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| 1 | BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity显示文摘基础编辑() ,包含 cytidine 脱氨基酶和催化地有缺点的 Cas9,广泛地被用来执行基础编辑。然而,狭窄的编辑窗口是限制它的实用程序。这里,我们开发了依照到由熔化 10 的 U (T) 范围(加) 的更大的 C 为招募 GCN4 肽拷贝到 nCas9 (D10A ) 的编程作为基础编辑命名的一种新编辑技术 scFv-APOBEC-UGI-GB1 到目标地点。新系统完成与一扇拓宽的窗户的基础编辑,导致一个增加的指向染色体的范围。有趣地,新系统很产出更少讨厌的 indels 和 non-C-to-T 变换。我们也通过站 codons (iSTOP ) 的正式就职越过整个染色体在基因混乱表明了它的潜在的使用。一起拿,加系统与编辑窗口和提高的忠实增加提供一个新编辑工具。 | Wen Jiang Songjie Feng Shisheng Huang Wenxia Yu Guanglei Li Guang Yang Yajing Liu Yu Zhang Lei Zhang Yu Hou Jia Chen Jieping Chen Xingxu Huang | 2018 | Cell Research2018，28，8： | 20 |
| 2 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 3 | Differentiation degree combination weighting method for investment decision-making risk assessment in power grid construction projects显示文摘Power grid construction projects are distinguished by their wide variety,high investment,long payback period,and close relation to national development and human welfare.To improve the investment accuracy in such projects and effectively prevent investment risks,this paper proposes an investment optimization decision-making method for multiple power grid construction projects under a certain investment scale.Firstly,an in-depth analysis of the characteristics and development requirements of China’s power grid projects was performed.Thereafter,the time sequence and holographic method was adopted to conduct multi-dimensional,multi-perspective risk assessment of different parts of power grid projects,and a holographic risk assessment index system was developed.Moreover,an investment decision model considering the comprehensive risk based on combination weighting was developed according to the output and input of power grid construction projects.A new combination weighting optimization method that takes into account the investment willingness of enterprises was designed to improve the current weighting evaluation methods.Finally,the validity and applicability of the proposed evaluation method were verified by case examples. | Yuan Chang Chenmiao Liu Minghua Liu Wenxia Liu Zongqi Liu Heng Zhang Yan Zheng | 2019 | Global Energy Interconnection2019，2，5： | 5 |
| 4 | Wind farm polymerization influences on security and economic operation in power system based on Copula function显示文摘Wind speed dependences on different areas in a wind farm have influences on security and economic operation in power system.In order to simulate the correlation of wind speed series between different positions,this paper applies Copula function and rank correlation matrix methods to measure the coherence of wind speed in a wind farm.The correlated wind sample space is established.According to active power output characteristics of wind turbines,the polymerization model in a wind farm can be achieved.Monte Carlo optimal power flow is applied to IEEE-30 and IEEE-300 bus systems based on the principle of energy saving dispatching.The study shows that the accuracy of outputs is improved,thus reducing the fluctuation ranges in unit generating costs and power flow in branches while considering wind speed polymerization.This approach provides a new method to improve the effectiveness of energy saving dispatching and system operation arrangement.Results have been tested to be effective. | Xiong PAN Zhuo LIU Wenxia LIU Yanqing LI | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 4 |
| 5 | Dual pH and glucose sensitive gel gated mesoporous silica nanoparticles for drug delivery显示文摘A low molecular weight gelator with dual pH and glucose sensitive moieties was synthesized. The gelator penetrated in the mesopores of silica nanoparticles(MSNs) and formed low molecular weight gel(LMWG) as gate to fabricate dual pH and glucose responsive nano drug delivery system. Antidiabetic drug was loaded in the gel caped MSNs, the drug release was responsive to the pH and glucose levels and the drug release could be controlled via the stimuli sensitivity of gel. | Wenxia Gao Yalong Hu Long Xu Miaochang Liu Huayue Wu Bin He | 2018 | Chinese Chemical Letters2018，29，12： | 4 |
