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| 1 | Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation显示文摘Severe acute pancreatitis-associated acute lung injury(SAP-ALI) is a serious disease associated with high mortality. Emodin has been applied to alleviate SAP-ALI;however, the mechanism remains unclear. We report that the therapeutic role of emodin in attenuating SAP-ALI is partly dependent on an exosomal mechanism. SAP rats had increased levels of plasma exosomes with altered protein contents compared to the sham rats. These infused plasma exosomes tended to accumulate in the lungs and promoted the hyper-activation of alveolar macrophages and inflammatory damage. Conversely,emodin treatment decreased the plasma/pancreatic exosome levels in the SAP rats. Emodin-primed exosomes showed less pro-inflammatory effects in alveolar macrophages and lung tissues than SAP exosomes. In detail, emodin-primed exosomes suppressed the NF-κB pathway to reduce the activation of alveolar macrophage and ameliorate lung inflammation by regulating PPARγ pathway, while these effects were amplified/abolished by PPARγ agonist/antagonist. Blockage of pancreatic acinar cell exosome biogenesis also exhibited suppression of alveolar macrophage activation and reduction of lung inflammation. This study suggests a vital role of exosomes in participating inflammation-associated organ-injury,and indicates emodin can attenuate SAP-ALI by reducing the pancreatic exosome-mediated alveolar macrophage activation. | Qian Hu Jiaqi Yao Xiajia Wu Juan Li Guixiang Li Wenfu Tang Jingping Liu Meihua Wan | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 7 |
| 2 | Catalyst-Free In Situ Carbon Nanotube Growth in Confined Space via High Temperature Gradient显示文摘Carbonaceous materials,such as graphite,carbon nanotubes(CNTs),and graphene,are in high demand for a broad range of applications,including batteries,capacitors,and composite materials.Studies on the transformation between diferent types of carbon,especially from abundant and low-cost carbon to high-end carbon allotropes,have received surging interest.Here,we report that,without a catalyst or an external carbon source,biomass-derived amorphous carbon and defective reduced graphene oxide(RGO)can be quickly transformed into CNTs in highly confned spaces by high temperature Joule heating.Combined with experimental measurements and molecular dynamics simulations,we propose that Joule heating induces a high local temperature at defect sites due to the corresponding high local resistance.Te resultant temperature gradient in amorphous carbon or RGO drives the migration of carbon atoms and promotes the growth of CNTs without using a catalyst or external carbon source.Our fndings on the growth of CNTs in confned spaces by fast high temperature Joule heating shed light on the controlled transition between diferent carbon allotropes,which can be extended to the growth of other high aspect ratio nanomaterials. | Chaoji Chen Yanan Chen Shuze Zhu Jiaqi Dai Glenn Pastel Yonggang Yao Dapeng Liu Yanbin Wang Jiayu Wan Teng Li Wei Luo Liangbing Hu | 2018 | Research2018，，1： | 2 |
| 3 | Late Cenozoic geological evolu- tion of the foreland basin bordering the West Kunlun range in Pulu area: Constraints on timing of uplift of no,hem margin of the Ti- betan Plateau显示文摘 | Wang Erchie Wan Jinglin Liu Jiaqi | 2003 | Journal of Geophysical Research2003，108，8： | 1 |
| 4 | ACCEL: an efflcient and privacy-preserving federated logistic regression scheme over vertically partitioned data显示文摘Dear editor,With the age of big data coming, massive data are being generated distributedly all the time and stored as the form of data islands;meanwhile, data privacy and security are strengthened with the introduction of some privacy laws, which thus bring huge challenges to traditional centralized machine learning. Consequently, federated learning(FL) [1], which can construct global machine learning models over multiple participants while keeping their data localized, gains widespread attention and shows its vast prospects in many fields [2]. | Jiaqi ZHAO Hui ZHU Fengwei WANG Rongxing LU Hui LI Zhongmin ZHOU Haitao WAN | 2022 | Science China(Information Sciences)2022，65，7： | 1 |
| 5 | Macrophage immuno- modulatory activity of polysaccharides isolated from Glycyrrhiza ura- lensis fish 显示文摘 | Anwei Cheng Fachun Wan Jiaqi Wang | 2008 | Int Immunopharmacol2008，8，1： | 1 |
