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| 1 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 2 | Molecular biomarkers for gestational diabetes mellitus and postpartum diabetes显示文摘Gestational diabetes mellitus(GDM)is a growing public health problem worldwide that threatens both maternal and fetal health.Identifying individuals at high risk for GDM and diabetes after GDM is particularly useful for early intervention and prevention of disease progression.In the last decades,a number of studies have used metabolomics,genomics,and proteomic approaches to investigate associations between biomolecules and GDM progression.These studies clearly demonstrate that various biomarkers reflect pathological changes in GDM.The established markers have potential use as screening and diagnostic tools in GDM and in postpartum diabetes research.In the present review,we summarize recent studies of metabolites,single-nucleotide polymorphisms,microRNAs,and proteins associated with GDM and its transition to postpartum diabetes,with a focus on their predictive value in screeningand diagnosis. | Wenqian Lu Cheng Hu | 2022 | Chinese Medical Journal2022，135，16： | 9 |
| 3 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 4 | Quantitative distinction of the relative actions of climate change and human activities on vegetation evolution in the Yellow River Basin of China during 1981-2019显示文摘Under the combined influence of climate change and human activities,vegetation ecosystem has undergone profound changes.It can be seen that there are obvious differences in the evolution patterns and driving mechanisms of vegetation ecosystem in different historical periods.Therefore,it is urgent to identify and reveal the dominant factors and their contribution rates in the vegetation change cycle.Based on the data of climate elements(sunshine hours,precipitation and temperature),human activities(population intensity and GDP intensity)and other natural factors(altitude,slope and aspect),this study explored the spatial and temporal evolution patterns of vegetation NDVI in the Yellow River Basin of China from 1989 to 2019 through a residual method,a trend analysis,and a gravity center model,and quantitatively distinguished the relative actions of climate change and human activities on vegetation evolution based on Geodetector model.The results showed that the spatial distribution of vegetation NDVI in the Yellow River Basin showed a decreasing trend from southeast to northwest.During 1981-2019,the temporal variation of vegetation NDVI showed an overall increasing trend.The gravity centers of average vegetation NDVI during the study period was distributed in Zhenyuan County,Gansu Province,and the center moved northeastwards from 1981 to 2019.During 1981-2000 and 2001-2019,the proportion of vegetation restoration areas promoted by the combined action of climate change and human activities was the largest.During the study period(1981-2019),the dominant factors influencing vegetation NDVI shifted from natural factors to human activities.These results could provide decision support for the protection and restoration of vegetation ecosystem in the Yellow River Basin. | LIU Yifeng GUO Bing LU Miao ZANG Wenqian YU Tao CHEN Donghua | 2023 | Journal of Arid Land2023，15，1： | 2 |
| 5 | SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling显示文摘Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth.However,for a significant portion of human cancer,how Hippo signaling is perturbed remains unknown.To answer this question,we performed a genome-wide screening for genes that affect the Hippo pathway in Drosophila and cross-referenced the hit genes with human cancer genome.In our screen,Prosap was identified as a novel regulator of the Hippo pathway that potently affects tissue growth.Interestingly,a mammalian homolog of Prosap,SHANK2,is the most frequently amplified gene on 11 q13,a major tumor amplicon in human cancer.Gene amplification profile in this 11q13 amplicon clearly indicates selective pressure for SHANK2 amplification.More