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| 1 | Microstructure and tensile behavior of hot extruded AZ91 alloys at room temperature显示文摘AZ91 alloys were prepared by hot extrusion and its microstructure and tensile behavior at room temperature were investigated. Compared to as-cast ingot, the grain size of hot-extruded material is morerefined, the intermetallic phase Mg17Al12 is broken and dispersed discontinuously. Both strength and elongation of AZ91 are improved by hotextrusion. Tensile behavior and fracture surface of the experimental material were studied. Due to the change in microstructure, the fracture mechanism of extruded material is different from that of as-cast ingot, the latter is mainly a brittle fracture. Ductile fracture plays arole in hot-extruded AZ91 failure at room temperature. | Yuanyuan Li, Datong Zhang, Ying Liu, Yan Long, and Weiping ChenCollege of Mechanical Engineering, South China University of Technology Guangzhou 510640, China | 2002 | Journal of University of Science and Technology Beijing2002，9，5： | 10 |
| 2 | INTERCROPPING:FEED MORE PEOPLE AND BUILD MORE SUSTAINABLE AGROECOSYSTEMS显示文摘Intercropping is a traditional farming system that increases crop diversity to strengthen agroecosystem functions while decreasing chemical inputs and minimizing negative environmental effects of crop production.Intercropping is currently considerable interest because of its importance in sustainable agriculture.Here,we synthesize the factors that make intercropping a sustainable means of food production by integrating biodiversity of natural ecosystems and crop diversity.In addition to well-known yield increases,intercropping can also increase yield stability over the long term and increase systemic resistance to plant diseases,pests and other unfavorable factors(e.g.,nutrient deficiencies).The efficient use of resources can save mineral fertilizer inputs,reduce environmental pollution risks and greenhouse gas emissions caused by agriculture,thus mitigating global climate change.Intercropping potentially increases above-and belowground biodiversity of various taxa at field scale,consequently it enhances ecosystem services.Complementarity and selection effects allow a better understanding the mechanisms behind enhanced ecosystem functioning.The development of mechanization is essential for largescale application of intercropping.Agroecosystem multifunctionality and soil health should be priority topics in future research on intercropping. | Hao YANG Weiping ZHANG Long LI | 2021 | Frontiers of Agricultural Science and Engineering2021，8，3： | 5 |
| 3 | Fabrication of Iron-base Alloy by Spark Plasma Sintering显示文摘元素的混合粉末是的 Fe-2Cu-2Ni-lMo-0.8C (wt %) 很快,在由火花血浆 sintering 的 6 min 以内的 sintered,和当泉华材料的 densificationdegree 和性能上的 sintering 参数的效果被调查。结果证明当脉搏电流和经常的电流的合适的联合为 sintering 被采用时,当泉华材料的密度和拐弯力量到达了最大值,是 7.61x 10 ~ 3 kg/m^3 和 1540 MPa 分别地。它的相应破裂形态学是描绘的著名计算机生产厂商他混合可锻,内部小粒并且劈开破裂。 | Yuanyuan LI Xiaoqiang LI Yah LONG Wei XIA Min ZHU Weiping CHEN | 2006 | Journal of Materials Science & Technology2006，22，2： | 2 |
| 4 | Chemoattractive effect on the effector cells of the supernatants from melanoma cells transfected with the interleukin-2 (IL-2), IL-4 or IL-6 gene显示文摘 | Xuetao Cao Guoyou Chen Long He Weiping Zhang Yizhi Yu TianXing Ye | 1998 | Journal of Cancer Research and Clinical Oncology1998，，2： | 1 |
| 5 | Lymphotactin gene modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity显示文摘 | CAO Xuetao ZHANG Weiping HE Long | 1998 | The Journal of Immunology1998，161，： | 1 |
| 6 | Enhanced therapeutic efficacy of tumorRNA pulsed dendritic cells aftergenetic modification with lymphotactin显示文摘 | Weiping Zhang Long He ZhengLong Yuan | 1999 | Human GeneTherapy1999，10，： | 1 |
| 7 | Carrier-free nanodrugs for stemness inhibition-enhanced photodynamic therapy显示文摘Cancer stem cell(CSC)has been considered a key driver of tumor growth,recurrence,and metastasis due to its self-renewal and tumor initiation capacities called stemness.Stemness is also responsible for the high resistance of CSC to current therapeutic strategies,including photodynamic therapy(PDT)and chemotherapy.In this study,a carrier-free nanodrug(designated as MKCe6 nanoparticle[NP])selfassembled by photosensitizer chlorin e6(Ce6)and stemness inhibitor MK-0752 was prepared for effective tumor repression.Stemness inhibition caused by MK-0752 could sensitize CSCs to PDT.Benefiting from the high drug-loading capacity and efficient cellular internalization,MKCe6 NPs exhibited good performance in PDT and stemness inhibition.In this way,effective tumor growth repression and tumorigenesis inhibition by MKCe6 NPs were observed both in vitro and in vivo.This self-delivery nanodrug for stemness inhibition-enhanced photodynamic therapy may provide new insights for clinical cancer therapy. | Yuwei Liu Kaiqi Long Tianyi Wang Weirong Kang Weiping Wang | 2023 | Aggregate2023，4，3： | 0 |
