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| 1 | Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness显示文摘听觉缺陷被看作世界范围的最流行的缺陷。在世界上的几乎 6 亿个人受不了温和或中等的听觉缺陷,一估计了 10% 人的人口。基因因素在这混乱的致病起一个重要作用。世袭听觉损失被划分成 syndromic 听觉损失(与另外的异例联系了) 并且 non-syndromic 听觉损失(没与另外的异例联系) 。约 80% 基因聋是 non-syndromic。根据听见损失的频率,世袭 non-syndromic 听觉损失能被划分成高度 -- ,中间 -- ,低 -- ,并且全部频率的听觉损失。中间频率的 sensorineural 听觉损失,或一张碗状的听力敏度图的听力测的发现,是不平常的。直到现在,仅仅, 7 loci 被连接了到中间频率的听觉损失。四仅仅基因 midfrequency 聋基因,也就是 DFNA10 (EYA4 ) , DFNA8/12 (TECTA ) , DFNA13 (COL11A2 ) , DFNA44 (CCDC50 ) ,迄今为止被报导了。这评论总结四基因的研究进步引起注意到中间频率的聋基因。 | Wenjun Xia Fei Liu Duan Ma | 2016 | Frontiers of Medicine2016，10，2： | 8 |
| 2 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 3 | Effect of Gubenfangxiao decoction on respiratory syncytial virus-induced asthma and expression of asthma susceptibility gene orosomucoid 1-like protein 3 in mice显示文摘OBJECTIVE: To investigate the effect of Gubenfangxiao decoction(GBFXD) on respiratory-syncytial-virus(RSV)-induced asthma and the expression of asthma susceptibility gene, orosomucoid 1-like protein 3(ORMDL3) in mice.METHODS: Seventy-two female BALB/c mice were randomly assigned to normal, model, GBFXD high dose, GBFXD moderate dose, GBFXD low dose and montelukast groups. An asthma model was induced via intraperitoneal injection and aerosol inhalation of ovalbumin(OVA) and repeated intranasal instillation of RSV in all mice, except those in the normal group. All treatments were administered at the first onset of asthma(within 8 weeks of model establishment) and the mice were euthanized after 28 days of treatment. The levels of transforming growth factor-β(TGF-β) and interleukin-6(IL-6) in bronchoalveolar lavage fluid(BALF) of the mice were measured and the expression of asthma susceptibility gene ORMDL3 in lung tissue was determined using real-time polymerase chain reaction(RT-PCR) and western blotting.RESULTS: Expression of ORMDL3 and levels of TGF-β and IL-6 were significantly higher in the model group(P < 0.05, P < 0.01) compared with the normal mice. Levels of ORMDL3, TGF-β and IL-6 were significantly lower in all three GBFXD treated groups(P < 0.05) compared with the model group.However, the levels in the GBFXD treatment groups did not differ significantly from the montelukast group.CONCLUSION: GBFXD had a therapeutic effect in this experimental model. The functional mechanism of GBFXD may involve multiple factors, including alleviation of airway inflammation, down-regulation of asthma susceptibility gene ORMDL3 and inhibition of airway remodeling. | Huang Zhengguang Gao Lijuan Zhao Xia Ling Hao Chen Wenjun | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 7 |
| 4 | Failure probability estimation of overhead transmission lines considering spatial and temporal variation in severe weather显示文摘Estimation for weather-related failure probability of overhead transmission lines is essential in the reliability assessment of a power system.This paper analyzes the outage and weather data of 110 kV overhead transmission lines in the Guangxi Zhuang Autonomous Region of China during 2011–2014.The result reveals obvious uneven distributions of outage events for time and space due to the spatial and temporal variation of severe weather.Based on the results, an estimation method is proposed in this paper.Split and aggregation is used to smooth the outage and weather data.The poisson model is adopted in our method to investigate the statistic characteristics of transmission line outage events.Regression analysis is applied to obtain the correlation between the weather intensity and history failure rate.Furthermore the method proposed is validated against the empirical outage data. | Shuai YANG Wenjun ZHOU Shiyang ZHU Le WANG Lisha YE Xuezhi XIA Han LI | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，1： | 5 |
