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| 1 | Research Progress on Heat Stress of Rice at Flowering Stage显示文摘Global warming has caused frequent occurrence of heat stress at the flowering stage of single-season rice in the Yangtze River region of China, which results in declines of spikelet fertility and yield in rice. Rice flowering stage is the most sensitive period to high temperatures, and therefore, the key for heat stress happening is the flowering stage coinciding with high temperature, which causes spikelet fertility decreasing in heat-sensitive varieties, and is the major factor for heat injury differences among various rice planting regions. With the development of rice breeding, temperature indexes for heat stress has been converted from daily maximum temperature of 35 oC to 38 oC with the stress duration of more than 3 d. During the flowering stage, anther dehiscence inhibition and low pollen shedding onto the stigma are two main reasons for spikelet fertility reduction under high temperatures. At panicle initiation stage, high temperatures aggravate spikelet degeneration, and destroy floral organ development. Various types of rice varieties coexist in production, and indica-japonica hybrid rice demonstrates the highest heat resistance in general, followed by indica and japonica rice varieties. In production, avoiding high temperature is the main strategy of preventing heat stress, and planting suitable cultivars and adjustment of sowing date are the most effective measures. Irrigation is an effective real-time cultivation measure to decline the canopy temperature during the rice flowering stage. We suggested that further study should be focused on exploring heat injury differences among different rice variety types, and innovating rice-planting methods according to planting system changes in rice planting regions with extreme heat stress. Meanwhile, high temperature monitor and warning systems should be improved to achieve optimal heat stress management efficiencies. | WANG Yaliang WANG Lei ZHOU Jianxia HU Shengbo CHEN Huizhe XIANG Jing ZHANG Yikai ZENG Yongjun SHI Qinghua ZHU Defeng ZHANG Yuping | 2019 | Rice science2019，26，1： | 13 |
| 2 | Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy显示文摘Dbait is a small double-stranded DNA molecule that has been utilized as a radiosensitizer to enhance the sensitivity of glioma to radiotherapy(RT). However, there is no effective drug delivery system to effectively overcome the blood–brain barrier(BBB). The aim of this study was to develop a gene delivery system by using the BBB and glioma dual-targeting and microenvironment-responsive micelles(ch-Kn(s-s)R8-An) to deliver Dbait into glioma for RT. Angiopep-2 can target the low-density lipoprotein receptor-related protein-1(LRP1) that is overexpressed on brain capillary endothelial cells(BCECs) and glioma cells. In particular, due to upregulated matrix metalloproteinase 2(MMP-2) in the tumor microenvironment, we utilized MMP-2-responsive peptides as the enzymatically degradable linkers to conjugate angiopep-2. The results showed that ch-Kn(s-s)R8-An micelles maintained a reasonable size(80–160 nm) with a moderate distribution and a decreased mean diameter from the cross-linking as well as exhibited low critical micelle concentration(CMC) with positive surface charge, ranging from 15 to40 mV. The ch-K5(s-s)R8-An/pEGFP showed high gene transfection efficiency in vitro, improved uptake in glioma cells and good biocompatibility in vitro and in vivo. In addition, the combination of ch-K5(s-s)R8-An/Dbait with RT significantly inhibited the growth of U251 cells in vitro. Thus, ch-K5(s-s)R8-An/Dbait may prove to be a promising gene delivery system to target glioma and enhance the efficacy of RT on U251 cells. | Xiuxiu Jiao Yuan Yu Jianxia Meng Mei He Charles Jian Zhang Wenqian Geng Baoyue Ding Zhuo Wang Xueying Ding | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 13 |
