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| 1 | Human colorectal cancer-specific CCAT1-L IncRNA regulates long-range chromatin interactions at the MYC locus显示文摘人的 8q24 基因沙漠包含多重 enhancers 形式织物特定的远程的染色质与 MYC oncogene 循环,但是染色质在 MYC 地点循环怎么被调整,仍然保持糟糕理解。这里,我们表明那长 noncoding RNA (lncRNA ) , CCAT1-L,从一个地点在人的 colorectal 癌症明确地被抄录 MYC 在上游的 515 kb。这 lncRNA 在 MYC transcriptional 规定起一个作用并且支持远程的染色质循环。重要地, CCAT1-L 地点位于强壮的超级提高以内并且离 MYC 空间地靠近。CCAT1-L 击倒在 MYC 倡导者和它的 enhancers 之间的减少的远程的相互作用。另外, CCAT1-L 与 CTCF 交往并且在这些环区域调制染色质符合构造。这些结果揭示一个重要角色一以前在在 MYC 地点的基因规定的 unannotated lncRNA。 | Jian-Feng Xiang Qing-Fei Yin Tian Chen Yang Zhang Xiao-Ou Zhang Zheng Wu Shaofeng Zhang Hai-Bin Wang Junhui Ge Xutiua Lu Li Yang Ling-Ling Chen | 2014 | Cell Research2014，24，5： | 67 |
| 2 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 3 | Experimental investigation on micro-dynamic behavior of gas explosion suppression with SiO_2 fine powders显示文摘To study the effect of inert dust on gas explosion suppression mechanism,SiO_2 fine powders were sprayed to suppress premixed CH_4-Air gas explosion in a 20 L spherical experimental system.In the experiment,high speed schlieren image system was adopted to record explosion flame propagation behaviors,meanwhile,pressure transducers and ion current probes were used to clearly record the explosion flame dynamic characteristics.The experimental results show that the SiO_2 fine powders suppressed evidently the... | Xianfeng Chen,~(1,2,a)) Yin Zhang,~1 Qingming Zhang,~2 Shaofeng Ren,~1 and Jianxing Wu~1 1)School of Natural Resources and Environmental Engineering,Wuhan University of Technology, Wuhan 430070,China 2)State Key Laboratory of Explosion Science and Technology,Beijing Institute of Technology, Beijing 100081,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，3： | 8 |
| 4 | Influence of Non-smooth Surface on Tribological Properties of Glass Fiber-epoxy Resin Composite Sliding against Stainless Steel under Natural Seawater Lubrication显示文摘With the development of bionics, the bionic non-smooth surfaces are introduced to the field of tribology. Although non-smooth surface has been studied widely, the studies of non-smooth surface under the natural seawater lubrication are still very fewer, especially experimental research. The influences of smooth and non-smooth surface on the frictional properties of the glass fiber-epoxy resin composite(GF/EPR) coupled with stainless steel 316 L are investigated under natural seawater lubrication in this paper. The tested non-smooth surfaces include the surfaces with semi-spherical pits, the conical pits, the cone-cylinder combined pits, the cylindrical pits and through holes. The friction and wear tests are performed using a ring-on-disc test rig under 60 N load and 1000 r/min rotational speed. The tests results show that GF/EPR with bionic non-smooth surface has quite lower friction coefficient and better wear resistance than GF/EPR with smooth surface without pits. The average friction coefficient of GF/EPR with semi-spherical pits is 0.088, which shows the largest reduction is approximately 63.18% of GF/EPR with smooth surface. In addition, the wear debris on the worn surfaces of GF/EPR are observed by a confocal scanning laser microscope. It is shown that the primary wear mechanism is the abrasive wear. The research results provide some design parameters for non-smooth surface, and the experiment results can serve as a beneficial supplement to non-smooth surface study. | WU Shaofeng GAO Dianrong LIANG Yingna CHEN Bo | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 7 |
