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| 1 | Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics显示文摘SI RT6 is an important histone modifying protein that regulates DNA repair,telomere maintenance,energy me-tabolism,and target gene expression.Recently SIRT6 has been identifi ed as a tumor suppressor and is down-regulated in certain cancer types,but not in other can-cers.From deposited gene profi ling studies we found that SIRT6 was overexpressed in prostate tumors,compared with normal or paratumor prostate tissues.Tissue micro-array studies confi rmed the higher levels of SIRT6 in both prostate tumor tissues and prostate cancer cells than in their normal counterparts.Knockdown of SIRT6 in human prostate cancer cells led to sub-G1 phase arrest of cell cy-cle,increased apoptosis,elevated DNA damage level and decrease in BCL2 gene expression.Moreover,SIRT6-de-fi ciency reduced cell viability and enhanced chemothera-peutics sensitivity.Taken together,this study provides the fi rst evidence of SIRT6 overexpression in human prostate cancer,and SIRT6 regulation could be exploited for pros-tate cancer therapy. | Yewei Liu Qian Reuben Xie Boshi Wang Jiaxiang Shao Tingting Zhang Tengyuan Liu Gang Huang Weiliang Xia | 2013 | Protein & Cell2013，4，9： | 17 |
| 2 | Myocardial infarction secondary prevention study (MISPS)显示文摘Background Traditional Chinese medicine (TCM), especially herbal medicine, has been widely used in China and now is also being increasingly used in other countries for the treatment of cardiovascular diseases. Although many studies have demonstrated that certain Chinese herbal products are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its safety, effectiveness are necessary.QiShen YiQi Dripping Pills (QSYQDP) is a herbal preparation clinically used in the treatment and prevention of coronary artery disease. Preliminary observations have shown its safety and effectiveness. Methods/Design This randomized, controlled trial will recruit 3600 patients with a history of myocardial infarction. Patients will be randomized into two groups by a Centr-Randomized System. One group receives QSYQDP, the other group receive aspirin. This trial protocol will describe eligibility criteria, detailed information on the treatment definition, blinding, endpoints, statistical methods, sample size determination, data management, legal aspects, and the current status of the trial. Discussion This trial is one of the first randomized, controlled clinical trial to evaluate the efficacy and safety of traditional Chinese herbal medicine in the treatment and secondary prevention of coronary artery disease. The results of this study should help to define the role of TCM in modern medical care, as well as to provide the management strategy for CAD patients in China and other countries. | Hongcai SHANG Guohua DAI Junhua HANG Yaozu XIANG Yang WANG Junping ZHANG Wuxun DU Jingyuan MAO Chen YAO Weiliang WENG Tiancai WEN Boli ZHANG | 2006 | Journal of Geriatric Cardiology2006，3，2： | 14 |
| 3 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 4 | Study on the deactivation and regeneration of the ZSM-5 catalyst used in methanol to olefins显示文摘ZSM-5 zeolite catalyst modified by a trace of metal cations shows high activity and high selectivity for the reaction of methanol to olefins (MTO), but it inclines to deactivate during the reaction. In this paper, the mechanism of the catalyst deactivation and the regeneration method were studied by X-ray diffraction (XRD), N2 adsorption-desorption, infrared spectra (IR), and infrared spectra coupled with NH3 molecular probes (IR-NH3). These characterizations indicated that coke formation was the main reason for the catalyst deactivation. To regenerate the deactivated catalyst, two methods, i.e., calcination and methanol leaching, were used. N2 adsorption-desorption, IR and IR-NH3 characteriza-tions showed that both methods can eliminate coke deposited on the catalyst and make the catalyst reactivated. XRD showed that the structure of the catalyst did not change after regeneration. Interestingly, the regenerated catalyst even showed better catalytic performance of the MTO reaction than the fresh one. Besides, the calcination regeneration can eliminate coke more completely, however, the methanol leaching method can be more easily carried out in situ in the reactor. | Jingchang Zhang Haibin Zhang Xiuying Yang Zhong Huang Weiliang Cao | 2011 | Journal of Natural Gas Chemistry2011，20，3： | 8 |
