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| 1 | Unsteady aerodynamic modeling at high angles of attack using support vector machines显示文摘Accurate aerodynamic models are the basis of flight simulation and control law design.Mathematically modeling unsteady aerodynamics at high angles of attack bears great difficulties in model structure determination and parameter estimation due to little understanding of the flow mechanism.Support vector machines(SVMs)based on statistical learning theory provide a novel tool for nonlinear system modeling.The work presented here examines the feasibility of applying SVMs to high angle-of-attack unsteady aerodynamic modeling field.Mainly,after a review of SVMs,several issues associated with unsteady aerodynamic modeling by use of SVMs are discussed in detail,such as selection of input variables,selection of output variables and determination of SVM parameters.The least squares SVM(LS-SVM)models are set up from certain dynamic wind tunnel test data of a delta wing and an aircraft configuration,and then used to predict the aerodynamic responses in other tests.The predictions are in good agreement with the test data,which indicates the satisfying learning and generalization performance of LS-SVMs. | Wang Qing Qian Weiqi He Kaifeng | 2015 | Chinese Journal of Aeronautics2015，28，3： | 21 |
| 2 | Aerodynamic Modeling and Parameter Estimation from QAR Data of an Airplane Approaching a High-altitude Airport显示文摘Aerodynamic modeling and parameter estimation from quick accesses recorder (QAR) data is an important technical way to analyze the effects of highland weather conditions upon aerodynamic characteristics of airplane. It is also an essential content of flight accident analysis. The related techniques are developed in the present paper, including the geometric method for angle of attack and sideslip angle estimation, the extended Kalman filter associated with modified Bryson-Frazier smoother (EKF-MBF) method for aerodynamic coefficient identification, the radial basis function (RBF) neural network method for aerodynamic modeling, and the Delta method for stability/control derivative estimation. As an application example, the QAR data of a civil airplane approaching a high-altitude airport are processed and the aerodynamic coefficient and derivative estimates are obtained. The estimation results are reasonable, which shows that the developed techniques are feasible. The causes for the distribution of aerodynamic derivative estimates are analyzed. Accordingly, several measures to improve estimation accuracy are put forward. | WANG Qing WU Kaiyuan ZHANG Tianjiao KONG Yi'nan QIAN Weiqi | 2012 | Chinese Journal of Aeronautics2012，25，3： | 19 |
| 3 | TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling显示文摘Osteoporosis is an osteolytic disorder commonly associated with excessive osteoclast formation.Transcriptional coactivator with PDZ-binding motif(TAZ)is a key downstream effector of the Hippo signaling pathway;it was suggested to be involved in the regulation of bone homeostasis.However,the exact role of TAZ in osteoclasts has not yet been established.In this study,we demonstrated that global knockout and osteoclast-specific knockout of TAZ led to a low-bone mass phenotype due to elevated osteoclast formation,which was further evidenced by in vitro osteoclast formation assays.Moreover,the overexpression of TAZ inhibited RANKL-induced osteoclast formation,whereas silencing of TAZ reduced it.Mechanistically,TAZ bound to TGF-activated kinase 1(TAK1)and reciprocally inhibited NF-κB signaling,suppressing osteoclast differentiation.Collectively,our findings highlight an essential role of TAZ in the regulation of osteoclastogenesis in osteoporosis and its underlying mechanism. | Wanlei Yang Xuanyuan Lu Tan Zhang Weiqi Han Jianlei Li Wei He Yewei Jia Kangxian Zhao An Qin Yu Qian | 2021 | Bone Research2021，9，3： | 6 |