importantly,across the human cancer genome,SHANK2 is the most frequently amplified gene that is not located within the Myc amplicon.Further studies in multiple human cell lines confirmed that SHANK2 overexpression causes deregulation of Hippo signaling through competitive binding for a LATS1 activator,and as a potential oncogene,SHANK2 promotes cellular transformation and tumor formation in vivo.In cancer cell lines with deregulated Hippo pathway,depletion of SHANK2 restores Hippo signaling and ceases cellular proliferation.Taken together,these results suggest that SHANK2 is an evolutionarily conserved Hippo pathway regulator,commonly amplified in human cancer and potently promotes cancer.Our study for the first time illustrated oncogenic function of SHANK2,one of the most frequently amplified gene in human cancer.Furthermore,given that in normal adult tissues,SHANK2 s expression is largely restricted to the nervous system,SHANK2 may represent an interesting target for anticancer therapy. | Liang Xu Peixue Li Xue Hao Yi Lu Mingxian Liu Wenqian Song Lin Shan Jiao Yu Hongyu Ding Shishuang Chen Ailing Yang Yi Arial Zeng Lei Zhang Hai Jiang | 2021 | Protein & Cell2021，12，3： | 1 |
| 6 | Microparticles released by Listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity显示文摘在在为 T 房间有免疫力的回答处理和细菌的抗原的表示的巨噬细胞和树枝状的房间之间的相互影响仍然保持糟糕理解。用 Listeria monocytogenes (Lm ) 感染模型,我们证明树枝状的房间(DC ) 要求巨噬细胞的支持对 Lm 感染得到保护的免疫。DC 自己在收起 Lm 是低效的但是能够收起感染 Lm 的巨噬细胞释放的 microparticles (MP ) 。这些 MP 把 Lm 抗原转移了到 DC,允许 DC 介绍 Lm 抗原给受动器 T 房间。调停 MP 的 Lm 抗原转移要求了 MHC 一级参予,自从在巨噬细胞的 MHC 一级缺乏导致了 T 房间激活的重要减小。而且,有从感染 Lm 的巨噬细胞的 MP 的老鼠的种痘对 Lm 感染生产了强壮的保护的免疫。我们这里在 Lm 感染期间识别在巨噬细胞和 DC 之间的一个内在的抗原转移节目,并且强调巨噬细胞也在得到 DC 的 Lm 特定的 T 房间回答起一个必要作用。 | Yi Zhang Ruihua Zhang Huafeng Zhang Jing Liu Zhuoshun Yang Pingwei Xu Wenqian Cai Geming Lu Miao Cui Reto A Schwendener Huang-Zhong Shi Huabao Xiong Bo Huang | 2012 | Cellular & Molecular Immunology2012，9，6： | 1 |
| 7 | Genome-wide characterization of graft-transmissible mRNA-coding P450 genes of cucumber(Cucumis sativus L.)显示文摘P450(cytochrome P450)is a supergene family,which is involved in various metabolic pathways in plants.Based on previous study,we found some of cucumber P450 mRNAs were systemic mobile in cucumber/pumpkin grafts.However,the reason that why P450 mRNAs were endorsed as signaling,and what specific motif(s)did they harbored is not clear yet.Here,we first identified 221 CsaP450 genes in cucumber genomewide level.Combining with graft-transmissiblemRNAs datasets in cucumber,we elucidated 15mobile-CsaP450-coding genes,of which 5 and 10 belonged to A-type and non-A type respectively.Compared with Arabidopsis and pumpkin(Cucubit moschata)graft-induced-transmissible P450 mRNAs,a phylogenetic treewas constructed and divided into eight clans by usingmultiple-sequence alignment.Gene ontology(GO)enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)annotations indicated that the expression patterns of the mobile-mRNA-coding CsaP450 genes in different tissues of cucumber was specifically enriched in oxidoreductase activity and secondary metabolic pathways.The structures and motifs of these 15 mobile-mRNA-coding CsaP450 genes and their types of regulatory elements told that the proportion of CU-rich motifs was higher than nonmobile-mRNA-coding CsaP450 genes.The integrated analysis of mobility direction and mRNA abundance of 15 mobilemRNA-coding CsaP450 genes allowed to conclude that there was rarely relationship between them.The study provided a new insight into the relationship between the motifs and functional characterization of mobile-mRNA-coding P450 genes of cucumber in genome-wide levels. | Tao Wang Xiaohong Lu Chenggang Xiang Xiaojun Li Wenqian Liu QingWang Zixi Liu Lihong Gao Wenna Zhang | 2023 | Horticultural Plant Journal2023，9，2： | 1 |
