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| 1 | Research Progress on Heat Stress of Rice at Flowering Stage显示文摘Global warming has caused frequent occurrence of heat stress at the flowering stage of single-season rice in the Yangtze River region of China, which results in declines of spikelet fertility and yield in rice. Rice flowering stage is the most sensitive period to high temperatures, and therefore, the key for heat stress happening is the flowering stage coinciding with high temperature, which causes spikelet fertility decreasing in heat-sensitive varieties, and is the major factor for heat injury differences among various rice planting regions. With the development of rice breeding, temperature indexes for heat stress has been converted from daily maximum temperature of 35 oC to 38 oC with the stress duration of more than 3 d. During the flowering stage, anther dehiscence inhibition and low pollen shedding onto the stigma are two main reasons for spikelet fertility reduction under high temperatures. At panicle initiation stage, high temperatures aggravate spikelet degeneration, and destroy floral organ development. Various types of rice varieties coexist in production, and indica-japonica hybrid rice demonstrates the highest heat resistance in general, followed by indica and japonica rice varieties. In production, avoiding high temperature is the main strategy of preventing heat stress, and planting suitable cultivars and adjustment of sowing date are the most effective measures. Irrigation is an effective real-time cultivation measure to decline the canopy temperature during the rice flowering stage. We suggested that further study should be focused on exploring heat injury differences among different rice variety types, and innovating rice-planting methods according to planting system changes in rice planting regions with extreme heat stress. Meanwhile, high temperature monitor and warning systems should be improved to achieve optimal heat stress management efficiencies. | WANG Yaliang WANG Lei ZHOU Jianxia HU Shengbo CHEN Huizhe XIANG Jing ZHANG Yikai ZENG Yongjun SHI Qinghua ZHU Defeng ZHANG Yuping | 2019 | Rice science2019，26，1： | 13 |
| 2 | Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy显示文摘Dbait is a small double-stranded DNA molecule that has been utilized as a radiosensitizer to enhance the sensitivity of glioma to radiotherapy(RT). However, there is no effective drug delivery system to effectively overcome the blood–brain barrier(BBB). The aim of this study was to develop a gene delivery system by using the BBB and glioma dual-targeting and microenvironment-responsive micelles(ch-Kn(s-s)R8-An) to deliver Dbait into glioma for RT. Angiopep-2 can target the low-density lipoprotein receptor-related protein-1(LRP1) that is overexpressed on brain capillary endothelial cells(BCECs) and glioma cells. In particular, due to upregulated matrix metalloproteinase 2(MMP-2) in the tumor microenvironment, we utilized MMP-2-responsive peptides as the enzymatically degradable linkers to conjugate angiopep-2. The results showed that ch-Kn(s-s)R8-An micelles maintained a reasonable size(80–160 nm) with a moderate distribution and a decreased mean diameter from the cross-linking as well as exhibited low critical micelle concentration(CMC) with positive surface charge, ranging from 15 to40 mV. The ch-K5(s-s)R8-An/pEGFP showed high gene transfection efficiency in vitro, improved uptake in glioma cells and good biocompatibility in vitro and in vivo. In addition, the combination of ch-K5(s-s)R8-An/Dbait with RT significantly inhibited the growth of U251 cells in vitro. Thus, ch-K5(s-s)R8-An/Dbait may prove to be a promising gene delivery system to target glioma and enhance the efficacy of RT on U251 cells. | Xiuxiu Jiao Yuan Yu Jianxia Meng Mei He Charles Jian Zhang Wenqian Geng Baoyue Ding Zhuo Wang Xueying Ding | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 13 |
| 3 | Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects显示文摘Dear Editor,Genetic engineering of T cells to express chimeric antigen receptors(CARs)is an efficient approach for clinical therapy of hematological malignancies(Kuwana et al.,1987;Eshhar et al.,1993;Barrett et al.,2014).The CARs endow T cells with the ability to recognize specific antigens and bind them in an MHC-independent mariner,thereby overcoming some of the mechanisms that mediate tumor immune escape.In addition,by providing co-stimulatory signals,CARs endow T cells with enhanced cytotoxicity and persistence compared with primary T cells.A typical CAR comprises a single-chain variable frag me nt(scFv)derived from a monoclonal an tibody(mAb)for an tige n recog nition and signaling domains for co?activation(Eshhar et al.,1993;Sadelain et al.,2013). | Jianxia Zhou Liyuan Jin Fuping Wang Yuan Zhang Bing Liu Tongbiao Zhao | 2019 | Protein & Cell2019，10，10： | 7 |
