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| 1 | Dual-Material Electron Beam Selective Melting:Hardware Development and Validation Studies显示文摘Electron beam selective melting(EBSM) is an additive manufacturing technique that directly fabricates three-dimensional parts in a layerwise fashion by using an electron beam to scan and melt metal powder. In recent years, EBSM has been successfully used in the additive manufacturing of a variety of materials. Previous research focused on the EBSM process of a single material. In this study, a novel EBSM process capable of building a gradient structure with dual metal materials was developed, and a powder-supplying method based on vibration was put forward. Two different powders can be supplied individually and then mixed. Two materials were used in this study: Ti6Al4 V powder and Ti47Al2Cr2 Nb powder. Ti6Al4 V has excellent strength and plasticity at room temperature, while Ti47Al2Cr2 Nb has excellent performance at high temperature, but is very brittle. A Ti6Al4V/Ti47Al2Cr2 Nb gradient material was successfully fabricated by the developed system. The microstructures and chemical compositions were characterized by optical microscopy, scanning microscopy, and electron microprobe analysis. Results showed that the interface thickness was about 300 μm. The interface was free of cracks, and the chemical compositions exhibited a staircase-like change within the interface. | Chao Guo Wenjun Ge Feng Lin | 2015 | Engineering2015，1，1： | 11 |
| 2 | Highly dispersed Pt clusters encapsulated in MIL-125-NH_(2) via in situ auto-reduction method for photocatalytic H_(2) production under visible light显示文摘Efficient hydrogen production via photocatalysis with high utilization efficiency of Pt cocatalyst is of great importance for sustainable development. In this work, we report an in situ auto-reduction strategy to encapsulate highly dispersed Pt clusters inside the cages of MIL-125-NH_(2). The amino groups in MIL-125-NH_(2) first react with formaldehyde to form reducing groups (i.e.,–NH-CH_(2)OH), which can in situ auto-reduce the confined Pt^(2+) ions to ultrasmall Pt clusters within the cavities. With optimized Pt content, photocatalytic H_(2) production over the obtained Pt(1.5)/MIL-125-NH-CH_(2)OH catalyst with 1.43 wt.% Pt loading achieved as high as 4,496.4 µmol·g^(-1)·h^(-1) under visible light (λ > 420 nm) due to the facilitated transfer and separation of the photo-induced charger carriers arising from the synergetic effects between highly dispersed Pt clusters and MIL-125-NH-CH_(2)OH framework. This in situ auto-reduction strategy may be extended to encapsulate various kinds of metal or alloy clusters/nanoparticles within amino-functioned metal-organic frameworks (MOFs) with superior properties and excellent performance. | Xiubing Huang Xiangjun Li Qingjie Luan Kaiyue Zhang Zhenyu Wu Baozhen Li Zuoshuai Xi Wenjun Dong Ge Wang | 2021 | Nano Research2021，14，11： | 2 |
| 3 | Synthesis of confined Ag nanowires within mesoporous silica via double solvent technique and their catalytic properties显示文摘 | Xiubing Huang Wenjun Dong Ge Wang Mu Yang Li Tan Yanhui Feng Xinxin Zhang | 2011 | Journal of Colloid And Interface Science2011，，1： | 1 |
| 4 | Hiking trails and tourism impact assessment in protected area:Jiuzhaigou Biosphere Reserve,China显示文摘 | Li Wenjun Ge Xiaodong Liu Chunyan | 2005 | Environmental Monitoring and Assessment2005，108，： | 1 |
| 5 | Decorating cobalt phosphide and rhodium on reduced graphene oxide for high-efficiency hydrogen evolution reaction显示文摘Electrochemical reduction of water to hydrogen holds great promise for clean energy,while its widespread application relies on the development of efficient catalysts with large surface area,abundant exposed active sites and superior electron conductivity.Herein,we report a facile strategy to configure an electrocatalyst composed of cobalt phosphide and rhodium uniformly anchored on reduced graphene oxide for hydrogen generation.The hybrids effectively integrate the exposed active sites,electron conductivity and synergistic effect of the catalyst.Electrochemical tests exhibit that the catalyst shows superior hydrogen evolution reaction catalytic activity and stability,with a small Tafel slope of 43 m V dec-1.Overpotentials as low as 29 and 72 mV are required to achieve current densities of 2 and 10 mA cm-2in 0.5M H2SO4,respectively.The hybrid constitution with highly active sites on conductive substrate is a new strategy to synthesize extremely efficient electrocatalysts.Especially,the efficient synergistic effect among cobalt phosphide,rhodium and reduced graphene oxide provides a novel approach for configuring electrocatalysts with high electron efficiency. | Haiyan Zheng Xiubing Huang Hongyi Gao Wenjun Dong Guilong Lu Xiao Chen Ge Wang | 2019 | Journal of Energy Chemistry2019，28，7： | 1 |