| 8 | An outbreak of Mycobacterium marinum infection associated with handling seabass in China显示文摘To the Editor:Mycobacterium marinum is a nontuberculous mycobacterium that can cause opportunistic infections in humans,ranging from a single cutaneous lesion to disseminated disease.[1]It was first isolated from a fish in 1926 and identified as a cause of human infection in 1951.[1]The estimated annual incidence ranges from 0.04 to 0.27 per 100,000 persons in different countries.Outbreaks of M.marinum infections related to handling fish are not common,but have also been reported. | Qing Zhao Fangfang Bao Zihao Mi Zhenzhen Wang Pengcheng Huai Qing Pan Zheng Pang Yaoming Li Nan Cao Xiaotong Xue Buyan Li Xuechao Chen Jinliang Wang Yanxia Cui Wenqian Chang Yuan Zhang Zhenhua Yue Yongxia Liu Zhenhua Wang Weiguo Yan Jinyong Li Hongqing Tian Xianmei Lu Guizhi Zhou Jianjun Liu Hong Liu Furen Zhang | 2022 | Chinese Medical Journal2022，135，21： | 1 |
| 9 | High piezo/photocatalytic efficiency of Ag/Bi_(5)O_(7)I nanocomposite using mechanical and solar energy for N2 fixation and methyl orange degradation显示文摘In this work,Ag/Bi_(5)O_(7)I nanocomposite was prepared and firstly applied in piezo/photocatalytic reduction of N2 to NH3 and methyl orange(MO)degradation.Bi_(5)O_(7)I was synthesized via a hydrothermal-calcination method and shows nanorods morphology.Ag nanoparticles(NPs)were photo deposited on the Bi_(5)O_(7)I nanorods as electron trappers to improve the spatial separation of charge carriers,which was confirmed via XPS,TEM,and electronic chemical analyses.The catalytic test indicates that Bi_(5)O_(7)I presents the piezoelectric-like behavior,while the loading of Ag NPs can strengthen the character.Under ultrasonic vibration,the optimal Ag/Bi_(5)O_(7)I presents high efficiency in MO degradation.The degradation rate is determined to be 0.033 min1,which is 4.7 folds faster than that of Bi_(5)O_(7)I.The Ag/Bi_(5)O_(7)I also presents a high performance in piezocatalytic N2 fixation.The piezocatalytic NH3 generation rate reaches 65.4 μmol L^(-1)g^(-1)h^(-1)with water as a hole scavenger.The addition of methanol can hasten the piezoelectric catalytic reaction.Interestingly,when ultrasonic vibration and light irradiation simultaneously act on the Ag/Bi_(5)O_(7)I catalyst,higher performance in NH3 generation and MO degradation is observed.However,due to the weak adhesion of Ag NPs,some Ag NPs would fall off from the Bi_(5)O_(7)I surface under long-term ultrasonic vibration,which would greatly reduce the piezoelectric catalytic performance.This result indicates that a strong binding force is required when preparing the piezoelectric composite catalyst.The current work provides new insights for the development of highly efficient catalysts that can use multiple energies. | Lu Chen Wenqian Zhang Junfeng Wang Xiaojing Li Yi Li Xin Hu Leihong Zhao Ying Wu Yiming He | 2023 | Green Energy & Environment2023，8，1： | 1 |
| 10 | Impaired immunomodulatory ability of bone marrow mesenchymal stem cells on CD4 + T cells in aplastic anemia显示文摘 | Jianping Li Shihong Lu Shaoguang Yang Wen Xing Jianming Feng Wenqian Li Qinjun Zhao Hao Wu Meili Ge Fengxia Ma Hui Zhao Bin Liu Lei Zhang Yizhou Zheng Zhong Chao Han | 2012 | Results in Immunology2012，，： | 1 |
| 11 | Schistosomiasis Surveillance--China,2015−2018显示文摘Background The prevalence of schistosomiasis in China is at the lowest level in history,and sentinel surveillance sites of schistosomiasis have fully covered all epidemic areas of China.This article has analyzed the surveillance data for the last four years and can help guide the next stage of surveillance work at the national level,including the scope of surveillance,surveillance content,and surveillance methods,etc.Methods Data from the National Schistosomiasis Surveillance System were collected.The infection rate of schistosomiasis among the human population,livestock,snails,and the change of the breeding area of snails in sentinel surveillance sites for four consecutive years were analyzed,and the trends in schistosomiasis prevalence in surveillance sites were determined.Results The prevalence of schistosomiasis in all sentinel surveillance sites of China showed downward trends from 2015 to 2018 with infection rates decreasing in this time period for local human population(0.05%to 0.00%),the floating