| 4 | Differences and Similarities of Photocatalysis and Electrocatalysis in Two-Dimensional Nanomaterials:Strategies,Traps,Applications and Challenges显示文摘Photocatalysis and electrocatalysis have been essential parts of electrochemical processes for over half a century.Recent progress in the controllable synthesis of 2D nanomaterials has exhibited enhanced catalytic performance compared to bulk materials.This has led to significant interest in the exploitation of 2D nanomaterials for catalysis.There have been a variety of excellent reviews on 2D nanomaterials for catalysis,but related issues of differences and similarities between photocatalysis and electrocatalysis in 2D nanomaterials are still vacant.Here,we provide a comprehensive overview on the differences and similarities of photocatalysis and electrocatalysis in the latest 2D nanomaterials.Strategies and traps for performance enhancement of 2D nanocatalysts are highlighted,which point out the differences and similarities of series issues for photocatalysis and electrocatalysis.In addition,2D nanocatalysts and their catalytic applications are discussed.Finally,opportunities,challenges and development directions for 2D nanocatalysts are described.The intention of this review is to inspire and direct interest in this research realm for the creation of future 2D nanomaterials for photocatalysis and electrocatalysis. | Weiqi Qian Suwen Xu Xiaoming Zhang Chuanbo Li Weiyou Yang Chris RBowen Ya Yang | 2021 | Nano-Micro Letters2021，13，10： | 4 |
| 5 | Chimeric Newcastle Disease Virus-like Particles Containing DC-Binding Peptide-Fused Haemagglutinin Protect Chickens from Virulent Newcastle Disease Virus and H9N2 Avian Influenza Virus Challenge显示文摘Newcastle disease virus(NDV)and H9N2 subtype Avian influenza virus(AIV)are two notorious avian respiratory pathogens that cause great losses in the poultry industry.Current inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses,while an attenuated live vaccine bears the risk of mutation.Dendritic cell(DC)targeting strategies are attractive for their potent mucosal and adaptive immune-stimulating ability against respiratory pathogens.In this study,DC-binding peptide(DCpep)-decorated chimeric virus-like particles(cVLPs),containing NDV haemagglutinin–neuraminidase(HN)and AIV haemagglutinin(HA),were developed as a DC-targeting mucosal vaccine candidate.DCpep-decorated cVLPs activated DCs in vitro,and induced potent immune stimulation in chickens,with enhanced secretory immunoglobulin A(sIgA)secretion and splenic T cell differentiation.40μg cVLPs can provide full protection against the challenge with homologous,heterologous NDV strains,and AIV H9N2.In addition,DCpep-decorated cVLPs could induce a better immune response when administered intranasally than intramuscularly,as indicated by robust s IgA secretion and a reduced virus shedding period.Taken together,this chimericVLPs are a promising vaccine candidate to control NDV and AIV H9N2 and a useful platform bearing multivalent antigens. | Xiaohong Xu Jing Qian Lingsong Qin Jindou Li Cong Xue Jiaxin Ding Weiqi Wang Wei Ding Renfu Yin Ningyi Jin Zhuang Ding | 2020 | Virologica Sinica2020，35，4： | 4 |
| 6 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 7 | Recent progress in targeted delivery vectors based on biomimetic nanoparticles显示文摘Over the past decades,great interest has been given to biomimetic nanoparticles(BNPs)since the rise of targeted drug delivery systems and biomimetic nanotechnology.Biological vectors including cell membranes,extracellular vesicles(EVs),and viruses are considered promising candidates for targeted delivery owing to their biocompatibility and biodegradability.BNPs,the integration of biological vectors and functional agents,are anticipated to load cargos or camouflage synthetic nanoparticles to achieve targeted delivery.Despite their excellent intrinsic properties,natural vectors are deliberately modified to endow multiple functions such as good permeability,improved loading capability,and high specificity.Through structural modification and transformation of the vectors,they are pervasively utilized as more effective vehicles that can deliver contrast agents,chemotherapy drugs,nucleic acids,and genes to target sites for refractory disease therapy.This review summarizes recent adva门ces in targeted delivery vectors based on cell membranes,EVs,and viruses,highlighting the potential applications of BNPs in the fields of biomedical imaging and therapy industry,as well as discussing the possibility of clinical translation and exploitation trend of these BNPs. | Li Chen Weiqi Hong Wenyan Ren Ting Xu Zhiyong Qian Zhiyao He | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 2 |