| 6 | Late Quater- nary slip rate of the South Heli Shan Fault (northern Hexi Corri- dor, NW China) and its implications for northeastward growth of the Tibetan Plateau显示文摘 | Zheng Wenjun Zhang Peizheng Ge Weipeng | 2013 | Tectonics2013，32，2： | 1 |
| 7 | Synthesis, Characterization, and Biological Application of Size-Controlled Nanocrystalline NaYF4:Yb, Er Infrared-to-Visible Up-Conversion Phosphors显示文摘 | Guangshun Yi Huachang Lu Shuying Zhao Yue Ge Wenjun Yang Depu Chen and Lianghong Guo | 2004 | Journal of Nann Letters2004，4，11： | 1 |
| 8 | Discovery of the Surface Rupture Zone on the South of Helishan in Gaotai,Gansu Province显示文摘According to a new investigation in the northern Hexi corridor,the remains of two surface rupture zones were discovered on the southern margin fault of the Helishan. One rupture has a length of approximately 7km and the other 10km. The two surface rupture zones might have been produced by the latest earthquake event. On the surface rupture is continuous scarp and free face caused by the rupture. The scarp is about 1 ~ 1. 5m high and on some sites,nearly up to 2m. According to the OSL results,the latest T1 terrace and higher flood plain forming in 3000a B. P. are dislocated by the fault. The above reveals the rupture age to be later than the T1 terrace. However,in the historical data and earthquake catalogue,we didn't find related information about the fault and surface rupture in this area. The 180 A. D. Biaoshi M8. 0 earthquake and the 756 A. D. Zhangye-Jiuquan M7. 0 earthquake are documented in historical data. It is inferred by textual research that the two earthquakes are related to the northern marginal fault of Yumushan in the south of the basin. Due to a lack of reliable evidence,there are still many arguments on this inferred conclusion. Thus we hold that the two surface rupture zones were produced by one of the two large earthquakes or other unrecorded historical event. The research on the activity and surface rupture of this fault can offer valuable information for the tectonic study and strong earthquake risk estimates of this region in the future. | Zheng Wenjun Zhang Peizhen Yuan Daoyang Ge Weipeng Liu Jianhui | 2010 | Earthquake Research in China2010，24，1： | 1 |
| 9 | A unique Janus PdZn-Co catalyst for enhanced photocatalytic syngas production from CO_(2) and H_(2)O显示文摘The development of excellent catalyst to achieve photocatalytic syngas production from CO_(2) and H_(2)O is a prospective and sustainable strategy to alleviate environment and energy crisis. In this study, a unique Janus PdZn-Co catalyst is prepared by annealed the Pd/IRMOF-3(Co, Zn) precursor. Due to the strong interaction, the electron transfers from PdZn terminal to Co terminal in the Janus structure. The electron-received Co terminal facilitates Co sites coordinate with the electrophilic C atom of CO_(2) and the electron-donated PdZn center is easier to coordinate with nucleophilic O atoms of H_(2)O or C=O bonds.The charge redistribution enhances the absorption of CO_(2) and H2O, which promotes H_(2) evolution and CO production. In addition, the carbon shell effectively suppresses the metal core agglomeration and facilitates the electron transmission from photosensitizer to metallic active sites. Meanwhile, the ratio of CO/H_(2) can be regulated(~3:1 to 2:1) by adjusting the proportion of Co and PdZn. The Janus structure and graphite carbon synergistically play a profound impact on improving the photocatalytic performance.The optimized PdZn-Co catalyst exhibits a superior photocatalytic CO production rate(20.03 μmol/h) and the H_(2) generation rate(9.90 μmol/h) with a ratio of CO/H_(2)= 2.02. | Dongxue Zhou Xiangdong Xue Qingjie Luan Liguo Zhang Baozhen Li Xing Wang Wenjun Dong Ge Wang Changmin Hou | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 10 | Short review on liquid membrane technology