population(0.020% to 0.003%),and cattle(0.037% to 0.000%).No infected snails were found during the period.From 2015 to 2018,the total area of newly found habitats of snails(Oncomelania hupensis,O.hupensis)were 34,730 m^(2),1,367,694 m^(2),18,944 m^(2),and 50,420 m^(2),and the total area of re-emergent habitats of snails(O.hupensis)were 822,194 m^(2),1,391,779 m^(2),1,516,292 m^(2),and 1,750,558 m^(2),respectively.Conclusions and Implications for Public Health Practice The prevalence of schistosomiasis in human and livestock is going down and is sustained at a very low level,but new and re-emerging habitats of O.hupensis are new challenges regardless of the achievement of schistosomiasis control.Therefore,two actions are necessary to effectively further reduce the transmission risk of schistosomiasis:1)taking effective measures to control the source of infection of schistosomiasis;and 2)reducing the breeding areas of O.hupensis. | Yinlong Li Hui Dang Lijuan Zhang Guangping Li Xiaowei Shan Min Yuan Songjun Ding Yun Feng Meifen Shen Jia Xu Yanjun Jin Haijuan Du Wencheng Lu Wenqian Tang Dianwei Jiang Yi Yuan Shan Lyu Shizhu Li Xiao-nong Zhou | 2020 | China CDC weekly2020，2，3： | 0 |
| 12 | Experimental Study of Falling-film Mode Transitions between Horizontal Tubes in CaCl_2/Water Absorber显示文摘It is important to accurately predict the flow mode especially intertube falling-film mode of absorbent for its great impact on the heat and mass transfer in a horizontal tube absorber. In this paper, a test facility used to study falling-film outside horizontal tubes was built, and experiments were conducted to explore the intertube mode transitions with water-calcium chloride(CaCl2/water) solution in quiescent surroundings. The correlations which are more suitable for predicting CaCl2/water solution intertube mode transitions were developed. In general, the transitional Re will decrease with the solution concentration increasing, and its effects increase with the transitions from droplet mode to sheet mode. Hysteresis exists in all the mode transitions, and it is more obvious for low concentration solutions. The results may be an important support for modeling, designing and operating of CaCl2/water falling-film absorber. | XU Zhen SUN Wenqian LU Yuan XIAO Yunhan XIE Yingchun | 2014 | Journal of Thermal Science2014，23，4： | 0 |
| 13 | Multiplex CRISPR/Cas9-mediated knockout of soybean LNK2 advances flowering time显示文摘Flowering time is an important agronomic trait for soybean yield and adaptation. However, the genetic basis of soybean adaptation to diverse latitudes is still not clear. Four NIGHT LIGHT-INDUCIBLE AND CLOCK-REGULATED 2(LNK2) homeologs of Arabidopsis thaliana LNK2 were identified in soybean. Three single-guide RNAs were designed for editing the four LNK2 genes. A transgene-free homozygous quadruple mutant of the LNK2 genes was developed using the CRISPR(clustered regularly interspaced short palindromic repeats)/Cas9(CRISPR-associated protein 9). Under long-day(LD) conditions, the quadruple mutant flowered significantly earlier than the wild-type(WT). Quantitative real-time PCR(q RT-PCR)revealed that transcript levels of LNK2 were significantly lower in the quadruple mutant than in the WT under LD conditions. LNK2 promoted the expression of the legume-specific E1 gene and repressed the expression of FT2 a. Genetic markers were developed to identify LNK2 mutants for soybean breeding.These results indicate that CRISPR/Cas9-mediated targeted mutagenesis of four LNK2 genes shortens flowering time in soybean. Our findings identify novel components in flowering-time control in soybean and may be beneficial for further soybean breeding in high-latitude environments. | Zhaobo Li Qun Cheng Zhuoran Gan Zhihong Hou Yuhang Zhang Yongli Li Haiyang Li Haiyang Nan Cen Yang Linnan Chen Sijia Lu Wenqian Shi Liyu Chen Yanping Wang Chao Fang Liping Kong Tong Su Shichen Li Kun Kou Lingshuang Wang Fanjiang Kong Baohui Liu Lidong Dong | 2021 | The Crop Journal2021，9，4： | 0 |
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