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| 1 | The Inhibitory Effect of Oridonin on the Growth of Fifteen Human Cancer Cell Lines显示文摘OBJECTIVE To study the inhibitory effect of oridonin on the growth of cancer cells. METHODS Fifteen human cancer cell lines were subjected to various concentrations of oridonin in culture medium. The inhibitory rate of cell growth was measured by the MTT assay, and compared with a negative con- trol and 5-Fu-positive control. RESULTS The 50% inhibiting concentration (IC50) and maximal inhibition (Imax) of oridonin shown by studying the growth of the cancer cell lines were as follows: leukemias (HL60 cells: 3.9 μg/ml and 73.8%, K562 cells: 4.3 μg/ml and 76.2%); esophageal cancers(SHEEC cells: 15.4 μg/ml and 99.2%, Eca109 cells: 15.1 μg/ml and 84.6%, TE1 cells: 4.0 μg/ml and 70.2%); gastric cancers (BGC823 cells: 7.6 μg/ml and 98.7%, SGC7901 cells: 12.3 μg/ml and 85.7%); colon cancers (HT29 cells: 13.6 μg/ml and 97.2%, HCT cells: 14.5 μg/ml and 96.5%); liver cancers (Bel7402 cells: 15.2 μg/ml and 89.2%, HepG2 cells: 7.1 μg/ml and 88.3%); pancreatic cancer (PC3 cells: 11.3 μg/ml and 68.4%); lung cancer (A549 cells: 18.6 μg/ml and 98.0% ); breast cancer (MCF7 cells: 18.4 μg/ml and 84.7%); uterine cervix cancer (Hela cells: 13.7 μg/ml and 98.5%). CONCLUSION Oridonin had a relatively wide anti-tumor spectrum, and a relatively strong inhibitory effect on the growth of the 15 human cancer cells. Inhibitory effects were concentration dependent. | Junhui Chen Shaobin Wang Dongyang Chen Guisheng Chang Qingfeng Xin Shoujun Yuan Zhongying Shen | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 32 |
| 2 | Stage-progressive distribution pattern of the Lungmachi black graptolitic shales from Guizhou to Chongqing, Central China显示文摘The Lungmachi Formation is widely distributed in Guizhou, Chongqing and the adjacent area. It is important for the study of Silurian biostratigraphy and shale-gas investigation. Based on those biostratigraphically well-studied sections from Guiyang to Huayingshan, we reveal the stage-progressive distribution pattern of the Lungmachi black shales. The distribution of the Lungmachi black shales in the studying area can be subdivided into four geographic belts from the south to the north,reflecting the joint effect of regional and global environmental changes. The graptolite depth zonation model was adopted herein to infer the water depth of major graptolite assemblages from the black shales. The changes in the water depth indicate two major stages. The first stage is named the transgressive distribution stage which ranged from the Persculptograptus persculptus Biozone(LM1, upper Hirnantian) to the Coronograptus cyphus Biozone(LM5, upper Rhuddanian), an interval mostly controlled by global sea-level rise. The second stage, ranging from the Demirastrites triangulatus Biozone(LM6, lower Aeronian) to the Spirograptus guerichi Biozone(LM9, lower Telychian), is named the regressive shrinking stage, during which the black shales were gradually replaced by mixed-facies or carbonate sediments from the south to the north, representing the effects of the persistent uplifting of the Central Guizhou Oldland. | CHEN Xu FAN JunXuan WANG WenHui WANG HongYan NIE HaiKuan SHI XueWen WEN ZhiDong CHEN DongYang LI WenJie | 2017 | Science China Earth Sciences2017，60，6： | 23 |
| 3 | Superconvergence of a Nonconforming Finite Element Approximation to Viscoelasticity Type Equations on Anisotropic Meshes显示文摘The main aim of this paper is to study the approximation to viscoelasticity type equations with a Crouzeix-Raviart type nonconforming finite element on the anisotropic meshes. The superclose property of the exact solution and the optimal error estimate of its derivative with respect to time are derived by using some novel techniques. Moreover, employing a postprocessing technique, the global superconvergence property for the discretization error of the postprocessed discrete solution to the solution itself is studied. | Dongyang Shi Yucheng Peng Shaochun Chen | 2006 | Numerical Mathematics A Journal of Chinese Universities(English Series)2006，15，4： | 21 |
