The in-plane characteristics of the cosine honeycomb are compared with accordion honeycomb through analytical models and experiments. Finally, the application of the cosine honeycomb on a variable camber wing is studied. Studies show that mechanical model agrees well with results of FEM and experiments. The transverse non-dimensional elastic modulus of the cosine honeycomb increases (decreases) when the wavelength or the wall width increases (decreases), or when the amplitude decreases (increases). Compared with accordion honeycomb, the transverse non-dimensional elastic modulus of the cosine honeycomb is smaller, which means the driving force is smaller and the power consumption is less during deformation. In addition, the cosine honeycomb can satisfy the deform- ing requirements of the variable camber wing. | Liu Weidong Zhu Hua Zhou Shengqiang Bai Yalei Wang Yuan Zhao Chunsheng | 2013 | Chinese Journal of Aeronautics2013，26，4： | 10 |
| 6 | High-temperature infrared camouflage with efficient thermal management显示文摘High-temperature infrared(IR)camouflage is crucial to the effective concealment of high-temperature objects but remains a challenging issue,as the thermal radiation of an object is proportional to the fourth power of temperature(T4).Here,we experimentally demonstrate high-temperature IR camouflage with efficient thermal management.By combining a silica aerogel for thermal insulation and a Ge/ZnS multilayer wavelength-selective emitter for simultaneous radiative cooling(high emittance in the 5-8μm non-atmospheric window)and IR camouflage(low emittance in the 8-14μm atmospheric window),the surface temperature of an object is reduced from 873 to 410 K.The IR camouflage is demonstrated by indoor/outdoor(with/without earthshine)radiation temperatures of 310/248 K for an object at 873/623 K and a 78% reduction in with-earthshine lock-on range.This scheme may introduce opportunities for high-temperature thermal management and infrared signal processing. | Huanzheng Zhu Qiang Li Chunqi Zheng Yu Hong Ziquan Xu HanWang Weidong Shen Sandeep Kaur Pintu Ghosh Min Qiu | 2020 | Light(Science & Applications)2020，9，1： | 8 |
| 7 | Testing the mantle plume hypothesis: an IODP effort to drill into the Kamchatka-Okhotsk Sea basement显示文摘The great mantle plume debate(GPD) has been going on for ~15 years(Foulger and Natland, 2003;Anderson, 2004; Niu, 2005; Davies, 2005; Foulger, 2005; Campbell, 2005; Campbell and Davies, 2006),centered on whether mantle plumes exist as a result of Earth's cooling or whether their existence is purely required for convenience in explaining certain Earth phenomena(Niu, 2005). Despite the mounting evidence that many of the so-called plumes may be localized melting anomalies, the debate is likely to continue. We recognize that the slow progress of the debate results from communication difficulties.Many debaters may not truly appreciate(1) what the mantle plume hypothesis actually is, and(2) none of the petrological, geochemical and geophysical methods widely used can actually provide smoking-gun evidence for or against mantle plume hypothesis. In this short paper, we clarify these issues, and elaborate a geologically effective approach to test the hypothesis. According to the mantle plume hypothesis, a thermal mantle plume must originate from the thermal boundary layer at the core-mantle boundary(CMB), and a large mantle plume head is required to carry the material from the deep mantle to the surface. The plume head product in ocean basins is the oceanic plateau, which is a lithospheric terrane that is large(1000's km across), thick(>200 km), shallow(2–4 km