and their applications in biochemical engineering显示文摘As a branch of membrane separation technology,liquid membrane has attracted great attention and expanded investigations in biological chemical engineering,with life and health concern in ecosystems.Composed of membrane solvent and mobile carrier,liquid membrane was acquired of function,performing the facilitated mass transfer across the diffusive solvent,so as for the separation and delivery achievement with efficacy.In this review,two types of liquid membrane are mainly focused,respectively on supported liquid membrane(SLM)of membrane solvent supporter in necessity,and on emulsion liquid membrane(ELM)of the required interfacial stabilizers and homogenization.Accordingly,the transfer mechanism,compositions,structure and features of SLM and ELM are introduced respectively.Moreover,the current investigations of liquid membrane have been discussed,focusing on the improvements of efficacy and stability in separation&detection,encapsulation and delivery,so as to scale up the favorable and efficient application with bio-life concern.Prospectively,this review could provide comprehensive insight into the bio-applications of liquid membrane,and guidelines for the further investigations on the efficacy and long-term applicable stability,in order to realize the industrialization. | Wenjun Zhang Wenshu Ge Min Li Shuangqing Li Minqiang Jiang Xiujuan Zhang Gaohong He | 2022 | Chinese Journal of Chemical Engineering2022，35，9： | 0 |
| 11 | Roles of pH in the NH_(4)^(+)-induced corrosion of AZ31 magnesium alloy in chloride environment显示文摘Corrosion behavior of AZ31 magnesium alloy in NH_(4)^(+)-bearing chloride solution with controlled pH was investigated by weight loss experiment, hydrogen collection, and electrochemical test combined with surface morphology and topography observation. The results show that NH_(4)^(+) and pH of the solution can affect the corrosion of AZ31 magnesium alloy. The existence of NH4+affects the formation and dissolution of corrosion products, which makes the protective effect of the corrosion product layer weaker. The change of pH value not only affects the corrosion mechanism of AZ31, but also alters the concentration of NH_(4)^(+) ions in the solution, which further influences the corrosion product layer of AZ31, and finally makes the corrosion of AZ31 change significantly. | Feng Ge Jiaxuan Yin Yue Liu Wenjun Leng Xin Wang Zhongyu Cui | 2022 | Journal of Magnesium and Alloys2022，10，11： | 0 |
| 12 | Synthesis of N-TiO2@NH2-M IL-88(Fe)Core-shell Structure for Efficient Fenton Effect Assisted Methylene Blue Degradation Under Visible Light显示文摘Core-shell TiO2-based photocatalysts with specific composition,morphology,and functionality have attracted considerable attention for their excellent degradation properties on organic pollutants via a photocatalytic oxidation process.Herein,a N-TiO2@NH2-MIL-88(Fe)core-shell structure was prepared by coating NH2-MIL-88(Fe)on nitrogen-doped TiO2(N-TiO2)nanoparticles.Introduction of heteroatom nitrogen to pure TiOz expands the spectra response range,leading to enhanced quantum efficiency of photocatalyst.Furthermore.loading NH2-MIL-88(Fe)or N-TiOz improved the adsorption ability of the nanocomposites due to the porous tunnels of NH2-MIL-88(Fe).The resulted core-shell N-TiO2@NH2-MIL-88(Fe)nanocomposites realized the transfer of photo excited electrons from N-TiOz to NH2-MIL-88(Fe)rapidly,partially reduced Fe to Fe^2+in NH^2+MIL-88(Fe),and further enhanced the Fenton effect on efficiently degrading methylene blue dye(MB)under visible light(>420 nm)with the assistance of H2O2. | YUAN Huiting REN Huizhen LI Minning LI Zetong LIU Mingrui DONG Wenjun WANG Ge ZHUANG Tao | 2020 | Chemical Research in Chinese Universities2020，36，6： | 0 |
