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| 1 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 2 | Constrained large-eddy simulation and detached eddy simulation of flow past a commercial aircraft at 14 degrees angle of attack显示文摘With the development of computational power and numerical algorithms,computational fluid dynamics(CFD) has become an important strategy for the design of aircraft,which significantly reduces the reliance on wind-tunnel and flight tests.In this paper,we conducted a numerical investigation on the flow past a full commercial aircraft at Mach number 0.2 and 14 degrees angle of attack by means of Reynolds-averaged Navier-Stokes(RANS),detached-eddy simulation(DES) and our newly developed constrained large-eddy simulation(CLES).The objective of this paper is to study the capability of these models in simulating turbulent flows.To our knowledge,this is the first large-eddy simulation method for full commercial aircraft simulation.The results show that the CLES can predict the mean statistical quantities well,qualitatively consistent with traditional methods,and can capture more small-scale structures near the surface of the aircraft with massive separations.Our study demonstrates that CLES is a promising alternative for simulating real engineering turbulent flows. | CHEN ShiYi CHEN YingChun XIA ZhenHua QU Kun SHI YiPeng XIAO ZuoLi LIU QiuHong CAI QingDong LIU Feng LEE Cunbiao ZHANG RiKui CAI JinSheng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 14 |
| 3 | An Atypical Thioredoxin Imparts Early Resistance to Sugarcane Mosaic Virus in Maize显示文摘 | Qingqing Liu Huanhuan Liu Yangqing Gong Yongfu Tao Lu Jiang Weiliang Zuo Qin Yang Jianrong Ye Jinsheng Lai Jianyu Wu Thomas Lubberstedt Mingliang Xu | 2017 | Molecular Plant2017，10，3： | 14 |
| 4 | Analysis of 2D Flow and Heat Transfer Modeling in Fracture of Porous Media显示文摘Heat and mass transfer between porous media and fluid is a complex coupling process, which is widely used in various fields of engineering applications, especially for natural and artificial fractures in oil and gas extraction. In this study, a new method is proposed to deal with the flow and heat transfer problem of steady flow in a fracture. The fluid flow in a fracture was described using the same method as Mohais, who considered a fracture as a channel with porous wall, and the perturbation method was used to solve the mathematical model. Unlike previous studies, the shear jump boundary condition proposed by Ochoa-Tapia and Whitaker was used at the interface between the fluid and porous media. The main methods were perturbation analysis and the application of shear jump boundary conditions. The influence of permeability, channel width, shear jump degree and effective dynamic viscosity on the flow and heat transfer in the channel was studied by analysing the analytical solution. The distribution of axial velocity in the channel with the change of the typical parameters and the sensitivity of the heat transfer was obtained. | GUO Chunsheng NIAN Xianbo LIU Yong QI Chao SONG Jinsheng YU Wenhe | 2017 | Journal of Thermal Science2017，26，4： | 9 |
| 5 | Curative effect of scraping therapies on lumbar muscle strain显示文摘OBJECTIVE:To explore factors influencing the curative effect of scraping therapies (at acupoints or along channels) and to determine the relationship of scraping site and strength to curative effect. METHODS: Two hundred and ten patients with lumbar muscle strain were divided into five groups with 42 patients each.The 'scraping therapy at acupoint until appearance of skin eruptions' and 'scraping therapy along channel until appearance of skin eruptions' groups were treated with a 4-daycourse. The 'scraping therapy at acupoint without appearance of skin eruptions', 'scraping therapy along channel without appearance of skin eruptions', and acupuncture groups were treated with a 2-day course.The five groups were treated with seven courses. The visual analog scale (VAS), oswestry disability index (ODI), and lumbago scores were recorded in the five groups before treatment, after each treatment, and in follow-up visits one month and three months after treatment. RESULTS: VAS, ODI, and lumbago scores after treatment improved in the five groups (P<0.01). There was a statistical difference (P<0.01) in the change of VAS scores by appearance of skin eruptions and scraping site. CONCLUSION: Scraping therapy can effectively alleviate lumbago symptoms. The appearance of skin eruptions and scraping therapy along channels can enhance the curative effect of scraping therapy. | Yingying Wang Li Yang Jinsheng Yang Jinhong Yang Zhibin Liu Feng Chen Dongxia Liu Haiguang Yuan Liang Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 7 |