| 8 | Genetic abnormalities assist in pathological diagnosis and EBVpositive cell density impact survival in Chinese angioimmunoblastic T-cell lymphoma patients显示文摘Objective:To explore the application of genetic abnormalities in the diagnosis of angioimmunoblastic T-cell lymphoma(AITL)and the reliable pathological prognostic factors.Methods:This study included 53 AITL cases,which were reviewed for morphological patterns,immunophenotypes,presence of Hodgkin and Reed-Sternberg(HRS)-like cells,and co-occurrence of B cell proliferation.The Epstein-Barr virus(EBV)-positive cells in tissues were counted,and cases were classified into“EBV encoded RNA(EBER)high-density”group if>50/HPF.Targeted exome sequencing was performed.Results:Mutation data can assist AITL diagnosis:1)with considerable HRS-like cells(20 cases):RHOA mutated in 14 cases(IDH2 co-mutated in 3 cases,4 cases with rare RHOA mutation),TET2 was mutated in 5 cases(1 case comutated with DNMT3A),and DNMT3A mutated in 1 case;2)accompanied with B cell lymphoma(7 cases):RHOA mutated in 4 cases(1 case had IDH2 mutation),TET2 mutated in 2 cases and DNMT3A mutated in 1 case;3)mimic peripheral T cell lymphoma,not otherwise specified(5 cases):RHOA mutated in 2 cases(IDH2 co-mutated in 1 case),TET2 mutated in 3 cases,and DNMT3A mutated in 1 case;4)pattern 1(1 case),RHOA and TET2 co-mutated.Besides RHOAG17V(30/35),rare variant included RHOAK18N,RHOAR68H,RHOAC83Y,RHOAD120G and RHOAG17del,IDH2R172 co-mutated with IDH2M397V in one case.There were recurrent mutations of FAT3,PCLO and PIEZO1 and genes of epigenetic remodeling,T-cell activation,APC and PI3K/AKT pathway.EBER high-density independently indicated adverse overall survival and progression-free survival(P=0.046 and P=0.008,KaplanMeier/log-rank).Conclusions:Over half AITL cases might be confused in diagnosis for certain conditions without mutation data.Targeted exome sequencing with a comprehensive panel is crucial to detect both hot-spot and rare mutation variants for RHOA and IDH2 and other recurrent mutated genes in addition to TET2 and DNMT3A.EBER highdensity independently indicated adverse survival. | Yunfei Shi Haojie Wang Yanfei Liu Mengping Long Ning Ding Lan Mi Yumei Lai Lixin Zhou Xinting Diao Xianghong Li Weiping Liu Jun Zhu | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
| 9 | Analysis on Development Potential of Millettia Specisoa Champ Industry in Guangdong Province显示文摘In recent years,Millettia specisoa Champ has attracted extensive attention because of its high medicinal and edible value. This paper will summarize the composition and application of Millettia specisoa Champ,analyze the advantages and existing problems in developing Millettia specisoa Champ industry in Guangdong Province according to the demand for Millettia specisoa Champ and the present situation in Guangdong Province,and put forward reasonable countermeasures and suggestions. | Shuaipeng MA Jing LI Weiping LONG Shouxing WEI Xindao TAN Qianquan MA Bilan HUANG | 2014 | Asian Agricultural Research2014，6，10： | 0 |
| 10 | Molecular evidence of introgressive hybridization between related species Jankowski's Bunting(Emberiza jankowskii)and Meadow Bunting(Emberiza cioides)(Aves:Passeriformes)显示文摘Natural hybridization,which often occurs between closely related species exhibiting sympatric or parapatric distributions,is an important source of genetic variation within populations.The closely related Jankowski’s Bunting(Emberiza jankowskii)and Meadow Bunting(E.cioides)are similar in morphology and genetics,occupy overlapping niches,and are sympatric in eastern Inner Mongolia.Previous studies have reported trans-species polymorphisms of alleles between the two species,as well as an unexpectedly high genetic diversity of the endangered E.jankowskii.We speculate that introgressive hybridization has occurred between the two species and contributed to the additional unexpected variation to E.jankowskii.We used mitochondrial NADH dehydrogenase subunit 2(ND2)gene and 15 nuclear microsatellite markers to compare the genetic diversity of E.jankowskii and E.cioides,and inferred the origin of trans-species polymorphisms