high above the surrounding seafloors), buoyant(~1% less dense than the surrounding lithosphere), and thus must be preserved in the surface geology(Niu et al., 2003). The Hawaiian volcanism has been considered as the surface expression of a type mantle plume, but it does not seem to have a(known) plume head product. If this is true, the Hawaiian mantle plume in particular and the mantle plume hypothesis in general must be questioned. Therefore, whether there is an oceanic plateau-like product for the Hawaiian volcanism is key to testing the mantle plume hypothesis, and the Kamchatka-Okhotsk Sea basement is the best candidate to find out if it is indeed the Hawaiian mantle plume head product or not(Niu et al., 2003; Niu, 2004). | Yaoling Niu Xuefa Shi Tiegang Li Shiguo Wu Weidong Sun Rixiang Zhu | 2017 | Science Bulletin2017，62，21： | 8 |
| 8 | Topology optimization of support structure of telescope skin based on bit-matrix representation NSGA-II显示文摘Non-dominated sorting genetic algorithm II(NSGA-II)with multiple constraints handling is employed for multi-objective optimization of the topological structure of telescope skin,in which a bit-matrix is used as the representation of a chromosome,and genetic algorithm(GA)operators are introduced based on the matrix.Objectives including mass,in-plane performance,and out-of-plane load-bearing ability of the individuals are obtained by fnite element analysis(FEA)using ANSYS,and the matrix-based optimization algorithm is realized in MATLAB by handling multiple constraints such as structural connectivity and in-plane strain requirements.Feasible confgurations of the support structure are achieved.The results confrm that the matrix-based NSGA-II with multiple constraints handling provides an effective method for two-dimensional multi-objective topology optimization. | Liu Weidong Zhu Hua Wang Yiping Zhou Shengqiang Bai Yalei Zhao Chunsheng | 2013 | Chinese Journal of Aeronautics2013，26，6： | 7 |
| 9 | Satellite-derived surface water pCO_2 and air-sea CO_2 fluxes in the northern South China Sea in summer显示文摘An empirical approach is presented for the estimation of the partial pressure of carbon dioxide (pCO2) and air-sea CO2 fluxes in the northern South China Sea in summer using satellite-derived sea surface temperatures (SSTs), chlorophyll-a (Chl a) concentrations, and wind fields. Two algorithms were tested. The first used an SST-dependent equation, and the other involved the introduction of Chl a. Regression equations were developed for summer based on in situ data obtained in July, 2004. Using the monthly average SST and Chl a fields derived from the advanced very high resolution radiometer (AVHRR) and the SeaWiFS (sea-viewing wide field of view sensor), respectively, the monthly pCO2 fields were computed. The derived pCO2 was compared with the shipboard pCO2 observations conducted in July, 2000. This resulted in a root-mean-square error of 4.6 latm, suggesting that the satellite-derived pCO2 was in general agreement with the in situ observations. The air-sea CO2 flux was further computed with the aid of the monthly mean QuikSCAT wind speed. We contend that more shipboard data are necessary for refining the empirical algorithms and reducing the uncertainty in the results. | Yu Zhu Shaoling Shang Weidong Zhai Minhan Dai | 2009 | Progress in Natural Science:Materials International2009，19，6： | 7 |
