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| 1 | Mega-shoaling in carbonate platform of the Middle Triassic Leikoupo Formation,Sichuan Basin, Southwest China显示文摘Shoaling is a common type of sedimentation in the evolution of carbonate platform,and commonly has poor continuity.This paper presents a newly discovered and rare type of shoaling,i.e.,mega-shoaling in nearly basin scale,which is developed in the Middle Triassic Leikoupo Formation of the Sichuan Basin,southwest China.During the Leikoupo time,the studied Sichuan Basin experienced hot and dry climate conditions and developed a carbonate platform within a restricted epicontinental sea.In B sub-layer of the Lei-1-1 sub-member of the Leikoupo Formation a series of grainstones of shoal facies accumulated throughout almost the entire basin,thereby generating features associated with basin-scale mega-shoaling.By detailed core examination and microscopic observation of thin sections,it is shown that the lithology of this set of grainstones is dominated by doloarenite(calcarenite)followed by oolitic dolomite(limestone).In addition,it contains three types of sedimentary sequences characterized by upward-coarsening and upward-shallowing as the followings:restricted lagoon to platform interior beach;restricted lagoon to platform interior beach and to platform flat;and tidal flat to peritidal beach.Subsequently,a multicyclic stratigraphic division and correlation revealed that this set of grainstones can be well traced and compared horizontally,and is generally isochronous.In addition,a template for logging facies,established based on core calibrations and logging data,was employed to analyze the 235 wells in the basin.The results demonstrate the shoal grainstones to be 10–40 m thick with a15×104km2continuous distribution area.These findings indicate that the carbonate platform developed mega-shoals within a short period of time.The genesis of such a mega-shoaling was investigated by focusing on various shoaling conditions,such as paleo-tectonics,paleo-geomorphology,paleo-climate,sea-level changes,and palaeo-hydrodynamics.A specific combination of independent geological factors creates beneficial geomorphologic conditions for the mega-shoaling including a quiescent paleo-tectonic environment,relatively flat paleo-geomorphology and evaporites filling up and leveling off.In addition,a stably settling carbonate platform underwent sea-level fluctuations through swift transgressions and protracted regressions,which is not only conducive to continuous,multicyclic and superimposed vertical development of grain beaches but also beneficial for the horizontal migration,coalescence and superimposition of individual grain beaches.As a consequence,large-scale and continuously-distributed grain beach sedimentation emerges and mega-shoals develop. | TAN XiuCheng LI Ling LIU Hong CAO Jian WU XiaoQing ZHOU SuYan SHI XueWen | 2014 | Science China Earth Sciences2014，57，3： | 12 |
| 2 | Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture显示文摘We established a stroke-prone renovascular hypertensive rat model by bilateral constriction of the renal artery with sliver loop clips. After ten weeks, middle cerebral artery occlusion was induced for 2 hours. The rats then received electro-acupuncture at Baihui (DU 20) and Dazhui (DU 14) after onset of ischemia for 30 days. In situ hybridization study showed that electroacupuncture significantly reduced the number of neurocan mRNA-positive cells in the ischemic penumbra and hippocampal tissues of rats. Electron microscopy results demonstrated that the structure of neurons and blood vessels in the ischemic tissues were restored with electroacupuncture. Overall, these data suggest that electroacupuncture may protect neurons against ischemic reperfusion injury in stroke-prone renovascular hypertensive rats, which may be regulated by downregulation of expression of nerve inhibitory factor neurocan mRNA. | Feng Tan Saiying Wan Haike Wu Qiwen HUO Jinliang Wang Wenlin Chen Meifeng Fang Xiaolin Liu Xuewen Wang Jingbo Sun | 2011 | Neural Regeneration Research2011，6，36： | 8 |