| 5 | Experimental Study on Influence of Dimples on Lubrication Performance of Glass Fiber-epoxy Resin Composite under Natural Seawater Lubrication显示文摘Bionic non-smooth surface is widely applied in metal and ceramics materials. In order to introduce this technology to high pressure seawater pump, the influence of bionic non-smooth surface on the engineering plastics used in pump should be investigated. The comparative tests are carried out with a ring-on-disc configuration under 800, 1000, 1200 and 1400 r/min in order to research the influence of the bionic non-smooth surface on glass fiber-epoxy resin composite(GF/EPR) under natural seawater lubrication. The disc surfaces are textured with five kinds of pits, which are semi-spherical, conical, cone-cylinder combined, cylindrical pits and through holes, respectively. A smooth surface is tested as reference. The results show that the lubrication performance of dimpled GF/EPR sample is much better than that of the smooth sample under all rotational speeds. The semi-spherical pits surface has more obvious friction reduction than the others, which shows that the least reduction is approximately 43.29% of smooth surface under 1200 r/min. However, the wear level is only marginally influenced by dimples. The surface morphology investigations disclose severe modifications caused by abrasive wear primarily. The results are helpful to vary friction properties of GF/EPR by non-smooth surface, or provide references to the design of non-smooth surfaces under certain condition. | WU Shaofeng GAO Dianrong LIANG Yingna CHEN Bo | 2017 | Chinese Journal of Mechanical Engineering2017，30，1： | 6 |
| 6 | Photochemical indicators of ozone sensitivity: application in the Pearl River Delta, China显示文摘 | Lyumeng Ye Xuemei Wang Shaofeng Fan Weihua Chen Ming Chang Shengzhen Zhou Zhiyong Wu Qi Fan | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 5 |
| 7 | APPLICATION OF PARAMETRIC DERIVATION METHOD TO THE CALCULATION OF PEIERLS ENERGY AND PEIERLS STRESS IN LATTICE THEORY显示文摘Applying the parametric derivation method,Peierls energy and Peierls stress are calculated with a non-sinusoidal force law in the lattice theory,while the results obtained by the power-series expansion according to sinusoidal law can be deduced as a limiting case of non- sinusoidal law.The simplified expressions of Peierls energy and Peierls stress are obtained for the limit of wide and narrow.Peierls energy and Peierls stress decrease monotonically with the factor of modification of force law.Present results can be used expediently for prediction of the correct order of magnitude of Peierls stress for materials. | Xiaozhi Wu Shaofeng Wang | 2007 | Acta Mechanica Solida Sinica2007，20，4： | 4 |
| 8 | Assessment of outcomes of hearing and speech rehabilitation in children with cochlear implantation显示文摘Objectives:This study aimed to assess the effect of hearing and speech rehabilitation in patients with Nurotron■cochlear implants.Design:Ninety-eight paediatric patients with bilateral severe-to-profound sensorineural deafness who received cochlear implantation were divided into three groups according to age:group A(≤3 years),group B(4-7 years),and group C(8-16 years).All patients were followed up for one year for hearing and speech performance after the surgery.The comprehensive Auditory Perception Assessment,MAIS,CAP and SIR hearing and speech assessments and rating materials were used for assessment before the surgery and at 3,6,and 12 months after implant activation.Results:The scores of patients in the open-set speech assessment,Chinese Auditory Perception Assessment,MAIS,CAP and SIR significantly improved after cochlear implantation in all age groups.The younger the age at implantation,the better the results.Moreover,the hearing and speech performance of cochlear implant recipients gradually improved with the extension of rehabilitation time.Conclusions:Nurotron■Venus^TM cochlear implantation can improve the hearing and speech performance of patients with bilateral severe-to-profound sensorineural deafness. | Shaofeng Liu Fang Wang Peipei Chen Na Zuo Cheng Wu Jun Ma Jingjiang Huang Chuanxi Wang | 2019 | Journal of Otology2019，14，2： | 4 |