| 6 | First light of the 1.8-m solar telescope–CLST显示文摘Large-aperture solar telescopes play an important role in solar observations and research,and require high temporal and spatial resolution[1].To solve some fundamental problems such as the solar dynamo,coronal heating,and the triggering of major solar eruptions,the spatial resolution for solar-atmosphere observation should reach at least 0.1 arcsec[2]. | ChangHui Rao NaiTing Gu XueJun Rao Cheng Li LanQiang Zhang JinLong Huang Lin Kong Ming Zhang YunTao Cheng Yi Pu Hua Bao YouMing Guo YangYi Liu JinSheng Yang LiBo Zhong ChangJun Wang Kai Fang XiaoJun Zhang DongHong Chen Cheng Wang XinLong Fan ZhiWu Yan KeLe Chen XiYa Wei Lei Zhu Hong Liu YongJian Wan Hao Xian WenLi Ma | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 6 |
| 7 | Anaerobic benzene biodegradation by a pure bacterial culture of Bacillus cereus under nitrate reducing conditions显示文摘A pure culture using benzene as sole carbon and energy sources was isolated by screening procedure from gasoline contaminated soil.The analysis of the 16S rDNA gene sequence,morphological and physiological characteristics showed that the isolated strain was a member of genus Bacillus cereus.The biodegradation performance of benzene by B.cereus was evaluated,and the results showed that benzene could be efficiently biodegraded when the initial benzene concentration was below 150 mg/L.The metabolites of anaerobic nitrate-dependent benzene oxidation by strain B.cereus were identified as phenol and benzoate.The results of substrate interaction between binary combinations for benzene,phenol and benzoate showed that the simultaneous presence of benzene stimulated the degradation of benzoate,whereas the addition of benzene inhibited the degradation of phenol.Benzene degradation by B.cereus was enhanced by the addition of phenol and benzoate,the enhanced effects were more pronounced at higher concentration.To our knowledge,this is the first report that the isolated bacterial culture of B.cereus can efficiently degraded benzene under nitrate reducing conditions. | Junfeng Dou Aizhong Ding Xiang Liu Yongchao Du Dong Deng Jinsheng Wang | 2010 | Journal of Environmental Sciences2010，22，5： | 6 |
| 8 | Aerodynamic configuration integration design of hypersonic cruise aircraft with inward-turning inlets显示文摘In this work, a novel airframe/propulsion integration design method of the wing-body configuration for hypersonic cruise aircraft is proposed, where the configuration is integrated with inward-turning inlets. With the help of this method, the major design concern of balancing the aerodynamic performance against the requirements for efficient propulsion can be well addressed. A novel geometric parametrically modelling method based on a combination of patched class and shape transition(CST) and COONs surface is proposed to represent the configuration, especially a complex configuration with an irregular inlet lip shape. The modelling method enlarges the design space of components on the premise of guaranteeing the configuration integrity via special constraints imposed on the interface across adjacent surfaces. A basic flow inside a cone shaped by a dual-inflection-point generatrix is optimized to generate the inward-turning inlet with improvements of both compression efficiency and flow uniformity. The performance improvement mechanism of this basic flow is the compression velocity variation induced by the variation of the generatrix slope along the flow path. At the design point, numerical simulation results show that the lift-to-drag ratio of the configuration is as high as 5.2 and the inlet works well with a high level of compression efficiency and flow uniformity. The design result also has a good performance on off-design conditions. The achievement of all the design targets turns out that the integration design method proposed in this paper is efficient and practical. | Jifei WANG Jinsheng CAI Chuanzhen LIU Yanhui DUAN Yaojie YU | 2017 | Chinese Journal of Aeronautics2017，30，4： | 5 |