| 5 | Real-time dynamics of soliton triplets in fiber lasers显示文摘The evolution of soliton molecules emphasizes the complex soliton dynamics akin to matter molecules.Beyond the simplest soliton molecule-a soliton pair constituted by two bound pulses-soliton molecules with more constituents have more degrees of freedom because of the temporal pulse separations and relative phases.Here we detailedly characterize the transient dynamics of soliton triplets in fiber lasers by using the dispersive Fourier transform measurement.A particular form of leading,central,and tailing pulses is constructed to shed new light on more intriguing scenarios and fuel the molecular analogy.Especially the vibrating dynamics of the central and tailing pulses are captured near the regime of equally spaced soliton triplets,which is reminiscent of the recurrent timing jitters within multi-pulse structures.Further insights enable acess into a universal form of unequally spaced soliton triplets interpreted as 2+1 soliton molecules.Different binding strengths of intramo-lecular and intermolecular bonds are validated with respect to the diverse internal motions involved in this soliton triplet molcule.All these findings unveil the transient dynamics with more degrees of freedom as well as highlight the possible application for all-optical bit storage. | YIYANG LUO RAN XIA PERRY PING SHUM WENJUN NI YUSONG LIU HUY QUOC LAM QIZHEN SUN XIAHUI TANG LUMING ZHAO | 2020 | Photonics Research2020，8，6： | 3 |
| 6 | Optical Image Encryption Based on Mixed Chaotic Maps and Single-Shot Digital Holography显示文摘Random phase masks play a key role in optical image encryption schemes based on double random phase technique. In this paper, a mixed chaotic method is proposed, which can efficiently solve some weaknesses that one-dimensional(1-D) single chaotic maps encounter to generate random phase masks. Based on the chaotic random phase masks, optical image encryption and decryption are realized with a single-shot digital holographic technique. In the proposed encryption scheme, the initial value and parameters of mixed chaotic maps serve as secret keys,which is convenient for the key management and transmission. Moreover, it also possesses high resistance against statistical attack, brute-force attack, noise attack and shear attack. Simulation results and security analysis verify the validity and security of the proposed encryption scheme. | Yonggang Su Chen Tang Xia Chen Biyuan Li Wenjun Xu Zhenkun Lei | 2017 | Transactions of Tianjin University2017，23，2： | 3 |
| 7 | Research on the Production Process of Apple Clear Juice Beverage显示文摘[Objective] The study aimed to determine the formula and production process of apple clear juice beverage. [Method] Concentrated apple juice was used as the raw material in this experiment, apple clear juice beverage was produced through dilution, blending, color protection, sterilization and other key processes. By using orthogonal test, the best formula of the apple clear juice beverage was determined, and then the color protection effects of three color protection agents Cys, NaHSO3 and VC on the apple clear juice beverage were compared. [Result] The best formula of the apple clear juice beverage was composed of 0.15% citric acid, 0.20% sodium citrate, 0.06% tannic acid, 6% white sugar and 16% concentrated apple juice. Besides, there was a big difference among the three kinds of color protection agents (Cys, NaHSO3 and VC) in the color protection effects on the apple clear juice beverage. Considering the quality safety of the product, 0.60% VC was chosen as the best color protection agent. [Conclusion] The research could provide theoretical references for using concentrated apple juice to produce apple clear juice beverage. | ZHU Xia HAN Shunyu YANG Xueshan WANG Jin SHENG Wenjun ZHANG Bo | 2012 | Chinese Food Science2012，1，4： | 3 |
| 8 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 9 | Conferring receptors on recipient cells with extracellular vesicles for targeted drug delivery显示文摘Triple negative breast cancer(TNBC)is a heterogeneous subset of breast cancer characterized by its lack of estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2(HER2),which altogether prevents TNBC from being treated effectively.For many years,the treatment paradigms and overall survival of patients with TNBC have remained largely stagnant.Recent attempts to convert cold tumors to hot tumors by promoting antigen presentation have shown increased T cell