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| 1 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 2 | Late Miocene Red River submarine fan,northwestern South China Sea显示文摘A huge submarine fan is discovered through the research of the seismic and borehole data in the binding site of Yinggehai basin and Qiongdongnan basin in northwestern South China Sea.The fan,mainly formed during Late Miocene (Huangliu period) has an area over 10000 km 2 and maximum thickness of over 2000 m.It is characterized by a wedge-shaped oblique progradation configuration on the dip profile and a hummocky bidirectional progradation configuration on the strike profile.The core and Logging data from the well YC35-1-2 located in the front side of the fan indicate that sandy gravity flow deposits are predominant in lower Huangliu Formation and change to interbeds of sand and mud in upper Huangliu Formation.The fan is interpreted as a sand/mud-rich submarine fan in combination with the bathyal geological background of Huangliu period.A preliminary analysis of provenance indicates that neither the Guiren Uplift in the west nor the Hainan Uplift in the north can serve as the major provenance for the submarine fan.The provenance is considered to be from the Red River,based on the sedimentary facies study of the Huangliu Formation in Yinggehai basin.The fan is thus named as 'Red River submarine fan'.The Red River depositional system consists of the Red River submarine fan,the Red River delta,and associated submarine canyons.The discovery of the Red River submarine fan provides important information for the research of the uplift of Tibetan Plateau and the evolvement of Red River Fault Zone.Furthermore,it also points out a new direction for the deepwater hydrocarbon exploration in the northern South China Sea. | WANG YingMin XU Qiang LI Dong HAN JianHui LU Ming WANG YongFeng LI WeiGuo WANG HaiRong | 2011 | Chinese Science Bulletin2011，56，14： | 28 |
| 3 | 中医药治疗高血压作用机制的研究进展显示文摘高血压是一种以体循环动脉压升高为主要临床表现的疾病,其发病机制复杂。随着近年来中医药事业的发展,中医药治疗高血压不仅能够控制血压,在改善症状、提高患者生活质量等方面也起到良好作用。其作用机制主要有:(1)对肾素血管紧张素醛固酮系统(RAAS)的作用:中医药主要通过抑制肾素的作用、抑制血管紧张素转换酶的活性、拮抗血管紧张素Ⅱ(AngⅡ)受体3个关键点,下调心脏糜蛋白酶信号通路,下调AngⅡ1型受体(AT1R)的mRNA表达而控制血压水平;(2)抑制血管运动中枢和抑制交感神经或阻断神经节的作用,从而抑制交感神经活动;(3)内皮功能障碍是高血压发生发展的重要原因之一,保护血管内皮是防治高血压的关键。中医药能够通过磷脂酰肌醇3激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)/缺氧诱导因子(HIF)信号通路上调内皮型一氧化氮合酶(eNOS)的表达,增加Krüppel样因子4(KLF4)磷酸化促进内皮细胞增殖,从而改善血管内皮功能,具有减少血管内皮细胞黏附分子(CD54、CD62P)的表达,抑制白细胞和内皮细胞黏附及抑制血管壁炎症等作用;(4)中医药可以上调PI3Kp85mRNA和胰岛素受体底物1(IRS1)蛋白,从而改善胰岛素抵抗进而稳定血压;(5)中医药干预高血压与细胞膜离子通道的作用主要通过开放ATP敏感性钾通道(KATP)、内向整流钾通道(Kir)和电压门控钾通道(Kv)等诱导血管舒张功能、参与Ca^(2+)/一氧化氮/环磷酸鸟苷(cGMP)通路引起血管内皮舒张从而控制血压。 | Rongzhong Xu Weiguo Chen | 2017 | 中华高血压杂志2017，25，2： | 15 |
| 4 | Forecasting China’s natural gas consumption based on a combination model显示文摘Ensuring a sufficient energy supply is essential to a country. Natural gas constitutes a vital part in energy supply and therefore forecasting natural gas consumption reliably and accurately is an essential part of a country's energy policy. Over the years, studies have shown that a combinative model gives better projected results compared to a single model. In this study, we used Polynomial Curve and Moving Average Combination Projection (PCMACP) model to estimate the future natural gas consumption in China from 2009 to 2015. The new proposed PCMACP model shows more reliable and accurate results: its Mean Absolute Percentage Error (MAPE) is less than those of any previous models within the investigated range. According to the PCMACP model, the average annual growth rate will increase for the next 7 years and the amount of natural gas consumption will reach 171600 million cubic meters in 2015 in China. | Gang Xu Weiguo W ang | 2010 | Journal of Natural Gas Chemistry2010，19，5： | 10 |
