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| 1 | Controlling factors on the submarine canyon system: A case study of the Central Canyon System in the Qiongdongnan Basin, northern South China Sea显示文摘Based on an integrated analysis of high-resolution 2D/3D seismic data and drilling results, this study analyzes the tectonicsedimentary evolution of the Qiongdongnan Basin(QDNB) since the late Miocene, and discusses the controlling factors on the formation and development of the Central Canyon System(CCS). The sediment failures caused by the relative sea level falling might have discharged deposits from the slope to the canyon. The two suits of the infillings, i.e., turbidites and mass transport complex(MTC), were derived from the northwestern source and northern source, respectively. The sediment supplies, which differ significantly among different areas, might have led to the variations observed in the internal architectures. Tectonic transformation around 11.6 Ma had provided the tectonic setting for the CCS and formed an axial sub-basin in the central part of the Changchang Depression, which could be called the rudiment of the CCS. The tectonic activity of the Red River Fault(RRF) at about 5.7 Ma might have strengthened the hydrodynamics of the deposits at the junction of the Yinggehai Basin(YGHB) and the QDNB to trigger a high-energy turbidity current. The MTC from the northern continental slope system might have been constrained by the Southern Uplift, functioning as a barrier for the infillings of the CCS. Thanks to a sufficient sediment supply during the Holocene period and the paleo-seafloor morphology, the relief of modern central canyon with the starving landform in the eastern Changchang Depression might have been accentuated by deposition of sediments and vertical growth along the canyon flanks, where collapse deposits were widely developed. Corresponding to the segmentation of the CCS, the forming mechanisms of the canyon between the three segments would be different. The turbidite channel in the head area had likely been triggered by the abundant sediment supply from the northwestern source together with the fault activity at about 5.7 Ma of the RRF. The formation and evolution of the canyon in the western segment were caused by combined effects of the turbidite channel from the northwestern source, the MTC from the northern continental slope, and the paleo-seafloor geomorphology. In the eastern segment, the canyon was constrained by the tectonic transformation occurring at approximately 11.6 Ma and the insufficient sediment supply from the wide-gentle slope. | SU Ming ZHANG Cheng XIE XiNong WANG ZhenFeng JIANG Tao HE YunLong ZHANG CuiMei | 2014 | Science China Earth Sciences2014，57，10： | 21 |
| 2 | Biological drug and drug delivery-mediated immunotherapy显示文摘The initiation and development of major infammatory diseases,i.e.,cancer,vascular infammation,and some autoimmune diseases are closely linked to the immune system.Biologics-based immunotherapy is exerting a critical role against these diseases,whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo,poor penetration across biological barriers,and rapid clearance by the reticuloendothelial system.Drug delivery strategies are potent to promote their delivery.Herein,we reviewed the potential targets for immunotherapy against the major infammatory diseases,discussed the biologics and drug delivery systems involved in the immunotherapy,particularly highlighted the approved therapy tactics,and finally offer perspectives in this feld. | Qingqing Xiao Xiaotong Li Yi Li Zhenfeng Wu Chenjie Xu Zhongjian Chen Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 15 |