| 3 | Efficient full-path optical calculation of scalar and vector diffraction using the Bluestein method显示文摘Efficient calculation of the light diffraction in free space is of great significance for tracing electromagnetic field propagation and predicting the performance of optical systems such as microscopy,photolithography,and manipulation.However,existing calculation methods suffer from low computational efficiency and poor flexibility.Here,we present a fast and flexible calculation method for computing scalar and vector diffraction in the corresponding optical regimes using the Bluestein method.The computation time can be substantially reduced to the sub-second level,which is 105 faster than that achieved by the direct integration approach(~hours level)and 102 faster than that achieved by the fast Fourier transform method(~minutes level).The high efficiency facilitates the ultrafast evaluation of light propagation in diverse optical systems.Furthermore,the region of interest and the sampling numbers can be arbitrarily chosen,endowing the proposed method with superior flexibility.Based on these results,full-path calculation of a complex optical system is readily demonstrated and verified by experimental results,laying a foundation for real-time light field analysis for realistic optical implementation such as imaging,laser processing,and optical manipulation. | Yanlei Hu Zhongyu Wang Xuewen Wang Shengyun Ji Chenchu Zhang Jiawen Li Wulin Zhu Dong Wu Jiaru Chu | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 4 | Synthesis of Osthole Derivatives with Grignard Reagents and Their Larvicidal Activities on Mosquitoes显示文摘osthole 的结构被修改了对蚊子改进它的 larvicidal 活动。有 Grignard 试剂的 osthole 衍生物的新有效合成被开发了,它作为倡导者采用 CuI 和 LiCl 并且盖住大量底层负担得起相应产品在对好收益(多达 83%) 温和。简历活动评估证明几个产品比 osthole 展出了更好的活动。 | Ming Liu Yang Liu Xuewen Hua Changchun Wu Sha Zhou Baolei Wang Zhengming Li | 2015 | Chinese Journal of Chemistry2015，33，12： | 4 |
| 5 | Design, Synthesis and Herbicidal Activity of Novel Sulfonylureas Containing Tetrahydrophthalimide Substructure显示文摘 | HUA Xuewen ZHOU Sha CHEN Minggui ZHANG Dongkai LIU Ming LIU Jingbo WU Changchun LIU Yang LI Yonghong LI Zhengming | 2016 | Chemical Research in Chinese Universities2016，32，3： | 3 |
| 6 | Construction of a recombinant lentivirus containing human microRNA-7-3 and its inhibitory effects on glioma proliferation显示文摘In the present study, we constructed a lentivirus, FIV-CMV-GFP-miR-7-3, containing the microRNA-7-3 gene and the green fluorescent protein gene, and used it to transfect human glioma U251 cells. Fluorescence microscopy showed that 80% of U251 cells expressed green fluorescence. Real-time reverse transcription PCR showed that microRNA-7-3 RNA expression in U251 cells was significantly increased. Proliferation was slowed in transfected U251 cells, and most cells were in the G 1 phase of the cell cycle. In addition, the expression of the serine/threonine protein kinase 2 was decreased. Results suggested that transfection with a lentivirus carrying microRNA-7-3 can effectively suppress epidermal growth factor receptor pathway activity in U251 cells, arrest cell cycle transition from G 1 phase to S phase and inhibit glioma cell growth. | Lun Dong Chongxu Han Hengzhu Zhang Xuewen Gu Jian Li Yongkang Wu Xiaodong Wang | 2012 | Neural Regeneration Research2012，7，27： | 3 |
| 7 | Association among lifestyle, clinical examination, polymorphisms in CDH1 gene and Traditional Chinese Medicine syndrome differentiation of gastric cancer显示文摘OBJECTIVE:To explore the association among lifestyle,clinical examination,polymorphisms in CDH1 gene and Traditional Chinese Medicine(TCM)syndrome differentiation of gastric cancer(GC). METHODS:A hospital-based population of 387 GC patients was investigated in Jiangsu province.Relevant information regarding lifestyle and clinical examination were collected by a standard questionnaire.Four known single nucleotide polymorphisms(SNPs)in CDH1 were investigated by polymerase chain reaction-ligation detection reaction methods.Statistical