| 6 | A facile approach to fabrication of bifunctional magnetic-optical Fe3O4@ZnS microspheres 显示文摘 | YU Xuegang WAN Jiaqi SHAN Yan | 2009 | Chem Mater2009，21，： | 1 |
| 7 | Late Cenozoic geological evolution of the foreland basin bordering the West Kunlun range in Pulu area: Constraints on timing of uplift of northern margin of the Tibetan Plateau显示文摘 | Erchie Wang Jinglin Wan Jiaqi Liu | 2003 | Journal of Geophysical Research2003，108，138： | 1 |
| 8 | Facile synthesis of superparamagnetic magnetite nanoparticles in liquid polyols显示文摘 | Cai Wei Wan Jiaqi | 2007 | Journal of Colloid and Interface Science2007，305，2： | 1 |
| 9 | Late Cenozoic geological evolution of the foreland basin bordering the West Kunlun range in Pulu area:Constraints on timing of uplift of northern margin of the Tibetan Plateau 显示文摘 | Erchie Wang Jinglin Wan Jiaqi Liu et el | 2003 | Journal of Geophysical Research2003，1088，： | 1 |
| 10 | Facile synthesis of zinc ferrite nanoparticles as non-lanthanide T1MRI contrast agents显示文摘 | Wan Jiaqi Jiang Xuehui Li Hui | 2012 | Journal of Materials Chemistry2012，22，13： | 1 |
| 11 | Facile synthesis of superparamagnetic magnetite nanopartieles in liquid polyols 显示文摘 | Wei Cai Jiaqi Wan | 2007 | Journal of Colloid and Interface Science2007，305，： | 1 |
| 12 | Restricted feeding regimens improve white striping associated muscular defects in broiler chickens显示文摘The current study investigated the effects of intermittent feeding(IF)and fasting strategies at different times post–hatch on muscle growth and white striping(WS)breast development.In the first trial,32 one-day-old Abor Acre broilers were fed ad libitum(AL)for 3 d post–hatch and then randomly allotted into 4 feeding strategies including AL,1h-IF group(1 h IF,4 times feeding/d,1 h each time),1.5h-IF(1.5 h IF,4 times feeding/d,1.5 h each time),and fasting(1d acute fasting,6 d free access to feed)groups and fed for 7 d.Although angiogenic genes including VEGFA,VEGFR1,and VEGFR2,and myogenic genes including MYOG and MYOD were upregulated(P<0.05),the breast muscle satellite cell(SC)number and PAX7,MYF5 expression were decreased by the IF strategies(P<0.05).One-day fasting at 6 d of age also upregulated angiogenic genes and MYOD expression(P<0.05),downregulated MYF5 expression(P<0.05),but did not change SC number(P>0.05).In the second trial,384 one-day-old birds were fed AL for 1 wk and then randomly allotted to the above 4 feeding strategies starting at 8 d of age until 42 d of age.Similarly,IF and fasting strategies upregulated the expression of angiogenic and myogenic genes(P<0.05).Both 1h-IF and 1.5h-IF increased breast muscle SC number(P<0.05).At slaughter,breast muscle fiber diameter of 1.5h-IF was smaller but the SC number was larger than that of the birds fed AL(P<0.05).The IF and fasting strategies prevented WS development,and reduced breast WS scores and triglyceride content(P<0.05)without changing the body weight(P>0.05).Fasting and 1h-IF reduced the expression of adipogenic genes ZNF423 and PDGFRα(P<0.05).Moreover,IF and fasting strategies reduced fibrosis in breast muscle and reduced skeletal muscle-specific E3 ubiquitin ligases(TRIM63 and MAFBX)(P<0.05).Fasting significantly reduced CASPASE-3 in breast muscle(P<0.05).In conclusion,IF starting in the first week decreases SC number.Compared to AL,IF or fasting promotes muscular angiogenesis,increases SC number,prevents muscle degeneration,and prevents the development of WS without impairing the growth performance of broiler chickens. | Hammed Ayansola Yanhui Luo Yan Wan Xiaoxiao Yu Jiaqi Lei Kewei Yu Chaoyong Liao Yuming Guo Bingkun Zhang Bo Wang | 2023 | Animal Nutrition2023，，1： | 0 |
| 13 | China Biodiversity Observation Network for better global sustainability developments显示文摘Biodiversity is undergoing unprecedented changes characterized by long-term,complex,and lagging consequences[1].Understanding the dynamic changes of biodiversity is essential for the conservation of biodiversity[2].Biodiversity monitoring is periodic measurements of biodiversity within a given area,such as data collection regarding the structure and function of ecosystems,the composition and distribution of species,and environmental factors.Based on the collected data,analyses could be performed to determine the trends of biodiversity change and potential drivers and assist in the evaluation of conservation effectiveness and decision-making[2,3]. | Jianfeng Yi Fangzhou Ma Jiaqi Li Wei Liu Yun Cao Yaqiong Wan Chenbin Wang Mengmeng Chen Dandan Yu Haigen Xu | 2022 | Eco-Environment & Health2022，1，4： | 0 |