| 3 | Structure and kinematic analysis of the deepwater area of the Qiongdongnan Basin through a seismic interpretation and analogue modeling experiments显示文摘Located at the northwest continental slope of the South China Sea, the Qiongdongnan Basin bears valley-shaped bathymetry deepening toward east. It is separated from the Yinggehai Basin through NW-trending Indo-ChinaRed River shear zone, and connected with NW subsea basin through the Xisha Trough. Along with the rapid progress of the deepwater exploration, large amounts of high resolution geophysical and geological data were accumulated. Scientific researches about deepwater basins kept revealing brand new tectonic and sedimentary discoveries. In order to summarize the structural features and main controlling factors of the deepwater Qiongdongnan Basin, a series of researches on basin architecture, fault activities, tectonic deformation and evolution were carried out. In reference to analogue modeling experiments, a tectonic situation and a basin formation mechanism were discussed. The researches indicate that: the northern boundary of the Qiongdongnan Basin is strongly controlled by No. 2 fault. The overlapping control of two stress fields from the east and the west made the central depression zone extremely thinned. Combined with the changed stress field, the segmentation of a preexisting weakness zone made the sags in the east experiencing different rifting histories from the west ones. The NE-trending west segment of the Qiongdongnan Basin experienced strong rifting during Eocene, while the roughly EW-trending sags in the east segment show strong rifting during late Eocene and early Oligocene.Local structures such as NW-trending basal fault and inherited uplifts controlled the lateral segmentation. So first order factors such as regional stress field and preexisting weakness zone controlled the basin zonation, while the second order factors determined the segmentation from east to west. | SUN Zhen WANG Zhenfeng SUN Zhipeng WANG Zhangwen ZHANG Wei HE Lijuan | 2015 | Acta Oceanologica Sinica2015，34，4： | 10 |
| 4 | Evolution of deepwater sedimentary environments and its implication for hydrocarbon exploration in Qiongdongnan Basin, northwestern South China Sea显示文摘Over the past several years, a number of hydrocarbon reservoirs have been discovered in the deepwater area of Qiongdongnan Basin, northwestern South China Sea. These oil/gas fields demonstrate that the evolution of the deepwater sedimentary environment are controlling the formation and distribution of large-scale clastic reservoirs. Integration between seismic and borehole data were necessary to best clarify the distribution and quality of these deepwater reservoirs. Geochemical and paleobiological evidence from discrete samples was also applied to document specific information regarding the sedimentary environment. Results show that the Qiongdongnan Basin has existed as a thriving marine environment since Oligocene, when several rifting depressions developed throughout the entire Qiongdongnan Basin. Triggered by the faults activities, several distinct provenances supplied the coarse sediments, transporting and depositing them in deep parts of the rifting depressions. A fan delta system then formed nearby the source in the deeper area of these rifting depressions. The sedimentary environment of Qiongdongnan gradiationally became deepwater since early Miocene.Consequently, abundances of sediments were transported from Hainan Island and Southern Uplift, and then sunk into the basin center. The submarine fans revealed by many boreholes in this area verified them as good reservoir. Because the area reached its lowest sea level at late Miocene and the Southern Uplift subsidenced under sea level, not providing any sediment, so that the carbonate mesa and biorhythms characteristic of this area also developed during this period. In the west part of Qiongdongnan Basin, sediments transported from Vietnam increased in response to the Tibetan Uplift. Consequently, a central canyon developed along the center of Qiongdongnan Basin, which has been confirmed by several boreholes as a favorable hydrocarbon reservoir. The clarification of the deepwater sedimentary environment's evolution is potentially highly beneficial to future hydrocarbon exploration in the deepwater area of Qiongdongnan Basin. | WANG Zhenfeng JIANG Tao ZHANG Daojun WANG Yahui ZUO Qianmei HE Weijun | 2015 | Acta Oceanologica Sinica2015，34，4： | 6 |
