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| 1 | Biological drug and drug delivery-mediated immunotherapy显示文摘The initiation and development of major infammatory diseases,i.e.,cancer,vascular infammation,and some autoimmune diseases are closely linked to the immune system.Biologics-based immunotherapy is exerting a critical role against these diseases,whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo,poor penetration across biological barriers,and rapid clearance by the reticuloendothelial system.Drug delivery strategies are potent to promote their delivery.Herein,we reviewed the potential targets for immunotherapy against the major infammatory diseases,discussed the biologics and drug delivery systems involved in the immunotherapy,particularly highlighted the approved therapy tactics,and finally offer perspectives in this feld. | Qingqing Xiao Xiaotong Li Yi Li Zhenfeng Wu Chenjie Xu Zhongjian Chen Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 15 |
| 2 | Facile synthesis of Li3V2(PO4)3/C cathode material for lithium-ion battery via freeze-drying显示文摘In this work, we report a facile route for the synthesis of Li3V2(PO4)3/C cathode material via freezedrying and then calcination. The effect of calcination temperature on the electrochemical properties of the Li3V2(PO4)3/C is also investigated. When used as a lithium-ion battery cathode, the optimized Li3V2(PO4)3/C (LVP-800) through calcination at 800 ℃ exhibits a high initial charge and discharge capacity. The excellent electrochemical performance of LVP-800 is attributed to the good crystallinity and uniform morphology of the electrode material. In addition, the residual carbon can also improve the conductivity and buffer the volume expansion during the Li-ion extraction/reinsertion. Meanwhile, charge compensation also plays an important role in excellent electrochemical performance. | Shuainan Guo Ying Bai Zhenfeng Geng Feng Wu Chuan Wu | 2019 | Journal of Energy Chemistry2019，28，5： | 8 |
| 3 | Synthesis,functionalization,and nanomedical applications of functional magnetic nanoparticles显示文摘Synthesis of magnetic nanoparticles(MNPs) is one of the most active research areas in advanced materials. MNPs that have magnetic properties and other functionalities have been demonstrated to show great promise in nanomedical applications. This review summarizes the current MNPs preparation,functionalization and stabilization methods. It also analyzes the detailed features of MNPs. And furthermore it highlights some actual case analyses of these MNPs for disease therapy, drug delivery,hyperthermia, bioseparation and bioimaging applications. | Zhou Chen Cao Wu Zhenfeng Zhang Wangping Wu Xuefeng Wang Zhiqiang Yu | 2018 | Chinese Chemical Letters2018，29，11： | 7 |
| 4 | Effects of litter quality and climate change along an elevational gradient on litter decomposition of subalpine forests, Eastern Tibetan Plateau, China显示文摘Temperature and freeze-thaw events are two key factors controlling litter decomposition in cold biomes.Predicted global warming and changes in freeze-thaw cycles therefore may directly or indirectly impact litter decomposition in those ecosystems. Here, we conducted a2-year-long litter decomposition experiment along an elevational gradient from 3000 to 3600 m to determine the potential effects of litter quality, climate warming and freeze-thaw on the mass losses of three litter types [dragon spruce(Picea asperata Mast.), red birch(Betula albosinensis Burk.), and minjiang fir(Abies faxoniana Rehd. et Wild)]. Marked differences in mass loss were observed among the litter types and sampling dates. Decay constant(k) values of red birch were significantly higher than those of the needle litters. However, mass losses between elevations did not differ significantly for any litter type.During the winter, lost mass contributed 18.3–28.8 % of the net loss rates of the first year. Statistical analysis showed that the relationships between mass loss and litter chemistry or their ratios varied with decomposition periods. Our results indicated that short-term field incubations could overestimate the k value of litter decomposition.Considerable mass was lost from subalpine forest litters during the wintertime. Potential future warming may not affect the litter decomposition in the subalpine forest ecosystems of eastern Tibetan Plateau. | Zhenfeng Xu Jianxiao Zhu Fuzhong Wu Yang Liu Bo Tan Wanqin Yang | 2016 | Journal of Forestry Research2016，27，3： | 6 |