| 5 | Mobile Edge Computing and Field Trial Results for 5G Low Latency Scenario显示文摘Through enabling the IT and cloud computation capacities at Radio Access Network(RAN),Mobile Edge Computing(MEC) makes it possible to deploy and provide services locally.Therefore,MEC becomes the potential technology to satisfy the requirements of 5G network to a certain extent,due to its functions of services localization,local breakout,caching,computation offloading,network context information exposure,etc.Especially,MEC can decrease the end-to-end latency dramatically through service localization and caching,which is key requirement of 5G low latency scenario.However,the performance of MEC still needs to be evaluated and verified for future deployment.Thus,the concept of MEC is introduced into5 G architecture and analyzed for different 5G scenarios in this paper.Secondly,the evaluation of MEC performance is conducted and analyzed in detail,especially for network end-to-end latency.In addition,some challenges of the MEC are also discussed for future deployment. | Jianmin Zhang Weiliang Xie Fengyi Yang Qi Bi | 2016 | China Communications2016，13，S2： | 7 |
| 6 | Effects of redox-active interlayer anions on the oxygen evolution reactivity of NiFe-layered double hydroxide nanosheets显示文摘镍铁分层的双氢氧化物(NiFe-LDH ) nanosheets 显示出最佳的氧进化反应(OER ) 性能;然而,在 OER 活动的设置的离子的角色仍然保持不清楚。在这个工作,我们证明 NiFe-LDHs 的活动能被设置的阴离子与不同氧化还原作用潜力定制。而 NiFe-LDHs 与高氧化还原作用潜力(低减少能力)的阴离子设置了,有低氧化还原作用潜力(高减少能力)的阴离子的置闰例如次磷酸盐,与 240 mV 的低 OER 过电位和 36.9 mV/dec 的一个小 Tafel 斜坡导致 NiFe-LDHs ,例如 fluorion ,显示出 370 mV 的高过电位和 80.8 mV/dec 的一个 Tafel 斜坡。OER 活动与标准氧化还原作用潜力显示出令人吃惊的线性关联。密度功能的理论计算和 X 光检查光电子光谱学分析显示设置的阴离子改变在表面暴露了的金属原子的电子结构。有低标准氧化还原作用潜力和强壮的减少能力的阴离子把更多的电子转移到氢氧化物层。这增加表面金属地点的电子密度并且稳定他们的高原子价的状态,其形成在 OER 过程以前作为关键步被知道。 | Daojin Zhou Zhao Cai Yongmin Bi Weiliang Tian Ma Luo Qian Zhang Qixian Xie Jindi Wang Yaping Li Yun Kuang Xue Duan Michal Bajdich Samira Siahrostami Xiaoming Sun | 2018 | Nano Research2018，11，3： | 6 |
| 7 | An overview of the development history and technical progress of China's coal-fired power industry显示文摘As the main power source of China, coalfired power industry has achieved a great progress in installed capacity, manufacturing technologies, thermal efficiency, as well as pollutant control during the past century. With the fast development of renewable energies, coal-fired power industry is experiencing a strategic transformation. To specify the development of coal-fired power industry, its development history is reviewed and the technical progresses on aspects of thermal efficiency, pollutants control and peaking shaving capacity are discussed. It is concluded that the role of China's coal-fired power source would be transformed from the dominant position to a base position in power source structure. Considering the sustainable development of coal-fired power industry in energy conservation, emission control, and utilization of renewable energies, it is suggested that the national average thermal efficiency should be improved by continual up-gradation of units by using advanced technologies and eliminating outdated capacity. Moreover, the emission standard of air pollutants should not be stricter any more in coal-fired power industry. Furthermore, the huge amount of combined heat and power (CHP) coal-fired units should be operated in a decoupled way, so as to release more than 350 GW regulation capacity for the grid to accept more renewable energy power. | Weiliang WANG Zheng LI Junfu LYU Hai ZHANG Guangxi YUE Weidou NI | 2019 | Frontiers in Energy2019，13，3： | 6 |