| 10 | Variations of energy metabolism and adenosine Triphosphatase activity in gastric mucosa in chronic atrophic gastritis rats with Qi deficiency and blood stasis syndrome and effect of Zhiweifangbian capsule显示文摘OBJECTIVE: To study the effects of Zhiweifangbian (ZWFB) capsule on lactic dehydrogenase (LDH), succinic dehydrogenase (SDH) and ATPase activities in gastric mucosa of chronic atrophic gastritis (CAG) rats with Qi deficiency and blood stasis syndrome. METHODS: Totally 90 rats were randomly divided into 2 groups: normal group (n=10) and modelgroup (n=80). The CAG rat model of Qi deficiency and blood stasis type was induced by synthetic methods. After modeling for 12 weeks and the successful CAG model was determined, the CAG model rats were divided by random number table into model group (MG), ZWFB high-dose group (ZWFBH), ZWFB middle-dose group (ZWFBM), ZWFB low-dose group (ZWFBL) and Weimeisu group (WM), 9 rats in each group. The rats in the normal and model groups were intragastrically administrated with distilled water, 10 mL/kg every day; the ZWFB high-dose group with ZWFB, 0.6 g/ kg -1 · d -1 ; the ZWFB middle-dose group with ZWFB, 0.3 g/kg -1 · d -1 ; the ZWFB low-dose group with ZWFB, 0.15 g/kg -1 · d -1 , and the WM group with suspension of WM , 0.25 g/kg -1 · d -1 . The treatment was given for 90 consecutive days. Then general survival states were observed and the activities of LDH, SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase in gastric mucosa tissue were detected. RESULTS: Compared with the normal group, activity of LDH in the gastric mucosa (P<0.05) and activities of SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase significantly decreased in the normal group (P<0.05). Compared with the model group the activity of LDH decreased and activities of SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase significantly increased in the high dose ZWFB group (P<0.05). CONCLUSION: ZWFB capsule can promote energy metabolism and ATPase activity in the gastric mucosa cell, so as to protect the function of the gastric mucosa cell. | Yongqiang Duan Weidong Cheng Yingxia Cheng Hongyan Li Xueyan Li Liming Zhu Xiaoyi Yang | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 6 |
| 11 | Chaotic Phenomena Produced by the Spherical Vortices in the Beltrami Flows显示文摘We find a special type of Beltrami flows which has chaotic trajectories confined within a sphere or between two concentric spherical shells.We also find there exists the structure of chaotic manifold made from double-torus in some special cases. | SHI Changchun HUANG Yongnian ZHU Zhaoxuan SU Weidong DONG Yufei | 1992 | Chinese Physics Letters1992，9，10： | 5 |
| 12 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 13 | Comparison study on strategies to prepare nanocrystalline Li2ZrO3-based absorbents for CO2 capture at high temperatures显示文摘比较研究在策略上被进行了因为为 CO2 的综合 nanocrystalline Li2ZrO3 和 Kdoped Li2ZrO3 吸收剂在高温度捕获,包括固态并且液体阶段方法,柠檬酸盐线路,和帮助淀粉的大音阶的第五音胶化方法与 freeze-drying 结合了技术。包括举起率和吸收能力,吸收性质被 thermogravimetric 分析(TGA ) 在不同 CO2 部分压力综合吸收剂调查。nanosized Li2ZrO3 晶体由柠檬酸盐线路展览综合了更快的举起并且一更高,将近, stoichiometric 吸收能力比那些综合了由固态并且液体阶段方法。做 K 进 Li2ZrO3 能显著地改进 CO2 的举起率,特别在低 CO2 部分压力。为做 K 的 Li2ZrO3 的合成,而帮助淀粉的大音阶的第五音胶化方法与 freeze-drying 结合了,柠檬酸盐线路有差的重制度和可伸缩性技术在上面可再现、容易可伸缩,并且因此综合的吸收剂拥有优秀 CO2 俘获性质。 | Qiang XIAO Xiaodan TANG Yefeng LIU Yijun ZHONG Weidong ZHU | 2013 | Frontiers of Chemical Science and Engineering2013，7，3： | 5 |
| 14 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 15 | Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma显示文摘Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically,THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients. | Demeng Chen Zhiqiang Zhao Zixin Huang Du-Chu Chen Xin-Xing Zhu Yi-Ze Wang Ya-Wei Yan Shaojun Tang Subha Madhavan Weiyi Ni Zhan-peng Huang Wen Li Weidong Ji Huangxuan Shen Shuibin Lin Yi-Zhou Jiang | 2018 | Bone Research2018，6，2： | 5 |