| 5 | Hypertrophic adenoids in patients with nasopharyngeal carcinoma:appearance at magnetic resonance imaging before and after treatment显示文摘Introduction:Patients with nasopharyngeal carcinoma(NPC) sporadically develop abnormal adenoids.Nasopharyngeal adenoids are usually included in the gross tumor volume(GTV) but may have different therapeutic responses than tumor tissue.Therefore,distinguishing adenoids from tumor tissue may be required for precise and efficient chemoradiotherapy and radiotherapy.We characterized nasopharyngeal adenoids and investigated the therapeutic responses of NPC and nasopharyngeal adenoids using magnetic resonance imaging(MRI).Methods:MRI data from 40 NPC patients with a coexisting adenoid mass before and after treatment were analyzed.The features of the adenoid masses,including location,striped appearance,size,interface,symmetry/asymmetry,and cysts,were evaluated.Treatment response were scored according to the World Health Organization guidelines.Results:A striped appearance was observed in 36 cases before treatment and in all cases after treatment.In these 36 cases,the average GTVs including and excluding the uninvolved adenoids were 19.8 cm^3 and 14.8 cm^3,respectively.The average percentage change after excluding the uninvolved adenoids from the GTV was 31.0%.Stable disease in the adenoids was identified in 27(96.4%) of 28 patients after neoadjuvant chemotherapy,while NPC clearly regressed.Partial adenoid responses were identified in 33(82.5%) of 40 patients at 3 months after chemoradiotherapy or radiotherapy,whereas complete tumor responses were achieved in all patients.Six months after treatment,the adenoids continued to atrophy but did not disappear,and tumor recurrence was not found.Conclusions:Nasopharyngeal adenoids and carcinoma tissue in NPC patients can be distinguished by using MRI and have different responses to chemoradiotherapy and radiotherapy.These findings contribute to better delineating the GTV of NPC,based on which spatially optimized strategies can be developed to render precise and efficient chemoradiotherapy and radiotherapy.Additionally,we observed a clear difference in the responses of these two tissue types to current therapies.This finding may reduce or avoid unnecessary biopsies or overtreatment. | Yao-Pan Wu Pei-Qiang Cai Li Tian Jie-Hua Xu Richard Alan Mitteer Jr Yi Fan Zhenfeng Zhang | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 6 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 7 | Metal phenolic network-stabilized nanocrystals of andrographolide to alleviate macrophage-mediated inflammation in-vitro显示文摘Macrophages play a crucial role in initiating,maintaining,and resolving inflammation through the phenotypic shift,inducing or inhibiting the production of inflammatory cytokines.Therefore,macrophages are potential targets for treating inflammatory diseases.Andrographolide(AND)is a potent anti-inflammatory drug that can reduce pro-inflammatory cytokines and suppress NF-κB/MAPK pathway in activated macrophages.Although AND has many medicinal properties,its lower water solubility and first-pass effect in the liver have hindered its clinical application.In this context,by using a metal phenolic network as a stabilizer,we designed and prepared highly stabilized AND nanocrystals(AND-MPN Ns)with high drug loading capacity to facilitate the clinical application of AND.Our findings showed that AND-MPN Ns could be used to enhance the anti-inflammation in-vitro via macrophage polarization,reducing proinflammatory cytokines IL-6 and TNF-α,and suppressing the NF-κB signaling pathway activation.The results demonstrated the potential of AND-MPN Ns to combat inflammatory diseases effectively. | Kosheli Thapa Magar George Frimpong Boafo Makhloufi Zoulikha Xiaohong Jiang Xiaotong Li Qingqing Xiao Xuyang Xing Xiaochun Wang Lifang Fan Zhenfeng Wu Wei He | 2023 | Chinese Chemical Letters2023，34，1： | 2 |
| 8 | Electroacupuncture enhances hippocampal NSCs proliferation in cerebral ischemia-reperfusion injured rats via activation of notch signaling pathway显示文摘 | Jing Tao Bin Chen Yanling Gao Shanli Yang Jia Huang Xin Jiang Yayin Wu Jun Peng Zhenfeng Hong Lidian Chen | 2014 | International Journal of Neuroscience2014，，3： | 2 |
| 9 | Green Synthesis of Mechanical Robust Superhydrophobic CNT@PU Coatings with High Flexibility for Extensive Applications显示文摘Superhydrophobic coatings with high flexibility and mechanical durability can well address many practical application problems.To this end,we proposed and fabricated a kind of bio-based superhydrophobic(multi-walled carbon nanotubes)CNT@PU(polyurethane)coatings.It was demonstrated that the CNT@PU coatings with 64%soft segment content possessed the preferable bonding strength(5B)with metal substrates.The multi-walled carbon nanotubes,as additive materials,were used to construct the microscopic structures of the coating surfaces,which made polyurethane surface superhydrophobic(water contact angle being 156.9°,and water sliding angle being 4.3°).Furthermore,the high bonding strength between CNT and coating matrix led to robust mechanical durability of supertiydrophobic CNT@PU coatings,and the coatings remained superhydrophobicity after 10 cycles of abrasion under 100 g load pressure.Also,the superhydrophobic coatings could well resist 5 cycles of tape-peeling action,and presented outstanding flexibility.The supernydrophobic CNT@PU coatings with high flexibility and mechanical durability could be applied to various substrates suggesting their big potential in future real-world application. | Zhengwei Wu Yizhou Shen Jie Tao Zhenfeng Jia Haifeng Chen Jiawei Jiang Zhen Wang | 2021 | Journal of Bionic Engineering2021，18，1： | 1 |