| 5 | Longitudinal non-vascular transport pathways originating from acupuncture points in extremities visualised in human body显示文摘A subcutaneous transport pathway in humans has been previously visualised by injection of a paramagnetic tracer into the specific region of skin.In the current study,we further investigated the behaviours of imaging tracers in the transport pathways using imaging techniques.Three types of imaging tracers,including Gd-DTPA,iodised oil,and fluorescein sodium,were hypodermically injected into different acupuncture points of healthy volunteers to visualise the transport pathways by magnetic resonance imaging(MRI),X-ray,CT,and a digital fluorescein camera.Several longitudinal transport pathways in the arms and feet,which represent venous vessels and subcutaneous transport pathways(STPs) without well-defined boundaries,were visualised by MRI.Among the visualised veins,the partial walls of a few veins were enhanced by Gd-DTPA.The fluorescent images further indicated that STPs likely represent boundless pathways.The findings in this study suggested that specific anatomical structures within the subcutaneous tissues or the partial walls of certain veins werenot vascular conduits but rather represented unique transport pathways in humans that warrant extensive future studies. | Hongyi Li Jiabin Tong Weiguo Cao Min Chen Hua Li Hong Dai Liang Xu Xiaoliang Chen | 2014 | Chinese Science Bulletin2014，59，35： | 10 |
| 6 | Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway显示文摘Lotus seed is well known as traditional food and medicine,but its skin is usually discarded.Recent studies have shown that lotus seed skin contains a high concentration of proanthocyanidins that have multi-functions,such as antioxidation,anti-inflammation,and anti-cancer effects.In the present study,we aimed to isolate and purify the proanthocyanidins from lotus seed skin by acetone extraction and rotary evaporation,identify their chemical structures by HPLC-MS-MS and NMR,and further investigate the antioxidant properties of the extract purified by macroporous resin (PMR) from lotus seed skin both in vitro and in vivo.The results showed that PMR mainly contained oligomeric proanthocyanidins,especially dimeric procyanidin B1 (PB1),procyanidin B2 and procyanidin B4.Although it had limited ability to directly scavenge radicals in vitro,PMR could significantly enhance the expressions of antioxidant proteins via activation of nuclear factory-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway in HepG2 cells.Molecular data revealed that PB1,a major component in PMR,stabilized Nrf2 by inhibiting the ubiquitination of Nrf2,which led to subsequent activation of the Nrf2-ARE pathway,including the enhancements of Nrf2 nuclear translocation,Nrf2-ARE binding and ARE transcriptional activity.Moreover,the in vivo results in high fat diet-induced mice further verified the powerful antioxidant property of PMR.These results revealed that lotus seed skin is a promising resource for functional food development. | Tao Li Qili Li Weiguo Wu Yong Li De-xing Hou Hua Xu Baodong Zheng Shaoxiao Zeng Yang Shan Xiangyang Lu Fangming Deng Si Qin | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 8 |
| 7 | Experiments on mechanical properties of salt rocks under cyclic loading显示文摘The primary purpose of underground gas storages is to provide gas for seasonal consumptions or strategic reserve.The periodical operations of gas injection and extraction lead to cyclic loading on the walls and surrounding rocks of gas storages.To investigate the mechanical behaviors of different host rocks in bedded salt deposit,laboratory experiments were conducted on the samples of rock salt,thenardite,glauberite and gypsum.The mechanical properties of rock samples under monotonic and cyclic loadings were studied.Testing results show that,under monotonic loading,the uniaxial compressive stress(UCS) of glauberite is the largest(17.3 MPa),while that of rock salt is the smallest(14.0 MPa).The UCSs of thenardite and gypsum are 16.3 and 14.6 MPa,respectively.The maximum strain at the peak strength of rock salt(halite) is much greater than those of the other three rocks.The elastic moduli of halite,thenardite,glauberite and