infiltration and significantly induced immune responses for tumor killing.Inspired by this concept,the expression of specific targetable antigens on TNBC cells may further benefit relevant targeted drug delivery.In this study,we successfully conferred sufficient HER2 on the surface of TNBC MDA-MB-231 cells via simple EV-plasma membrane fusion with HER2+extracellular vesicles(EV)derived from HER2 overexpressing BT-474 cells.Subsequently,anti-HER2 antibody conjugated paclitaxel-loaded liposomes were used for HER2-targeted drug delivery.Our findings demonstrated this HER2 grafting,in conjunction with targeted drug delivery,can improve the treatment efficacy in vitro and in vivo.This novel approach represents a facile method of altering cell membrane antigen presentation via convenient EVs uptake and may pave the way for the burgeoning wave of targeted therapy and/or immunotherapy. | Zachary Quinn Wenjun Mao Yiqiu Xia Rhea John Yuan Wan | 2021 | Bioactive Materials2021，6，3： | 3 |
| 10 | High-temperature mechanical properties of as-extruded AZ80 magnesium alloy at different strain rates显示文摘The mechanical properties of as-extruded AZ80 magnesium alloy at temperatures of 450-525℃ and strain rates of 3.0 s^(−1)and 0.15 s^(−1)were investigated by tensile tests.Zero ductility of alloy appeared at 500℃ with a strain rate of 0.15 s^(−1),while the zero strength and zero ductility of the alloy were obtained nearly simultaneously at 525℃ with a strain rate of 3.0 s^(−1).The results indicated that the lower strain rate accelerated the arrival of zero ductility.As the temperature increased,the failure mode of the alloy developed from trans-granular fracture to cleavage fracture and then to inter-granular fracture with the feature of sugar-like grains and fusion traces.The existence of the low-melting composite ofβ-Mg_(17)Al_(12) and Al_(8)Mn_(5) particles segregated near the Mg_(17)Al_(12) phase along grain boundaries were demonstrated to be the reason for the brittle fracturing of the AZ80 alloy at high temperatures.Furthermore,microstructural evolution at temperatures approaching the solidus temperature was discussed to clarify magnesium alloy’s high temperature deformation mechanism. | Wenjun Liu Bin Jiang Hongchen Xiang Qing Ye Shengqi Xia Siqiang Chen Jiangfeng Song Yanlong Ma Mingbo Yang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，7： | 3 |
| 11 | Isolation and identification of lactic acid bacteria from Tarag in Eastern Inner Mongolia of China by 16S rRNA sequences and DGGE analysis显示文摘 | Wenjun Liu Qiuhua Bao Jirimutu Manjun Qing Siriguleng Xia Chen Ting Sun Meihua Li Jiachao Zhang Jie Yu Menghe Bilige Tiansong Sun Heping Zhang | 2011 | Microbiological Research2011，，2： | 2 |
| 12 | Stable confinement of Fe/Fe_(3)C in Fe,N-codoped carbon nanotube towards robust zinc-air batteries显示文摘Catalytic oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)have garnered great attention as the key character in metal-air batteries.Herein,we developed a superior nonprecious bifunctional oxygen electrocatalyst,fabricated through spatial confinement of Fe/Fe_(3)C nanocrystals in pyridinic N and Fe-Nx rich carbon nanotubes(Fe/Fe_(3)C-N-CNTs).During ORR,the resultant electrocatalyst exhibits positive onset pote ntial of 1.0 V(vs.RHE),large half-wave potentials of 0.88 V(vs.RHE),which is more positive than Pt/C(0.98 V and 0.83 V,respectively).Remarkably,Fe/Fe_(3)C-N-CNTs exhibits outstanding durability and great methanol tolerance,exceeding Pt/C and most reported nonprecious metal-based oxygen reduction electrocatalysts.Moreover,Fe/Fe_(3)C-N-CNTs show a markedly low potential at j=10 mA/cm^(2),small Tafel slopes and extremely high stability for OER.Impressively,the Fe/Fe_(3)C-N-CNTs-based Zn-air batteries demonstrate high power density of 183 mW/cm^(2)and robust charge/discharge stability.It is revealed that the spatial confinement effect can impede the aggregation and corrosion of Fe/Fe_(3)C nanocrystals.Meanwhile,Fe/Fe_(3)C and Fe-Nx play synergistic effect on boosting the ORR/OER activity,which provides an important guideline for construction of inexpensive nonprecious metal-carbon hybrid nanomaterials. | Lingbo Zong Xin Chen Shuming Dou Kaicai Fan Zumin Wang Wenjun Zhang Yunmei Du Jie Xu Xiaofei Jia Qi Zhang Xia Li Yida Deng Yanan Chen Lei Wang | 2021 | Chinese Chemical Letters2021，32，3： | 2 |