| 8 | Biomimetic strategies for tendon/ligament-to-bone interface regeneration显示文摘Tendon/ligament-to-bone healing poses a formidable clinical challenge due to the complex structure,composition,cell population and mechanics of the interface.With rapid advances in tissue engineering,a variety of strategies including advanced biomaterials,bioactive growth factors and multiple stem cell lineages have been developed to facilitate the healing of this tissue interface.Given the important role of structure-function relationship,the review begins with a brief description of enthesis structure and composition.Next,the biomimetic biomaterials including decellularized extracellular matrix scaffolds and synthetic-/natural-origin scaffolds are critically examined.Then,the key roles of the combination,concentration and location of various growth factors in biomimetic application are emphasized.After that,the various stem cell sources and culture systems are described.At last,we discuss unmet needs and existing challenges in the ideal strategies for tendon/ligament-to-bone regeneration and highlight emerging strategies in the field. | Tingyun Lei Tao Zhang Wei Ju Xiao Chen Boon Chin Heng Weiliang Shen Zi Yin | 2021 | Bioactive Materials2021，6，8： | 6 |
| 9 | How Off-farm Employment Affects Technical Efficiency of China's Farms" The Case of Jiangsu显示文摘 | Linxiu Zhang Weiliang Su Tor Eriksson Chengfang Liu | 2016 | China & World Economy2016，24，3： | 6 |
| 10 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。 | Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 5 |
| 11 | Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage显示文摘SIRT6 是 NAD +-dependent histone deacetylase 并且在 genomic 稳定性, DNA 修理,新陈代谢的动态平衡和几疾病的规定被含有。在服的局部缺血和氧 / 葡萄糖剥夺(OGD ) 的 SIRT6 的效果被报导了,然而,处于氧化压力损坏的 SIRT6 的角色仍然保持不清楚。这里,我们使用了 SH-SY5Y neuronal 房间并且发现 SIRT6 的 overexpression 导致了减少的房间生存能力并且在氧化应力下面增加了坏死的房间死亡和反应的氧种类(ROS ) 生产。机械学的学习表明 SIRT6 经由 AKT 与 autophagy 禁止者 3 麻省发信号和处理的变细导致了 autophagy 或 autophagy 相关的蛋白质 Atg5 击倒救的 H 2 O 2-induced neuronal 损害。相反地, SIRT6 抑制压制了 autophagy 并且减少了氧化导致压力的 neuronal 损坏。这些结果建议 SIRT6 可能是为 neuroprotection 的一个潜在的治疗学的目标。 | Jiaxiang Shao Xiao Yang Tengyuan Liu Tingting Zhang Qian Reuben Xie Weiliang Xia | 2016 | Protein & Cell2016，7，4： | 5 |
| 12 | Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression显示文摘 | Dandan Yu Yong Zhang Gege Chen Yongsheng Xie Zhijian Xu Shuaikang Chang Liangning Hu Bo Li Wenxuan Bu Yingcong Wang Wenqin Xiao Xi Sun Gaomei Chang Lu Gao Sujing Qiang Xiaosong Wu Weiliang Zhu Jumei Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 4 |
| 13 | Synthesis,characterization and magnetic properties of near monodisperse Fe_3O_4 sub-microspheres显示文摘Near monodisperse Fe3O4 sub-microspheres with an average diameter of 170 nm have been synthesized by a solvothermal reduction method, using K3[Fe(CN)6] as the raw material in the absence of any surfactants at 200℃ for 24 h. The products were detected by XRD, FESEM, TEM, and XPS. The investigation of the reaction parameters indicates that ethylene glycol plays a key role both as reducing agent and solvent. In addition, the reaction time and temperature also have important influences on the final product. The hysteresis loop of the near monodisperse Fe3O4 sub-microspheres shows a ferromagnetic behavior with saturation magnetization of 60.8 emu/g and coercivity of 124.7 Oe. | ZHANG JunHao KONG QingHong LU WeiLiang LIU He | 2009 | Chinese Science Bulletin2009，54，14： | 4 |
| 14 | DCZ0801,a novel compound,induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma显示文摘Multiple myeloma(MM)is a refractory malignant hematological malignancy,and many therapeutic strategies have been developed to cure patients with MM.DCZ0801 is a compound that consists of oxophenamide and pterostilbene.The role of these compounds in hematological cancers such as MM has yet to be studied.In this study,we explored the potential mechanism of DCZ0801 action,its anti-tumor activity both in vitro and in vivo on MM.This study was carried out via cell cycle proliferation assay,apoptotic analysis,western blot analysis,and examination of xenotransplantation model of tumors.The in vitro studies