| 4 | Divergent Projection Patterns Revealed by Reconstruction of Individual Neurons in Orbitofrontal Cortex显示文摘The orbitofrontal cortex(OFC)is involved in diverse brain functions via its extensive projections to multiple target regions.There is a growing understanding of the overall outputs of the OFC at the population level,but reports of the projection patterns of individual OFC neurons across different cortical layers remain rare.Here,by combining neuronal sparse and bright labeling with a whole-brain florescence imaging system(fMOST),we obtained an uninterrupted three-dimensional whole-brain dataset and achieved the full morphological reconstruction of 25 OFC pyramidal neurons.We compared the wholebrain projection targets of these individual OFC neurons in different cortical layers as well as in the same cortical layer.We found cortical layer-dependent projections characterized by divergent patterns for information delivery.Our study not only provides a structural basis for understanding the principles of laminar organizations in the OFC,but also provides clues for future functional and behavioral studies on OFC pyramidal neurons. | Junjun Wang Pei Sun Xiaohua Lv Sen Jin Anan Li Jianxia Kuang Ning Li Yadong Gang Rui Guo Shaoqun Zeng Fuqiang Xu Yu-Hui Zhang | 2021 | Neuroscience Bulletin2021，37，4： | 5 |
| 5 | Contamination trends of polybrominated diphenyl ethers, organochlorine pesticides and heavy metals in sediments from Dagu Drainage River estuary, Tianjin显示文摘Concentrations of polybrominated diphenyl ethers (PBDEs), organochlorine pesticides (OCPs) and heavy metals in two sediment cores, taken from the Dagu Drainage River, were determined. The contamination trends of these three kinds of compounds were obtained. The results showed that concentrations of PBDEs increased in recent years; there were new contamination sources for OCPs in this area; contamination levels of heavy metals had no significant change in the last several years. Comparing the results of these two cores, erosion and dilution of seawater had different effects on the transportation of these compounds. | LU JianXia WANG YaWei ZHANG QingHua GAO ErLe JIANG GuiBint | 2007 | Chinese Science Bulletin2007，52，10： | 5 |
| 6 | The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients. | Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 7 | Structural and magnetic properties of Sm_2Fe_(17-x)Nb_x (x = 0-4) alloys prepared by HDDR processes and their nitrides显示文摘Sm2Fe17-xNbxNy (x = 0-4) powder was synthesized by HDDR treatment and nitrogenation. The effects of partial Nb substitution for Fe on the structural and magnetic properties of Sm2Fe17?xNbx alloys and their nitrides were investigated. It was seen that Sm2(Fe,Nb)17 phase exists in both annealed and HDDR-treated Sm2Fe17?xNbx alloys. However, its content is decreased with the increase in Nb substitution. In annealed alloys, Sm2(Fe,Nb)17 phase becomes unstable and will dissociate into SmFe2 and Fe-rich phases when x > 1.5. With HDDR-treatment, the Nb concentration in recombined Sm2(Fe,Nb)17 phase is decreased, and the content of Fe-rich phases is increased. Sm2Fe17?xNbx powder exhibits dendritic cracks and fine particles with a size of less than 300 nm. In nitrogenated alloys, N atoms mainly enter 2:17-type phase to form Sm2(Fe,Nb)17Ny. Partial Nb atoms in Sm2(Fe,Nb)17Ny phase will be released or excluded by nitrogen atoms. Fe-rich phases increase, and are followed by the amorphous Sm2(Fe,Nb)17Ny phase. Nb substitution for Fe with x = 0.5 and 1.0 in Sm2Fe17?xNbxNy powders increases the coercivity and remanence. But when x is greater than 2.0, Nb substitution will dete- riorate the magnetic properties. | SUN Jibing CUI Chunxiang ZHANG Ying LI lin GAO Jianxia LIU Yuling | 2006 | Rare Metals2006，25，2： | 4 |
| 8 | Alterations of peripheral CD4^(+)CD25^(+)Foxp3^(+)T regulatory cells in mice with STZ-induced diabetes显示文摘Complications arising from abnormal immune responses are the major causes of mortality and morbidity in diabetic patients.CD4^(+)CD25^(+)T regulatory cells(Tregs)play pivotal roles in controlling immune homeostasis,immunity and tolerance.The effect of hyperglycemia on CD4^(+)CD25^(+)Tregs has not yet been addressed.Here we used streptozotocin(STZ)-induced diabetic mice to study the effects of long-term hyperglycemia on CD4^(+)CD25^(+)Tregs in vivo.Four months after the onset of diabetes,the frequency of CD4^(+)CD25^(+)Foxp3^(+)T regulatory cells was significantly elevated in the spleen,peripheral blood lymphocytes(PBLs),peripheral