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| 1 | Determination of metastable zone and induction time of analgin for cooling crystallization显示文摘The solubility, metastable zone width, and induction time of analgin for unseeded batch cooling crystallization in ethanol–aqueous system were experimentally determined. The solubility data could be well described by the van't Hoff equation model. The metastable zone width at various cooling rates was measured, and some parameters of nucleation kinetic were calculated using the Ny'vlt theory. Furthermore, the induction period of various temperatures and supersaturation ratios was also measured. According to classical nucleation theory, some nucleation parameters and interfacial energy was calculated through the induction time(t_(ind)) data. Homogeneous nucleation tended to occur when the supersaturation is high, whereas heterogeneous nucleation was more likely to occur when the supersaturation is low. | Ling Zhou Zhao Wang Meijing Zhang Mingxia Guo Shijie Xu Qiuxiang Yin | 2017 | Chinese Journal of Chemical Engineering2017，25，3： | 7 |
| 2 | Neuropeptide Y and leptin receptor expression in the hypothalamus of rats with chronic immobilization stress显示文摘In this study, Sprague-Dawley rats were immobilized to a frame for 3 hours a day for 21 days to establish a model of chronic immobilization stress. The body weight and food intake of rats subjected to chronic immobilization stress were significantly decreased compared with the control group. Dual-labeling immunofluorescence revealed that the expression of leptin receptor and the co-localization coeffient in these leptic receptor neurons in the arcuate nucleus of the hypothalamus were both upregulated, while the number of neuropeptide Y neurons was decreased. Chronic immobilization stress induced high expression of leptin receptor in the arcuate nucleus and suppressed the synthesis and secretion of neuropeptide Y, thereby disrupting the pathways in the arcuate nucleus that regulate feeding behavior, resulting in diminished food intake and reduced body weight. | Shaoxian Wang Jiaxu Chen Guangxin Yue Minghua Bai Meijing Kou Zhongye Jin | 2013 | Neural Regeneration Research2013，8，18： | 6 |
| 3 | Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats显示文摘Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly.To establish a hyperhomocysteinemic pregnant rat model,2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation.Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction.Results showed that systolic blood pressure,proteinuria/creatinine ratio,and plasma homocysteine levels in the hyperhomocys-teinemic pregnant rats increased significantly,and that body weight and brain weight of rat pups significantly decreased.Folic acid supplementation markedly reversed the above-mentioned abnormal changes of hyperhomocysteinemic pregnant rats and rat pups.These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia-induced preeclampsia in pregnant rats without influencing brain development of rat pups. | Jun Wang Yan Cui Jing Ge Meijing Ma | 2012 | Neural Regeneration Research2012，7，25： | 4 |
| 4 | New opportunities and challenges of natural products research:When target identification meets single-cell multiomics显示文摘Natural products, and especially the active ingredients found in traditional Chinese medicine(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in TCM. As such,traditional remedies provide shortcuts for the development of original new drugs in China, and increasing numbers of natural products are showing great therapeutic potential in various diseases. This paper reviews the molecular mechanisms of action of natural products from different sources used in the treatment of inflammatory diseases and cancer, introduces the methods and newly emerging technologies used to identify and validate the targets of natural active ingredients, enumerates the expansive list of TCM used to treat inflammatory diseases and cancer, and summarizes the patterns of action of emerging technologies such as single-cell multiomics, network pharmacology, and artificial intelligence in the pharmacological studies of natural products to provide insights for the development of innovative natural product-based drugs. Our hope is that we can make use of advances in target identification and singlecell multiomics to obtain a deeper understanding of actions of mechanisms of natural products that will allow innovation and revitalization of TCM and its swift industrialization and internationalization. | Yuyu Zhu Zijun Ouyang Haojie Du Meijing Wang Jiaojiao Wang Haiyan Sun Lingdong Kong Qiang Xu Hongyue Ma Yang Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 3 |