| 4 | A landscape shape index-based sampling approach for land cover accuracy assessment显示文摘Spatial sampling design is one of the key steps in land cover accuracy assessment,and many traditional sampling approaches may not achieve credible spatial sampling due to the high spatial heterogeneity of land cover.This paper characterizes the spatial heterogeneity with three-level LSIs and determines the subsequent sample sizes and their spatial distributions.The three-level LSIs are rLSI in a region,cLSI for each land cover class and uLSI in each geographic sampling unit in the region.The rLSIs are used to derive appropriate sample sizes in the target regions.The cLSIs are used to assure that larger sample numbers are allocated to land cover classes with higher spatial heterogeneity.The uLSIs provide useful measures for selecting optimal geographic units in which sample sites will be located.This LSI-based sampling approach can derive the sample sizes and determine their distributions in an adaptive way according to the spatial heterogeneity.An experimental case study further demonstrates that the LSI-based sampling approach obtains more appropriate sample sizes for each region,sufficient sample numbers for rare classes,and optimal sample distributions in the geographical space. | CHEN Fei CHEN Jun WU Hao HOU DongYang ZHANG WeiWei ZHANG Jun ZHOU XiaoGuang CHEN LiJun | 2016 | Science China(Information Sciences)2016，59，12： | 17 |
| 5 | A Nonconforming Arbitrary Quadrilateral Finite Element Method for Approximating Maxwell's Equations显示文摘The main aim of this paper is to provide convergence analysis of Quasi-Wilson nonconforming finite element to Maxwell's equations under arbitrary quadrilateral meshes.The error estimates are derived,which are the same as those for conforming elements under conventional regular meshes. | Dongyang Shi Lifang Pei Shaochun Chen | 2007 | Numerical Mathematics A Journal of Chinese Universities(English Series)2007，16，4： | 9 |
| 6 | Identification of a novel mutation in POU3F4 for prenatal diagnosis in a Chinese family with X-linked nonsyndromic hearing loss显示文摘We present the clinical and genetic findings for a Chinese family with X-linked non-syndromic hearing loss in which the affected males showed congenital profound sensorineural hearing impairment. In two affected brothers, the computer tomography of temporal bone showed bilateral dilation of the internal auditory canal with fistulous communication between the lateral canal and the basal cochlear turn, which is consistent with the typical DFNX2 phenotype. A missense mutation (c.647G→A) in the POU3F4 gene caused a substitu- tion from glycine to glutamic acid at position 216 (p.G216E), and this mutation was found to consistently cosegregate with the deafness phenotype in the family. The mutation resulted in the loss of function of the POU3F4 by decreasing the affinity between the protein and DNA, as shown in silico by the structural analysis. Prenatal diagnosis of pregnant proband of this family revealed the c.647G→A muta- tion in DNA extracted from the amniotic fluid surrounding the fetus. The appropriate use of genetic testing and prenatal diagnosis plays a key role in reducing the recurrence of genetic defects in high-risk families. | Jianzhong Li Jing Cheng Yanping Lu Yu Lu Airing Chen YiSun Dongyang Kang Xin Zhang Pu Dai Dongyi Han Huijun Yuan | 2010 | Journal of Genetics and Genomics2010，37，12： | 9 |
| 7 | Influence of Tip Clearance on Performance of a Contra-Rotating Fan显示文摘Influences of tip clearance on the tip flow and associated loss mechanism in a contra-rotating axial flow fan hasbeen studied in the paper, based on three dimensional numerical results. The results with different tip clearanceare compared in terms of stage efficiency, relative total pressure loss coefficient, flow angle. It is found that theefficiency of the contra-rotating fan changes almost linearly with increment of the tip clearance, however, efficiencyof the rear rotor is observed to decrease more dramatically than that of the forward rotor given same tipclearance variation. The analysis on the flow structure indicates that the tip region flow field is qualitatively similarin both rotors. However, with the same clearance value, the leakage flow in the rear rotor is effected by a tipleakage vortex of greater intensity caused by relative loading levels and the inter rotor interaction. | Jian Xu Chunqing Tan Haisheng Chen Yangli Zhu Dongyang Zhang | 2009 | Journal of Thermal Science2009，18，3： | 6 |