| 6 | A photocleavable low molecular weight hydrogel for light-triggered drug delivery显示文摘A photocleavable low-molecular-weight hydrogelator (LMWG) was synthesized based on coumarin derivative.~1H NMR and UV spectroscopy study suggested that the gelator had good gelling ability, and the driving force for the gelation were hydrogen bonding and π-π stacking. This molecular hydrogel exhibited satisfied photocleavage at C-N bond in 7-amino coumarin with the light irradiation (365 nm,77.5 mW/cm^2). The promising photo-triggered drug release of antineoplastics cytarabine hydrochloride has been obtained, due to the photocleavage motived gel-sol transition. | Qihong Liu Hao Wang Guotao Li Miaochang Liu Jinchang Ding Xiaobo Huang Wenxia Gao Huayue Wu | 2019 | Chinese Chemical Letters2019，30，2： | 4 |
| 7 | Moisture-induced degradation of the narrow-band red-emitting SrLiAl3N4:Eu2+phosphor显示文摘The degradation of materials plays an important role in their application and service process. In this work, the moisture-induced degradation of SrLiAl3 N4:Eu2+(SLAN), a very promising narrow-band redemitting phosphor, was comprehensively investigated by treating it in two different moisture conditions in order to reveal the potential mechanism and optimize the luminescence properties. The degradation rate gradually slows down with the decreasing environmental humidity indicating that water plays a key role in the degradation. Moreover, we take the other option with 100% humidity at different temperatures for rapid degradation. In the rapid degradation, the luminescence of SLAN is quenched quickly and the phase and micro structure change obviously, with the phosphor being bleached. The host turns into NH_3, Al_2 O_3, Sr_3 Al_2(OH)_(12) and LiAl_2(OH)_7 finally. It is further confirmed that the rapid degradation occurs with the help of water and the phosphor is oxidized during this process. | Wenxia Li Zhen Song Dianpeng Cui Zhiguo Xia Quanlin Liu | 2018 | Journal of Rare Earths2018，36，4： | 4 |
| 8 | Creation of aromatic maize by CRISPR/Cas显示文摘Aroma is an important quality parameter for breeding in rice(Oryza sativa).For example,the aromatic rice varieties basmati and jasmine rice,with a popcorn-like scent,are popular worldwide and routinely command a price premium.2-acetyl-1-pyrroline(2AP)is a key flavor compound among over 200 volatiles identified in fragrant rice.A naturally fragrant germplasm exists in multiple plant species besides rice,which all exhibit lower activity of BETAINE ALDEHYDE DEHYDROGENASE 2(BADH2).However,no equivalent aromatic germplasm has been described in maize(Zea mays).Here,we characterized the two maize BADH2 homologs,ZmBADH2a and ZmBADH2b.We generated zmbadh2a and zmbadh2b single mutants and the zmbadh2a-zmbadh2b double mutant by CRISPR/Cas in four inbred lines.A popcorn-like scent was only noticeable in seeds from the double mutant,but not from either single mutant or in wild type.In agreement,we only detected 2AP in fresh kernels and dried mature seeds from the double mutant,which accumulated between 0.028 and 0.723 mg/kg 2AP.These results suggest that ZmBADH2a and ZmBADH2b redundantly participate in 2AP biosynthesis in maize,and represent the creation of the world's first aromatic maize by simultaneous genome editing of the two BADH2 genes. | Yanxiao Wang Xiaoqin Liu Xiuxiu Zheng Wenxia Wang Xunqing Yin Haifeng Liu Changle Ma Xiaomu Niu Jian-Kang Zhu Fei Wang | 2021 | Journal of Integrative Plant Biology2021，63，9： | 3 |
| 9 | Efficient base editing in G/C-rich regions to model androgen insensitivity syndrome显示文摘Dear Editor, Most disease-associated genomic mutations are base substitutions and approximately half of pathogenic human single nucleotide polymorphisms (SNPs)are related to C-to-T substitutions in the ClinVar database.Base editors (BEs),which combine Casg-DIOA nickase and APOBEC (apolipoprotein B mRNA editing enzyme,catalytic polypeptide-like)or AID (activation-induced deaminase)cytidine deaminase family members, have been successfully applied to mediate C-to-T conversion in vitro and in vivo, providing a powerful tool to model or repair diseaserelated human SNPs. | Jianan Li Zhen Liu Shisheng Huang Xiao Wang Guanglei Li Yuting Xu Wenxia Yu Shanshan Chen Yu Zhang Hanhui Ma Zunfu Ke Jia Chen Qiang Sun Xingxu Huang | 2019 | Cell Research2019，29，2： | 3 |