| 9 | Development and application of magnesium alloy parts for automotive OEMs:A review显示文摘China is currently vigorously implementing the“energy conservation and emission reduction”and“dual carbon”strategies.As the most resource-advantaged light metal material in China,Magnesium(Mg)alloy is progressively expanding its application in automobile,rail transportation,aerospace,medical,and electronic products.Chongqing University,Shanghai Jiaotong University,and Australian National University have conducted extensive research on the preparation,properties,and processes of Mg alloys.In the past 20 years,the proportion of Mg alloy in the automotive industry has gradually expanded,whereas currently the design and development of Mg alloy parts for automobiles has rarely been reported.Thus,the application models and typical parts cases of Mg alloy are summarized mainly from the four systems of the whole vehicle(body system,chassis system,powertrain system,interior,and exterior system).Subsequently,two actual original equipment manufacturers(OEM)cases are used to introduce the development logic of reliable die-cast Mg alloy,including forward design,formability analysis,process design analysis,structural redesign,manufacturing,and testing,aiming to share the methods,processes,and focus of attention of automotive OEMs for developing Mg alloy parts to enhance the confidence and motivation of applying Mg alloy in automotive field.Eventually,the multiple challenges faced by Mg alloy materials are sorted out and how to face these challenges are discussed.National policies and regulations,environmental protection and energy saving,and consumer demand will continue to promote the application of Mg. | Bo Liu Jian Yang Xiaoyu Zhang Qin Yang Jinsheng Zhang Xiaoqing Li | 2023 | Journal of Magnesium and Alloys2023，11，1： | 5 |
| 10 | Microwave-Assisted Decarboxylation of Sodium Oleate and Renewable Hydrocarbon Fuel Production显示文摘The carboxyl terminal of sodium oleate has a stronger polarity than that of oleic acid;this terminal is more likely to be dipole polarized and ionically conductive in a microwave field.Sodium oleate was used as the model compound to study the decarboxylation of oleic acid leading to hydrocarbon formation via microwave-assisted pyrolysis technology.The pyrolysis gas,liquid,and solid products were precisely analyzed to deduce the mechanism for decarboxylation of sodium oleate.Microwave energy was able to selectively heat the carboxyl terminal of sodium oleate.During decarboxylation,the double bond in the long hydrocarbon chain formed a p-πconjugated system with the carbanion intermediate.The resulting p-πconjugated system was more stable and beneficial to the pyrolysis reaction(decarboxylation,terminal allylation,isomerization,and aromatization).The physical properties of pyrolysis liquid were generally similar to those of diesel fuel,thereby demonstrating the possible use of microwaves for controlling the decarboxylation of sodium oleate in order to manufacture renewable hydrocarbon fuels. | Wang Yunpu Liu Yuhuan Ruan Rongsheng Wen Pingwei Wan Yiqin Zhang Jinsheng | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，3： | 5 |
| 11 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 12 | Identification and Fine Mapping of rhm1 Locus for Resistance to Southern Corn Leaf Blight in Maize显示文摘rhm1 is a major recessive disease resistance locus for Southern corn leaf blight (SCLB).To further narrow down its genetic position,F 2 population and BC 1 F 1 population derived from the cross between resistant (H95 rhm) and susceptible parents (H95) of maize (Zea mays) were constructed.Using newly developed markers,rhm1 was initially delimited within an interval of 2.5 Mb,and then finally mapped to a 8.56 kb interval between InDel marker IDP961-503 and simple sequence repeat (SSR) marker A194149-1.Three polymorphic markers IDP961-504,IDP B2-3 and A194149-2 were shown to be co-segregated with the rhm1 locus.Sequence analysis of the 8.56 kb DNA fragment revealed that it contained only one putative gene with a predicted amino acid sequence identical to lysine histidine transporter 1 (LHT1).Comparative sequence analysis indicated that the LHT1 in H95 rhm harbors a 354 bp insertion in its third exon as compared with that of susceptible alleles in B73,H95 and Mo17.The 354 bp insertion resulted in a truncation of the predicted protein of candidate resistance allele (LHT1-H95 rhm).Our results strongly suggest LHT1 as the candidate gene for rhm1 against SCLB.The tightly linked molecular markers developed in this study can be directly used for molecular breeding of resistance to Southern corn leaf blight in maize. | Yuanzeng Zhao Xiaomin Lu Chaoxian Liu Haiying Guan Mei Zhang Zhongfeng Li Hongwei Cai Jinsheng Lai | 2012 | Journal of Integrative Plant Biology2012，54，5： | 4 |
| 13 | TEACHING INTONATION TO CHINESE STUDENTS OF ENGLISH显示文摘In teaching English pronunciation,intonationoften poses difficulties to Chinese teachers.This paperpresents an approach of intonation teaching whichconsists of the following points:1)compare Chineseand English intonation;2)analyze the structure ofEnglish intonation;3)guide practice through imita-tion;4)emphasize the functions of English intona-tion. | Liu Yunhong Zhang Jinsheng PLA Foreign Languages University | 2000 | Chinese Journal of Applied Linguistics2000，23，2： | 4 |