| 3 | Effects of two polybrominated diphenyl ethers(BDE-47,BDE-209) on the swimming behavior, population growth and reproduction of the rotifer Brachionus plicatilis显示文摘Polybrominated diphenyl ethers(PBDEs) are new kinds of persistent organic pollutants(POPs) and their potential threats to the equilibrium and sustainability of marine ecosystems have raised worldwide concerns. Here, two kinds of PBDEs, tetra-BDE(BDE-47)and deca-BDE(BDE-209) were applied, and their toxic effects on the swimming behavior,population growth and reproduction of Brachionus plicatilis were investigated. The results showed that:(1) The actual concentrations of BDE-47 and-209 in the seawater phase measured by GC–MS(Gas Chromatography-Mass Spectrometer) were much lower than their nominal concentrations.(2) In accordance with the 24-hr acute tests, BDE-209 did not show any obvious swimming inhibition to rotifers, but a good correlation did exist between the swimming inhibition rate and BDE-47 concentration suggesting that BDE-47 is more toxic than BDE-209.(3) Both BDE-47 and-209 had a significant influence on the population growth and reproduction parameters of B. plicatilis including the population growth rate, the ratio of ovigerous females/non-ovigerous females(OF/NOF), the ratio of mictic females/amictic females(MF/AF), resting egg production and the mictic rate, which indicate that these parameters in B. plicatilis population were suitable for monitoring and assessing PBDEs. Our results suggest that BDE-47 and-209 are not acute lethal toxicants and may pose a low risk to marine rotifers at environmental concentrations for short-term exposure. They also accumulate differently into rotifers. Further research data are needed to understand the mechanisms responsible for the effects caused by PBDEs and to assess their risks accurately. | Jingjing Sha You Wang Jianxia Lv Hong Wang Hongmei Chen Leilei Qi Xuexi Tang | 2015 | Journal of Environmental Sciences2015，27，2： | 9 |
| 4 | Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects显示文摘Dear Editor,Genetic engineering of T cells to express chimeric antigen receptors(CARs)is an efficient approach for clinical therapy of hematological malignancies(Kuwana et al.,1987;Eshhar et al.,1993;Barrett et al.,2014).The CARs endow T cells with the ability to recognize specific antigens and bind them in an MHC-independent mariner,thereby overcoming some of the mechanisms that mediate tumor immune escape.In addition,by providing co-stimulatory signals,CARs endow T cells with enhanced cytotoxicity and persistence compared with primary T cells.A typical CAR comprises a single-chain variable frag me nt(scFv)derived from a monoclonal an tibody(mAb)for an tige n recog nition and signaling domains for co?activation(Eshhar et al.,1993;Sadelain et al.,2013). | Jianxia Zhou Liyuan Jin Fuping Wang Yuan Zhang Bing Liu Tongbiao Zhao | 2019 | Protein & Cell2019，10，10： | 7 |
| 5 | Divergent Projection Patterns Revealed by Reconstruction of Individual Neurons in Orbitofrontal Cortex显示文摘The orbitofrontal cortex(OFC)is involved in diverse brain functions via its extensive projections to multiple target regions.There is a growing understanding of the overall outputs of the OFC at the population level,but reports of the projection patterns of individual OFC neurons across different cortical layers remain rare.Here,by combining neuronal sparse and bright labeling with a whole-brain florescence imaging system(fMOST),we obtained an uninterrupted three-dimensional whole-brain dataset and achieved the full morphological reconstruction of 25 OFC pyramidal neurons.We compared the wholebrain projection targets of these individual OFC neurons in different cortical layers as well as in the same cortical layer.We found cortical layer-dependent projections characterized by divergent patterns for information delivery.Our study not only provides a structural basis for understanding the principles of laminar organizations in the OFC,but also provides clues for future functional and behavioral studies on OFC pyramidal neurons. | Junjun Wang Pei Sun Xiaohua Lv Sen Jin Anan Li Jianxia Kuang Ning Li Yadong Gang Rui Guo Shaoqun Zeng Fuqiang Xu Yu-Hui Zhang | 2021 | Neuroscience Bulletin2021，37，4： | 5 |
| 6 | Contamination trends of polybrominated diphenyl ethers, organochlorine pesticides and heavy metals in sediments from Dagu Drainage River estuary, Tianjin显示文摘Concentrations of polybrominated diphenyl ethers (PBDEs), organochlorine pesticides (OCPs) and heavy metals in two sediment cores, taken from the Dagu Drainage River, were determined. The contamination trends of these three kinds of compounds were obtained. The results showed that concentrations of PBDEs increased in recent years; there were new contamination sources for OCPs in this area; contamination levels of heavy metals had no significant change in the last several years. Comparing the results of these two cores, erosion and dilution of seawater had different effects on the transportation of these compounds. | LU JianXia WANG YaWei ZHANG QingHua GAO ErLe JIANG GuiBint | 2007 | Chinese Science Bulletin2007，52，10： | 5 |