analysis was conducted by SPSS 16.0 software.RESULTS:The results showed that meal duration and the status of glutamic pyruvic transaminase were significantly associated with TCM syndrome differentiation of GC(both P<0.05).None of the four SNPs in the E-cadherin(CDH1)gene achieved significant differences in their distributions among the nine syndrome types of GC(both P>0.05).However,significant differences were observed in rs13689 genotype distributions between several pairs of syndrome types of GC,suggesting that rs13689 is correlated with the syndrome differentiation of GC.CONCLUSION:Integrated analysis of lifestyle,clinical examination and CDH1 gene polymorphisms can contribute to a better understanding of the GC syndrome types and may improve the efficacy of interventions by stratifying disease according to TCM criteria. | Junfeng Zhang Zhen Zhan Juan Wu Chunbing Zhang Yaping Yang Shujuan Tong Ruiping Wang Xuewen Yang Wei Dong | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 3 |
| 8 | Magnetic energy injection in GRB 080913显示文摘GRB 080913,with a spectroscopically determined redshift of z=6.7,was the record holder for being the most remote stellar object before the discovery of the recent gamma-ray burst GRB 090423,whose redshift is about 8.2.The gradually accumulated high redshift GRB sample has shed light on the origin and physical properties of GRBs during the cosmic re-ionization epoch.Here,we present a detailed numerical fit to the multi-wavelength data of the optical afterglow of GRB 080913 and then constrain its circumburst environment and the other model parameters.We conclude that the late optical/X-ray plateau at about one day since the burst is due to the Poynting-flux dominated injection from the central engine which is very likely a massive spinning black hole with super strong magnetic fields. | LIU XueWen,WU XueFeng & LU Tan Purple Mountain Observatory,Chinese Academy of Sciences,Nanjing 210008,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，S1： | 2 |
| 9 | Signaling pathways in obesity:mechanisms and therapeutic interventions显示文摘Obesity is a complex,chronic disease and global public health challenge.Characterized by excessive fat accumulation in the body,obesity sharply increases the risk of several diseases,such as type 2 diabetes,cardiovascular disease,and nonalcoholic fatty liver disease,and is linked to lower life expectancy.Although lifestyle intervention(diet and exercise)has remarkable effects on weight management,achieving long-term success at weight loss is extremely challenging,and the prevalence of obesity continues to rise worldwide.Over the past decades,the pathophysiology of obesity has been extensively investigated,and an increasing number of signal transduction pathways have been implicated in obesity,making it possible to fight obesity in a more effective and precise way.In this review,we summarize recent advances in the pathogenesis of obesity from both experimental and clinical studies,focusing on signaling pathways and their roles in the regulation of food intake,glucose homeostasis,adipogenesis,thermogenesis,and chronic inflammation.We also discuss the current antiobesity drugs,as well as weight loss compounds in clinical trials,that target these signals.The evolving knowledge of signaling transduction may shed light on the future direction of obesity research,as we move into a new era of precision medicine. | Xue Wen Bohan Zhang Beiyi Wu aitao Xiao Zehua Li Ruoyu Li Xuewen Xu Tao Li | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 10 | Identification of powdery mildew resistance loci in wheat by integrating genome-wide association study(GWAS) and linkage mapping显示文摘Wheat powdery mildew(Blumeria graminis f.sp.tritici, Bgt) is a disease of increasing importance globally due to the adoption of high yielding varieties and modern sustainable farming technologies.Growing resistant cultivars is a preferred approach to managing this disease, and novel powdery mildew resistance genes are urgently needed for new cultivar development.A genome-wide association study was