| 5 | Vertical migration through faults and hydrocarbon accumulation patterns in deepwater areas of the Qiongdongnan Basin显示文摘In the Qiongdongnan Basin, faults are well developed. Based on the drilling results, the traps controlled two or more faults are oil-rich. However, when only one fault cut through the sand body, there is no sign for hydrocarbon accumulation in the sandstone. In terms of this phenomenon, the principle of reservoir-forming controlled by fault terrace is proposed, i.e., when the single fault activates, because of the incompressibility of pore water, the resistance of pore and the direction of buoyancy, it is impossible for hydrocarbon to accumulate in sandstone. But when there are two or more faults, one of the faults acts as the spillway so the hydrocarbon could fill in the pore of sandstone through other faults. In total five gas bearing structures and four failure traps are considered, as examples to demonstrate our findings. According to this theory, it is well-advised that south steep slope zone of Baodao-Changchang Depression, south gentle slope zone of Lingshui Depression, north steep slope zone of Lingshui Depression, and north steep slope zone of Baodao Depression are the most favorable step-fault zones, which are the main exploration direction in next stage. | WANG Zhenfeng LIU Zhen CAO Shang SUN Zhipeng ZUO Qianmei WANG Yahui HE Weijun | 2014 | Acta Oceanologica Sinica2014，33，12： | 4 |
| 6 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 7 | Metal phenolic network-stabilized nanocrystals of andrographolide to alleviate macrophage-mediated inflammation in-vitro显示文摘Macrophages play a crucial role in initiating,maintaining,and resolving inflammation through the phenotypic shift,inducing or inhibiting the production of inflammatory cytokines.Therefore,macrophages are potential targets for treating inflammatory diseases.Andrographolide(AND)is a potent anti-inflammatory drug that can reduce pro-inflammatory cytokines and suppress NF-κB/MAPK pathway in activated macrophages.Although AND has many medicinal properties,its lower water solubility and first-pass effect in the liver have hindered its clinical application.In this context,by using a metal phenolic network as a stabilizer,we designed and prepared highly stabilized AND nanocrystals(AND-MPN Ns)with high drug loading capacity to facilitate the clinical application of AND.Our findings showed that AND-MPN Ns could be used to enhance the anti-inflammation in-vitro via macrophage polarization,reducing proinflammatory cytokines IL-6 and TNF-α,and suppressing the NF-κB signaling pathway activation.The results demonstrated the potential of AND-MPN Ns to combat inflammatory diseases effectively. | Kosheli Thapa Magar George Frimpong Boafo Makhloufi Zoulikha Xiaohong Jiang Xiaotong Li Qingqing Xiao Xuyang Xing Xiaochun Wang Lifang Fan Zhenfeng Wu Wei He | 2023 | Chinese Chemical Letters2023，34，1： | 2 |
| 8 | Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma显示文摘我们以前在 hepatocellular 癌(HCC ) 识别了体的拷贝数字改变(CNA ) 的 1 241 个区域。在现在的学习,我们发现那新奇周期性的焦点的 amplicon, 1q24.1-24.2,在 HCC 指向 MPZL1 基因。尤其是,在 MPZL1 和 HCC 标本的 intrahepatic 转移的表示层次之间有积极关联。MPZL1 能显著地提高 HCC 房间的迁移、变形的潜力。而且,我们发现 MPZL1 由支持 HCC 房间移植的机制之一由导致支持 metastatic 蛋白质的 phosphorylation 和激活, cortactin。另外,我们发现 Src kinase 调停 cortactin 的 phosphorylation 和激活由 MPZL1 overexpression 导致了。一起拿,这些调查结果建议 MPZL1 是拷贝数字扩大的一个周期性的区域在 HCC 目标为 1q24.1-24.2 的新奇支持 metastatic 基因。 | Deshui Jia Ying Jing Zhenfeng Zhang Li Liu Jie Ding Fangyu Zhao Chao Ge Qifeng Wang Taoyang Chen Ming Yao Jinjun Li Jianren Gu Xianghuo He | 2014 | Cell Research2014，24，2： | 2 |
