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| 1 | A Phytophthora capsid Effector Targets ACD11 Binding Partners that Regulate ROS-Mediated Defense Response in Arabidopsis显示文摘Reactive oxygen species (ROS) play a vital role in plant immune response, but the genes involved in the regulation of ROS are scantily reported. Phytophthora pathogens produce a large number of effectors to promote infection, but the modes of action adopted are largely unknown. Here, we report that RxLR207 could activate ROS-mediated cell death in Nicotiana benthamiana and was essential for virulence of P. capsici. We found that this effector targeted BPA1 (binding partner of ACD11) and four members of BPLs (BPAl-Like proteins)in Arabidopsis, and the bpa1 and bpl mutants had enhanced ROS accumulation and cell death under biotic or abiotic stresses. Furthermore, we showed that BPA1 and several BPLs functioned redundantly in plant immunity to P. capsici. We discovered that BPA1 and all six BPLs interacted with ACD11, and stabilization of ACD11 was impaired in the bpa 1, bpl2, bpl3, and bpl4 mutants. RxLR207 could promote the degradation of BPA1, BPL1, BPL2, and BPL4 to disrupt ACD11 stabilization in a 26S proteasome-dependent manner. Taken together, these fin dings indicate the important roles of Arabidopsis BPA1 and its homologs in ROS homeostasis and defense response, highlighting the usefulness of a pathogen effector-directed approach as a promising strategy for the discovery of novel plant immune regulators. | Qi Li Gan Ai Danyu Shen Fen Zou Ji Wang Tian Bai Yanyu Chen Shutian Li Meixiang Zhang Maofeng Jing Daolong Dou | 2019 | Molecular Plant2019，12，4： | 5 |
| 2 | Optimization of denitrifying phosphorus removal in a predenitrification anaerobic/anoxic/post-aeration+nitrification sequence batch reactor(pre-A_(2)NSBR)system:Nitrate recycling,carbon/nitrogen ratio and carbon source type显示文摘Because the efficiency of biological nutrient removal is always limited by the deficient carbon source for the low carbon/nitrogen(C/N)ratio in real domestic sewage,the denitrifying phosphorus removal(DNPR)was developed as a simple and efficient method to remove nitrogen and phosphorous.In addition,this method has the advantage of saving aeration energy while reducing the sludge production.In this context,a pre-denitrification anaerobic/anoxic/post-aeration+nitrification sequence batch reactor(pre-A_(2)NSBR)system,which could also reduce high ammonia effluent concentration in the traditional two-sludge DNPR process,is proposed in this work.The pre-A_(2)NSBR process was mainly composed of a DNPR SBR and a nitrifying SBR,operating as alternating anaerobic/anoxic/post-aeration+nitrification sequence.Herein,the long-term performance of different nitrate recycling ratios(0-300%)and C/N ratios(2.5-8.8),carbon source type,and functional microbial community were studied.The results showed that the removal efficiency of total inorganic nitrogen(TIN,including NH4^(+)-N,NO_(2)^(-)-N,and NO_(3)^(-)-N)gradually increased with the nitrate recycling ratios,and the system reached the highest DNPR efficiency of 94.45% at the nitrate recycling ratio of 300%.The optimum C/N ratio was around 3.9-7.3 with a nitrogen and phosphorus removal efficiency of 80.15%and 93.57%,respectively.The acetate was proved to be a high-quality carbon source for DNPR process.The results of fluorescence in situ hybridization(FISH)analysis indicated that nitrifiers and phosphorus accumulating organisms(PAOs)were accumulated with a proportion of 19.41%and 26.48%,respectively. | Weihua Zhao Meixiang Wang Jianwei Li Yu Huang Baikun Li Cong Pan Xiyao Li Yongzhen Peng | 2018 | Frontiers of Environmental Science & Engineering2018，12，5： | 3 |
| 3 | Advances in heterocyclic ketene aminals显示文摘Recent developments in the study of the reactions of heterocyclic ketene aminals are reviewed with the emphases on regioselective alkylation, acylation and glycosylation reactions, and on the aza-ene reactions with α,β-unsaturated compounds, azo and carbonyl compounds. Reactions with 1,3-dipoles and other reagents to synthesize fused heterocycles are also discussed. | WANG Meixiang and HUANG Zhitang(Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China) | 2002 | Progress in Natural Science:Materials International2002，12，4： | 2 |