gypsum are 3.0,4.2,5.1 and 6.8 GPa,respectively.Under cyclic loading,the peak strengths of the rock specimens are deteriorated except for rock salt.The peak strengths of thenardite,glauberite and gypsum decrease by 33.7%,19.1% and 35.5%,respectively;and the strains of the three rocks at the peak strengths are almost the same.However,the strain of rock salt at the peak strength increases by 1.98%,twice more than that under monotonic loading.Under monotonic loading,deformation of the tested rock salt,thenardite and glauberite shows in an elastoplastic style.However,it changes to a ductile style under cyclic loading.Brittle deformation and failure are only observed for gypsum.The results should be helpful for engineering design and operation of gas storage in bedded salt deposit. | Weiguo Liang Chuanda Zhang Hongbo Gao Xiaoqin Yang Suguo Xu Yangsheng Zhao | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，1： | 8 |
| 8 | Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer显示文摘Intravesical chemotherapy has been recommended after the gold standard of transurethral resection of the bladder tumor to prevent bladder cancer(BC)from local recurrence in the clinic.However,due to rapid urine excretion and barrier protection of the bladder wall,the clinical performances of chemotherapeutic drugs are severely compromised.In the present work,a smart positively charged disulfide-crosslinked nanogel of oligoarginine-poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine)(R_(9)-PEG-P(LP-co-LC))was prepared to prolong the retention period and enhance the penetration capability of chemotherapeutic agent toward the bladder wall.PEG significantly improved the aqueous dispersibility of the 10-hydroxycamptothecin(HCPT)-loaded R_(9)-PEG-P(LP-co-LC)(i.e.,R_(9)NG/HCPT)and enhanced the mucoadhesive capability by the nonspecific interaction between PEG chain and the bladder mucosa accompanied with the electrostatic interaction between the cationic R_(9)and negatively charged bladder mucosa.Besides,R_(9),as a cell-penetrating peptide,efficiently penetrated through the cell membrane and delivered carried cargo.The disulfide bond endowed the selective release behavior of HCPT triggered by the intracellular reductive microenvironment.As an advanced chemotherapeutic nanoformulation,the smart R_(9)NG/HCPT demonstrated superior cytotoxicity against human BC 5637 cells in vitro and remarkably enhanced tumor suppression activity toward orthotopic BC models of mouse and rat in vivo,indicating its great potential in the clinical intravesical BC chemotherapy. | Hui Guo Faping Li Heping Qiu Weiguo Xu Pengqiang Li Yuchuan Hou Jianxun Ding Xuesi Chen | 2020 | Research2020，，1： | 7 |
| 9 | Effect of vegetation type, wetting intensity, and nitrogen supply on external carbon stimulated heterotrophic respiration and microbial biomass carbon in forest soils显示文摘By using packed soil-core incubation experiments,we have studied stimulating effects of addition of external carbon(C)(glucose,6.4 g Cm^(-2))on heterotrophic respiration and microbial biomass C of a mature broadleaf and Korean pine mixed forest(BKPF)and an adjacent white birch forest(WBF)soil under different wetting intensities(55%and 80%WFPS,water-filled pore space)and nitrogen(N)supply(NH_4C1 and KNO_3,4.5 g Nm^(-2))conditions.The results showed that for the control,the cumulative carbon dioxide(CO_2)flux from WBF soil during the 15-day incubation ranged from 5.44 to 5.82 g CO_2-Cm^(-2),which was significantly larger than that from BKPF soil(2.86 to 3.36 g CO_2-Cm^(-2)).With increasing wetting intensity,the cumulative CO_2 flux from the control was decreased for the WBF soil,whereas an increase in the CO_2 flux was observed in the BKPF soil(P<0.05).The addition of NH_4C1 or KNO_3 alone significantly reduced the cumulative CO_2 fluxes by 9.2%-21.6%from the two soils,especially from WBF soil at low wetting intensity.The addition of glucose alone significantly increased soil heterotrophic respiration,microbial biomass C(MBC),and