| 14 | Predicting the Incident Cases of Emerging Infectious Disease Using a Bayesian Probability Model--China,February 2020显示文摘What is already known about this topic?The exact number of incident cases of emerging infectious diseases on a daily basis is of great importance to the disease control and prevention,but it is not directly available from the current surveillance system in time.What is added by this report?In this study,a Bayesian statistical method was proposed to estimate the posterior parameters of the gamma probability distribution of the lag time between the onset date and the reporting time based on the surveillance data.And then the posterior parameters and corresponding cumulative gamma probability distribution were used to predict the actual number of new incident cases and the number of unreported cases per day.The proposed method was used for predicting COVID-19 incident cases from February 5 to February 26,2020.The final results show that Bayesian probability model predictions based on data reported by February 28,2020 are very close to those actually reported a month later.What are the implications for public health practice?This research provides a Bayesian statistical approach for early estimation of the actual number of cases of incidence based on surveillance data,which is of great value in the prevention and control practice of epidemics. | Yewu Zhang Xiaofeng Wang Yanfei Li Siyu Wu Ming Wan Xuemei Su Shigui Yang Hanjiang Lai Zhongwei Jia Jiaqi Ma | 2020 | China CDC weekly2020，2，52： | 0 |
| 15 | Multi-objective Model Predictive Control of Grid-connected Three-level Inverter Based on Hierarchical Optimization显示文摘In order to solve the problem of weighting factors selection in the conventional finite-control-set model predictive control for a grid-connected three-level inverter,an improved multi-objective model predictive control without weighting factors based on hierarchical optimization is proposed.Four control objectives are considered in this strategy.The grid current and neutral-point voltage of the DC-link are taken as the objectives in the first optimization hierarchy,and by using fuzzy satisfaction decision,several feasible candidates of voltage vectors are determined.Then,the average switching frequency and common-mode voltage are optimized in the second hierarchy.The average ranking criterion is introduced to sort the objective functions,and the best voltage vector is obtained to realize the coordinated control of multiple objectives.At last,the effectiveness of the proposed strategy is verified by simulation results. | Ting Liu Yong Li Li Jiang Jianghu Wan Jiaqi Yu Chao Ding Yijia Cao | 2021 | Chinese Journal of Electrical Engineering2021，7，1： | 0 |
| 16 | Dispersed distribution derived integrated anode for lithium ion battery显示文摘With the development of portable communication devices and electric vehicles, there is a great need for energy storage devices with lighter weight and higher energy density. In this paper, a new method by combining waster-paper-synthesized conductive paper(CP) and active material Mn O2 together is developed to obtain a new type of anode without any binder for lithium ion batteries. By this way, we can obtain low density anode with active material in CP, instead of the commonly-used heavy metal current collector. Also, binder has been abandoned, which are usually used to combine active material into anode, to further decrease weight. The multi walled carbon nanotube(MWCNT) was added in serves as a component of CP and the conductive agent for active material. Compared to traditional anode coated on Cu current collector, the CP-combined anode can greatly improve the electrochemical performance of active material Mn O2. It can let more particles to fully participate in the reaction and therefore boost the specific capacity to a great extent(about 3 times higher). It delivered an initial specific capacity of 1629.9 m A h g^-1 at a current density of 100 m A g^-1 and maintained about 67% even after 100 cycles.What’s more, it shows reversible capacity of about 260 m A h g^-1 at high current density of 1000 m A h g^-1.Our original synthesis method of anode, which shows far-reaching referential value and environmental significance, can be generalized to other electrodes and other battery systems. | Boya Zhang Dongxiang Li Jiaqi Wan | 2019 | Journal of Materials Science & Technology2019，35，10： | 0 |
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