| 8 | ACCURACY ANALYSIS OF 12-PARAMETER RECTANGULAR PLATE ELEMENTS WITH GEOMETRIC SYMMETRY显示文摘In this paper, it is proved that the double set parameter rectangular plate elements with geometric symmetry possess a very special convergence property, i.e., the consistency error due to nonconformity is of order O(h2) which is one order higher than that of ACM element and rectangular generalized conforming element proposed by Y. Q. Long, although all these elements have the same asympotical rate of convergence O(h) in the energy norm. This particular property seems to be never seen before for other nonconforming rectangular plate elements. | SHI Dongyang CHEN Shaochun (Department of Mathematics, Zhengzhou University, Zhengzhou 450052, China) | 2000 | Systems Science and Mathematical Sciences2000，13，2： | 6 |
| 9 | Selectivity enhancement of quaternized poly(arylene ether ketone)membranes by ion segregation for vanadium redox flow batteries显示文摘Quaternary ammonium densely functionalized octa-benzylmethyl-containing poly(arylene ether ketone)s(QA-OMPAEKs) with ion exchange capacities(IECs) ranging from 1.23 to 2.21 mmol g^(-1) were synthesized from:(1) Ullmann coupling extension of tetra-benzylmethyl-containing bisphenol A;(2) condensation polymerization with activated dihalide in the presence of K_2CO_3;(3) selective bromination using N-bromosuccinimide; and(4) quantitative quaternization using trimethylamine. Both smallangle X-ray scattering(SAXS) and transmission electron microscope(TEM) characterizations revealed distinct nano-phase separation in QA-OMPAEKs as a result of the dense quaternization. The QA-OMPAEK-20 with an IEC of 1.98 mmol g^(-1) exhibited a high SO_4^(2-) conductivity of 11.4 mS cm^(-1) and a low VO^(2+) permeability of 0.06×10^(-12) m^2 s^(-1) at room temperature,leading to a dramatically higher ion selectivity than Nafion N212. Consequently, the vanadium redox flow battery(VRFB)assembled with QA-OMPAEK-20 achieved a Coulombic efficiency of 96.9% and an energy efficiency of 84.8% at a current density of 50 mA cm^(-2), which were much higher than those of the batteries assembled with Nafion N212 and a home-made control membrane without distinct nano-phase separation. Therefore, ion segregation is demonstrated to be a strategical route for the design of high performance anion exchange membranes(AEMs) for VRFBs. | Yu Chen Zhongcheng Liu Meijin Lin Qilang Lin Bihai Tong Dongyang Chen | 2019 | Science China Chemistry2019，62，4： | 6 |
| 10 | Deformation Uniformity of Cold-Rolled Q235 Steel Rebar by FEM in Bending and Rolling Processes显示文摘An analytic model based on ANSYS/LS-DYNA has been developed on the cold rolling process for Q235 steel rebar with 12 mm in diameter. The elastic-plastic finite element method (FEM) and the cold deformation resistance model of Q235 steel were adopted in this model. Deformation uniformity of the final product has been analyzed using this model. The results indicate that the uniformity of the final product is obtained only as the centerline of the bending rolls is vertical to the centerline of the driven roll and parallel to the centerline of the drive roll in the whole rolling process. Besides, the number of the bending rolls must even realize the continuous bending and reverse bending process. Also, the number of the bending rolls must match the deformation degree of the workpiece in the cold rolling process. The validity of this finite element model was verified by the size and distribution of grains from the billet to the rebar in a practical cold rolling process. | SUI Feng-li1, CHEN Qi-wei1, ZHU Guo-hui1, LIU Bao-dong2 (1. Anhui Key Laboratory of Materials and Processing, School of Materials Science and Engineering, Anhui University of Technology, Maanshan 243002, Anhui, China 2. Dongyang Steel Making Co Ltd, Shenyang 110026, Liaoning, China) | 2012 | Journal of Iron and Steel Research(International)2012，19，8： | 4 |