| 10 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 11 | From unusual suspect to serial killer: Cyanotoxins boosted by climate change may jeopardize megafauna显示文摘The recent mass mortality event of more than 330 African elephants in Botswana has been attributed to biotoxins produced by cyanobacteria;however,scientific evidence for this is lacking.Here,by synthesizing multiple sources of data,we show that,during the past decades,the widespread hypertrophic waters in Southern Africa have entailed an extremely high risk and frequent exposure of cyanotoxins to the wildlife within this area,which functions as a hotspot of mammal species richness.The hot and dry climatic extremes have most likely acted as the primary trigger of the recent and perhaps also of prehistoric mass mortality events.As such climate extremes are projected to become more frequent in Southern Africa in the near future,there is a risk that similar tragedies may take place,rendering African megafauna species,especially those that are already endangered,in risk of extinction.Moreover,cyanotoxin poisoning amplified by climate change may have unexpected cascading effects on human societies.Seen within this perspective,the tragic mass death of the world's largest terrestrial mammal species serves as an alarming early warning signal of future environmental catastrophes in Southern Africa.We suggest that systematic,quantitative cyanotoxin risk assessments are made and precautionary actions to mitigate the risks are taken without hesitation to ensure the health and sustainability of the megafauna and human societies within the region. | Haijun Wang Chi Xu Ying Liu Erik Jeppesen Jens-Christian Svenning Jianguo Wu Wenxia Zhang Tianjun Zhou Puze Wang Shingirai Nangombe Jinge Ma Hongtao Duan Jingyun Fang Ping Xie | 2021 | The Innovation2021，2，2： | 3 |
| 12 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 13 | Micro and nanolattice fabrication using projection micro litho stereo exposure additive manufacturing techniques and synchrotron X-ray 3D imaging-based defect characterization显示文摘Synchrotron radiation X-ray micro-computed tomography(SR-μCT)is a 3D imaging technique that is widely employed for the characterization of defects in advanced materials and structures.In this study,we characterize several typical defects in octettruss and re-entrant 3D lattice structures by using SR-μCT.The 3D micro-lattice structures are manufactured using projection micro litho stereo exposure(PμLSE)additive manufacturing technology.The as-fabricated 3D lattice samples are characterized using optical microscopy,and subsequently,by SR-μCT.Further more,a statistical analysis is performed to characterize the surface roughness and internal defects qualitatively,whereby the statistical geometrical parameters of struts along different directions and strut joints are analyzed and classified.Consequently,several typical defects are identified:(1)holes at the joints of the strut and irregular diameter deviations of the strut in the octet-truss lattice structure;(2)irregular diameter variations,bulges,dislocations,grooves,accumulations,and torsion in the re-entrant lattice structure.All of these defects are related to the building direction,the weight of the structure,bubbles,dust,and impurities during the PμLSE additive manufacturing process. | HU WenXia LIU LiWu WU WenWang XI Li LENG JinSong FANG DaiNing | 2020 | Science China(Technological Sciences)2020，63，4： | 2 |
| 14 | Foil-like receptor agonists induce apoptosis in mouse 3-cell lymphoma cells by altering NF-κB activation显示文摘 | Nandini Arunkumar Chaohong Liu Haiying Hang Wenxia Song | 2013 | Cellular & Molecular Immunology2013，10，4： | 2 |
| 15 | An ultrasound-triggered cation chelation and reassembly route to one-dimensional Ni-rich cathode material enabling fast charging and stable cycling of Li-ion batteries显示文摘Ni-rich oxides,LiNixMnyCozO2(NMC),are among leading candidates for cathode materials in Li-ion batteries.However,they are mostly fabricated by coprecipitation approach under complex conditions,which usually produces large secondary particles composed of aggregated primary particles.Undesirable cation mixing and crack propagation upon cycling block ion and electron transport,result in fast capacity fading and poor rate capability.Herein,we present an ultrasound-triggered cation chelation and reassembly route