| 9 | An overview of amphoteric ion exchange membranes for vanadium redox flow batteries显示文摘Vanadium redox flow battery(VRB),as the most promising large-scale electrical energy storage units,has attracted extensive attention.Amphoteric ion exchange membrane(AIEM),as the core part of VRB,separates electrolyte on both sides of electrolytic tank and conducts H+.The AIEM with cation and anion groups possesses excellent performances,such as high ion conductivity(σ),low vanadium ion permeability(Pvn+),relative stability and low cost.However,the performance of AIEM directly depends on the chemical structure of polymers.In addition to ensuring foundational physical performance,ion selectivity of AIEM is significant since the crossover of vanadium ion with various valences may reduce the battery capacity.In this paper,AIEMs for VRB and their chemical structures as well as synthesis approaches to realize all kinds of high-performing AIEMs are reviewed.The current trend and future direction of prospective materials for the VRB separators are documented in detail as well. | Lei Liu Chao Wang Zhenfeng He Rajib Das Binbin Dong Xiaofeng Xie Zhanhu Guo | 2021 | Journal of Materials Science & Technology2021，，10： | 1 |
| 10 | Polyethylene glycol radical-initiated aerobic propargylic oxidation in dense carbon dioxide显示文摘The selective aerobic oxidation of alkynes to correspondingα,β-acetylenic ketones was achieved in polyethylene glycol/dense CO2/O2 biphasic system without any catalyst or additive.The effects of reaction parameters,e.g.temperature,CO2 pressure,PEG molecular weight and loading on the reaction were carefully examined.Moreover,various substrates worked well in the presence of PEG 1000 under 5 MPa of CO2 and 2 MPa of O2 at 100℃for 12 to 24 h and acceptable yield and selectivity could be obtained in most cases.Preliminary mechanistic investigations were also discussed. | Zhenfeng Diao Bin Li Bing Yu Anhua Liu Liangnian He | 2013 | Journal of Energy Chemistry2013，22，3： | 1 |
| 11 | Synergistic effect of aluminum hydroxide and expandable graphite on the flame retardancy of polyisocyanurate–polyurethane foams显示文摘 | Wanjin Wang Kui He Quanxiao Dong Ning Zhu Yong Fan Feng Wang Yibing Xia Haifeng Li Jing Wang Zhen Yuan Erpo Wang Zhenfeng Lai Tao Kong Xia Wang Hongwen Ma Mingshu Yang | 2014 | J. Appl. Polym. Sci2014，，4： | 1 |
| 12 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 13 | A supramolecular gel based on an adenine symmetrically grafted Anderson-type polyoxometalate complex显示文摘An Anderson-type polyoxometalate was covalently decorated by using adenine on both sides.Through cation substitution,we obtained a new hybrid building block with long alkyl chains for supramolecular gels.According to the synergetic effect of hydrogen bonding of inter adenine units and van der Waals interaction of side alkyl chains,the DODA 3 [A-MnMo 6-A] gelator can stabilize solvent and self-assemble into fibrous structure,forming supramolecular gel.In addition,the reversible sol-gel transformation was achieved by controlling environmental temperature.Scanning electron microscopy,transmission electron microscopy and X-ray diffraction were used to characterize the gel morphology and structure.As a result,we proposed the possible mechanism of gel formation and sol-gel transformation. | HE ZhenFeng AI Hui LI Bao WU LiXin | 2012 | Chinese Science Bulletin2012，57，33： | 1 |
| 14 | Pulmonary endothelium-targeted nanoassembly of indomethacin and superoxide dismutase relieves lung inflammation显示文摘Lung inflammation is an essential inducer of various diseases and is closely related to pulmonary-endothelium dysfunction.Herein,we propose a pulmonary endothelium-targeted codelivery system of anti-inflammatory indomethacin(IND)and antioxidant superoxide dismutase(SOD)by assembling the biopharmaceutical SOD onto the“vector”of rod-like pure IND crystals,followed by coating with anti-ICAM-1 antibody(Ab)for targeting endothelial cells.The codelivery system has a 237 nm diameter in length and extremely high drug loading of 39%IND and 2.3%SOD.Pharmacokinetics and