between the two species by phylogenetic reconstruction and Bayesian cluster analysis.The two species could be clearly distinguished by population cluster analysis.Despite the large number of mutational differences,we still detected sharing of major haplotypes and the presence of hybrids between the two species.Our study confirmed that weak introgressive hybridization has occurred between sympatric E.jankowskii and E.cioides,which may be mediated by female E.cioides individuals,and that interspecific introgression has contributed to the maintenance of high genetic diversity in E.jankowskii.While being wary of the potential negative effects of introgressive hybridization,we suggest that expanding the habitat of E.jankowskii remains the most effective conservation strategy at present. | Long Huang Lishi Zhang Dan Li Rongfei Yan Weiping Shang Yunlei Jiang Shi Li | 2022 | Avian Research2022，13，2： | 0 |
| 11 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform under construction at IMP.It is a 5 year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in Material Sciences,Astrophysics,Atomic Physics and Highly Charged Ion Physics,LEAF has been designed and constructed with the state of the art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals. | Sun Liangting Yang Yao Lu Liang Guo Yuhui Liu Xiaojun Jing Long Li Libin Sun Liepeng Gao Zheng Ma Hongyi Jin Xiaofeng Zhai Yuhan Xu Xianbo Shi Longbo Xing Chaochao Liu Yuting Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jia Huan Zhang Bin Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Zhu Li Li Jiaqing Lu Wang Guo Junwei Li Chenxing Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 12 | 非免疫缺陷原发性中枢神经系统淋巴瘤17例临床分析(英文)显示文摘Objective: The aim of this study was to investigate the clinical manifestations of primary central nervous system lymphoma (PCNSL) with non-immune deficiency and explore effective methods for its diagnosis and treatment. Methods: The clinical, imaging and pathological data from 17 cases with PCNSL in our hospital from March 2006 to April 2009 were analyzed. The immunologic function test for all 17 cases was confirmed as normal. Four of them received stereotactie brain biopsy while the other patients were given full or partial resection. Fifteen of them were given both radiotherapy and chemotherapy after surgery. High-dose Methotrexate (HD-MTX) (2.0g/m2) was used via intravenous infusion once per week for three times. From week 4, patients began radiotherapy. Six cases with abnormal cerebrospinal fluid were given whole central nervous system radiotherapy, and 9 cases with normal cerebrospinal fluid were given only whole brain radiotherapy. Two of them were without any additional treatment after surgery. Sixteen of 17 cases were followed up for 9-48 months. Therapeutic efficacy, toxic and side effect were investigated. Results: Six cases, who were given HD-MTX chemotherapy and whole central nervous system radiotherapy, had grade 3 leukopenia, but other toxic and side effect above grade 3 were not observed. Two patients having no chemotherapy and radiotherapy recurred in one month, but there was only one recurred case in three months among 15 cases who had both chemotherapy and radiotherapy. One of them lost fellow-up. The 2-year survival rate was 69.2%. Conclusion: There is no specific clinical manifestation for PCNSL. The pathological examination is a reliable method to confirm PCNSL. Recurrence may occur after surgery alone, however, the combination of HD-MTX chemotherapy and radiotherapy is an effective and safe therapeutic option, which might improve the treatment efficiency and survival rate. | Weiping Tao Zhiwei Wang Long Wu | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，1： | 0 |
| 13 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform constructing at IMP.It is a 5-year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in material sciences,astrophysics,atomic physics and highly charged ion physics,LEAF has been designed and constructed with the state-of-the-art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals.The layout of LEAF is given in Fig.1. | Sun Liangting Lu Liang Jia Huan Yang Yao Zhang Bin Guo Yuhui Gao Zheng Ma Hongyi Jin Xiaofeng Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jing Long Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Liu Xiaojun Li Jiaqing Lu Wang Guo Junwei Yang Long Li Libin Sun Liepeng Shi Longbo Li Chenxing Ma Wei Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
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