| 13 | Biosynthesis of phycocyanobilin in recombinant Escherichia coli显示文摘The recombinant expression of phycocyanobilin(PCB)was carried out in Escherichia coli,and the best fermentation conditions of recombinant E.coli biosynthesized PCB are optimized in the response surface methodology to improve PCB production.The recombinant PCB is extracted,isolated,and purified by methanol and chloroform extraction.Recombinant PCB is validated in UV-vis spectroscopy,high-pressure liquid chromatography,and mass spectrometry.In addition,the anti-oxidant activities of the recombinant PCB are determined.The best induction conditions that optimized by Design Expert 8.0 software include:lactose concentration 4 mmol/L,induction temperature 24.69℃,induction time 4.6 h,and induction duration 13.57 h,under which the PCB expression level reached approximately 13 mg PCB/L,which is more than four times of previously reported 3 mg PCB/L.The maximum absorption peak of the recombinant PCB is located at 680 nm with a high fluorescence intensity of 470 nm.The recombinant PCB has a good ability to scavenge 2,2-diphenyl-1-picrylhydrazyl(DPPH)free radicals. | MA Chengbo LI Wenjun GE Baosheng LIN Jian QIN Song | 2020 | Journal of Oceanology and Limnology2020，38，2： | 0 |
| 14 | Large scale air pollution prediction with deep convolutional networks显示文摘Although considerable success has been achieved in urban air quality prediction(AQP) with machine learning techniques, accurate and long-term prediction is still challenging. One of the key issues for existing AQP approaches is that air quality monitoring stations are sparsely distributed, typically with around ten monitoring stations per city. As air quality may change abruptly in a local area, it is difficult to perform AQP accurately in areas that are far away from observation points. In addition, due to the large distance between every two monitoring stations, we cannot effectively leverage spatial relations among them to improve the AQP accuracy. In this paper, thanks to the development of low-cost air quality sensors, we are now able to collect a large-scale air quality dataset with 393 deployed air quality monitoring stations in a 120 km × 70 km region, which is more than ten times denser than existing AQP datasets. Further,we present a novel method to handle the data effectively. Specifically, we first convert the observed data from irregularly distributed monitoring stations into a regular image-like pollution map, which can then be processed with advanced deep convolutional networks. The experimental results show that the proposed approach can simultaneously model the temporal and spatial relations in our large-scale densely-observed dataset, leading to significantly improved AQP results. | Gao HUANG Chunjiang GE Tianyu XIONG Shiji SONG Le YANG Baoxian LIU Wenjun YIN Cheng WU | 2021 | Science China(Information Sciences)2021，64，9： | 0 |
| 15 | Textual Research on the Historical Data of the 1573 AD Minxian Earthquake in Gansu Province and Discussion on Its Seismogenic Structure显示文摘According to the detailed study of the historical earthquake records and causative structure of the Minxian M6(1/2) earthquake in 1573 {A.D.}, we have found that the most grievous disaster area lies nearby the Minxian county seat (Minzhou county at that time). So, we have identified the extremely seismic area of the 1573 {A.D.} The Minxian M6(1/2) earthquake was located in Minxian city, the intensity of the meizoseismal region is Ⅷ~Ⅸ, the epicenter is 34.4°N, 104.0°E, the location precision is Ⅱ and the deviation of location is less than or equal to 25km. Tectonically, this area lies in the transition region of stress transfer and structural transform between the east Kunlun fault and the northern margin of the west Qinling fault. The differential activity of the Lintan-Dangchang fault zone is obvious, and only parts of the segment put up Holocene activity. There are landslides and rock bursts of different sizes in the meizoseismal region. By integrated analysis, we conclude that the Minxian-Dangchang segment of the Lintan-Dangchang fault is the seismogenic structure of the 1573 A.D. M6(1/2) Minxian earthquake, in Gansu Province. | Zheng Wenjun Lei Zhongsheng Yuan Daoyang He Wengui Ge Weipeng LiuXingwang | 2007 | Earthquake Research in China2007，21，4： | 0 |