| 5 | Thermodynamic properties of metamizol monohydrate in pure and binary solvents at temperatures from(283.15 to 313.15) K显示文摘The thermodynamic properties of metamizol monohydrate in pure solvents(methanol,ethanol,n-propanol and isopropanol) and two binary mixed solvent systems including(methanol+ethanol) and(methanol+isopropanol) were measured from 283.15 K to 313.15 K by gravimetric method under atmospheric pressure thought as 0.1 MPa.The modi fied Apelblat equation,the CNIBS/R-K equation,the Hybrid model and the NRTL model were used to correlate the solubility of metamizol monohydrate,respectively.The results show that the solubility of metamizol monohydrate in all the tested solvents increases with the rising temperature which means that it has temperature dependence.What's more,the effects of solvent components of the binary solvent mixtures on solubility were discussed,it illustrates that the increasing of the molar fraction of methanol gives the system a greater dissolving power.Furthermore,according to the NRTL model,the enthalpy,the Gibbs energy and the entropy of the mixing process were also obtained and discussed. | Mingxia Guo Qiuxiang Yin Chang Wang Yaohui Huang Yang Li Zaixiang Zhang Xia Zhang Zhao Wang Meijing Zhang Ling Zhou | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 3 |
| 6 | Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: Role of the 55 kDa TNF receptor (TNFR1)显示文摘 | Paul R. Crisostomo Meijing Wang Christine M. Herring Troy A. Markel Kirstan K. Meldrum Keith D. Lillemoe Daniel R. Meldrum | 2006 | Journal of Molecular and Cellular Cardiology2006，，1： | 1 |
| 7 | TNF RECEPTOR 2, NOT TNF RECEPTOR 1, ENHANCES MESENCHYMAL STEM CELL-MEDIATED CARDIAC PROTECTION FOLLOWING ACUTE ISCHEMIA显示文摘 | Megan L. Kelly Meijing Wang Paul R. Crisostomo Aaron M. Abarbanell Jeremy L. Herrmann Brent R. Weil Daniel R. Meldrum | 2010 | Shock2010，，6： | 1 |
| 8 | P38 mitogen activated pro- tein kinase mediates both death signaling and functional depression in the heart显示文摘 | Meijing Wang Ben MT Mark WT | 2005 | Ann Thorac Surg2005，80，： | 1 |
| 9 | Nitric oxide suppresses the secretion of vascular from human mescnchymal stem cell 显示文摘 | Wang Yue Crisostomo P R Wang Meijing | 2008 | Shock2008，30，5： | 1 |
| 10 | SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice显示文摘Dear Editor,The loss of PINK1/Parkin-dependent mitochondrial clearance causes loss of dopaminergic neurons in the substantia nigra and contributes to the pathogenesis of Parkinson's disease(PD).Several kinases were reported to regulate the ubiquitin E3 ligase activity of Parkin through phosphorylation but the involvement of protein tyrosine phosphatase(PTPase)for Parkin activity remains elusive. | Wen Liu Meijing Wang Lihong Shen Yuyu Zhu Hongyue Ma Bo Liu Liang Ouyang Wenjie Guo Qiang Xu Yang Sun | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 11 | High Li + conduction in NASICON-type Li 1+ x Y x Zr 2? x (PO 4 ) 3 at room temperature显示文摘 | Yutao Li Meijing Liu Kai Liu Chang- An Wang | 2013 | Journal of Power Sources2013，，： | 1 |
| 12 | p38 Mitogen Activated Protein Kinase Mediates Both Death Signaling and Functional Depression in the Heart显示文摘 | Meijing Wang Ben M. Tsai Mark W. Turrentine Yousuf Mahomed John W. Brown Daniel R. Meldrum | 2005 | The Annals of Thoracic Surgery2005，，6： | 1 |
| 13 | Sliding modecontrol for uncertain neutral system with time~delays显示文摘 | Qu Shaocheng Gong Meijing Wang yongji | 2009 | Kybemetes2009，38，： | 1 |
| 14 | Identification and Genetic Analysis of a Novel Allelic Variation of Brittle-1 with Endosperm Mutant in Maize显示文摘Endosperm mutants are critical to the studies on both starch synthesis and metabolism and genetic improvement of starch quality in maize.In the present study,a novel maize endosperm mutant A0178 of natural variation was used as the experimental material and identified and then characterized.Through phenotypic identification,genetic analysis,main ingredients measurement and embryo rescue,development of genetic mapping population from A0178,the endosperm mutant gene was located.The results showed that the mutant exhibited extremely low germination ability as attributed to the inhibited embryo development,and amounts of sugars were accumulated in the mutant seeds and more sugars content was detected at 23 days after pollination(DAP)in A0178 than B73.Employing genetic linkage analysis,the mutant trait was mapped in the bin 5.04 on chromosome 5.Sequence analysis showed that two sites of base transversion and insertion presented in the protein coding region and non-coding region of the mutant brittle-1(bt1),the adenylate translocator encoding gene involved in the starch synthesis.The single base insertion in the coding region cause frameshift mutation,early termination and lose of function of Brittle-1(BT1).All results suggested that bt1 is a novel allelic gene and the causal gene of this endosperm mutant,providing insights on the mechanism of endosperm formation in maize. | Sen Wang Fei Zheng Meijing Zhang Jun Tu Yanping Chen Jianhua Yuan Qingchang Meng | 2020 | Phyton-International Journal of Experimental Botany2020，89，4： | 1 |