| 7 | The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients. | Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 8 | Synergy methodology for multi-objective operational control of reservoirs in Yellow River basin显示文摘This paper presents an application of synergy methodology to a multi- objective operational control of reservoirs. This methodology enables a comprehensive consideration of multi-objectives which may be conflicting and non commensurate such as municipal and industrial water supply, flood protection, and hydroelectric power generation etc. On the basis of the synergy theory, a harmony degree model of sub- system was established to describe the coordination magnitude. Combined with information entropy, a harmony degree entropy was proposed to determine the water resources evolvement direction. While implementing the control, an initial scheme for reservoir operation was obtained from simulation first, then control was carried out according to the harmony degree and harmony degree entropy by applying synergy theory. The application of the methodology to reservoir system in the Yellow River was reported in this paper through a case study. | HUANG Qiang CHANG Jianxia WANG Yimin PENG Shaoming | 2004 | Science China(Technological Sciences)2004，47，z1： | 3 |
| 9 | Optimal four-impulse rendezvous between coplanar elliptical orbits显示文摘Rendezvous in circular or near circular orbits has been investigated in great detail,while rendezvous in arbitrary eccentricity elliptical orbits is not sufficiently explored.Among the various optimization methods proposed for fuel optimal orbital rendezvous,Lawden's primer vector theory is favored by many researchers with its clear physical concept and simplicity in solution.Prussing has applied the primer vector optimization theory to minimum-fuel,multiple-impulse,time-fixed orbital rendezvous in a near circular orbit and achieved great success.Extending Prussing's work,this paper will employ the primer vector theory to study trajectory optimization problems of arbitrary eccentricity elliptical orbit rendezvous.Based on linearized equations of relative motion on elliptical reference orbit (referred to as T-H equations),the primer vector theory is used to deal with time-fixed multiple-impulse optimal rendezvous between two coplanar,coaxial elliptical orbits with arbitrary large eccentricity.A parameter adjustment method is developed for the prime vector to satisfy the Lawden's necessary condition for the optimal solution.Finally,the optimal multiple-impulse rendezvous solution including the time,direction and magnitudes of the impulse is obtained by solving the two-point boundary value problem.The rendezvous error of the linearized equation is also analyzed.The simulation results confirmed the analyzed results that the rendezvous error is small for the small eccentricity case and is large for the higher eccentricity.For better rendezvous accuracy of high eccentricity orbits,a combined method of multiplier penalty function with the simplex search method is used for local optimization.The simplex search method is sensitive to the initial values of optimization variables,but the simulation results show that initial values with the primer vector theory,and the local optimization algorithm can improve the rendezvous accuracy effectively with fast convergence,because the optimal results obtained by the primer vector theory are already very close to the actual optimal solution.If the initial values are taken randomly,it is difficult to converge to the optimal solution. | WANG JianXia BAOYIN HeXi LI JunFeng SUN FuChun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 3 |