| 10 | Vertical distribution and temporal evolution of formaldehyde and glyoxal derived from MAX-DOAS observations:The indicative role of VOC sources显示文摘Formaldehyde(HCHO)and glyoxal(CHOCHO)are important oxidization intermediates of most volatile organic compounds(VOCs),but their vertical evolution in urban areas is not well understood.Vertical profiles of HCHO,CHOCHO,and nitrogen dioxide(NO_(2))were retrieved from ground-based Multi-Axis Differential Optical Absorption Spectroscopy(MAXDOAS)observations in Hefei,China.HCHO and CHOCHO vertical profiles prefer to occur at higher altitudes compared to NO_(2),which might be caused by the photochemistry-oxidation of longer-lived VOCs at higher altitudes.Monthly means of HCHO concentrations were higher in summer,while enhanced amounts of NO_(2)were mainly observed in winter.CHOCHO exhibited a hump-like seasonal variation,with higher monthly-averaged values not only occurred in warm months(July-August)but also in cold months(November-December).Peak values mainly occurred during noon for HCHO but emerged in the morning for CHOCHO and NO_(2),suggesting that HCHO is stronger link to photochemistry than CHOCHO.We further use the glyoxal to formaldehyde ratio(GFR)to investigate the VOC sources at different altitudes.The lowest GFR value is almost found in the altitude from 0.2 to 0.4 km,and then rises rapidly as the altitude increases.The GFR results indicate that the largest contributor of the precursor VOC is biogenic VOCs at lower altitudes,while at higher altitudes is anthropogenic VOCs.Our findings provide a lot more insight into VOC sources at vertical direction,but more verification is recommended to be done in the future. | Qianqian Hong Cheng Liu Qihou Hu Yanli Zhang Chengzhi Xing Jinping Ou Wei Tan Haoran Liu Xiaoqing Huang Zhenfeng Wu | 2022 | Journal of Environmental Sciences2022，34，12： | 1 |
| 11 | Development of a novel hollow fiber cation-exchange membrane from bromomethylated poly (2,6-dimethyl- 1,4-phenylene oxide) for removal of heavy-metal ions显示文摘 | Cheng Zhenfeng Wu Yonghui Wang Na | 2010 | Industrial Engineering Chemistry Research2010，49，7： | 1 |
| 12 | Spatio-temporal-spectral observation model for urban remote sensing显示文摘Taking cities as objects being observed,urban remote sensing is an important branch of remote sensing.Given the complexity of the urban scenes,urban remote sensing observation requires data with a high temporal resolution,high spatial resolution,and high spectral resolution.To the best of our knowledge,however,no satellite owns all the above character-istics.Thus,it is necessary to coordinate data from existing remote sensing satellites to meet the needs of urban observation.In this study,we abstracted the urban remote sensing observation process and proposed an urban spatio-temporal-spectral observation model,filling the gap of no existing urban remote sensing framework.In this study,we present four applications to elaborate on the specific applications of the proposed model:1)a spatiotemporal fusion model for synthesizing ideal data,2)a spatio-spectral observation model for urban vegetation biomass estimation,3)a temporal-spectral observation model for urban flood mapping,and 4)a spatio-temporal-spectral model for impervious surface extraction.We believe that the proposed model,although in a conceptual stage,can largely benefit urban observation by providing a new data fusion paradigm. | Zhenfeng Shao Wenfu Wu Deren Li | 2021 | Geo-Spatial Information Science2021，24，3： | 1 |
| 13 | On an open problem of Guo-Skiba显示文摘 | Zhenfeng WU Wenbin GUO Baojun LI | 2016 | Frontiers of Mathematics in China2016，11，6： | 1 |
| 14 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 15 | The development of Fructus corni quality standard considering the effects of processing显示文摘The quality standards for Fructus Comi have been established based on the effects of the manufacturing processes.Three critical process parameters(CPPs)of extraction,filtration,and concentration to prepare Fructus Comi concentrate were identified by Plackett-Burman design with a single batch of Fructus Corni,which were heating medium temperature,extraction time,and water addition.Morroniside yield,loganin yield,and dry matter yield were process critical quality attributes(CQAs).CPPs arranged with a Box-Behnken design were applied to treat different batches of Fructus Comi After constructing a model that included CPPs,material propertie s,and process CQAs,loganin content was found to be the critical material attribute(CMA).The design space was calculated with a probability method.According to the limits of process CQAs,the minimum content of loganin in Fructus Corni was calculated with an error propagation method,which was 6.92 mg·g^(-1).When the content of loganin in Fructus Corni reaches up to 6.92 mg·g^(-1),the material is considered high-quality and is most suitable for the process.High-quality material can be used for production of Fructus Comi concentrate.This method can also be used to set material quality standards for other Chinese medicines. | Xingchu Gong Junlin Guo Jingjing Pan Zhenfeng Wu | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 1 |