performed on a panel of 1292 wheat landraces and historical cultivars using 5011 single nucleotide polymorphism(SNP)markers.The association panel was evaluated for reactions to three Bgt inoculants, OKS(14)-B-3-1, OKS(14)-C-2-1, and Bgt15.Linkage disequilibrum(LD) analysis indicated that genome-wide LD decayed to 0.1 at 23 Mb, and population structure analysis revealed seven subgroups in the panel.Association analysis using a mixed linear model(MLM) identified three loci for powdery mildew resistance on chromosome 2 B, designated QPm.stars-2BL1,QPm.stars-2BL2, and QPm.stars-2BL3.To evaluate the efficacy of GWAS in gene discovery,QPm.stars-2BL2 was validated using F2 and F2:3 populations derived from PI420646 × OK1059060-126135-3.Linkage analysis delimited the powdery mildew resistance gene in PI 420646 to an interval where QPm.stars-2BL2 was located, lending credence to the GWAS results.QPm.stars-2BL1 and QPm.stars-2BL3, which were associated with four SNPs located at 457.7–461.7 Mb and two SNPs located at 696.6–715.9 Mb in the Chinese Spring reference IWGSC RefSeq v1.0, respectively, are likely novel loci for powdery mildew resistance and can be used in wheat breeding to improve powdery mildew resistance. | Genqiao Li Xiangyang Xu Chengcheng Tan Brett F.Carver Guihua Bai Xuewen Wang J.Michael Bonman Yanqi Wu Robert Hunger Christina Cowger | 2019 | The Crop Journal2019，7，3： | 2 |
| 11 | Flexible electronic eardrum显示文摘有高敏感和快反应速度的灵活 mechanosensors 可以推进保健设备的便携、可植入的应用,例如即时心率,脉搏,并且呼吸监视。在这份报纸,我们与 micro-structured 金字塔数组基于围单人赛的碳 nanotubes,聚乙烯,和 poly-dimethylsiloxane 介绍新奇灵活电子鼓膜(EE ) 。EE 设备在在 20-13,000 Hz 的一个频率领域以内检测并且记录声音显示出高敏感,高 signal-to-noise 比率(约 55 dB ) ,和快反应时间(76.9 s ) 。为健全察觉的机制被调查,敏感用微观结构,厚度,和紧张状态是坚定的。我们也证明设备能区分人的声音。灵活电子鼓膜的这崭新的表演为象可植入的听觉的生物电子和个人语音识别那样的许多应用程序有含意。 | Yang Gu Xuewen Wang Wen Gu Yongjin Wu Tie Li Ting Zhang | 2017 | Nano Research2017，10，8： | 2 |
| 12 | Synthesis of graphene oxide nanoribbons/chitosan composite membranes for the removal of uranium from aqueous solutions显示文摘In this study,a graphene oxide nanoribbons/chitosan(GONRs/CTS)composite membrane was successfully prepared by encapsulating CTS into GONRs,which were unzipped from multi-walled carbon nanotubes.The GONRs/CTS composite membrane so prepared was characterized using scanning electron microscopy,X-Ray diffraction and Fourier transform infrared spectroscopy.The effects of the experimental conditions such as the pH(2-7),adsorbent dosage(10-50mg),experimental time(5min-32h),uranium concentration(25-300mg·L^-1),experimental temperature(298K-328K)on the adsorption properties of the composite membrane for the removaal of U(VI)were investigated.The results showed that the U(VI)adsorption process of the GONRs/CTS composite membrane was pH-dependent,rapid,spontaneous and endothermic.The adsorption process followed the pseudosecondary kinetics and Langmuir models.The maximum U(VI)adsorption capacity of the GONRs/CTS composite membrane was calculated to be 320mg·g^-1.Hence,the GONRs/CTS composite membrane prepared in this study was found to be suitable for separating and recovering uranium from wastewater. | Xuewen Hu Yun Wang Jinbo Ou Yang Yang Li Peng Wu Hengju Zhang Dingzhong Yuan Yan Liu Zhenyu Wu Zhirong Liu | 2020 | Frontiers of Chemical Science and Engineering2020，14，6： | 1 |
| 13 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 14 | Fabrication and characteristics of nano LiFePO 4 /C composites with high capacity and high rate using nano Fe 2 O 3 as raw materials显示文摘 | BaoHua Rong YanWen Lu XueWen Liu QingLin Chen Kun Tang HuaZhen Yang XingYun Wu Fei Shen YanBin Chen YueFeng Tang YanFeng Chen | 2014 | Nano Energy2014，，： | 1 |