| 16 | TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNAPKcs cytosolic retention and DNA damage显示文摘Clinical application of doxorubicin(DOX)is heavily hindered by DOX cardiotoxicity.Several theories were postulated for DOX cardiotoxicity including DNA damage and DNA damage response(DDR),although the mechanism(s)involved remains to be elucidated.This study evaluated the potential role of TBC domain family member 15(TBC1D15)in DOX cardiotoxicity.Tamoxifen-induced cardiac-specific Tbcldi5 knockout(Tbcldi5^(CKO))or Tbcldi5 knockin(Tbcldi5^(CKI))male mice were challenged with a single dose of DOx prior to cardiac assessment 1 week or 4 weeks following DOX challenge.Adenoviruses encoding TBC1D15 or containing shRNA targeting Tbcld15 were used for Tbcld15 overexpression or knockdown in isolated primary mouse cardiomyocytes.Our results re-vealed that DOX evoked upregulation of TBC1D15 with compromised myocardial function and overt mortality,the effects of which were ameliorated and accentuated by Tbcldi5 deletion and Tbcld15 overexpression,respectively.DOX overtly evoked apoptotic cell death,the effect of which was alleviated and exacerbated by Tbcld15 knockout and overexpression,respectively.Meanwhile,DOX provoked mitochondrial membrane potential collapse,oxidative stress and DNA damage,the effects of which were mitigated and exacerbated by Tbcld15 knockdown and overexpression,respectively.Further scrutiny revealed that TBC1D15 fostered cytosolic accumulation of the cardinal DDR element DNA-dependent protein kinase catalytic subunit(DNA-PKcs).Liquid chromatography-tandem mass spectrometry and coimmunoprecipitation denoted an interaction between TBCID15 and DNA-PKcs at the segment 594-624 of TBC1D15.Moreover,overexpression of TBC1D15 mutant(A594-624,deletion of segment 594-624)failed to elicit accentuation of DOX-induced cytosolic retention of DNA-PKcs,DNA damage and cardiomyocyte apoptosis by TBC1D15 wild type.However,Tbcld15 deletion ameliorated DOXinduced cardiomyocyte contractile anomalies,apoptosis,mitochondrial anomalies,DNA damage and cytosolic DNA-PKcs accumulation,which were canceled off by DNA-PKcs inhibition or ATM activation.Taken together,our findings denoted a pivotal role for TBCID15 in DOX-induced DNA damage,mitochondrial injury,and apoptosis possibly through binding with DNA-PKcs and thus gate-keeping its cytosolic retention,a route to accentuation of cardiac contractile dysfunction in DOX-induced cardiotoxicity. | Wenjun Yu Haixia Xu Zhe Sun Yuxin Du Shiqun Sun Miyesaier Abudureyimu Mengjiao Zhang Jun Tao Junbo Ge Jun Ren Yingmei Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 17 | Clinical efficacy of low-dose emetine for patients with COVID-19:a real-world study显示文摘Objective:Emetine,an isoquinoline alkaloid that is enriched at high concentrations in the lung,has shown potent in vitro activity against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The aim of this study was to better understand the effectiveness of low-dose emetine for patients with coronavirus disease 2019(COVID-19).Methods:In this real-world study,63 patients with mild or common COVID-19 were recruited from Wuhan Fangcang Shelter Hospital and five COVID-19-designated hospitals in Anhui Province,China from February to March 2020.Thirty-nine patients from Wuhan Fangcang Shelter Hospital were assigned to a pragmatic randomized controlled clinical trial,and 24 patients from the 5 COVID-19-designated hospitals in Anhui Province underwent a real-world study.The medication course of emetine was less than 10 days.The main symptoms and adverse reactions of all patients were observed and recorded.The primary outcome measure was the time required for a negative SARS-CoV-2 RNA result or the negative result rate on day 10.Secondary outcomes included axillary temperature,transcutaneous oxygen saturation,and respiratory frequency recovery.The study was approved by the Ethics Committee of The First Affiliated Hospital of Anhui Medical University on February 20,2019(approval No.PJ2020-03-19)and was registered with the Chinese Clinical Trial Registry on February 20,2019(registration number:ChiCTR2000030022).Results:The oxygen saturation values were higher in the treatment group than in the control group on the first day after enrollment for patients treated at Fangcang Shelter Hospital.The axillary body temperature,respiratory rate,and oxygen saturation among patients in Fangcang Shelter Hospital were related to the time effect but not to the intervention measures.The respiratory rate and oxygen saturation of patients in the Anhui designated hospitals were related to the intervention measures but not to the time effect.The axillary body temperature of patients in Anhui designated hospitals was related to the time effect but not to the intervention measures.Conclusion:Our preliminary study shows that low-dose emetine combined with basic conventional antiviral drugs improves clinical symptoms in patients with mild and common COVID-19 without apparent adverse effects,suggesting that moderately increased doses of emetine may have good potential for treatment and prevention of COVID-19. | Song Fan Qi Zhen Cheng Chen Wenjun Wang Qibing Wu Huihui Ma Chengyuan Zhang Li Zhang Baojing Lu Huiyao Ge Liang Yong Bao Li Yafen Yu Weiwei Chen Yiwen Mao Guangbo Qu Li Su Aoli Wang Zhen Ding Haiwen Li Jin Zhang Yonglian Wang Yufeng Gao Xihai Xu Zhongming Zhu Jun Chen Long Zhang Hongqiang Liang Song Wu Meng Huang Quan Xia Ping Li Yehuan Sun Chaozhao Liang Wei Wei Qingsong Liu Liangdan Sun | 2021 | Journal of Bio-X Research2021，4，2： | 0 |