| 16 | THE EXTENSIVENESS AND SPECIFICITY OF EFFECT OF ELECTROACUPUNCTURE AT DIFFERENT ACUPOINTS ON NOCICEPTIVE RESPONSE OF CONVERGENT NEURONS IN TRIGEMINAL NUCLEUS CAUDALIS显示文摘Experiments were carried out on rats anaesthetized with uraethane. The sponta-neous discharges and nociceptive responses of convergent neurons in the right trigerninal nucleus cau-dalis(TNC) to noxious stimuli at receptive field (cheek) were recorded extracellularly with glass mi-cro-electrode. Electroacupuncture (EA ) was applied at bilateral ' Xiaguan' (ST 7 on face ) or 'Zusanli' (ST 36 on shank) acupoint with Iow (2V) and high (18V) intensity. The noclceptive re-sponse of convergent neurons in TNC could be inhihited by low intensity EA applied at 'Xiaguan' butnot 'Zusanlil', showing the specificity of acupoints. High intensity EA at either 'Xiaguan' or 'Zusan-li' also reduced the nociceptive responses, showing the analgesic extensiveness of acupoints. We sug-gest that 'the gate of control' mechanism plays a main role in low intensity EA and 'diffuse noxiousinhibitory controls' (DNIC) rnechanism does so in high intensity EA.The results suggest that we should pay attention to the location of acupoints, | Xu Weidong, Liu Xiang. Zhu Bing. He Xiaoling. Zhang ShouxinInstitute of Acupuncture and Moxibustion, China Academy of TCM Beijing 100700, China | 1995 | World Journal of Acupuncture-Moxibustion1995，5，2： | 5 |
| 17 | Inactivation of LARS2, located at the commonly deleted region 3p21.3, by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma显示文摘包括 3p21.3 区域,染色体 3p 的突变而产生之遗传的损失在 95100% 主要的鼻咽的癌(NPC ) 被发现活体检视,建议这个区域应该与 NPC 开发有关仔细怀有一些肿瘤 suppressor 基因(TSG ) 。在 3p21.3 定位的几 TSG 例如 RASSF1A, LTF 和 BLU,被表明了涉及 NPC 开发。LARS2 (leucyl-tRNA 合成酶 2, mitochondrial ) 另一基因位于染色体在 3p21.3 的 3 普通消除 region-1 (C3CER1 ) 。在这研究,我们在 NPC 集中了于 epigenetic 和 LARS2 的基因改变。LARS2 的 mRNA 表示被半量的反向的抄写聚合酶链反应(RTPCR ) 和即时 RTPCR 在 36 NPC 和 8 长期的鼻咽炎(NP ) 纸巾检测。随后, LARS2 的变化,突变而产生之遗传的损失,和 methylation 地位被聚合酶链 reaction-single-strand 符合构造多型性(PCR-SSCP ) 分析,同型结合的删除(HD ) 分析和 methylation 特定的聚合酶在主要 NPC 纸巾锁住反应。LARS2 的表示或下面规定都没在 78% 主要 NPC 纸巾被观察。没有变化,由定序的 PCR-SSCP 和 DNA 估计了,在倡导者区域和 exon 被发现在 NPC 纸巾的 1 LARS2,而 HD 在 LARS2 地点在 28% NPC 标本被检测。另外, LARS2 的 hypermethylation 在 64% NPC 样品被发现。我们的数据显示 LARS2 的那 inactivation 由基因并且 epigenetic 机制可以是在 NPC 的 carcinogenesis 的一个普通、重要的事件。 | Wen Zhou Xiangling Feng Hong Li Lei Wang Bin Zhu Weidong Liu Ming Zhao Kaitai Yao Caiping Ren | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 5 |
| 18 | Implementation of regional Acute Stroke Care Map increases thrombolysis rates for acute ischaemic stroke in Chinese urban area in only 3 months显示文摘Background The rate of intravenous thrombolysis for acute ischaemic stroke remains low in China.We investigated whether the implementation of a citywide Acute Stroke Care Map(ASCaM)is associated with an improvement of acute stroke care quality in a Chinese urban area.Methods The ASCaM comprises 10 improvement strategies and has been implemented through a network consisting of 20 tertiary hospitals.We identified 7827 patients with ischaemic stroke admitted from April to October 2017,and 506 patients underwent thrombolysis were finally included for analysis.Results Compared with‘pre-ASCaM period’,we observed an increased rate of administration of tissue plasminogen activator within 4.5 hours(65.4% vs 54.5%;adjusted OR,1.724;95% CI 1.21 to 2.45;p=0.003)during‘ASCaM period’.In multivariate analysis models,‘ASCaM period’was associated with a significant reduction in onset-to door time(114.1±55.7 vs 135.7±58.4 min,p=0.0002)and onset-to needle time(ONT)(169.2±58.1 