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| 1 | Nonlinear relationship between enteric-coated mycophenolate sodium dose and mycophenolic acid exposure in Han kidney transplantation recipients显示文摘The aim of the research was to investigate the pharmacokinetics(PK) of enteric-coated mycophenolate sodium(EC-MPS) by quantification of the active metabolite of mycophenolic acid(MPA)after multiple escalating oral doses in Han kidney transplant recipients. A total of 28 Han postoperative kidney transplant recipients were given a multiple-dose of 540, 720 or 900 mg of EC-MPS two times a day in combination with tacrolimus for 6 days. Blood specimens were collected at each time point from0 to 12 h after EC-MPS administration. MPA plasma concentrations were measured by UPLC–UV. The relationship between the EC-MPS dose and its PK parameters was assessed. In the range from 540 to900 mg, C_(max) and AUC_(0–12h) did not increase with dose escalation. The AUC_(0–12h), C_(max), C_0 and T_(max) for the 540 720 and 900 mg doses were not significantly different, respectively(P 40.05). AUC_0–12 h and C_(max) were increased less than proportionally with increasing EC-MPS dose levels. Inter-individual variability in AUC_(0–12h), C_(max) and C_0 were considerable. Nonlinear PK relationships were found from the doses of 540–900 mg of EC-MPS. | Jun Zhang Mengmeng Jia Lihua Zuo Na Li Yonggang Luo Zhi Sun Xiaojian Zhang Zhenfeng Zhu | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 3 |
| 2 | Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma显示文摘我们以前在 hepatocellular 癌(HCC ) 识别了体的拷贝数字改变(CNA ) 的 1 241 个区域。在现在的学习,我们发现那新奇周期性的焦点的 amplicon, 1q24.1-24.2,在 HCC 指向 MPZL1 基因。尤其是,在 MPZL1 和 HCC 标本的 intrahepatic 转移的表示层次之间有积极关联。MPZL1 能显著地提高 HCC 房间的迁移、变形的潜力。而且,我们发现 MPZL1 由支持 HCC 房间移植的机制之一由导致支持 metastatic 蛋白质的 phosphorylation 和激活, cortactin。另外,我们发现 Src kinase 调停 cortactin 的 phosphorylation 和激活由 MPZL1 overexpression 导致了。一起拿,这些调查结果建议 MPZL1 是拷贝数字扩大的一个周期性的区域在 HCC 目标为 1q24.1-24.2 的新奇支持 metastatic 基因。 | Deshui Jia Ying Jing Zhenfeng Zhang Li Liu Jie Ding Fangyu Zhao Chao Ge Qifeng Wang Taoyang Chen Ming Yao Jinjun Li Jianren Gu Xianghuo He | 2014 | Cell Research2014，24，2： | 2 |
| 3 | Electroacupuncture enhances hippocampal NSCs proliferation in cerebral ischemia-reperfusion injured rats via activation of notch signaling pathway显示文摘 | Jing Tao Bin Chen Yanling Gao Shanli Yang Jia Huang Xin Jiang Yayin Wu Jun Peng Zhenfeng Hong Lidian Chen | 2014 | International Journal of Neuroscience2014，，3： | 2 |
| 4 | Green Synthesis of Mechanical Robust Superhydrophobic CNT@PU Coatings with High Flexibility for Extensive Applications显示文摘Superhydrophobic coatings with high flexibility and mechanical durability can well address many practical application problems.To this end,we proposed and fabricated a kind of bio-based superhydrophobic(multi-walled carbon nanotubes)CNT@PU(polyurethane)coatings.It was demonstrated that the CNT@PU coatings with 64%soft segment content possessed the preferable bonding strength(5B)with metal substrates.The multi-walled carbon nanotubes,as additive materials,were used to construct the microscopic structures of the coating surfaces,which made polyurethane surface superhydrophobic(water contact angle being 156.9°,and water sliding angle being 4.3°).Furthermore,the high bonding strength between CNT and coating matrix led to robust mechanical durability of supertiydrophobic CNT@PU coatings,and the coatings remained superhydrophobicity after 10 cycles of abrasion under 100 g load pressure.Also,the superhydrophobic coatings could well resist 5 cycles of tape-peeling action,and presented outstanding flexibility.The supernydrophobic CNT@PU coatings with high flexibility and mechanical durability could be applied to various substrates suggesting their big potential in future real-world application. | Zhengwei Wu Yizhou Shen Jie Tao Zhenfeng Jia Haifeng Chen Jiawei Jiang Zhen Wang | 2021 | Journal of Bionic Engineering2021，18，1： | 1 |