microbial metabolic quotient.The glucose-induced cumulative CO_2 fluxes and soil MBC during the incubation ranged from 8.7 to 11.7 g CO_2-Cm^(-2)and from 7.4 to 23.9 g Cm^(-2),which are larger than the dose of added C.Hence,the addition of external carbon can increase the decomposition of soil native organic C.The glucose-induced average and maximum rates of CO_2 fluxes during the incubation were significantly influenced by wetting intensity(WI)and vegetation type(VT),and by WI×VT,NH_4Cl×VT and WI×VT×NH_4Cl(P<0.05).The addition of NH_4C1,instead of KNO_3 significantly decreased the glucose-induced MBC of WBF soil(P<0.05),whereas adding NH_4C1 and KNO_3 both significantly increased the glucose-induced MBC of BKPF soil at high moisture(P<0.05).According to the differences in soil labile C pools,MBC and CO_2 fluxes in the presence and absence of glucose,it can be concluded that the stimulating effects of glucose on soil heterotrophic respiration and MBC under temperate forests were dependent on vegetation type,soil moisture,and amount and type of the N added. | WU HaoHao XU XingKai DUAN CunTao LI TuanSheng CHENG WeiGuo | 2015 | Science China Earth Sciences2015，58，8： | 6 |
| 10 | Polymorphisms of chemokine receptors and its ligand alleles influencing genetic suscepti-bity to HIV-1 infection in eight ethnic groups in Chinese mainland显示文摘Limited genetic information is available concerning the polymorphisms of HIV-1 resistant genes in indigenous Chinese populations. The aim of this study is to identify the allelic frequencies of the chemokine and chemokine receptor genes in the Chinese mainland. Genomic DNA samples extracted from whole blood of 2318 subjects were analyzed by using PCR or PCR/restriction fragment length polymorphism (RFLP) assays, and further confirmed by direct DNA sequencing. Higher frequencies of mutant CCR2-64I (19.15%-28.79%) and SDF1-3’A (19.10% -29.86%) alleles were found in subjects of 8 ethnic groups in the Chinese mainland. In contrast, the △32 mutation in CCRS gene occurs at a very low frequency (0.0016, n=1287) in Han population. A relatively high frequency of CCR5-wt/△32 heterozygotes was observed in Uygurian and Mongolian populations. No A32 mutation allele was detected in Tibetan and other 4 ethnic groups in Yunnan Province. There was no CCR5-m303 mutation in subjects of any ethnic group in the Chinese | WANG Fusheng JIN lei LIU Mingxu HONG Weiguo SHI Hong LEI Zhouyun WANG Jiming DU Qingyou HOU Jing ZHANG Bing JIANG Jiandong WANG Yue LI Yueqi XU Anlong HUANG Honglian LIU Fajun | 2001 | Chinese Science Bulletin2001，46，12： | 6 |
| 11 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 12 | Spatial Correlation and Ecological Characteristics Analysis of Man-agement Area for Biodiversity Conservation and Relevant Regionalization显示文摘Formulation of different ecological zone plans according to the corresponding protection targets and the necessity of proper conservation policy is one of the measures to achieve the goal of ecological conservation in China.In order to clarify the interrelation among key ecological zone plans,this paper carried out the research on spatial relation of priority areas of biodiversity conservation and three key ecological areas(key ecological function areas,key regions of ecological service function,national nature reserves)and the research on ecological conditions,based on multi-scale ecological spatial theme information,which incorporates elements like ecological quality and type,and by the aid of spatial information analysis and GIS modeling.The results showed a contrastively fine spatial consistency with 68.8%of priority areas of biodiversity conservation overlapping with three key ecological areas.Although the environment in priority areas of biodiversity conservation were in good conditions,protection pressure is also increasing,powerful supervision and protection should not be ignored.The environmental conditions in the overlapping areas,as a whole,were superior to those in the non-overlapping areas.Since two areas have different characteristics,targeted protection measures should be formulated based on this difference,which will be very important for biodiversity conservation in priority areas of biodiversity conservation. | WANG Wenjie ZHENG Hua XU Chao JIANG Weiguo DU Yunhui WANG Wei ZHANG Zhe LIU Xiaofu | 2014 | Chinese Geographical Science2014，24，1： | 5 |