| 10 | A histological and biomechanical study of bone stress and bone remodeling around immediately loaded implants显示文摘Immediate loading(IL)increases the risk of marginal bone loss.The present study investigated the biomechanical response of peri-implant bone in rabbits after IL,aiming at optimizing load management.Ninety-six implants were installed bilaterally into femurs of 48 rabbits.Test implants on the left side created the maximal initial stress of 6.9 and 13.4 MPa in peri-implant bone and unloaded implants on the contralateral side were controls.Bone morphology and bone-implant interface strength were measured with histological examination and push-out testing during a 12-week observation period.Additionally,the animal data were incorporated into finite element(FE)models to calculate the bone stress distribution at different levels of osseointegration.Results showed that the stress was concentrated in the bone margin and the bone stress gradually decreased as osseointegration proceeded.A stress of about 2.0 MPa in peri-implant bone had a positive effect on new bone formation,osseointegration and bone-implant interface strength.Bone loss was observed in some specimens with stress exceeding 4.0 MPa.Data indicate that IL significantly increases bone stress during the early postoperative period,but the load-bearing capacity of peri-implant bone increases rapidly with an increase of bone-implant contact.Favorable bone responses may be continually promoted when the stress in peri-implant bone is maintained at a definite level.Accordingly,the progressive loading mode is recommended for IL implants. | HAN JingYun HOU JianXia ZHOU Gang WANG Chao FAN YuBo | 2014 | Science China(Life Sciences)2014，57，6： | 2 |
| 11 | VqMYB154 promotes polygene expression and enhances resistance to pathogens in Chinese wild grapevine显示文摘Resveratrol plays a crucial phytoalexin role in the grapevine and is beneficial to human health.However,the molecular mechanism of resveratrol accumulation in the enhancement of disease resistance is unclear.Here,we report that the transcription factor VqMYB154 from Vitis quinquangularis accession Danfeng-2 is strongly expressed under artificial inoculation with Uncinula necator and regulates resveratrol accumulation.Unlike its homolog,VqMYB154 has a pathogen-induced promoter and responds to stimulation by U.necator,Pseudomonas syringae,and other treatments.Yeast one-hybrid and GUS activity assays confirmed that VqMYB154 can activate the stilbene synthase genes VqSTS9,VqSTS32,and VqSTS42 by directly binding to their promoters.Overexpression of VqMYB154 in grape leaves resulted in activation of the stilbene pathway,upregulation of STS genes,and accumulation of stilbenoids.In addition,heterologous overexpression of VqMYB154 in Arabidopsis activated resistance-related genes and resulted in greater programmed cell death and accumulation of reactive oxygen species,which led to resistance against P.syringae.These results suggest that the transcription factor VqMYB154 from V.quinquangularis accession Danfeng-2 participates in the regulatory mechanism that improves the biosynthesis and accumulation of stilbenes and enhances resistance to disease in grapevine. | Changyue Jiang Dan Wang Jie Zhang Yan Xu Chaohong Zhang Jianxia Zhang Xiping Wang Yuejin Wang | 2021 | Horticulture Research2021，8，1： | 2 |
| 12 | Assessment of river basin habitat quality and its relationship with disturbance factors: A case study of the Tarim River Basin in Northwest China显示文摘The status of regional biodiversity is determined by habitat quality.The effective assessment of habitat quality can help balance the relationship between economic development and biodiversity conservation.Therefore,this study used the InVEST model to conduct a dynamic evaluation of the spatial and temporal changes in habitat quality of the Tarim River Basin in southern Xinjiang Uygur Autonomous Region of China by calc ulating the degradation degree levels for habitat types that were caused by threat factors from 1990 to 2018(represented by four periods of 1990,2000,2010 and 2018).Specifically,we used spatial autocorrelation analysis and Getis-Ord Gi*analysis to divide the study area into three heterogeneous units in terms of habitat quality:cold spot areas,hot spot areas and random areas.Hemeroby index,population density,gross domestic product(GDP),altitude and distance from water source(DWS)were then chosen as the main disturbance factors.Linear correlation and spatial regression models were subsequently used to analyze the influences of disturbance factors on habitat quality.The results demonstrated that the overall level of habitat quality in the TRB was poor,showing a continuous degradation state.The intensity of the negative correlation between habitat quality and Hemeroby index was proven to be strongest in cold spot areas,hot spot areas and random areas.The spatial lag model(SLM)was better suited to spatial regression analysis due to the spatial dependence of habitat quality and disturbance factors in heterogeneous units.By analyzing the model,Hemeroby index was found to have the greatest impact on habitat quality in the studied four periods(1990,2000,2010 and2018).The research results have potential guiding significance for the formulation of reasonable management policies in the TRB as well as other river basins in arid areas. | HE Bing CHANG Jianxia GUO Aijun WANG Yimin WANG Yan LI Zhehao | 2022 | Journal of Arid Land2022，14，2： | 2 |