| 5 | The effect of end-capping groups in A-D-A type non-fullerene acceptors on device performance of organic solar cells显示文摘A series of novel wide bandgap small molecules(IFT-ECA, IFT-M, IFT-TH and IFT-IC) based on the A-D-A structure with indenofluorene core, thiophene bridge, and different electron-deficient end-capping groups, were synthesized and used as non-fullerene acceptors in organic solar cells. The influences of end-capping groups on the device performance were studied.The four materials exhibited different physical and chemical properties due to the variation of end-capping groups, which further affect the exciton dissociation, charge transport, morphology of the bulk-heterojunction films and device performance. Among them, IFT-IC-based device delivered the best power conversion efficiency of 7.16% due to proper nano-scale phase separation morphology and high electron mobility, while the devices based on the other acceptors achieved lower device performance(4.14% for IFT-TH, <1% for IFT-ECA and IFT-M). Our results indicate the importance of choosing suitable electron-withdrawing groups to construct high-performance non-fullerene acceptors based on A-D-A motif. | Jianchao Jia Nannan Zheng Zhenfeng Wang Yunping Huang Chunhui Duan Fei Huang Yong Cao | 2017 | Science China Chemistry2017，60，11： | 1 |
| 6 | Electro-acupuncture at points of Zusanli and Quchi exerts anti-apoptotic effect through the modulation of PI3K/Akt signaling pathway显示文摘 | Xiehua Xue Yongmei You Jing Tao Xiaoqian Ye Jia Huang Shanli Yang Zhicheng Lin Zhenfeng Hong Jun Peng Lidian Chen | 2014 | Neuroscience Letters2014，，： | 1 |
| 7 | Effects of Ce on microstructure and mechanical properties of pure copper 显示文摘 | Zhang Zhenfeng Lin Gaoyong Zhang Shenghua Zhou Jia | 2007 | Materials Science and Engineering A2007，457，12： | 1 |
| 8 | Drag Reduction Characteristics of Microstructure Inspired by the Cross Section of Barchan Dunes under High Speed Flow Condition显示文摘A new type of microstructure inspired by the cross section of barchan dunes was proposed to reduce windage,which was considered as a passive drag reduction technology in aerospace manufacturing field.Computational fluid dynamics method was carried out to discuss the effect of the microstructure on the skin friction reduction under high velocity flow condition.Different microstructure heights were employed to survey the reduction of drag.The results illustrated that the appearance of microstructure led to a generation of pressure drag in non-smooth model(with microstructures inspired by cross section of barchan dune)in contrast to smooth model.However,the microstructure significantly increased the thickness of the low-speed fluid by 11.4%in the near-wall flow field,causing the low-speed fluid to rise and decreasing the velocity gradient near the wall,thereby reducing viscous resistance.In addition,high-speed fluid flowed above the microstructure units instead of along the inner side of the units due to the influence of micro-vortex,resulting in a reduction of friction near the surface.Further-more,micro-vortex was considered to be the significant internal factor to achieve turbulent drag reduction since it could not only reduce the viscous resistance by promoting the fluid flow above the microstructure but also pro-vide a reverse thrust force.The understanding of the mechanism of drag reduction provides theoretical guidance for further fabrication of drag reduction coatings using renewable materials. | Jiawei Jiang Yizhou Shen Jie Tao Zhenfeng Jia Xinyu Xie Chaojiao Zeng | 2022 | Journal of Renewable Materials2022，10，3： | 0 |
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