| 13 | Influence factors of methane hydrate formation from ice:Temperature,pressure and SDS surfactant显示文摘A series of experiments of forming hydrate from ice powders in different conditions have been carried out with constant volume method to evaluate the influence factors such as pressure, temperature, and SDS surfactant. The change of temperature and pressure were collected as a function of elapsed time, which were used to calculate the gas consumption and hydrate saturation during hydrate formation(pVT method). Based on the experimental results and the analysis, it is concluded that:(1) Both initial pressure and temperature have effect on the hydrate formation and temperature plays a more important role in the process;(2) heating and secondary pressurization will promote the gas hydrate formation and enhance the hydrate saturation as a result. Meanwhile, the promotion of heating seems to be more obvious than that of secondary pressurization;(3) different concentrations of SDS surfactant have clearly influence on the saturation of gas hydrate and there is an optimal concentration to promote the hydrate formation. | Weiguo Liu Yanghui Li Xiaohu Xu | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 5 |
| 14 | The effect of phase transition on the compressional wave velocity for a trachybasalt at high temperature and high pressure显示文摘Compressional wave velocities in a trachybasalt, from Yichuan County, Henan Province, have been measured at 2.0 GPa and up to 1 350℃ in a YJ-3000 t cubic-anvil highpressure apparatus. The run products have been gained at the same pressure but different temperatures. The observation of the thin sections of the run products indicates that, corresponding to the variation of the compressional wave velocity in the trachybasalt, the phase transition has taken place. The relationship between the change of the compressional wave velocity and the hydrous mineral dehydration, solid-solid phase transformation and partial melting has been discussed. The experimental data presented here are of great importance to elucidating the geological process in the earth’s interior. | Wenge Zhou Hongsen Xie Zhidan Zhao Weiguo Zhu Jie Guo Ji’an Xu | 1999 | Chinese Science Bulletin1999，44，15： | 5 |
| 15 | Calibration and brightness temperature algorithm of CE-1 Lunar Microwave Sounder (CELMS)显示文摘CE-1 Lunar Microwave Sounder (CELMS) is the first passive microwave radiometer in the world to sound the surface of the Moon in the lunar orbit at altitude of 200 km. The scientific objective of CELMS is to obtain global brightness temperature (TB) of the Moon, to retrieve information on lunar regolith, and to evaluate the distribution of helium-3 on the Moon implanted by solar wind. Before launch of CELMS, a series of experiments were carried out in laboratories to test the performances of the systems, and to calibrate the responses between the input of TB and the output of voltage from the receivers. However, the thermal condition exposed to CELMS is more complicated in lunar orbit than on the Earth, which makes the temperatures of different parts of CELMS wave vary greatly, and the cosmic background is not very clean due to the pointing of cold space antenna to the direction of the satellite running, which brings uncertainties into data-processing of CELMS when the temperature of cold space is used as a calibrator. Furthermore, the lack of knowledge on the lunar ingredients and compositions, distributions of physical temperatures, and properties on lunar microwave radiation leads to difficulties in validating the measurements and retrievals of CELMS. By analyzing the results of ground