| 13 | Antidiabetic effect of total flavonoids from Sanguis draxonis in type 2 diabetic rats显示文摘 | Fufeng Chen Hui Xiong Jianxia Wang | 2013 | Journal of Ethnopharmacology2013，149，3： | 1 |
| 14 | An Attempt of Data Exchange Between the Institutional Repository and the Information Environment for the Management of Scientific Research -ARP显示文摘 | Ma Jianxia Wang Yuanming Zhu Zhongming | 2009 | Library Collection Acquisitions and Technical Services2009，2009，1： | 1 |
| 15 | An Attempt of Data Exchange Between the Institutional Repository and the Information Environment for the Management of Scientific Research --ARP显示文摘 | Ma Jianxia Wang Yuanming Zhu Zhongming | 2009 | Library Collections Acquisitions and Technical Services2009，2009，1： | 1 |
| 16 | Identification of Abnormal 51 CTA/CTG Expansion as Probably the Shortest Pathogenic Allele for Spinocerebellar Ataxia-8 in China显示文摘Dear Editor,Spinocerebellar ataxias (SCAs) are a group of genetic disorders characterized by slowly progressive incoordination of gait and are often associated with poor coordination of the hands, speech, and eye movements. Frequently,atrophy of the cerebellum occurs. The genetic forms of ataxia are diagnosed by family history, physical examination, neuroimaging, and molecular genetic testing. | Minjin Wang Shuo Guo Wencong Yao Jun Wang Jianxia Tao Yanbing Zhou Binwu Ying | 2018 | Neuroscience Bulletin2018，34，5： | 1 |
| 17 | Polybrominated diphenyl ethers and organochlorine pesticides in sewage sludge of wastewater treatment plants in China显示文摘 | WANG Yawei ZHANG Qinghua LV Jianxia | 2007 | Chemosphere2007，68，9： | 1 |
| 18 | Antidiabeticeffect of total flavonoids from Sanguis draxonis in type 2diabetic rats 显示文摘 | Fufeng Chen Hui Xiong Jianxia Wang | 2013 | Journal of Ethnopharmacology2013，149，3： | 1 |
| 19 | iDental: A haptic-based dental simulator and its preliminary user evaluation显示文摘 | WANG Dangxiao ZHANG Yuru HOU Jianxia | 2012 | Haptics IEEE Transactions on2012，5，4： | 1 |
| 20 | Genomes of 12 fig wasps provide insights into the adaptation of pollinators to fig syconia显示文摘Figs and fig pollinators are one of the few classic textbook examples of obligate pollination mutualism.The specific dependence of fig pollinators on the relatively safe living environment with sufficient food sources in the enclosed fig syconia implies that they are vulnerable to habitat changes.However,there is still no extensive genomic evidence to reveal the evolutionary footprint of this long-term mutually beneficial symbiosis in fig pollinators.In fig syconia,there are also non-pollinator species.The non-pollinator species differ in their evolutionary and life histories from pollinators.We conducted comparative analyses on 11 newly sequenced fig wasp genomes and one previously published genome.The pollinators colonized the figs approximately 66.9 million years ago,consistent with the origin of host figs.Compared with nonpollinators,many more genes in pollinators were subject to relaxed selection.Seven genes were absent in pollinators in response to environmental stress and immune activation.Pollinators had more streamlined gene repertoires in the innate immune system,chemosensory toolbox,and detoxification system.Our results provide genomic evidence for the differentiation between pollinators and nonpollinators.The data suggest that owing to the long-term adaptation to the fig,some genes related to functions no longer required are absent in pollinators. | Jinhua Xiao Xianqin Wei Yi Zhou Zhaozhe Xin Yunheng Miao Hongxia Hou Jiaxing Li Dan Zhao Jing Liu Rui Chen Liming Niu Guangchang Ma Wenquan Zhen Shunmin He Jianxia Wang Xunfan Wei Weihao Dou Zhuoxiao Sui Haikuan Zhang Shilai Xing Miao Shi Dawei Huang | 2021 | Journal of Genetics and Genomics2021，48，3： | 1 |
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