| 11 | Tetra-alkylsulfonate functionalized poly(aryl ether) membranes with nanosized hydrophilic channels for efficient proton conduction显示文摘The microstructure of polymer electrolyte membranes plays a key role in ion conductivity and water transport.Herein,fluorinated poly(aryl ether)s with tetra-alkylsulfonate side chains(SFPAEs)have been successfully synthesized from the copolymerization of a newly developed tetra-allyl-containing bisphenol(TABP)monomer,followed by the thiol-ene addition with sodium 3-mercapto-1-propanesulfonate to attach the ionic groups at the end of the flexible chains.Being the first of its kind,the densely distributed and lengthy alkylsulfonate group possesses the benefit of ease to self-assemble into hydrophilic domains during membrane preparation via solution casting.Indeed,the TEM characterizations revealed that distinct hydrophilic channels of 1-2 nm width had been formed,much larger than those of a home-made control sample where only di-alkylsulfonate side chains were attached.The SFPAE-4-45 with an IECw of 2.0 mmol g^-1 exhibited an enhanced proton conductivity of 143.7 m S cm^-1 at room temperature,which was superior to that of Nafion 212(91.0 m S cm^-1).Furthermore,the oxidative stabilities of SFPAEs were significantly higher than those of non-fluorinated analogs in literature.This study offered a new route to engineering the pendent structure of ionomers for well-defined microscopic morphologies. | Lijun Zhou Junyang Zhu Meijin Lin Jiaqi Xu Zailai Xie Dongyang Chen | 2020 | Journal of Energy Chemistry2020，29，1： | 4 |
| 12 | Optimal dispatching method for integrated energy system based on robust economic model predictive control considering source-load power interval prediction显示文摘Effective source-load prediction and reasonable dispatching are crucial to realize the economic and reliable operations of integrated energy systems(IESs).They can overcome the challenges introduced by the uncertainties of new energies and various types of loads in the IES.Accordingly,a robust optimal dispatching method for the IES based on a robust economic model predictive control(REMPC)strategy considering source-load power interval prediction is proposed.First,an operation model of the IES is established,and an interval prediction model based on the bidirectional long short-term memory network optimized by beetle antenna search and bootstrap is formulated and applied to predict the photovoltaic power and the cooling,heating,and electrical loads.Then,an optimal dispatching scheme based on REMPC is devised for the IES.The source-load interval prediction results are used to improve the robustness of the REPMC and reduce the influence of source-load uncertainties on dispatching.An actual IES case is selected to conduct simulations;the results show that compared with other prediction techniques,the proposed method has higher prediction interval coverage probability and prediction interval normalized averaged width.Moreover,the operational cost of the IES is decreased by the REMPC strategy.With the devised dispatching scheme,the ability of the IES to handle the dispatching risk caused by prediction errors is enhanced.Improved dispatching robustness and operational economy are also achieved. | Yang Yu Jiali Li Dongyang Chen | 2022 | Global Energy Interconnection2022，5，5： | 3 |
| 13 | Glucose-derived hydrothermal carbons as energy storage booster for vanadium redox flow batteries显示文摘Fabricating of high performance electrodes by a sustainable and cost effective method is essential to the development of vanadium redox flow batteries(VRFBs).In this work,an effective strategy is proposed to deposit carbon nanoparticles on graphite felts by hydrothermal carbonization method.This in-situ method minimizes the drop off and aggregation of carbon nanoparticles during electrochemical testing.Such integration of felts and hydrothermal carbons(HTC)produces a new electrode that combines the outstanding electrical conductivity of felts with the effective redox active sites provided by the HTC coating layer.The presence of the amorphous carbon layers