biodistribution studies demonstrate the extended blood circulation and the strong pulmonary accumulation of the system after intravenous injection in the lipopolysaccharide(LPS)-induced inflammatory murine model.Particularly,the system allows a robust capacity to target pulmonary endothelium mostly due to the rod-shape and Ab coating effect.In vitro,the preparation shows the synergistic antiinflammatory and antioxidant effects in LPS-activated endothelial cells.In vivo,the preparation exhibits superior pharmacodynamic efficacy revealed by significantly downregulating the inflammatory/oxidative stress markers,such as TNF-a,IL-6,COX-2,and reactive oxygen species(ROS),in the lungs.In conclusion,the codelivery system based on rod-like pure crystals could well target the pulmonary endothelium and effectively alleviate lung inflammation.The study offers a promising approach to combat pulmonary endothelium-associated diseases. | Yi Yang Makhloufi Zoulikha Qingqing Xiao Feifei Huang Qi Jiang Xiaotong Li Zhenfeng Wu Wei He | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 15 | Bioinformatic analysis of embryo development related small heat shock protein Hsp26 in Artemia species显示文摘Artemia 胚胎能忍受极端温度,长期的血缺氧,干燥和紧张的条件的另外的宽变化。胚胎怎么熬过这些压力,是一个很有趣、未解决的题目。为了解决这个问题,我们分析了核苷酸并且为 Hsp26 推出了蛋白质顺序,对 Artemia 胚胎开发特定的分子的女伴。Hsp26 的 cDNAs 从八 Artemia 种被定序并且推断 Hsp26 氨基酸序列被分析。帮助计算机的分析显示 5-untranslated 区域和所有 3 introns 在开发期间为 Hsp26 基因表示包含许多通常认为的行动 cis 元素,包括热吃惊元素(HSE ) , Dfd, dl, CF2-II, Hb 和 AP-1 有约束力的地点。Hsp26 3-untranslated 终止者的第二等的结构为 transcriptional 结束包含基本结构基础。Hsp26 份额从另外的有机体与 sHSPs (小热吃惊蛋白质) 定序类似。推出的蛋白质的物理化学的性质蛋白质扑灭系数,等电位的点和 antigenic 地点例如理论分子的重量,也被获得。一七肽的原子本地化信号(NLS ) PFRRRMM 被发现,它建议 Hsp26 蛋白质被假设在原子核内被定位。特定的 phosphorylation 地点也是的丝氨酸, threonine 和酷氨酸和 kinase 的 phosphorylation 地点的数字在 Hsp26 蛋白质顺序定位了。这些研究将帮助我们完成 Hsp26 的更好的理解,为 sHSPs 的宽广含意在甲壳纲的动物胚胎开发工作。 | Jiaqing WANG Lin HOU Zhenfeng HE Daizong Li Lijuan JIANG | 2012 | Frontiers in Biology2012，7，4： | 0 |
| 16 | Research on system combination of machine translation based on Transformer显示文摘Influenced by its training corpus,the performance of different machine translation systems varies greatly.Aiming at achieving higher quality translations,system combination methods combine the translation results of multiple systems through statistical combination or neural network combination.This paper proposes a new multi-system translation combination method based on the Transformer architecture,which uses a multi-encoder to encode source sentences and the translation results of each system in order to realize encoder combination and decoder combination.The experimental verification on the Chinese-English translation task shows that this method has 1.2-2.35 more bilingual evaluation understudy(BLEU)points compared with the best single system results,0.71-3.12 more BLEU points compared with the statistical combination method,and 0.14-0.62 more BLEU points compared with the state-of-the-art neural network combination method.The experimental results demonstrate the effectiveness of the proposed system combination method based on Transformer. | 刘文斌 HE Yanqing LAN Tian WU Zhenfeng | 2023 | High Technology Letters2023，29，3： | 0 |
| 17 | Combination of photodynamic therapy and stimulator of interferon genes(STING)agonist inhibits colorectal tumor growth and recurrence显示文摘Dear Editor,Great progress has been made in the clinical use of photodynamic therapy(PDT)for the treatment of patients with superficial tumors[1].However,cancer recurrence and metastasis have limited the application of PDT in the treatment of solid tumors and advanced cancers.In this context,combining PDT with other complementary immunotherapy regimens may overcome these limitations of PDT[2]. | Yang Hao Sen Ma Zili Gu Alireza Haghparast Timo Schomann Zhenfeng Yu Yuanyuan He Xiaoxv Dong Luis J Cruz Peter ten Dijke | 2023 | Cancer Communications2023，43，4： | 0 |