| 9 | Circulating microRNA expression profile: a novel potential predictor for chronic nervous lesions显示文摘长期的神经病的疼痛的机制不是清楚的。浆液 microRNAs (miRNAs ) 可能为长期的紧张的损害显示出一个特殊特征。然而,很少为神经病的疼痛在传播 miRNAs 对变化被知道。因此,在传播 miRNAs 表示侧面变化因为神经病的疼痛被调查。在针的神经结扎(SNL ) 外科,和 microarray 分析被执行在 miRNA 表示侧面决定变化前后,浆液从老鼠被收集。在从一样的个人的浆液的煽动性的 cytokines 的表示包括 interleukin-6 (IL-6 ) ,肿瘤坏死因素 --(TNF-) ,并且单核白血球趋化性的 protein-1 (MCP-1 ) ,也被测量。结果证明 IL-6, TNF- ,和 MCP-1 的表示层次显著地在显著地与疼痛层次被相关的 SNL 老鼠被提高。有在 SNL 外科前后的显著地不同的表示层次的九 miRNAs 被 microarray 分析识别,它被量的即时聚合酶链反应分析进一步验证。与没有 SNL 外科的天真的老鼠相比,在在 SNL 外科以后的老鼠的浆液的五 miRNAs ( hsa-miR-221 , hsa-miR-34c , hsa-miR-21 , hsa-miR-30a-5p ,和 hsa-miR-206 )的表示被减少,四 miRNAs ( hsa-miR-31-5p , hsa-miR-133b , hsa-miR-22 ,和 hsa-miRPlus-A1087 )被增加,建议变化可以在神经病的疼痛的规定包含的那 miRNA 。TargetScan 被用来为这些 miRNAs 预言 mRNA 目标,并且结果证明有多重预言的目标地点的抄本属于神经病学地重要的小径。生物信息学分析表明几目标基因与房间发信号的激活有关与紧张的损害联系了。在这研究,在在神经病的疼痛条件下面的浆液的 miRNA 侧面的变化第一次被显示出,建议在浆液的那传播 miRNAs 侧面是为神经病的疼痛的一个潜在的预言者。 | Yongming Xu Xin Zhang Shaofeng Pu Junzhen Wu Yingying Lv Dongping Du | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 4 |
| 10 | Body sensor networks for ubiquitous healthcare显示文摘Body sensor networks provide a platform for ubiquitous healthcare, driving the diagnosis in hospital static environment to the daily life dynamic context. We realized the importance of sensing of activities, which is not only a dimension of human health but also important context information for diagnosis based on the physiologic data. This paper presents our ubiquitous healthcare system, uCare. It consists of uCare devices and a server system. Currently, the uCare system is designed for cardiovascular disease (CVD) examination and management. The uCare device has been tested in a trial in Beijing Hospital. The uCare system will be further tested in elderly care at home and exercise management in training to measure heart dynamics during training. | Wang, Shaofeng Ji, Lianying Li, Aiguang Wu, Jiankang | 2011 | 控制理论与应用(英文版)2011，9，1： | 3 |
| 11 | Insight into the structural evolution of porous and fractured media by forced aeration during heap leaching显示文摘Despite lots of techniques in improving the heap leaching performance,many constraints on the industrial applications remain.We proposed a correspondingly effective and new idea of introducing forced aeration to improve the bad permeability and leaching effect of Yangla Copper Mine(YCM)during heap leaching.The dual-media theory was employed to study the impact mechanism of forced aeration on the variations of porous and fractured media during the column leaching experiments.An X-Ray Computed Tomography(CT)set was utilized to perform the pore imaging of the specimens and the fracture morphology of the particles within the columns was analyzed by Scanning Electron Microscope(SEM)as aeration rate(AR)changed.The results show that there exists copious fine particles within the heap of YCM,the particle size distribution of which is not reasonable.The forced aeration can not only promote the development of the porous and fractured structures but effectively break the blocked seepage paths.Then the leaching degree is improved and the seepage performance of the solute within the solution is enhanced.Therefore,the forced aeration is probable of making the leaching performance greatly improved. | Yu Shaofeng Wu Aixiang Wang Yiming | 2019 | International Journal of Mining Science and Technology2019，29，5： | 3 |
| 12 | Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel- evoked neuropathic pain显示文摘 | Yongming Xu Guangxia Cheng Yanrong Zhu Xin Zhang Shaofeng Pu Junzhen Wu Yingying Lv Dongping Du | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 3 |