| 18 | Design,synthesis and SAR study of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors显示文摘The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms(MPNs).At present,there is still an obvious unmet medical need for selective JAK2 inhibitors in clinic.In this paper,a class of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors was obtained by combining drug design,synthesis and structure-activity relationship studies based on the previously identified lead Crizotinib.Among them,21 b exhibited high inhibitory activity against JAK2 with an IC_(50)of 9 nmol/L,moreover,it showed 276-and 184-fold selectivity over JAK1 and JAK3,respectively.Besides,21 b had a significant antiproliferative activity against HEL cells,and also inhibited the phosphorylation of JAK2 and its down-stream signaling pathway.These results indicated that2-aminopyridine compound 21 b had the potential to be developed as a selective JAK2 inhibitor for further study. | Dandan Liu Huan Ge Fangling Xu Yufang Xu Wenjun Liu Honglin Li Lili Zhu Yanyan Diao Zhenjiang Zhao | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 19 | Genome-wide meta-analysis identifies ten new psoriasis susceptibility loci in the Chinese population显示文摘Psoriasis is caused by many factors and is characterized by excessive proliferation of the epidermis and erythema with silver scales on the surface of the skin and concomitant with a variety of diseases(Griffiths et al., 2021). Despite the unclear aetiology,increasing evidence has demonstrated that genetic factors play key roles in the pathogenesis of psoriasis. | Weiwei Chen Wenjun Wang Liang Yong Qi Zhen Yafen Yu Huiyao Ge Yiwen Mao Lu Cao Ruixue Zhang Xia Hu Zhuo Li Yirui Wang Wencheng Fan Qiongqiong Xu Hui Zhang Shirui Chen Jing Wu Liangdan Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 0 |
| 20 | Causal Effect of Genetically Determined Blood Copper Concentrations on Multiple Diseases: A Mendelian Randomization and Phenome-Wide Association Study显示文摘Exposures to copper have become a health concern.We aim to explore the broad clinical effects of blood copper concentrations.A total of 376,346 Caucasian subjects were enrolled.We performed a Mendelian randomization and phenome-wide association study(MR-PheWAS)to evaluate the causal association between copper and a wide range of outcomes in UK Biobank,and we constructed a protein-protein interaction network.We found association between blood copper concentrations and five diseases in the overall population and nine diseases in male.MR analysis implicated a causal role of blood copper in five diseases(overall population),including prostate cancer(OR=0.87,95%CI 0.77-0.98),malignant and unknown neoplasms of the brain and nervous system(OR=0.58,95%CI 0.38-0.89),and hypertension(OR=0.94,95%CI 0.90-0.98),essential hypertension(OR=0.94,95%CI 0.90-0.98)and cancer of brain and nervous system(OR=0.63,95%CI 0.41-0.98).For male,except for dysphagia being newly associated with blood copper(OR=1.39,95%CI 1.18-1.63),other MR results were consistent with the overall population.In addition,the PPI network showed possible relationship between blood copper and four outcomes,namely brain cancer,prostate cancer,hypertension,and dysphagia.Blood copper may have causal association with prostate cancer,malignant and unknown neoplasms of the brain and nervous system,hypertension,and dysphagia.Considering that copper is modifiable,exploring whether regulation of copper levels can be used to optimize health outcomes might have public health importance. | Xiuming Feng Wenjun Yang Lulu Huang Hong Cheng Xiaoting Ge Gaohui Zan Yanli Tan Lili Xiao Chaoqun Liu Xing Chen Zengnan Mo Longman Li Xiaobo Yang | 2022 | Phenomics2022，2，4： | 0 |
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