| 13 | The surface rubbing effect on morphologies of LC droplets and electro-optic properties of flexible PDLC films显示文摘The flexible polymer dispersed liquid crystal (PDLC) film with threshold voltage V10 and saturation driving voltage V90 as low as 0.34 V/μm and 0.77 V/μm,respectively,has been prepared successfully by polymerization induced phase separation (PIPS). The surface rubbing effect on morphologies of liquid crystals (LC) droplets and electro-optic properties of PDLC films has been studied experimentally and theoretically. We use a CVC (Color Video Camera) and a SEM (Scan Electron Microscope) to detect and characterize morphologies of LC droplets in the net of polymer. The result reveals that almost all the smaller LC droplets exhibit in the rubbing direction uniformly,and the texture of PDLC is similar to that of H-PDLC. Meanwhile,compared with the sample of the non-rubbing disposal,the response time declines evidently by 11.2 ms (i.e.,the rising time τrise) and 27.2 ms (i.e.,the decaying time τdown),and the contrast ratio is improved from 18.5 to 35.9. Such a result can be attributed to the surface rubbing effect. | LIU GuoZhu XIA DuLing YANG WenJun HUANG ZiQiang | 2009 | Science China Chemistry2009，52，12： | 2 |
| 14 | Opposing functions of PLAG1 in plemorphic adenoma 显示文摘 | Yang Wang Wenjun Shang Xia lei | 2013 | Bintechnol Lett2013，35，9： | 1 |
| 15 | CA II, a potential biomarker by proteomic analysis, exerts significantinhibitory effect on the growth of colorectal cancer cells显示文摘 | Rui Zhou Wenjun Huang Yuqin Yao Yuxi Wang Ziqiang Li Bin Shao Jian Zhong Minghai Tang Shufang Liang Xia Zhao Aiping Tong Jinliang Yang | 2013 | International Journal of Oncology2013，，2： | 1 |
| 16 | Engineered extracellular vesicles for concurrent Anti-PDL1 immunotherapy and chemotherapy显示文摘Immune checkpoint inhibitors(ICI)targeting PD-1/PD-L1 have been approved for the treatment of a variety of cancers.However,the efficacy of antibody-based ICIs could be further improved by mitigating anti-drug antibodies,proteolytic cleavage,and on-target off-tumor toxicity.One strategy for accomplishing this is through the use of extracellular vesicles(EVs),cell derived submicron vesicles with many unique properties.We constructed an engineered MDA-MB-231 cell line for harvesting EVs.This was accomplished by overexpressing a high-affinity variant human PD-1 protein(havPD-1),while simultaneously knocking out intrinsic PD-L1 and beta-2 microglobulin.The engineered havPD-1 EVs reduced PD-L1 overexpressing cancer cell proliferation and induced cellular apoptosis.Moreover,the EVs were shown to efficiently block PD-L1 mediated T cell suppression.Meanwhile antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity were not observed.The havPD-1 EVs treatment resulted in robust anti-tumor activity in both preventative co-implantation and therapeutic xenograft tumor models reconstituted with human T cells.The efficacy of the havPD-1 EVs was shown to be comparable to clinical anti-PD1 monoclonal antibodies.Additionally,loading the havPD-1 EVs with a potent PARP inhibitor was shown to further augment treatment efficacy.In brief,the engineered universal EVs harboring havPD-1 proteins can be used for cancer concurrent immunotherapy and chemotherapy. | Yundi Chen Lixue Wang Mingfeng Zheng Chuandong Zhu Guosheng Wang Yiqiu Xia Ethan J.Blumenthal Wenjun Mao Yuan Wan | 2022 | Bioactive Materials2022，7，3： | 1 |
| 17 | Identification of Lactobacillus from koumiss by conventional and molecular methods显示文摘 | Junguo Wang Xia Chen Wenjun Liu Mei Yang Airidengcaicike Heping Zhang | 2008 | European Food Research and Technology2008，，5： | 1 |