revealed that DCZ0801 could inhibit cell proliferation and induce apoptosis by regulating both caspase-dependent and mitogen-activated protein kinase signaling pathways,inducing S-phase arrest of the cell cycle related to downregulation of CDK2,cyclin-A2,and CDC25A protein expression.The in vivo studies showed that DCZ0801 could significantly reduce the size of the tumors in nude mice.Our results demonstrated that DCZ0801 may emerge as the new therapeutic option for the patient with MM. | Ting Zhang Bo Li Qilin Feng Zhijian Xu Cheng Huang Huiqun Wu Zhangbo Chen Liangning Hu Lu Gao Peng Liu Guang Yang Hui Zhang Kang Lu Tingye Li Yi Tao Xiaosong Wu Jumei Shi Weiliang Zhu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 3 |
| 15 | ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine显示文摘Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated urgently.Herein,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://gffzz3ff3e9d9e9f64aa3hnfcpooco5qp06kxo.ffgz.tsg.suse.edu.cn/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 ingredients.To facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding activities.Importantly,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal materials.Moreover,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological networks.ETCM v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases. | Yanqiong Zhang Xin Li Yulong Shi Tong Chen Zhijian Xu Ping Wang Meng Yu Wenjia Chen Bing Li Zhiwei Jing Hong Jiang Lu Fu Wenjing Gao Yanhua Jiang Xia Du Zipeng Gong Weiliang Zhu Hongjun Yang Haiyu Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 3 |
| 16 | Identification of Graves’ophthalmology by laser-induced breakdown spectroscopy combined with machine learning method显示文摘Diagnosis of the Graves’ophthalmology remains a significant challenge.We identified between Graves’ophthalmology tissues and healthy controls by using laser-induced breakdown spectroscopy(LIBS)combined with machine learning method.In this work,the paraffin-embedded samples of the Graves’ophthalmology were prepared for LIBS spectra acquisition.The metallic elements(Na,K,Al,Ca),non-metallic element(O)and molecular bands((C-N),(C-O))were selected for diagnosing Graves’ophthalmology.The selected spectral lines were inputted into the supervised classification methods including linear discriminant analysis(LDA),support vector machine(SVM),k-nearest neighbor(ANN),and generalized regression neural network(GRNN),respectively.The results showed that the predicted accuracy rates of LDA,SVM,ANN,GRNN were 76.33%,96.28%,96.56%,and 96.33%,respectively.The sensitivity of four models were 75.89%,93.78%,96.78%,and 96.67%,respectively.The specificity of four models were 76.78%,98.78%,96.33%,and 96.00%,respectively.This demonstrated that LIBS assisted with a nonlinear model can be used to identify Graves’ophthalmopathy with a higher rate of accuracy.The ANN had the best performance by comparing the three nonlinear models.Therefore,LIBS combined with machine learning method can be an effective way to discriminate Graves’ophthalmology. | Jingjing LI Feng CHEN Guangqian HUANG Siyu ZHANG Weiliang WANG Yun TANG Yanwu CHU Jian YAO Lianbo GUO Fagang JIANG | 2021 | Frontiers of Optoelectronics2021，14，3： | 3 |
| 17 | Chloride ion ingress distribution within an alternate wetting-drying marine environment area显示文摘Concrete structures in an alternate wetting-drying area often suffer from severe chloride ion ingress more than those in other areas. Field tests of marine structures were conducted, and chloride concentration is found to reach a maximum value at a certain elevation. The surface concentration and diffusion coefficient of chloride ions at different elevations exhibit Gaussian unimodal curve distributions. Using the chloride ion unsaturated permeability model, the distribution regularity mechanism is analyzed. Finally, an improved indoor accelerated simulation experiment is proposed to simulate the rules governing chloride ion ingress into concrete structures in an alternate wetting-drying area. | XU Chen LI ZhiYuan JIN WeiLiang ZHANG Yi YAO ChangJian | 2012 | Science China(Technological Sciences)2012，55，4： | 3 |