| 13 | Crystal-KMC: Parallel Software for Lattice Dynamics Monte Carlo Simulation of Metal Materials显示文摘Kinetic Monte Carlo(KMC) is a widely used method for studying the evolution of materials at the microcosmic level. At present, while there are many simulation software programs based on this algorithm, most focus on the verification of a certain phenomenon and have no analog-scale requirement, so many are serial in nature. The dynamic Monte Carlo algorithm is implemented using a parallel framework called SPPARKS, but it does not support the Embedded Atom Method(EAM) potential, which is commonly used in the dynamic simulation of metal materials. Metal material — the preferred material for most containers and components — plays an important role in many fields, including construction engineering and transportation. In this paper, we propose and describe the development of a parallel software program called Crystal-KMC, which is specifically used to simulate the lattice dynamics of metallic materials. This software uses MPI to achieve a parallel multiprocessing mode, which avoid the limitations of serial software in the analog scale. Finally, we describe the use of the parallel-KMC simulation software Crystal-KMC in simulating the diffusion of vacancies in iron, and analyze the experimental results. In addition, we tested the performance of Crystal-KMC in 'meta-Era' supercomputing clusters, and the results show the Crystal-KMC parallel software to have good parallel speedup and scalability. | Jianjiang Li Peng Wei Shaofeng Yang Jie Wu Peng Liu Xinfu He | 2018 | Tsinghua Science and Technology2018，23，4： | 2 |
| 14 | Characterization of Fe5(AsO3)3Cl2(OH)4·5H2O,a new ferric arsenite hydroxychloride precipitated from FeCl3-As2O3-HCl solutions relevant to arsenic immobilization显示文摘Tooeleite(Fe6(As03)4 SO4(OH)4·4 H2 O)is widely precipitated for direct As(III)removal from sulfate-rich industrial effluents.However,whether or not Fe(III)-As(III)-Cl(-I)precipitate is produced in chloridizing leaching media for As immobilization is almost unknown.This work founded the existence of ferric arsenite(hydroxy)chloride as a new mineral for As(III)removal.Its chemical composition and solid characterization were subsequently studied by using scanning electron microscope with an energy dispersive spectrometer(SEM-EDS),X-ray diffraction(XRD),infrared(FT-IR),Raman spectroscopy and thermogravimetric(TG)curve.The results showed the formation of a yellow precipitate after 3-days reaction of Fe(III)/As(III)with molar ratio≈1.7 in chloride solution at pH 2.3 neutralized with NaOH.Compared with tooeleite,chemical analysis and solid characterization indicated that Cl(-I)replaces S04(-II)producing ferric arsenite hydroxychloride with formula Fe5(As03)3-Cl2(OH)4·5 H2 O.This new plate shaped solid showed better crytallinity than tooeleite,although it has similar morphology and characteristic bands to tooeleite.The FT-IR bands at 628,964 cm-1 and the Raman bands at 448,610,961 cm-1 were assigned to Fe-O or As(Ⅲ)-O-Fe or As(Ⅲ)-O bending/stretching vibration,indicating that both arsenite and chloride substituted for the position of sulfate for ferric arsenite hydro xychloride produced due to the lack of the SO42-vibrations.Cl-(I)also contributed to increase As removal efficiency in aqueous sulfate media under acidic pH conditions via the probable formation of sulfatechloride ferric arsenite. | Zidan Yuan Xu Ma Xing Wu Guoqing Zhang Xin Wang Shaofeng Wang Yongfeng Jia | 2020 | Journal of Environmental Sciences2020，32，4： | 2 |
| 15 | Tissue-engineered conduit using urine-derived stem cells seeded bacterial cellulose polymer in urinary reconstruction and diversion显示文摘 | Aase Bodin Shantaram Bharadwaj Shaofeng Wu Paul Gatenholm Anthony Atala Yuanyuan Zhang | 2010 | Biomaterials2010，，： | 1 |
| 16 | Evenly supported TiO2 on activated carbon fiber and its photocatalytic degradation property显示文摘 | WANG Xue WU Qiufang XUAN Shaofeng | 2011 | Advanced Materials Research2011，，： | 1 |
| 17 | EXTENDED CORE STRUCTURE OF DISSOCIATED EDGE DISLOCATIONS IN FCC CRYSTALS WITH CONSIDERATION OF DISCRETENESS显示文摘The extended core structure of the dissociated edge dislocation in Al, Au, Ag, Cu and Ni is determined within lattice theory of dislocation. The 2D dislocation equation governing the displacements is coupled by the restoring forces that are determined by the parameterization of the generalized stacking fault energies. The Ritz variational method is presented to solve the dislocation equation and the trial solution is constituted by two arctan-type functions with two undetermined parameters. The core widths of partial dislocations are wider than that obtained in generalized Peierls-Nabarro model due to the consideration of discreteness of crystal. | Xiaozhi Wu Shaofeng Wang Huili Zhang | 2008 | Acta Mechanica Solida Sinica2008，21，5： | 1 |