| 15 | Biophysical and functional characterizations of recombinant RimI acetyltransferase from Mycobacterium tuberculosis显示文摘Nα-acetylation is a universal protein modification related to a wide range of physiological processes in eukaryotes and prokaryotes. RimI, an Nα-acetyltransferase in Mycobacterium tuberculosis, is responsible for the acetylation of the α-amino group of the N-terminal residue in the ribosomal protein S18. Despite growing evidence that protein acetylation may be correlated with the pathogenesis of tuberculosis, no structural information is yet available for mechanistically understanding the MtRimI acetylation. To enable structural studies for MtRimI, we constructed a serial of recombinant MtRimI proteins and assessed their biochemical properties. We then chose an optimal construct MtRimIC21A4-153 and expressed and purified the truncated high-quality protein for further biophysical and functional characterizations. The 2D 1H-15N heteronuclear single quantum coherence spectrum of MtRimIC21A4-153 exhibits wider chemical shift dispersion and favorable peak isolation, indicating that MtRimIC21A4-153 is amendable for further structural determination. Moreover, bio-layer interferometry experiments showed that MtRimIC21A4-153 possessed similar micromolar affinity to full-length MtRimI for binding the hexapeptide substrate Ala-Arg-Tyr-Phe-Arg-Arg. Enzyme kinetic assays also exhibited that MtRimIC21A4-153 had almost identical enzymatic activity to MtRimI, indicating insignificant influence of the recombinant variations on enzymatic functions. Furthermore, binding sites of the peptide were predicted by molecular docking approach, suggesting that this substrate binds to MtRimI primarily through electrostatic and hydrogen bonding interactions. Our results lay a foundation for the further structural determination and dynamics detection of MtRimI. | Meijing Hou Jie Zhuang Shihui Fan Huilin Wang Chenyun Guo Hongwei Yao Donghai Lin Xinli Liao | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 0 |
| 16 | Chinese herbal compound Jinsiwei(金思维)improves synaptic plasticity in mice with sporadic Alzheimer’s disease induced by streptozotocin显示文摘OBJECTIVE:To investigate the efficacy of Jinsiwei(a patented Chinese herbal compound)on learning and memory impairment,the number of synapses and synaptic plasticity-related structural and functional protein expression in mice with sporadic Alzheimer’s disease(SAD)induced by streptozotocin.METHODS:Seventy-five C57/BL6J male mice were intracerebroventricularly injected with streptozotocin to establish the animal model of SAD.Mice were randomly divided into the model group(MG),donepezil group(DG),and the Jinsiwei high,medium,and low-dose groups(JH,JM,JL).Another fifteen C57/BL6J male mice were injected with artificial cerebrospinal fluid as the control group(CG).The intervention groups were intragastrically administrated with corresponding medicine,while the CG and MG were given 0.5%carboxymethyl cellulose by gavage.After 3 months,the Morris Water Maze test and step-down passive avoidance test were used to assess the learning and memory ability of mice.Synapses in hippocampal CA1 were observed by transmission electron microscope.Immunohistochemistry and western blotting were used to assess the distribution and expression levels of synaptic plasticity-related structural and functional proteins involving drebrin,cofilin,synapsin(syn),and N-methyl D-aspartate receptor subtype 2B(NR2B).RESULTS:The Morris Water Maze results showed that the escape latency in the Jinsiwei intervention groups was significantly shorter than that of the MG.Results of the step-down passive-avoidance test showed that the error times in the Jinsiwei intervention groups were significantly reduced compared with the MG.Transmission electron microscope results showed that the number of synapses in hippocampal CA1 was obviously increased in the Jinsiwei intervention groups compared with the MG.Immunohistochemical and western blotting results revealed that the positive cells and expression levels of drebrin,syn,and NR2B were significantly decreased in the MG and meanwhile cofilin significantly increased,while these changes were reversed after the Jinsiwei treatment.CONCLUSIONS:Jinsiwei can alleviate learning and memory impairments in a mouse model of SAD,increase the number of synapses and enhance synaptic plasticity via rescuing the expression of drebrin,syn,and NR2B and inhibiting cofilin expression. | TIAN Meijing HE Yannan ZHENG Mingcui QIN Gaofeng GONG Zhuoyan HUANG Shuaiyang WANG Pengwen | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 0 |