| 4 | Phosphorylation of a wheat aquaporin at two sites enhances both plant growth and defense显示文摘Eukaryotic aquaporins share the characteristic of functional multiplicity in transporting distinct substrates and regulating various processes,but the underlying molecular basis for this is largely unknown.Here,we report that the wheat(Triticum aestivum)aquaporin TaPIP2;10 undergoes phosphorylation to promote photosynthesis and productivity and to confer innate immunity against pathogens and a generalist aphid pest.In response to elevated atmospheric CO_(2)concentrations,TaPIP2;10 is phosphorylated at the serine residue S280 and thereafter transports CO_(2)into wheat cells,resulting in enhanced photosynthesis and increased grain yield.In response to apoplastic H_(2)O_(2) induced by pathogen or insect attacks,TaPIP2;10 is phosphorylated at S121 and this phosphorylated form transports H_(2)O_(2) into the cytoplasm,where H_(2)O_(2)intensifies host defenses,restricting further attacks.Wheat resistance and grain yield could be simultaneously increased by TaPIP2;10 overexpression or by expressing a TaPIP2;10 phosphomimic with aspartic acid substitutions at S121 and S280,thereby improving both crop productivity and immunity. | Kai Lu Xiaochen Chen Xiaohui Yao Yuyan An Xuan Wang Lina Qin Xiaoxu Li Zuodong Wang Shuo Liu Zhimao Sun Liyuan Zhang Lei Chen Baoyan Li Baoyou Liu Weiyang Wang Xinhua Ding Yonghua Yang Meixiang Zhang Shenshen Zou Hansong Dong | 2022 | Molecular Plant2022，15，11： | 2 |
| 5 | The downregulation of miR-200c/141 promotes ZEB1/2 expression and gastric cancer progression显示文摘 | Xinliang Zhou Yudong Wang Baoen Shan Jing Han Haifeng Zhu Yalei Lv Xiaojie Fan Meixiang Sang Xian-De Liu Wei Liu | 2015 | Medical Oncology2015，，1： | 2 |
| 6 | Molecular phylogeny of methylotrophs in a deep-sea sediment from a tropical west Pacific warm pool 显示文摘 | Wang Peng Wang Fengping Xu Meixiang | 2004 | FEMS Microbiol Ecol2004，47，： | 1 |
| 7 | Analysis of archaeal 16S rDNA from deep-sea sediments sam-ples显示文摘 | Xu Meixiang Wang fengping Xiao Xiang | | 0，，： | 1 |
| 8 | Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway显示文摘Spermatogenic dysfunction is one of the major secondary complications of diabetes;however,the underlying mechanisms remain ill-defined,and there is no available drug or strategy for the radical treatment of diabetic spermatogenic dysfunction.Therefore,the objective of this study is to investigate the protective effects of nicotinamide mononucleotide(NMN)on testicular spermatogenic function in streptozotocin(STZ)-induced diabetic mice.The results show that oral administration of NMN significantly increases the body and testis weight and the number of sperms.Moreover,the abnormal sperm count and the rate of sperm malformation are significantly decreased compared with the saline-treated diabetic mice.Histological analysis reveals that NMN treatment significantly increases the area and diameter of seminiferous tubules,accompanied by an increased number of spermatogenic cells and sperms.Immunohistochemistry and qRT-PCR results show that NMN increases Bcl-2 expression and decreases Bax expression in the testis.NMN also increases the protein expression of Vimentin and the mRNA expressions of WT1 and GATA4.In addition,qRT-PCR,western blot analysis and immunohistochemistry results also show that NMN increases the expressions of glycolysis-related rate-limiting enzymes including HK2,PKM2,and LDHA.In summary,this study demonstrates the protective effects of NMN on the testis in an STZ-induced diabetic mice model.NMN exerts its protective effects via reducing spermatogenic cell apoptosis by regulating glycolysis of Sertoli cells in diabetic mice.This study provides an experimental basis for the future clinical application of NMN in diabetes-induced spermatogenicdysfunction. | Duo Ma Linlin Hu Jinyuan Wang Min Luo Aihong Liang Xiaocan Lei Biyun Liao Meixiang Li Ming Xie Haicheng Li Yiwei Gong Dan Zi Xiangrun Li Xi Chen Xucai Liao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 1 |