| 16 | Niche characteristics of main population in ope:cast dump vegetation restoration process显示文摘 | Chu Zhenfeng Wu Xiangyun | 2007 | Journal of Liaoning Technical University:Natural Science:2007，26，2： | 1 |
| 17 | Soil C, N and P stocks and stoichiometry under different vegetation on the surface of the Leshan Giant Buddha显示文摘The accumulation of soil organic matter and nutrients is an important pathway in effectivelyunderstanding the mechanisms of plant settlement and rock weathering, while the characteristics ofsoil organic carbon (C), nitrogen (N) and phosphorus (P) under different vegetation remain unclear.In this study, the stocks and stoichiometry of soil organic C, N and P were determined in differentpositions and types of vegetation on the surface of the Leshan Giant Buddha. We found that the totalstocks of soil organic C, N and P were 1689.77, 134.6 and 29.48 kg, respectively, for the Buddha.The stocks of soil organic C, N and P under vascular plants were higher than those under othervegetation, with highest values observed under herb. Higher stocks per unit area (m2) of soil organicC, N and P were found on the left and right arms, shoulders, and two platforms. These results providea full primary picture in understanding soil organic C, N and P accumulation and distribution on thesurface of the Buddha, which could supply the fundamental data on weathering management of theBuddha and other similar open-air stone carvings. | Fujia Wu Wanqin Yang Bo Sun Tianyu Yang Xuli Chen Zhenfeng Xu Huixing Song | 2022 | Soil Ecology Letters2022，4，1： | 1 |
| 18 | A supramolecular gel based on an adenine symmetrically grafted Anderson-type polyoxometalate complex显示文摘An Anderson-type polyoxometalate was covalently decorated by using adenine on both sides.Through cation substitution,we obtained a new hybrid building block with long alkyl chains for supramolecular gels.According to the synergetic effect of hydrogen bonding of inter adenine units and van der Waals interaction of side alkyl chains,the DODA 3 [A-MnMo 6-A] gelator can stabilize solvent and self-assemble into fibrous structure,forming supramolecular gel.In addition,the reversible sol-gel transformation was achieved by controlling environmental temperature.Scanning electron microscopy,transmission electron microscopy and X-ray diffraction were used to characterize the gel morphology and structure.As a result,we proposed the possible mechanism of gel formation and sol-gel transformation. | HE ZhenFeng AI Hui LI Bao WU LiXin | 2012 | Chinese Science Bulletin2012，57，33： | 1 |
| 19 | Anti-Parkinsonian Therapy:Strategies for Crossing the Blood–Brain Barrier and Nano-Biological Effects of Nanomaterials显示文摘Parkinson’s disease(PD),a neurodegenerative disease that shows a high incidence in older individuals,is becoming increasingly prevalent.Unfortunately,there is no clinical cure for PD,and novel anti-PD drugs are therefore urgently required.However,the selective permeability of the blood–brain barrier(BBB)poses a huge challenge in the development of such drugs.Fortunately,through strategies based on the physiological characteristics of the BBB and other modifications,including enhancement of BBB permeability,nanotechnology can offer a solution to this problem and facilitate drug delivery across the BBB.Although nanomaterials are often used as carriers for PD treatment,their biological activity is ignored.Several studies in recent years have shown that nanomaterials can improve PD symptoms via their own nano-bio effects.In this review,we first summarize the physiological features of the BBB and then discuss the design of appropriate brain-targeted delivery nanoplatforms for PD treatment.Subsequently,we highlight the emerging strategies for crossing the BBB and the development of novel nanomaterials with anti-PD nano-biological effects.Finally,we discuss the current challenges in nanomaterial-based PD treatment and the future trends in this field.Our review emphasizes the clinical value of nanotechnology in PD treatment based on recent patents and could guide researchers working in this area in the future. | Guowang Cheng Yujing Liu Rui Ma Guopan Cheng Yucheng Guan Xiaojia Chen Zhenfeng Wu Tongkai Chen | 2022 | Nano-Micro Letters2022，14，6： | 1 |
| 20 | Catalytic oxidation of CO over Cux Ce1-xO2- x/ SBA-15/FeCrAl monolithic catalysts显示文摘 | Zhao Fuzhen Ji Shengfu Wu Pingyi Li Zhenfeng Li Chengyue | 2009 | Catalysis Today2009，147，1： | 1 |
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