| 15 | CoB and BN composites enabling integrated adsorption/catalysis to polysulfides for inhibiting shuttle-effect in Li-S batteries显示文摘Lithium-sulfur(Li-S)batteries are hampered by the infamous shuttle effect and slow redox kinetics,resulting in rapid capacity decay.Herein,a bifunctional catalysis CoB/BN@rGO with integrated structure and synergy effect between adsorption and catalysis is proposed to solve the above problems.The integrated CoB and BN are simultaneously and uniformly introduced on the rGO substrate through a one-step calcination strategy,applied to modify the cathode side of PP separator.The transition metal borides can catalyze the conversion of lithium polysulfides(Li_(2)Sn,n≥4),whereas the bond of B-S is too weak to absorb LPS.Thus BN introduced can effectively restrict the diffusion of polysulfides via strong chemisorption with LiSnLi+…N,while the rGO substrate ensures smooth electron transfer for redox reaction.Therefore,through the integrated adsorption/catalysis,the shuttle effect is suppressed,the kinetics of redox reaction is enhanced,and the capacity decay is reduced.Using CoB/BN@rGO modified PP separator,the Li-S batteries with high initial capacity(1450 mAh g^(-1)at 0.35 mA cm^(-2))and long-cycle stability(700 cycles at 1.74 mA cm^(-2)with a decay rate of 0.032%per cycle)are achieved.This work provides a novel insight for the preparation of bifunctional catalysis with integrated structure for long-life Li-S batteries. | Tianli Wu Ting Yang Jizong Zhang Xuewen Zheng Kunlin Liu Chengyang Wang Mingming Chen | 2021 | Journal of Energy Chemistry2021，30，8： | 1 |
| 16 | Enzymatic formation of curcumin in vitro and in vivo显示文摘 | Jiaqing wang Taotao Xiong Jie Zhou Hongjian He Dongdong Wu Xuewen Du Xingyi Li Bing Xu | 2018 | Nano Research2018，11，6： | 1 |
| 17 | Serum microRNA-155 as a potential biomarker for breast cancer screening显示文摘MicroRNAs(miRs) have been shown to be differentially expressed in the serum of cancer patients and controls,and can thus be used as biomarkers for cancer screening.We detected the expression level of miR-155 in the serum of female breast cancer patients and healthy controls to investigate whether serum miR-155 could discriminate patients with early-stage breast cancer.Serum samples were collected from 20 female patients with newly diagnosed breast cancer and 10 healthy controls.Real-time quantitative PCR was used to detect the expression level of miR-155.The expression level of miR-155 was significantly increased in the serum of breast cancer patients compared with in the serum of normal controls.MiR-155 may be useful as a blood-based biomarker for breast cancer screening. | ZHAO SuYing WU Qian GAO Fen ZHANG ChunBing YANG XueWen | 2012 | Chinese Science Bulletin2012，57，26： | 1 |
| 18 | Wearable Sweat Biosensors Refresh Personalized Health/Medical Diagnostics显示文摘Sweat contains a broad range of critical biomarkers including ions,small molecules,and macromolecules that may indirectly or directly reflect the health status of the human body and thereby help track disease progression.Wearable sweat biosensors enable the collection and analysis of sweat in situ,achieving real-time,continuous,and noninvasive monitoring of human biochemical parameters at the molecular level.This review summarizes the physiological/pathological information of sweat and wearable sweat biosensors.First,the production of sweat pertaining to various electrolytes,metabolites,and proteins is described.Then,the compositions of the wearable sweat biosensors are summarized,and the design of each subsystem is introduced in detail.The latest applications of wearable sweat biosensors for outdoor,hospital,and family monitoring are highlighted.Finally,the review provides a summary and an outlook on the future developments and challenges of wearable sweat biosensors with the aim of advancing the field of wearable sweat monitoring technology. | Wenhui Ji Jingyu Zhu Wanxia Wu Nanxiang Wang Jiqing Wang Jiansheng Wu Qiong Wu Xuewen Wang Changmin Yu Gaofeng Wei Lin Li Fengwei Huo | 2021 | Research2021，，1： | 1 |
| 19 | A Centralized Location Algorithm Based on RSSI in Large-scale Wireless Sensor Network 显示文摘 | Wu Xuewen Tang Dunye Qian Xinhong | 2011 | Procedia Engineering2011，15，1： | 1 |
| 20 | Structure design and numerical simulation of novel supersonic swirling separator显示文摘 | Wen Chuang Cao XueWen Wu LiangHong | 2010 | Zhongguo Shiyou Daxue Xuebao2010，34，4： | 1 |
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