| 8 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 9 | Relationships between land cover and the surface urban heat island: seasonal variability and effects of spatial and thematic resolution of land cover data on predicting land surface temperatures显示文摘 | ZHOU Weiqi QIAN Yuguo LI Xiaoma | 2014 | Landscape Ecology2014，29，： | 1 |
| 10 | Testing toxicity of multiple intravitreal injections of bevacizumab in rabbit eyes显示文摘 | Weiqi Xu Hong Wang Fenghua Wang Yuan Jiang Xian Zhang Wenqiu Wang Jin Qian Xun Xu Xiaodong Sun | 2010 | Canadian Journal of Ophthalmology/Journal canadien d’ophtalmologie2010，，4： | 1 |
| 11 | Testing toxicity of multiple intravitreal injections of bevacizumab in rabbit eyes显示文摘 | Weiqi Xu Hong Wang Fenghua Wang Yuan Jiang Xian Zhang Wenqiu Wang Jin Qian Xun Xu Xiaodong Sun | 2010 | Canadian Journal of Ophthalmology/Journal canadien d’ophtalmologie2010，，4： | 1 |
| 12 | Beyond city expansion:multi-scale environmental impacts of urban megaregion formation in China显示文摘Environmental degradation caused by rapid urbanization is a pressing global issue.However,little is known about how urban changes operate and affect environments across multiple scales.Focusing on China,we found urbanization was indeed massive from 2000 to 2015,but it was also very uneven,exhibiting high internal city dynamics.Urban areas in China as a whole became less green,warmer,and had exacerbated PM2.5 pollution.However,environmental impacts differed in newly developed versus older areas of cities.Adverse impacts were prominent in newly urbanized areas,while old urban areas generally showed improved environmental quality.In addition,regional environmental issues are emerging as cities expand,connect and interact to form urban megaregions.To turn urbanization into an opportunity for,rather than an obstacle to,sustainable development,we must move beyond documenting urban expansion to understand the environmental consequences of both internal city dynamics and the formation of urban megaregions. | Weiqi Zhou Wenjuan Yu Yuguo Qian Lijian Han Steward T.A.Pickett Jing Wang Weifeng Li Zhiyun Ouyang | 2022 | National Science Review2022，9，1： | 1 |
| 13 | Integrating structure and function:mapping the hierarchical spatial heterogeneity of urban landscapes显示文摘Background:Cities are social-ecological systems characterized by remarkably high spatial and temporal heterogeneity,which are closely related to myriad urban problems.However,the tools to map and quantify this heterogeneity are lacking.We here developed a new three-level classification scheme,by considering ecosystem types(level 1),urban function zones(level 2),and land cover elements(level 3),to map and quantify the hierarchical spatial heterogeneity of urban landscapes.Methods:We applied the scheme using an object-based approach for classification using very high spatial resolution imagery and a vector layer of building location and characteristics.We used a top-down classification procedure by conducting the classification in the order of ecosystem types,function zones,and land cover elements.The classification of the lower level was based on the results of the higher level.We used an objectbased methodology to carry out the three-level classification.Results:We found that the urban ecosystem type accounted for 45.3%of the land within the Shenzhen city administrative boundary.Within the urban ecosystem type,residential and industrial zones were the main zones,accounting for 38.4%and 33.8%,respectively.Tree canopy was the dominant element in Shenzhen city,accounting for 55.6%over all ecosystem types,which includes agricultural and forest.However,in the urban ecosystem type,the proportion of tree canopy was only 22.6%because most trees were distributed in the forest ecosystem type.The proportion of trees was 23.2% in industrial zones,2.2%higher than that