| 18 | 肝癌细胞模型库及其药物基因组学“蓝图”显示文摘文章简介原发性肝癌异质性显著,耐药性突出,预后不良。不同国家地区之间肝癌致病因素差异明显,对肝癌的精准治疗带来严重挑战。全球每年超过50%的新增病例和死亡病例均发生在中国。由大量细胞系构成的细胞系平台在乳腺癌、肺癌等癌症研究中证明细胞系平台能够模拟癌症的遗传异质性和药物响应,通过细胞系平台可以发现与药物敏感性相关的分子标志物。 | 邱志欣 李虹 章正涛 Zhenfeng Zhu Sheng He Xujun Wang Pengcheng Wang Jianjie Qin Liping Zhuang Wei Wang Fubo Xie Ying Gu Keke Zou Chao Li Chun Li Chenhua Wang Jin Cen Xiaotao Chen Yajing Shu Zhao Zhang Lulu Sun Lihua Min Yong Fu Xiaowu Huang Hui Lv He Zhou Yuan Ji Zhigang Zhang Zhiqiang Meng 施晓雷 张海斌 李亦学 惠利健 | 2020 | 科学新闻2020，，2： | 0 |
| 19 | Synthesis of pyrimidines from dinitrogen and carbon显示文摘The element nitrogen and nitrogenous compounds are vital to life.The synthesis of nitrogen-containing compounds using dinitrogen as the nitrogen source,not through ammonia,is of great interest and great value but remains a grand challenge.Herein,we describe a strategy to realize this transformation by combining the heterogeneous approach with the homogeneous methodology.The N_(2)molecule was first fixed with carbon and LiH through a one-pot heterogeneous process,forming Li_(2)CN_(2)as an’activated’nitrogen source with high efficiency.Then subsequent homogeneous treatments of Li_(2)CN_(2)to construct the organic synthon carbodiimide and the RNA/DNA building block pyrimidines were fulfilled.By using^(15)N_(2)as the feedstock,their corresponding^(15)N-labeled carbodiimide and pyrimidines were readily obtained.This homogeneous-heterogeneous synergy strategy will open a new chapter for N_(2)transformation. | Xianghui Shi Qianru Wang Chao Qin Li-Jun Wu Yuanjin Chen Gao-Xiang Wang Yongli Cai Wenbo Gao Teng He Junnian Wei Jianping Guo Ping Chen Zhenfeng Xi | 2022 | National Science Review2022，9，12： | 0 |
| 20 | A chromosome-level genome assembly for Erianthus fulvus provides insights into its biofuel potential and facilitates breeding for improvement of sugarcane显示文摘Erianthus produces substantial biomass,exhibits a good Brix value,and shows wide environmental adaptability,making it a potential biofuel plant.In contrast to closely related sorghum and sugarcane,Erianthus can grow in degraded soils,thus releasing pressure on agricultural lands used for biofuel production.However,the lack of genomic resources for Erianthus hinders its genetic improvement,thus limiting its potential for biofuel production.In the present study,we generated a chromosome-scale reference genome for Erianthus fulvus Nees.The genome size estimated by flow cytometry was 937 Mb,and the assembled genome size was 902 Mb,covering 96.26%of the estimated genome size.A total of 35065 proteincoding genes were predicted,and 67.89%of the genome was found to be repetitive.A recent wholegenome duplication occurred approximately 74.10 million years ago in the E.fulvus genome.Phylogenetic analysis showed that E.fulvus is evolutionarily closer to S.spontaneum and diverged after S.bicolor.Three of the 10 chromosomes of E.fulvus formed through rearrangements of ancestral chromosomes.Phylogenetic reconstruction of the Saccharum complex revealed a polyphyletic origin of the complex and a sister relationship of E.fulvus with Saccharum sp.,excluding S.arundinaceum.On the basis of the four amino acid residues that provide substrate specificity,the E.fulvus SWEET proteins were classified as monoand disaccharide sugar transporters.Ortho-QTL genes identified for 10 biofuel-related traits may aid in the rapid screening of E.fulvus populations to enhance breeding programs for improved biofuel production.The results of this study provide valuable insights for breeding programs aimed at improving biofuel production in E.fulvus and enhancing sugarcane introgression programs. | Ling Kui Aasim Majeed Xianhong Wang Zijiang Yang Jian Chen Lilian He Yining Di Xuzhen Li Zhenfeng Qian Yinming Jiao Guoyun Wang Lufeng Liu Rong Xu Shujie Gu Qinghui Yang Shuying Chen Hongbo Lou Yu Meng Linyan Xie Fu Xu Qingqing Shen Amit Singh Karl Gruber Yunbing Pan Tingting Hao Yang Dong Fusheng Li | 2023 | Plant Communications2023，4，4： | 0 |
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