| 9 | Melanoma-associated antigen genes – An update显示文摘 | Meixiang Sang Lifang Wang Chunyan Ding Xinliang Zhou Bin Wang Ling Wang Yishui Lian Baoen Shan | 2010 | Cancer Letters2010，，： | 1 |
| 10 | Seroepidemiology and genetic characterization of hepatitis E virus in the northeast of china显示文摘 | Yuanhua Yu Jingwei Sun Meixiang Liu Liliang Xia Chenyan Zhao Tim J Harrison Youchun Wang | 2009 | Infection Genetics and Evolution2009，，4： | 1 |
| 11 | Enzymatic desymmetrization of 3-alkyl- and 3-arylglutaronitriles, a simple and convenient approach to optically active 4-amino-3- phenylbutanoic acids 显示文摘 | Wang Meixiang Liu Chusheng Li Jisheng | 2001 | Tetrahedron : Asymmetry2001，12，： | 1 |
| 12 | Enantioselective biotransformations of nitfiles in organic synthesis 显示文摘 | Wang Meixiang | 2005 | Top Catal2005，35，： | 1 |
| 13 | Transport property of polyaniline and its molecular weight dependence显示文摘 | Yanhou Geng Ji Li Xiabin Jing Fosong Wang Zhenxing Liu Meixiang Wan | 1998 | Science in China Series B: Chemistry1998，，4： | 1 |
| 14 | Breast cancer; operation period of personalized psychological care显示文摘 | Sun Mengqing Wang Meixiang | 2011 | Nursing Research2011，5，3： | 1 |
| 15 | 显示文摘 | Zhang Zhiming Wang Liqun Deng Junying Wan Meixiang | 2008 | React Funct Polym2008，68，： | 1 |
| 16 | Interleukin-17 and acute coronary syndrom显示文摘Inflammation plays an important role in atherosclerosis, which is also crucial for acute coronary syndrome (ACS). Recent studies have revealed that interleukin (IL)-17, which was regarded as a pro-inflammatory cytokine, has a dual function in the progress of ACS. In this review, we sum up both experimental and clinical studies on the relevance of IL-17 to atherosclerosis and its complications, and summarize the research progress on the effect of IL-17 on the atherosclerotic plaque stability and ACS onset. Although the studies are controversial and the mechanism remains unclear we highlight the knowledge of the role of IL-17 in ACS and elucidate its potential mechanism. | Sheng-an SU Hong MA Li SHEN Meixiang XIANG Jian-an WANG | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，8： | 1 |
| 17 | Synthesis and self-assembly of novel oxacalix[2]arene[2]triazine amphiphiles显示文摘Heteracalixaromatics are an emerging generation of macrocyclic host molecules in supramolecular chemistry. As a typical example of heteracalixaromatics, oxacalix[2]arene[2]triazine adopts a shape-persistent 1,3-alternate conformation and can be easily functionalized. Taking it as a platform, a series of oxacalix[2]arene[2]triazine-based amphiphiles bearing long alkyl chains were synthesized through post-macrocyclization functionalization or 3+1 fragment coupling protocols. The self-assembly behavior of these amphiphiles in a mixture of tetrahydrofuran(THF) and water was investigated. Dynamic light scattering(DLS)measurements revealed that the size of the self-assembled aggregates is dependent on the structure of the amphiphiles. The long alkyl chain substituents and/or intermolecular hydrogen bonds were found to promote the self-assembly. | Ruibin Xu Baoyong Hou Dexian Wang Meixiang Wang | 2016 | Science China Chemistry2016，59，10： | 1 |
| 18 | 显示文摘 | Otto M C Wang Meixiang | 1997 | J Chem Soc Perkin Trans 11997，，21： | 1 |
| 19 | Single-layer white polymer light-emitting diodes based on an iridium (III) complex containing alkyltrifluorene picolinic acid显示文摘 | Yafei Wang Yu Liu Zhiyong Zhang Jian Luo Danyan Shi Hua Tan Gangtie Lei Meixiang Zhu Weiguo Zhu Yong Cao | 2011 | Dyes and Pigments2011，，3： | 1 |
| 20 | Novel cyclometalated platinum (II) complex containing alkyl-trifluorene picolinic acid as emitter for single-layer white PLEDs显示文摘 | Yafei Wang Yu Liu Xiaoshuang Li Hongrui Qi Meixiang Zhu Lei Wang Gangtie Lei Qiliang Wei Weiguo Zhu Junbiao Peng Yong Cao | 2010 | Organic Electronics2010，，12： | 1 |
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