| 18 | Remote Sensing-based Spatiotemporal Distribution of Grassland Aboveground Biomass and Its Response to Climate Change in the Hindu Kush Himalayan Region显示文摘The grassland in the Hindu Kush Himalayan(HKH) region is one of the large st and most biodiverse mountain grassland types in the world,and its ecosystem service functions have profound impacts on the sustainable development of the HKH region.Monitoring the spatiotemporal distribution of grassland aboveground biomass(AGB) accurately and quantifying its response to climate change are indispensable sources of information for sustainably managing grassland ecosystems in the HKH region.In this study,a pure vegetation index model(PVIM) was applied to estimate the long-term dynamics of grassland AGB in the HKH region during 2000-2018.We further quantified the response of grassland AGB to climate change(temperature and precipitation) by partial correlation and variance partitioning analyses and then compared their differences with elevation.Our results demonstrated that the grassland AGB predicted by the PVIM had a good linear relationship with the ground sampling data.The grassland AGB distribution pattern showed a decreasing trend from east to west across the HKH region except in the southern Himalayas.From 2000 to 2018,the mean AGB of the HKH region increased at a rate of 1.57 g/(m~2·yr) and ranged from 252.9(2000) to 307.8 g/m~2(2018).AGB had a positive correlation with precipitation in more than 80% of the grassland,and temperature was positively correlated with AGB in approximately half of the region.The change in grassland AGB was more responsive to the cumulative effect of annual precipitation,while it was more sensitive to the change in temperature in the growing season;in addition,the influence of climate varied at different elevations.Moreover,compared with that of temperature,the contribution of precipitation to grassland AGB change was greater in approximately 60% of the grassland,but the differences in the contribution for each climate factor were small between the two temporal scales at elevations over 2000 m.An accurate assessment of the temporal and spatial distributions of grassland AGB and the quantification of its response to climate change are of great significance for grassland management and sustainable development in the HKH region. | XU Cong LIU Wenjun ZHAO Dan HAO Yanbin XIA Anquan YAN Nana ZENG Yuan | 2022 | Chinese Geographical Science2022，32，5： | 1 |
| 19 | Lunar meteorites: witnesses of the composition and evolution of the Moon显示文摘Lunar meteorites are fragments of the Moon that escaped the gravity of the Moon following high-energy impacts by asteroids,subsequently fell to Earth.An inventory of 165 lunar meteorites has been developed since the discovery and identification of the first lunar meteorite,ALHA 81005,in 1979.Although the Apollo samples are much heavier in mass than lunar meteorites,the meteorites are still an important sample supplement for scientific research on the composition and history of the Moon.Apart from a small amount of unbrecciated crystalline rocks,the majority of lunar meteorites are breccias that can be classified into three groups:highland feldspathic breccia,mare basaltic breccia,and mingled(including fledspathic and basaltic clasts)breccia.The petrography of lunar rocks suggests that there are a series of rock types of anorthosite,basalt,gabbro,troctolite,norite and KREEP in the Moon.Although KREEP is rare in lunar rocks,KREEP components have been found in the increasing number of lunar meteorites.KREEP provides important information on lunar magmatic evolution,e.g.,the VHK KREEP clasts in SaU 169 may represent the pristine lunar magma(urKREEP).Six launching pairs of lunar meteorites have been proposed now,along with ten possible lunar launching sites.In addition,symplectite is often found in lunar basalts,which is a significant record of shock metamorphism on the lunar surface.Furthermore,isotopic ages and noble gases not only provide information on crystallization processes in lunar rocks and the formation of lunar crust,but also provide insight into shock events on the lunar surface. | MIAO Bingkui CHEN Hongyi XIA Zhipeng YAO Jie XIE Lanfang NI Wenjun ZHANG Chuantong | 2014 | Advances in Polar Science2014，25，2： | 1 |
| 20 | Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses显示文摘 | WANG Guan TANG Wenjun XIA Jianye | 2015 | Engineering in life sciences2015，15，1： | 1 |
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