| 14 | Genesis of the Gold Deposit in the Indus-Yarlung Tsangpo Suture Zone,Southern Tibet:Evidence from Geological and Geochemical Data显示文摘The Nianzha gold deposit,located in the central section of the Indus-Yarlung Tsangpo suture(IYS) zone in southern Tibet,is a large gold deposit(Au reserves of 25 tons with average grade of 3.08 g/t) controlled by a E-W striking fault that developed during the main stage of Indo-Asian collision(~65-41 Ma).The main orebody is 1760 m long and 5.15 m thick,and occurs in a fracture zone bordered by Cretaceous diorite in the hanging wall to the north and the Renbu tectonic melange in the footwall to the south.High-grade mineralization occurs in a fracture zone between diorite and ultramafic rock in the Renbu tectonic melange.The wall-rock alteration is characterized by silicification in the fracture zone,serpentinization and the formation of talc and magnesite in the ultramafic unit,and chloritization and the formation of epidote and calcite in diorite.Quartz veins associated with Au mineralization can be divided into three stages.Fluid inclusion data indicate that the deposit formed from H_2O-NaCl-organic gas fluids that homogenize at temperatures of 203℃-347℃ and have salinities of 0.35wt%-17.17wt%NaCl equivalent.The quartz veins yield δ^(18)O_(fluid) values of 0.15‰-10.45‰,low δD_(V-SMOW)values(-173‰ to-96‰),and the δ^(13)C values of-17.6‰ to-4.7‰,indicating the ore-forming fluids were a mix of metamorphic and sedimentary orogenic fluids with the addition of some meteoric and mantle-derived fluids.The pyrite within the diorite has δ^(34)S_(V-CDT) values of-2.9‰-1.9‰(average-1.1‰),^(206)Pb/^(204)Pb values of 18.47-18.64,^(207)Pb/^(204)Pb values of 15.64-15.74,and ^(208)Pb/^(204)Pb values of 38.71-39.27,all of which are indicative of the derivation of S and other ore-forming elements from deep in the mantle.The presence of the Nianzha,Bangbu,and Mayum gold deposits within the IYS zone indicates that this area is highly prospective for large orogenic gold deposits.We identified three types of mineralization within the IYS,namely Bangbu-type accretionary,Mayum-type microcontinent,and Nianzha-type ophiolite-associated orogenic Au deposits.The three types formed at different depths in an accretionary orogenic tectonic setting.The Bangbu type was formed at the deepest level and the Nianzha type at the shallowest. | ZHANG Xiong DENG Xueguo YANG Zhusen HOU Zengqian ZHENG Yuanchuan LIU Yingchao ZHAO Xiaoyan XU Bo PEI Yingru ZHOU Jinsheng ZHAO Miao YUAN Jianfei | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 4 |
| 15 | Rapid genome evolution in Pms1 region of rice revealed by comparative sequence analysis显示文摘Pms1, a locus for photoperiod sensitive genic male sterility in rice, was identified and mapped to chromosome 7 in previous studies. Here we report an effort to identify the candidate genes for Pms1 by comparative sequencing of BAC clones from two cultivars Minghui 63 and Nongken 58, the parents for the initial mapping population. Annotation and comparison of the sequences of the two clones resulted in a total of five potential candidates which should be functionally tested. We also conducted com-parative analysis of sequences of these two cultivars with two other cultivars, Nipponbare and 93-11, for which sequence data were available in public databases. The analysis revealed large differences in sequence composition among the four genotypes in the Pms1 region primarily due to retroelement activity leading to rapid recent growth and divergence of the genomes. High levels of polymorphism in the forms of indels and SNPs were found both in intra- and inter-subspecific comparisons. Dating analysis using LTRs of the retroelements in this region showed that the substitution rate of LTRs was much higher than reported in the literature. The results provided strong evidence for rapid genomic evolution of this region as a consequence of natural and artificial selection. | YU JinSheng FAN YouRong LIU Nan SHAN Yan LI XiangHua ZHANG QiFa | 2007 | Chinese Science Bulletin2007，52，7： | 4 |