| 18 | Reverse Microemulsion Synthesis and Characterization of Pd-Ag Bimetallic Alloy Catalysts Supported on Al_2O_3 for Acetylene Hydrogenation显示文摘Pd-Ag bimetallic alloy nanoparticles were synthesized by the reverse microemulsion method,and then deposited on Al2O3 to form the supported catalyst.The nanoparticles of Pd-Ag and Pd-Ag/Al2O3 samples were characterized by UV/Vis,HRTEM,EDX,XRD,and XPS.The test results indicated that Pd-Ag bimetallic alloy nanoparticles with a size of about 2 nm and a face-centered cubic(fcc) structure were formed in the measured area of microemulsion.The growth of nanoparticles was effectively limited within the droplet of micoremulsion.TEM image exhibited that the Pd-Ag alloy nanoparticles were well-dispersed on the Al2O3 support.The catalytic performance of various catalysts for selective hydrogenation of acetylene showed that a higher acetylene conversion and selectivity to ethylene upon acetylene hydrogenation was achieved on a nano-sized Pd-Ag bimetallic catalyst with a Pd/Ag alloy supported molar ratio of 1:1.5. | Wei Guobin Dai Wei Li Qian Cao Weiliang Zhang Jingchang | 2012 | China Petroleum Processing & Petrochemical Technology2012，14，3： | 3 |
| 19 | Applying high-performance computing in drug discovery and molecular simulation显示文摘In recent decades, high-performance computing(HPC) technologies and supercomputers in China have significantly advanced, resulting in remarkable achievements. Computational drug discovery and design,which is based on HPC and combines pharmaceutical chemistry and computational biology, has become a critical approach in drug research and development and is financially supported by the Chinese government. This approach has yielded a series of new algorithms in drug design, as well as new software and databases. This review mainly focuses on the application of HPC to the fields of drug discovery and molecular simulation at the Chinese Academy of Sciences, including virtual drug screening, molecular dynamics simulation, and protein folding. In addition, the potential future application of HPC in precision medicine is briefly discussed. | Tingting Liu Dong Lu Hao Zhang Mingyue Zheng Huaiyu Yang Yechun Xu Cheng Luo Weiliang Zhu Kunqian Yu Hualiang Jiang | 2016 | National Science Review2016，3，1： | 2 |
| 20 | Design of a Lightweight Force-Feedback Glove with a Large Workspace显示文摘A wearable force-feedback glove is a promising way to enhance the immersive sensation when a user interacts with virtual objects in virtual reality scenarios.Design challenges for such a glove include allowing a large fingertip workspace,providing a desired force sensation when simulating both free-and constrained-space interactions,and ensuring a lightweight structure.In this paper,we present a forcefeedback glove using a pneumatically actuated mechanism mounted on the dorsal side of the user’s hand.By means of a triple kinematic paired link with a curved sliding slot,a hybrid cam-linkage mechanism is proposed to transmit the resistance from the pneumatic piston rod to the fingertip.In order to obtain a large normal component of the feedback force on the user’s fingertip,the profile of the sliding slot was synthesized through an analysis of the force equilibrium on the triple kinematic paired link.A prototype five-fingered glove with a mass of 245 g was developed,and a wearable force-measurement system was constructed to permit the quantitative evaluation of the interaction performance in both free and constrained space.The experimental results confirm that the glove can achieve an average resistance of less than 0.1 N in free-space simulation and a maximum fingertip force of 4 N in constrained-space simulation.The experiment further confirms that this glove permits the finger to move freely to simulate typical grasping gestures. | Yukai Zheng Dangxiao Wang Ziqi Wang Yu Zhang Yuru Zhang Weiliang Xu | 2018 | Engineering2018，4，6： | 2 |
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