| 17 | Micro-Scanning Error Correction Technique for an Optical Micro-Scanning Thermal Microscope Imaging System显示文摘An error correction technique for the micro-scanning instrument of the optical micro-scanning thermal microscope imaging system is proposed. The technique is based on micro-scanning technology combined with the proposed second-order oversampling reconstruction algorithm and local gradient image reconstruction algorithm. In this paper, we describe the local gradient image reconstruction model, the error correction technique, down-sampling model and the error correction principle. In this paper, we use a Lena original image and four low-resolution images obtained from the standard half-pixel displacement to simulate and verify the effectiveness of the proposed technique. In order to verify the effectiveness of the proposed technique, two groups of low-resolution thermal microscope images are collected by the actual thermal microscope imaging system for experimental study. Simulations and experiments show that the proposed technique can reduce the optical micro-scanning errors, improve the imaging effect of the system and improve the system's spatial resolution. It can be applied to other electro-optical imaging systems to improve their resolution. | Meijing Gao Ying Han Qiushi Geng Yong Zhao Bozhi Zhang Liuzhu Wang | 2019 | Journal of Beijing Institute of Technology2019，28，3： | 0 |
| 18 | Precisely Controlled Two-Dimensional Rhombic Copolymer Micelles for Sensitive Flexible Tunneling Devices显示文摘Nanoscale two-dimensional(2D)organic materials have attracted significant interest on account of their unique properties,which result from their ultrathin and flat morphology.Supramolecular 2D nanomaterials prepared by bottom-up approaches have great potential in the creation of nanoscale devices with various applications,each controlled by the properties of its single-molecular components.Here,we report a uniform and controllable 2D rhombic micelles formed by block copolymers(BCPs)with poly(p-phenylenevinylene)(PPV)as core blocks.The supramolecular 2D nanostructures created in this way and driven byπ-πinteractions realize the precise separation of the semiconducting and insulating constituents of the constructed BCPs.With a vertical tunneling device design,the 2D rhombic micelles exhibited an on-off current ratio of>10^(4)and a high on-state current density of 6000 A cm^(−2)as the insulating layer was compressed by a conductive atomic force microscopy(C-AFM)probe.The tunneling device also shows a reproducible sensitivity on a flexible substrate,opening up potential flexible pressure sensor applications for such novel supramolecular 2D nanostructures. | Liang Han Hua Fan Yulin Zhu Meijing Wang Feng Pan Dapeng Yu Yue Zhao Feng He | 2021 | CCS Chemistry2021，3，5： | 0 |
| 19 | Reading Time and DNA Sequence Preference of TET3 CXXC Domain Revealed by Single-Molecule Profiling显示文摘Recognition of CpG dinucleotide DNA in epigenetic information flow plays a pivotal role for cellular differentiation and development.The TET3 CXXC domain binds to CpG DNA,serving a basic epigenetic information reading mechanism.During the selective recognition of a CpG motif by a CXXC domain from crowded binding sites in a gene sequence,the protein-DNA interactions are beyond CpG dinu-cleotide.However,the selective binding dynamics of CpG within a long DNA context by epigenetic enzymes have been rarely exploit-ed,which is hard for ensemble methods to probe.Here,we used single-molecule magnetic tweezers to quantitatively examine the dynamics of TET3's CXXC domain on a Hoxa9 promoter DNA.Our single-molecule binding profile revealed that CXXC-DNA interactions involve both CpG motifs and their flanking sequences.The residence time of TET3 CXXC differs by about 1000 times in five distin-guished CpG clusters in the context of a CpG island.Moreover,we performed multi-state hidden Markov modeling analysis on the zip-ping/unzipping dynamics of a CpG hairpin,discovering TET3 CXXC's preference on CpG motifs regarding the-2 to+2 flanking bases.Our results shed light on the selective binding dynamics of a CXXC on a gene sequence,facilitating studies on epigenetic information reading mechanisms. | Zeyu Wang Zhiqiang Cao Kangkang Ma Man Lu Meije Wang Han Gao Deshun Gong Lin Liang Zhongbo Yu | 2023 | Chinese Journal of Chemistry2023，41，10： | 0 |
| 20 | Translational perspective on bone-derived cytokines in inter-organ communications显示文摘OSTEOKINES IN INTER-ORGAN COMMUNICATIONS The concept of“organic wholeness”permeates all the fields of traditional Chinese medicine,which is also widely accepted by modern medicine.The wealth of knowledge regarding inter-organ communications generated in the latest decades provided solid evidence that human physiology and pathophysiology involve systematic interactions between multiple organs or tissues.Therefore,advancing our understanding of the inter-organ communication process is believed to provide a new perspective for treating various human diseases. | Fujun Jin Meijing Liu Dake Zhang Xiaogang Wang | 2023 | The Innovation2023，4，1： | 0 |
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