experiments and the measurements of CELMS in-orbit, along with our knowledge of the properties of lunar surface, here we give algorithms on calibration and antenna pattern correction (APC) of CELMS. We also describe in detail the principle of microwave transfer among the elements of CELMS, and discuss the method on testing calibration parameters of the system. In addition, the theory and model on correction antenna pattern of CELMS are developed by comparing antenna temperatures by CELMS with those simulated by microwave radiative transfer models. The global distribution of TB is given and the features of TB are analyzed. Our results show rich information included in TB on the properties of lunar regolith, especially the thickness and dielectric constant, which are nearly directly reflected by the differences of TB at day and those at night. | ZhenZhan Wang Yun Li XiaoHui Zhang Jiang JingShan ChuanDong Xu DeHai Zhang WeiGuo Zhang | 2010 | Science China Earth Sciences2010，53，9： | 5 |
| 16 | Improving MapReduce Performance by Balancing Skewed Loads显示文摘MapReduce has emerged as a popular computing model used in datacenters to process large amount of datasets.In the map phase,hash partitioning is employed to distribute data that sharing the same key across data center-scale cluster nodes.However,we observe that this approach can lead to uneven data distribution,which can result in skewed loads among reduce tasks,thus hamper performance of MapReduce systems.Moreover,worker nodes in MapReduce systems may differ in computing capability due to(1) multiple generations of hardware in non-virtualized data centers,or(2) co-location of virtual machines in virtualized data centers.The heterogeneity among cluster nodes exacerbates the negative effects of uneven data distribution.To improve MapReduce performance in heterogeneous clusters,we propose a novel load balancing approach in the reduce phase.This approach consists of two components:(1) performance prediction for reducers that run on heterogeneous nodes based on support vector machines models,and(2) heterogeneity-aware partitioning(HAP),which balances skewed data for reduce tasks.We implement this approach as a plug-in in current MapReduce system.Experimental results demonstrate that our proposed approach distributes work evenly among reduce tasks,and improves MapReduce performance with little overhead. | FAN Yuanquan WU Weiguo XU Yunlong CHEN Heng | 2014 | China Communications2014，11，8： | 4 |
| 17 | Prognostic value of clinicopathological characteristics in patients with pancreatic cancer显示文摘Background:The purpose of this study was to analyze me effects of all clinical characteristics on the overall survival time,in order to provide a basis for determining the prognostic factor of patients with pancreatic cancer.Methods:A total of 103 pancreatic cancer patients were admitted to the Department of Radiotherapy and Chemotherapy of the Ruijin Hospital,Shanghai Jiaotong University School of Medicine,between January 2002 and December 2012.There were 68 men and 35 women;the median age was 62 years.Diagnoses of pancreatic cancer in all patients were confirmed by histopathology,cytology,or clinical diagnosis.The Kaplan-Meier method was performed to calculate the overall survival rate.The log-rank method was used to examine the univariate analysis.The Cox regression model was performed for multivariate analysis.Results:The median survival time was 293 days,the 1-,2-,and 3-year survival rates were 27.18%,5.83%,and 1.94%,respectively.Cox regression analysis revealed that age(P=0.015),Karnofsky performance status(PS)(P=0.002),surgical types(P<0.001),and platelet counts(P<0.001) were independent prognostic factors affecting the overall survival of patients with pancreatic cancer.Conclusions:Pancreatic cancer had a poor prognosis,the general physical condition,age,the availability of radical surgery,and platelet counts were factors influencing the overall survival of patients with pancreatic cancer. | Mei Geng Haoping Xu Ruobing Ren Qing Qu Chengfang Shangguan Junwei Wu Jinsong Jiang Hao Li Weiguo Cao | 2015 | Chinese Journal of Cancer Research2015，27，5： | 4 |