lymph nodes(pLNs)and mesenteric LNs(mLNs).CD4^(+)CD25^(+)Tregs obtained from mice with diabetes displayed defective immunosuppressive functions and an activated/memory phenotype.Insulin administration rescued these changes in the CD4^(+)CD25^(+)Tregs of diabetic mice.The percentage of thymic CD4^(+)CD25^(+)naturally occurring Tregs(nTregs)and peripheral CD41Helios1Foxp31 nTregs were markedly enhanced in diabetic mice,indicating that thymic output contributed to the increased frequency of peripheral CD4^(+)CD25^(+)Tregs in diabetic mice.In an in vitro assay in which Tregs were induced fromCD4^(+)CD25^(+)T cells by transforming growth factor(TGF)-b,high glucose enhanced the efficiency of CD4^(+)CD25^(+)Foxp3^(+)T inducible Tregs(iTregs)induction.In addition,CD4^(+)CD25^(+)T cells from diabetic mice were more susceptible to CD4^(+)CD25^(+)Foxp3^(+)TiTreg differentiation than those cells from control mice.These data,together with the enhanced frequency of CD4^(+)CD25^(+)Foxp3^(+)T iTregs in the periphery of mice with diabetes,indicate that enhanced CD4^(+)CD25^(+)Foxp3^(+)T iTreg induction also contributes to a peripheral increase in CD4^(+)CD25^(+)Tregs in diabetic mice.Our data show that hyperglycemia may alter the frequency of CD4^(+)CD25^(+)Foxp3^(+)T Tregs in mice,which may result in late-state immune dysfunction in patients with diabetes. | Yu Zhen Lina Sun He Liu Kaizhong Duan Chun Zeng Lianjun Zhang Di Jin Jianxia Peng Wenjun Ding Yong Zhao | 2012 | Cellular & Molecular Immunology2012，9，1： | 4 |
| 9 | Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair显示文摘Over 300 billion of cells die every day in the human body,producing a large number of endogenous apoptotic extracellular vesicles(apoEVs).Also,allogenic stem cell transplantation,a commonly used therapeutic approach in current clinical practice,generates exogenous apoEVs.It is well known that phagocytic cells engulf and digest apoEVs to maintain the body’s homeostasis.In this study,we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair follicles.Mechanistically,apoEVs activate the Wnt/β-catenin pathway to facilitate their metabolism in a wave-like pattern.The migration of apoEVs is enhanced by treadmill exercise and inhibited by tail suspension,which is associated with the mechanical force-regulated expression of DKK1 in circulation.Furthermore,we show that exogenous apoEVs promote wound healing and hair growth via activation of Wnt/β-catenin pathway in skin and hair follicle mesenchymal stem cells.This study reveals a previously unrecognized metabolic pathway of apoEVs and opens a new avenue for exploring apoEV-based therapy for skin and hair disorders. | Lan Ma Chider Chen Dawei Liu Zhiqing Huang Jiaqi Li Haixiang Liu Ryan Tsz Kin Kwok Benzhong Tang Bingdong Sui Xiao Zhang Jianxia Tang Xueli Mao Weiying Huang Songtao Shi Xiaoxing Kou | 2023 | Bioactive Materials2023，，1： | 3 |
| 10 | TSC1 controls IL-1β expression in macrophages via mTORCl-dependent C/EBPβ pathway显示文摘 | Tao Yang Linnan Zhu Yanhua Zhai Qingjie Zhao Jianxia Peng Hongbing Zhang Zhongzhou Yang Lianfeng Zhang Wenjun Ding Yong Zhao | 2016 | Cellular & Molecular Immunology2016，13，5： | 3 |
| 11 | Developing institutional repositories network:Taking IR Grid at Chinese Academy of Sciences as an example显示文摘This paper introduces the current practice of building a network of institutional repositories(IRs)at Chinese Academy of Sciences(CAS),which is named CAS IR Grid.National Science Library(NSL)of CAS plays a leading role in the construction,promotion and implementation of CAS IR Grid.It aims to promote each institute of CAS to build IR of its own,and finally form the IR network of CAS institutes.NSL’s experience is introduced in coordinating and supporting institutes’building of their respective IRs and promoting IR services by adopting collaborative and progressive development strategies.Achievements made during the development of CAS IR Grid are described and challenges for its future development are discussed.The authors aim to provide best practices for developing a network of institutional repositories in research institute settings,which can serve as a practical reference to other institutions engaged in the similar task. | Zhongming ZHU Dongrong ZHANG Lin LI Jianxia MA Xiwen LIU | 2011 | Chinese Journal of Library and Information Science2011，，Z1： | 2 |