in residential zones.That information“hidden”in the usual statistical summaries scaled to the entire administrative unit of Shenzhen has great potential for improving urban management.Conclusions:This paper has taken the theoretical understanding of urban spatial heterogeneity and used it to generate a classification scheme that exploits remotely sensed imagery,infrastructural data available at a municipal level,and object-based spatial analysis.For effective planning and management,the hierarchical levels of landscape classification(level 1),the analysis of use and cover by urban zones(level 2),and the fundamental elements of land cover(level 3),each exposes different respects relevant to city plans and management. | Yuguo Qian Weiqi Zhou Steward T.A.Pickett Wenjuan Yu Dingpeng Xiong Weimin Wang Chuanbao Jing | 2020 | Ecological Processes2020，9，1： | 1 |
| 14 | Physico-chemical characterization, antioxidant and anticancer activities in vitro of a novel polysaccharide from Melia toosendan Sieb. Et Zucc fruit显示文摘 | Liang He Pengfei Ji XingGuo Gong Weiqi Li Junwen Cheng Hua Qian XianLiang Song | 2011 | International Journal of Biological Macromolecules2011，，3： | 1 |
| 15 | Single-nucleus profiling unveils a geroprotective role of the Foxo3 in primate skeletal muscle aging显示文摘Age-dependent loss of skeletal muscle mass and function is a feature of sarcopenia,and increases the risk of many aging-related metabolic diseases.Here,we report phenotypic and single-nucleus transcriptomic analyses of non-human primate skeletal muscle aging.A higher transcriptional fluctuation was observed in myonuclei relative to other interstitial cell types,indicating a higher susceptibility of skeletal muscle fiber to aging.We found a downregulation of Foxo3 in aged primate skeletal muscle,and identi-fied FOxo3 as a hub transcription factor maintaining skeletal muscle homeostasis.Through the establishment of a complementary experimental pipeline based on a human pluripotent stem cell-derived myotube model,we revealed that silence of Foxo3 accelerates human myotube senescence,whereas genetic activation of endogenous FOxO3 alleviates human myotube aging.Altogether,based on a combination of monkey skeletal muscle and human myotube aging research models,we unraveled the pivotal role of the FOxO3 in safeguarding primate skeletal muscle from aging,providing a comprehensive resource for the development of clinical diagnosis and targeted therapeutic interventions against human skeletal muscle aging and the onset of sarcopenia along with aging-relateddisorders. | Ying Jing Yuesheng Zuo Yang Yu Liang Sun Zhengrong Yu Shuai Ma Qian Zhao Guoqiang Sun Huifang Hu Jingyi Li Daoyuan Huang Lixiao Liu Jiaming Li Zijuan Xin Haoyan Huang Juan Carlos Izpisua Belmonte Weiqi Zhang Si Wang Jing Qu Guang-Hui Liu | 2023 | Protein & Cell2023，14，7： | 0 |
| 16 | Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration显示文摘Hair loss affects millions of people at some time in their life,and safe and efficient treatments for hair loss are a significant unmet medical need.We report that topical delivery of quercetin(Que)stimulates resting hair follicles to grow with rapid follicular keratinocyte proliferation and replenishes perifollicular microvasculature in mice.We construct dynamic single-cell transcriptome landscape over the course of hair regrowth and find that Que treatment stimulates the differentiation trajectory in the hair follicles and induces an angiogenic signature in dermal endothelial cells by activating HIF-1αin endothelial cells.Skin administration of a HIF-1αagonist partially recapitulates the pro-angiogenesis and hair-growing effects of Que.Together,these findings provide a molecular understanding for the efficacy of Que in hair regrowth,which underscores the translational potential of targeting the hair follicle niche as a strategy for regenerative medicine,and suggest a route of pharmacological intervention that may promote hair regrowth. | Qian Zhao Yandong Zheng Dongxin Zhao Liyun Zhao Lingling Geng Shuai Ma Yusheng Cai Chengyu Liu Yupeng Yan Juan Carlos Izpisua Belmonte Si Wang Weiqi Zhang Guang-Hui Liu Jing Qu | 2023 | Protein & Cell2023，14，6： | 0 |