on the felts is found to be able to promote the mass/charge transfer,and create oxygenated/nitrogenated active sites and hence enhances wettability.Consequently,the most optimized electrode based on a rational approach delivers an impressive electrochemical performance toward VRFBs in wide range of current densities from 200 to 500 mAcm^-2.The voltage efficiency(VE)of GFs-HTC is much higher than the VEs of the pristine GFs,especially at high current densities.It exhibits a 4.18 times increase in discharge capacity over the pristine graphite felt respectively,at a high current density of 400 mAcm^-2.The enhanced performance is attributed to the abundant active sites from amorphous hydrothermal carbon,which facilitates the fast electrochemical kinetics of vanadium redox reactions.This work evidences that the glucose-derived hydrothermal carbons as energy storage booster hold great promise in practical VRFBs application. | Jiugen Qiu Baobing Huang Yuchuan Liu Dongyang Chen Zailai Xie | 2020 | Journal of Energy Chemistry2020，29，6： | 2 |
| 14 | Accuracy analysis of quasi-Wilson element显示文摘 | Chen Shaochun Shi Dongyang | 2000 | Acta Mathematic Scientia2000，，： | 2 |
| 15 | Anisotropic interpolation and Quasi-Wilson element for narrow quadrilateral meshes显示文摘 | Chen Shaochu Shi Dongyang Zhao Yongcheng | 2004 | IMA Numer Anal2004，24，： | 2 |
| 16 | An AIEE polyelectrolyte as a light-up fluorescent probe for heparin sensing in full detection range显示文摘Polyelectrolyte PTPEPyH, containing tetraphenylethene (TPE) and pyridinium, was synthesized. Its optical properties were investigated with spectroscopies and the results showed that there were two emission-enhanced stages in the interaction between positive-charged PTPEPyH and negative-charged biomacromolecule heparin. The mechanism was very different due to the reduced non-radiative energy loss and the change of surroundings. The polyelectrolyte PTPEPyH, compared with ChS and HA, also showed high selectivity for heparin in the buffer solution and could be used as a potential bio-probe for heparin quantification in the clinical full range. | CHEN DongYang SHI JianBing WU YanMei TONG Bin ZHI JunGe DONG YuPing | 2013 | Science China Chemistry2013，56，9： | 2 |
| 17 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 18 | Development and validation of a UPLC–MS/MS assay for the determination of gemcitabine and its L-carnitine ester derivative in rat plasma and its application in oral pharmacokinetics显示文摘A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative(2’-deoxy-2’, 2’-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine, JDR) in rat plasma was developed and validated.The conventional plasma sample preparation method of nucleoside analogues is solidphase extraction(SPE) which is time-consuming and cost-expensive. In this study, gradient elution with small particles size solid phase was applied to effectively separate gemcitabine and JDR, and protein precipitation pretreatment was adopted to remove plasma protein and extract the analytes with high recovery(>81%). Method validation was performed as per the FDA guidelines, and the standard curves were found to be linear in the range of 5–4000 ng/ml for JDR and 4–4000 ng/ml for gemcitabine, respectively. The lower limit of quantitation(LLOQ)of gemcitabine and JDR was 4 and 5 ng/ml, respectively. The intra-day and inter-day precision and accuracy results were within the acceptable limits. Finally, the developed method was successfully applied to investigate the pharmacokinetic studies of JDR and gemcitabine after oral administration to rats. | Gang Wang Dongyang Zhao Hongxiang Chen Dawei Ding Longfa Kou Lifang Sun Chenxia Hao Xincong Li Kai Jia Qiming Kan Xiaohong Liu Zhonggui He Jin Sun | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 2 |
| 19 | Anisotropic interpolation and quasi-Wilsion element for narrow quadrilateral meshes显示文摘 | Shaochun Chen Dongyang Shi | 2004 | IMA Journal of Numerical Analysis2004，24，： | 1 |
| 20 | Asymptotically isometric copies of Co and l^1 in certain Banach spaces显示文摘 | Chen Dongyang | 2003 | J Math Anal Appl2003，284，： | 1 |
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