| 16 | Purification of starch and phosphorus wastewater using core-shell magnetic seeds prepared by sulfated roasting显示文摘Core-shell magnetic seeds with certain adsorption capacity that were prepared by sulfated roasting, served as the core of a magnetic separation technology for purification of starch wastewater. XRD and SEM results indicate that magnetite's surface transformed to be porous α-Fe_2O_3 structure. Compared with magnetite particles, the specific surface area was significantly improved to be 8.361 from 2.591 m^2/g, with little decrease in specific susceptibility. Zeta potential, FT-IR and XPS experiments indicate that both phosphate and starch adsorbed on the surface of the core-shell magnetic seeds by chemical adsorption, which fits well with the Langmuir adsorption model. The porous surface structure of magnetic seeds significantly contributes to the adsorption of phosphate and starch species, which can be efficiently removed to be 1.51 mg/L(phosphate) and 9.51 mg/L(starch) using magnetic separation. | Chunjie Du Jinsheng Yu Wei Sun Haisheng Han Yuehua Hu Pan Chen Panpan Hou Runqing Liu Li Wang Yue Yang Ruohua Liu Lei Sun | 2019 | Journal of Environmental Sciences2019，31，7： | 4 |
| 17 | Evolution and Domestication Footprints Uncovered from the Genomes of Coix显示文摘Coix lacryma-jobi,a plant species closely related to Zea and Sorghum,is an important food and medicinal crop in Asia.However,no reference genome of this species has been reported,and its exact phylogeny within the Andropogoneae remains unresolved.Here,we generated a high-quality genome assembly of coix comprising~1.73 Gb with 44485 predicted protein-coding genes.We found coix to be a typical diploid plant with an overall 1-to-1 syntenic relationship with the Sorghum genome,despite its drastic genome expansion(~2.3-fold)due mainly to the activity of transposable elements.Phylogenetic analysis revealed that coix diverged with sorghum~10.41 million years ago,which was~1.49 million years later than the divergence between sorghum and maize.Resequencing of 27 additional coix accessions revealed that they could be unambiguously separated into wild relatives and cultivars,and suggested that coix experienced a strong genetic bottleneck,resulting in the loss of about half of the genetic diversity during domestication,even though many traits have remained undomesticated.Our data not only provide novel comparative genomic and evolutionary insights into the Andropogoneae lineage,but also an important resource that will greatly benefit molecular breeding of this important crop. | Hongbing Liu Junpeng Shi Zexi Cai Yumin Huang Menglu Lv Huilong Du Qiang Gao Yi Zuo Zhaobin Dong Wei Huang Rui Qin Chengzhi Liang Jinsheng Lai Weiwei Jin | 2020 | Molecular Plant2020，13，2： | 4 |
| 18 | Linked Open Data Query Based on Natural Language显示文摘Linked open data(LOD) supports the SPARQL query strongly.A translation system from the natural language query to the SPARQL query based on the syntax rules is proposed.For a natural language query,a parsing method is proposed to represent the query intention and construct the corresponding query graph.The algorithms for obtaining and instantiating triple patterns are designed based on the rules.A mapping method for different types of graph nodes is lastly proposed to improve the recall.The experiments based on test data from QALD-4 are conducted.Compared with the other systems,our system is more easy and effective,and evaluation results are outstanding in the field of unsupervised learning. | LIU Jie LI Wei LUO Liming ZHOU Jianshe HAN Xu SHI Jinsheng | 2017 | Chinese Journal of Electronics2017，26，2： | 3 |
| 19 | Diagnosis and clinical manifestations of subacute combined degeneration of the spinal cord: Analysis of 21 cases显示文摘BACKGROUND: Subacute combined degeneration of the spinal cord is caused by vitamin B12 deficiency and is a kind of degenerative disease owing the characteristics of nervous system diseases. In addition, different patients have variously clinical manifestations and various prognoses after vitamin B12 therapy. OBJECTIVE: To investigate and analyze diagnosis, clinical manifestations and prognosis of subacute combined degeneration of the spinal cord. DESIGN: Case analysis. SETTING: Department of Neurology, the Third Hospital of Peking University. PARTICIPANTS: A total of 21 subacute combined degeneration of the spinal cord patients including 14 males and 7 females aged from 33 to 82 years were selected from Department of Neurology, the Third Hospital of Peking University from January 1999 to December 2005. Duration from onset to final diagnosis lasted for 1.5–108 months. All patients had typically clinical manifestations; meanwhile, level of serum vitamin B12 was decreased and/or vitamin B12 therapy was effective. All patients provided the confirmed consent. METHODS: Clinical data of 21 subacute combined degeneration of the spinal cord patients were retrospectively analyzed, while general data and