| 17 | A Study of the Dynamic Mechanisms and Effects of Allocating Emissions Permits under Endogenous Growth显示文摘排放权分配是碳交易机制设计中的重要部分,不同分配机制会影响长期增长路径,后者反过来也对减排政策效果带来影响。本文分析结果表明,静态的分配机制能够实现当期收益最大化,然而在内生经济增长机制下却会导致产出增速放缓。要实现跨期经济产出最优化,需要动态地对碳排放权的分配进行调整。在没有完全信息的情况下,通过依据产出调整各期排放权分配的机制,可以引导市场交易的结果逐渐向长期的最优增长路径逼近。 | Tang Weiqi Wu Libo Qian Haoqi | 2018 | Social Sciences in China2018，39，1： | 0 |
| 18 | Polydopamine nanolayer assisted internal photo-deposition of CdS nanocrystals for stable cosensitized photoanode显示文摘Hydrogen evolution via photo-electro-chemical(PEC)co-catalysis is potential for solving energy crisis and environmental issues.The rapidly advances of fabrication and broad applications of polydopamine(PDA)and its derivatives have drawn intense attentions in recent years.Herein,an ultrathin PDA coating with nanometer accuracy was conformally grown on TiO_(2) nanotube arrays(NTAs)via electrochemical polymerization,in which the polymer provided a platform for further photoinduced assembly of CdS nanocrystals in the embedded mode.The optimized CdS@PDA/TiO_(2) NTAs hierarchical heterostructure as photoanode gave an excellent PEC performance and exhibited outstanding stability under light irradiation.The photocurrent density was heightened to 5.48 mA·cm^(–2),which was beneficial to H_(2) evolution with a rate of 20μmol·h^(–1)·cm^(–2).The improvement of PEC activity was ascribed to co-photosensitization,optimized carriers transfer,and transport route arised from CdS embedding,resulting to provide a persistent driving force for charge separation based on secure heterojunction of CdS/TiO_(2) glued by PDA.The improvement of PEC stability was due to the inhibition of CdS photocorrosion covered by PDA shelter.This advance boded well for the development of PEC field founded on multifunctional PDA. | Na Li Lu Han Hainan Zhang Juntong Huang Xudong Luo Xibao Li Yuanhao Wang Weiqi Qian Ya Yang | 2022 | Nano Research2022，15，10： | 0 |
| 19 | Piezoelectric Materials for Controlling Electro-Chemical Processes显示文摘Piezoelectric materials have been analyzed for over 100 years,due to their ability to convert mechanical vibrations into electric charge or electric fields into a mechanical strain for sensor,energy harvesting,and actuator applications.A more recent development is the coupling of piezoelectricity and electro-chemistry,termed piezo-electro-chemistry,whereby the piezoelectrically induced electric charge or voltage under a mechanical stress can influence electro-chemical reactions.There is growing interest in such coupled systems,with a corresponding growth in the number of associated publications and patents.This review focuses on recent development of the piezo-electro-chemical coupling multiple systems based on various piezoelectric materials.It provides an overview of the basic characteristics of piezoelectric materials and comparison of operating conditions and their overall electro-chemical performance.The reported piezo-electro-chemical mechanisms are examined in detail.Comparisons are made between the ranges of material morphologies employed,and typical operating conditions are discussed.In addition,potential future directions and applications for the development of piezo-electro-chemical hybrid systems are described.This review provides a comprehensive overview of recent studies on how piezoelectric materials and devices have been applied to control electro-chemical processes,with an aim to inspire and direct future efforts in this emerging research field. | Weiqi Qian Weiyou Yang Yan Zhang Chris R.Bowen Ya Yang | 2020 | Nano-Micro Letters2020，12，11： | 0 |
| 20 | Computer simulation of intravascular ultrasound plaque images显示文摘一个方法被建议模仿 intravascular 动脉粥样硬化患者匾的超声(IVUS ) 图象。为了完成静态的 IVUS 匾图象,铃流和 guidewire 的模拟,人工制品被介绍进极的图象形成模型(PIFM ) ,并且含纤维,类脂化合物和石灰质的内容分别地在匾被综合。顺序的 IVUS 图象的模拟能被利用脉动的动脉的特征完成。静态的图象上的结果证明它以关联系数(CC ) 在 56.9% 超过 PIFM 方法,并且 24.3% 以相互的信息(MI ) 。顺序的图象上的结果证明它以 CC 在 51.0% 超过 PIFM 方法,并且 10.3% 以 MI。 | ZHANG Qi WANG Yuanyuan WANG Weiqi MA Jianying QIAN Juying GE Junbo | 2009 | Chinese Journal of Acoustics2009，28，4： | 0 |
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