vs 195.6±59.3 min,p<0.0001).Yet no change was found in door-to needle time.Clinical outcomes such as symptomatic intracranial haemorrhage,favourable functional outcome(modified Rankin Scale≤2)and in-hospital mortality remained unchanged.Conclusion The implementation of ASCaM was significantly associated with increased rates of intravenous thrombolysis and shorter ONT.The ASCaM may,in proof-of principle,serve as a model to reduce treatment delay and increase thrombolysis rates in Chinese urban areas and possibly other highly populated Asian regions. | Yi Sui Jianfeng Luo Chunyao Dong Liqiang Zheng Weijin Zhao Yao Zhang Ying Xian Huaguang Zheng Bernard Yan Mark Parsons Li Ren Ying Xiao Haoyue Zhu Lijie Ren Qi Fang Yi Yang Weidong Liu Bing Xu | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 19 | Development of an invasive brain machine interface with a monkey model显示文摘Brain-machine interfaces (BMIs) translate neural activities of the brain into specific instructions that can be carried out by external devices. BMIs have the potential to restore or augment motor functions of paralyzed patients suffering from spinal cord damage. The neural activities have been used to predict the 2D or 3D movement trajectory of monkey's arm or hand in many studies. However, there are few studies on decoding the wrist movement from neural activities in center-out paradigm. The present study developed an invasive BMI system with a monkey model using a 10×10-microelectrode array in the primary motor cortex. The monkey was trained to perform a two-dimensional forelimb wrist movement paradigm where neural activities and movement signals were simultaneous recorded. Results showed that neuronal firing rates highly correlated with forelimb wrist movement; > 70% (105/149) neurons exhibited specific firing changes during movement and > 36% (54/149) neurons were used to discriminate directional pairs. The neuronal firing rates were also used to predict the wrist moving directions and continuous trajectories of the forelimb wrist. The four directions could be classified with 96% accuracy using a support vector machine, and the correlation coefficients of trajectory prediction using a general regression neural network were above 0.8 for both horizontal and vertical directions. Results showed that this BMI system could predict monkey wrist movements in high accuracy through the use of neuronal firing information. | ZHANG QiaoSheng ZHANG ShaoMin HAO YaoYao ZHANG HuaiJian ZHU JunMing ZHAO Ting ZHANG JianMin WANG YiWen ZHENG XiaoXiang CHEN WeiDong | 2012 | Chinese Science Bulletin2012，57，16： | 4 |
| 20 | A new method of micro-motion parameters estimation based on cyclic autocorrelation function显示文摘Signals with sinusoidal frequency modulation(FM)are the general form of micro-Doppler signals in radar echoes from targets with micro-motions.This paper derives the cyclic autocorrelation function of a sinusoidal FM signal using its cyclostationary characteristics,and estimates the parameters of amplitude,modulation index,micro-motion period and noise power based on cyclic autocorrelation function.The estimation method is robust in noise environment when compared with conventional time-frequency analysis methods.Finally,the performances of estimation by utilizing the simulation data and darkroom measurement are shown in tables.The Monte-Carlo simulation results show that the estimator is asymptotically optimal at SNR above6 dB. | NIU Jie LI KangLe JIANG WeiDong LI Xiang KUANG GangYao ZHU HongYu | 2013 | Science China(Information Sciences)2013，56，10： | 4 |
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