| 18 | Tamoxifen attenuates reactive astrocyte-induced brain metastasis and drug resistance through the IL-6/STAT3 signaling pathway显示文摘Brain metastasis affects approxim ately 20%-30%of patients w ith triple-negative breast cancers(TNBCs).Even sm all metastatic lesions in the brain can trigg er severe neurological im pairm ents and result in extrem ely short survival time.Recently,active astrocytes were reported to be associated w ith brain metastases.However,how activated astrocytes regulate the behaviors of disseminated breast cancer cells in the brain remains unknown.In this study,human prim ary astrocytes were stim ulated w ith IL-1β to form active astrocytes to study the cross-talk between strom al cells(astrocytes)and TNBC cells in brain metastases.Our results showed that active astrocytes significantly increase the m alignancy of TNBC cells and prevent them from undergoing apoptosis caused by doxorubicin.We also found that the high level of IL-6 secreted by activated astrocytes was responsible for the drug resistance of breast cancer,which could be abolished by treatm ent of astrocytes with tam oxifen(TAM).The blockage of active astrocyte-derived IL-6 by a neutralizing antibody resulted in the attenuation of drug resistance,consequently enhancing the sensitivity of breast cancer cells to doxorubicin.Furthermore,the possible involved TAM-m odulated drug resistance mechanism may be associated with a decrease in IL-6 expression in astrocytes and the downregulation of MAPK and JAK2/STAT3 signaling in cancer cells.Our data suggested that TAMs might reduce drug resistance through the IL-6/JAK2/STAT3 signaling pathway,providing a possible therapy to treat brain metastasis in TNBCs,as estrogen receptor inhibitors(TAMs,etc.)can cross the blood-brain barrier. | Yongming Xu Yanrong Zhu Yong Yue Shaofeng Pu Junzhen Wu Yingying Lv Dongping Du | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 1 |
| 19 | Separation of structurally related estrogens using isocratic elution pressurized capillary electrochromatography显示文摘 | Shaofeng Liu Zenghong Xie Xiaoping Wu Xucong Lin Liangqia Guo Guonan Chen | 2005 | Journal of Chromatography A2005，，2： | 1 |
| 20 | Specific cross-dimerization of terminal alkynes via Pd/TMEDA catalysis显示文摘The cross-dimerization of terminal alkynes is the most straightforward and attractive approach to differently substituted 1,3-enynes,which are vital structural motifs in natural products,biologically active compounds,and organic functional materials,etc.However,due to the inherent issues of the stereo-,regio-,and chemoselectivity,the strategy is less explored and remains problematic in substrate scope,selectivity,and screening of catalytic system,etc.Herein,a specific cross-dimerization of terminal alkynes is developed under Pd/TMEDA catalysis,which produces a series of gem-1,3-enynes(58 examples)in totally moderate to high yields with outstanding functional group tolerance.A cyclopalladium compound might be the key imtermediate,which performs anti-addition-carbometallation,and leads to the exclusive cross-selectivity.The unprecedented features of the reaction,such as anti-addition-carbometallation,easy control of selectivity,wide range of the donor alkynes,and very simple catalytic conditions,allow it not only a facile and functionally diverse synthesis of 1,3-enynes,but also a substantial progress for the textbook reaction. | Lixin Liu Jianyu Dong Zuqi Fu Lebin Su Shaofeng Wu Qian Shang Shuang-Feng Yin Yongbo Zhou | 2022 | Science China Chemistry2022，65，12： | 1 |
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