| 12 | Altered serous levels of monoamine neurotransmitter metabolites in patients with refractory and non-refractory depression显示文摘The study examined plasma metabolite changes of monoamine neurotransmitters in patients with treatment-resistant depression (TRD) and non-TRD before and after therapy. All 30 TRD and 30 non-TRD patients met the diagnostic criteria for a depressive episode in accordance with the International Classification of Diseases, Tenth Revision. Before treatment, and at 4, 6, and 8 weeks after treatment, the plasma metabolite products of monoamine neurotransmitters in TRD group, including 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenyl ethylene glycol and homovanillic acid, were significantly lower than those in the non-TRD group. After two types of anti-depressive therapy with 5-serotonin and norepinephrine reuptake inhibitor, combined with psychotherapy, the Hamilton Depression Rating Scale scores were significantly reduced in both groups of patients, and the serous levels of 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenyl ethylene glycol were significantly increased. In contrast, the homovanillic acid level exhibited no significant change. The levels of plasma metabolite products of peripheral monoamine neurotransmitters in depressive patients may predict the degree of depression and the therapeutic effects of treatment. | Guiqing Zhang Yanxia Zhang Jianxia Yang Min Hu Yueqi Zhang Xia Liang | 2012 | Neural Regeneration Research2012，7，14： | 2 |
| 13 | VqMYB154 promotes polygene expression and enhances resistance to pathogens in Chinese wild grapevine显示文摘Resveratrol plays a crucial phytoalexin role in the grapevine and is beneficial to human health.However,the molecular mechanism of resveratrol accumulation in the enhancement of disease resistance is unclear.Here,we report that the transcription factor VqMYB154 from Vitis quinquangularis accession Danfeng-2 is strongly expressed under artificial inoculation with Uncinula necator and regulates resveratrol accumulation.Unlike its homolog,VqMYB154 has a pathogen-induced promoter and responds to stimulation by U.necator,Pseudomonas syringae,and other treatments.Yeast one-hybrid and GUS activity assays confirmed that VqMYB154 can activate the stilbene synthase genes VqSTS9,VqSTS32,and VqSTS42 by directly binding to their promoters.Overexpression of VqMYB154 in grape leaves resulted in activation of the stilbene pathway,upregulation of STS genes,and accumulation of stilbenoids.In addition,heterologous overexpression of VqMYB154 in Arabidopsis activated resistance-related genes and resulted in greater programmed cell death and accumulation of reactive oxygen species,which led to resistance against P.syringae.These results suggest that the transcription factor VqMYB154 from V.quinquangularis accession Danfeng-2 participates in the regulatory mechanism that improves the biosynthesis and accumulation of stilbenes and enhances resistance to disease in grapevine. | Changyue Jiang Dan Wang Jie Zhang Yan Xu Chaohong Zhang Jianxia Zhang Xiping Wang Yuejin Wang | 2021 | Horticulture Research2021，8，1： | 2 |
| 14 | Local Participation and Cultural Inclusion: A Case Study on Lunang's Tourism Development in the Context of Policy of Partner Assistance to Tibet显示文摘The term Lang is a place name,it means'Dragon Valley','fairy place to live'in the Tibetan language.In 1911,the Qing dynasty officer Chen Quzhen was posted here,stationed in Lunang Dongjiu.He later described the Lunang area as a place' | Yang Minghong Liu Jianxia Zhang Yingwei | 2016 | China Tibetology2016，，2： | 2 |
| 15 | Performance of mortar and concrete made with a fine aggregate of desert sand显示文摘 | ZHANG Gubxue SONG Jianxia YANG Jiansen | 2006 | Building and Environment2006，41，1： | 1 |
| 16 | Screening for thyroid dysfunction during the second trimester of pregnancy显示文摘 | Wei Qian Lijun Zhang Mi Han Shuzin Khor Jun Tao Mengfan Song Jianxia Fan | 2013 | Gynecological Endocrinology2013，，12： | 1 |
| 17 | Determination of puerarin, daidzein and rutin in Pueraria lobata (Wild.) Ohwi by capillary electrophoresis with electrochemical detection显示文摘 | Gang Chen Jianxia Zhang Jiannong Ye | 2001 | Journal of Chromatography A2001，，1： | 1 |
| 18 | Effects of electrode materials on the degradation, spectral characteristics, visual colour, and antioxidant capacity of cyanidin-3-glucoside and cyanidin-3- sophoroside during pulsed electric field (PEF) treatment显示文摘 | SUN Jianxia BAI Weibin ZHANG Yan | 2011 | Food Chemistry2011，128，3： | 1 |
| 19 | Performance of mortar and concrete made with a fine aggregate of desert sand显示文摘 | Zhang Guoxue Song Jianxia Yang Jiansen etc | 2006 | Building and Environment2006，41，11： | 1 |
| 20 | Effect of total phenolics from Laggera alata on acute and chronic inflammation models显示文摘 | Yihang Wu Changxin Zhou Liyan Song Xiangping Li Shuyun Shi Jianxia Mo Haiyong Chen Hua Bai Xiumei Wu Jun Zhao Rongping Zhang Xiaojiang Hao Handong Sun Yu Zhao | 2006 | Journal of Ethnopharmacology2006，，2： | 1 |
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