clinical characteristics were recorded at the same time. Levels of blood routine, serum vitamin B12 and homocysteine were measured at the phase of hospitalization. Normal value of serum vitamin B12 was 187–1 059 ng/L and normal value of serum homocysteine was 5– 15 μmol/L. All patients received neuroelectrophysiological examination and 15 patients received MRI examinations of spinal cord. After final diagnosis, patients were given vitamin B12 therapy. And follow-up was performed to investigate the prognosis. MAIN OUTCOME MEASURES: ① Levels of blood routine, serum vitamin B12 and homocysteine; ② results of neuroelectrophysiological examination; ③ results of MRI examination of spinal cord; ④ prognosis. RESULTS: Clinical data of 21 patients and follow-up data of 20 patients were involved in the final analysis and 1 patient was lost because of living in the other province. ① Clinical manifestations: All 21 patients had typically clinical manifestations. The original symptoms included numbness of lower and/or upper limbs (5 cases), unstable gait (3 cases), limb asthenia (4 cases), limb numbness combined with light asthenia (5 cases), limb numbness combined with unskillful activity (3 cases), and limb numbness combined with unstable gait (1 case). ② Experimental results: Eight subacute combined degeneration of the spinal cord patients accompanied with mild-severe anemia and mean corpuscular volume of 13 patients were increased. Among 13 subacute combined degeneration of the spinal cord patients not administrating vitamin B12 before hospitalization, the levels of serum vitamin B12 of 2 patients were not measured but those of other patients were decreased. After vitamin B12 therapy,the levels of serum vitamin B12 of 8 patients were normal or increased. In addition, the levels of serum homocysteine of 6 patients were not measured but those of 7 patients were increased. While, the levels of homocysteine of 5 following-up patients were normal. The levels of serum vitamin B12 of 8 patients who received with vitamin B12 therapy before hospitalization were normal or increased. Among them,the levels of homocysteine were not measured in 4 patients, those of 3 patients were increased, and that of 1 patient was normal. ③ Results of neuroelectrophysiological examination: Among all patients, 95% (20/21) patients had abnormal sensory-evoked potential, 89% (8/9) patients had abnormal motor evoked potential, 67% (10/15) patients had abnormal nerve conduction, 13% (2/15) patients had neurogenic muscle injury showed by electromyography (EMG), 70% (7/10) patients had abnormal brain-stem auditory evoked potential, and 40% (4/10) patients had abnormal visual evokedpotential. ④ Results of MRI examination of spinal cord: MRI examination demonstrated that 40% (6/15) patients had spinal cord lesion, but spinal cord lesion disappeared in 2 patients during follow up. In addition, clinical manifestations of patients were improved after standard vitamin B12 therapy. CONCLUSION: Nervous system lesion caused by vitamin B12 deficiency is not only involved in spinal cord, also in peripheral nerve, optic nerve, auditory pathway, etc. Diagnosis of the lesion depends on clinical characteristics and level of serum vitamin B12. Especially, neuroelectrophysiological examination, measurement of homocysteine and MRI examination of spinal cord are beneficial for diagnosis and evaluation of therapeutic effects. | Yanhong Shou Caifeng Li Dongsheng Fan Yang Shen Jun Zhang Weizhong Xiao Shuqing Zhao Jinsheng Liu Wei Sui | 2007 | Neural Regeneration Research2007，2，2： | 3 |
| 20 | Modified Carbothermal Synthesis of TiC Whiskers显示文摘A new approach to the massive production of TiC whiskers with high purity and low cost was presented. It is a modified carbothermal reduction method (MCTR) characterized by argon stream flowing vertically and passing through the interior of the mixture of raw materials. It is found for the first time that there is an optimum flow of the upward flowing argon stream, at which large quantity of high quality TiC can be obtained. This paper described the new method, analyzed the mechanism and conditions for the formation of high purity TiC whiskers on a large scale, and compared MCTR with the traditional carbothermal reduction method (TCTR). Based on the analysis and comparison, it is concluded that in order to produce high quality transition metal carbides, nitrides and carbonitrides with low cost TCTR must be replaced by MCTR. | Ruixiang Cao Cuirong Liu Zhisheng Wu Jinsheng Pan | 2011 | Journal of Materials Science & Technology2011，27，11： | 3 |
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