| 18 | Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery显示文摘Cancer the rapy with nanoscale drug formulations has made significant progress in the past few decades.However,the selective accumulation and release of therapeutic agents in the lesion sites are still great challenges.To this end,we developed a cRGD-decorated pH-responsive polyion complex(PIC)micelle for intracellular targeted delivery of doxorubicin(DOX)to upregulate tumor inhibition and reduce toxicity.The PIC micelle was self-assembled via the electrostatic interaction between the positively charged cRGD-modified poly(ethylene glycol)-block-poly(L-lysine)and the anionic acid-sensitive 2,3-dimethylmaleic anhydride-modified doxorubicin(DAD).The decoration of cRGD enhanced the cell internalization of PIC micelle through the specific recognition ofαvβ3 integrin on the membrane of tumor cells.The active DOX was released under intracellular acidic microenvironment after endocytosis following the decomposition of DAD.Moreover,the targeted PIC micelle exhibited enhanced inhibition efficacies toward hepatoma in vitro and in vivo compared with the insensitive controls.The smart multifunctional micelle provides a promising platform for target intracellular delivery of therapeutic agent in cancer therapy. | Pan Zheng Yang Liu Jinjin Chen Weiguo Xu Gao Li Jianxun Ding | 2020 | Chinese Chemical Letters2020，31，5： | 4 |
| 19 | Exceptional mechanical properties of AZ31 alloy wire by combination of cold drawing and EPT显示文摘A 0.66 mm-diameter AZ31 alloy wire with ultimate tensile strength of 400 MPa and elongation of 28.5%was successfully prepared via the combination of cold-drawing and electropulsing treatment processing(EPT).Microstructure observation showed that the grain size of EPTed samples was refined to about 1μm and the basal texture strength with maxima texture index was weakened to 7.18.EPT can significantly accelerate recrystallization by enhancing the mobility of dislocation and atomic diffusion due to the coupling of the thermal and athermal effects.Finally,uniform ultrafine-grained structure was obtained in the EPTed samples by static recrystallization completed in a very short time(30 s)at relatively low temperature(433 K). | Zhaohui Shan Jing Bai Jianfeng Fan Hongfei Wu Hua Zhang Qiang Zhang Yucheng Wu Weiguo Li Hongbiao Dong Bingshe Xu | 2020 | Journal of Materials Science & Technology2020，47，16： | 3 |
| 20 | Distribution and anomaly of microwave emission at Lunar South Pole显示文摘Investigation on Lunar polar area is almost every lunar mission’s primary objective in recent years. The rationale behind it is that illumination and ice resources in this area can be potentially very helpful for constructing lunar human base. In this paper, we analyze microwave radiometric characteristics of the Moon by using the newly acquired Chang’E-1 Lunar Microwave Sounder (CELMS) data. Microwave brightness temperature at Lunar South Pole (LSP) is distributed regularly with a style of 'ring-in-ring', decreasing from equator to pole. Regolith temperature gradient is bigger at lunar equator than at polar area. Brightness temperature diurnal difference decreases with observation frequency. Microwave brightness temperature distribution maps at LSP and Lunar North Pole (LNP) have been made based on the analysis. It is found that microwave brightness temperature becomes to synchronize with elevation beyond -85° latitude. This phenomenon is related to lightening condition and indicates temperature distribution at LSP. The brightness temperature anomaly cold points are potentially cold trap areas for water or ice while hot points imply plenty of illumination resources there. | WeiGuo Zhang JingShan Jiang HeGuang Liu XiaoHui Zhang DeHai Zhang DiHui Li ChuanDong Xu | 2010 | Science China Earth Sciences2010，53，3： | 3 |
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