for synthesizing one-dimensional precursor with homogeneous element distribution at the atomic level.This process is accomplished by the synergistic combination of ultrasound and surfactant,which can disperse reactants and remove hydration shells surrounding cations so as to accelerate chelating reaction,and then separate and assemble chelates into one dimensional structure.The whole synthesis time is only 20 min(8.9 min of ultrasonic working time)in an open vessel under natural ambient conditions.One-dimensional LiNi0.6Mn0.2Co0.2O2 has a high reversible capacity(184 mAh·g^−1 at 0.1 C)and long cycling stability(95.1%and 82.4%capacity retention for 100 and 1000 cycles,respectively).The short charging time of 76 s is realized at super high current rate of 20 C,which is very important to improve the competitiveness of electric vehicles relative to fuel vehicles.Our synthetic approach can provide a general strategy for the growth of mixed-metal-EDTA chelate precursors by changing the feeding ratio of Ni2+,Mn2+and Co2+cations in reaction for fabricating NMC cathode materials with other compositions. | Yongjian Lai Zhaojie Li Wenxia Zhao Xiaoning Cheng Shuo Xu Xiao Yu Yong Liu | 2020 | Nano Research2020，13，12： | 2 |
| 16 | Reliability Assessment of a Cyber Physical Microgrid System in Island Mode显示文摘As cyber physical systems,microgrids(MGs),with distributed generations and energy management systems,can improve the reliability of power supply for customers in MGs.To quantify the reliability of isolated MGs,a cyber-physical assessment model is proposed.In this model,the circuit breakers and distributed energy resources are treated as the coupling elements between the cyber system and physical system,where the circuit breakers are uniquely modelled by using the Markov process theory based on the indirect interdependencies between cyber physical elements.For the cyber system,the reliability model of communication networks is formulated based on the link connectivity evaluation method.For the physical system,a system state generating method is presented to account for the optimal operation strategy,which considers the influence of the optimization strategy on the failure consequence analysis.With the proposed cyber and physical reliability models,the sequential Monte Carlo(SMC)simulation method is adopted to assess the reliability of islanded MGs.Simulations are carried out on a test system,and results verify the feasibility and effectiveness of proposed assessment method.Furthermore,one application of the proposed method is on the parameter setting of the cyber system,in terms of enhancing MGs reliability. | Jing Guo Wenxia Liu Furqan R.Syed Jianhua Zhang | 2019 | CSEE Journal of Power and Energy Systems2019，5，1： | 2 |
| 17 | Immune activities comparison of polysaccharide and polysaccharide-protein complex from Lycium barbarum L.显示文摘 | Xiaorui Zhang Yingjie Li Junping Cheng Gang Liu Chunhui Qi Wenxia Zhou Yongxiang Zhang | 2014 | International Journal of Biological Macromolecules2014，，： | 1 |
| 18 | Preparation of hydrophobic transparent paper via using polydimethylsiloxane as transparent agent显示文摘Transparent paper with good hydrophobicity and flexibility was expected to act as an alternative substrate in fabrication of flexible electronics.However,conventional paper made of cellulose fibers was opaque and hydrophilic without undergoing special processing.Herein,cellulose fiber paper was treated by impregnating with hydrolyzed tetraethyl orthosilicate(TEOS)followed by coating with hydrophobic polydimethylsiloxane(PDMS)to prepare hydrophobic transparent pa-per.The results showed that silica nanoparticles produced by the TEOS hydrolysis improved the paper transparency to some extent,increased the paper thermal stability,but still remained the hydrophilicity of paper.After the paper was further coated with the PDMS and the PDMS was consolidated,the paper became clearly transparent and hydrophobic.The processed paper had a transmittance of more than 90%at 550 nm.The water contact angle of the paper reached about 110°.This work provided a new approach for the fabrication of hydrophobic transparent paper with conventional cellulose fiber paper. | Feixiang Guan Zhaoping Song Furong Xin Huili Wang Dehai Yu Guodong Li Wenxia Liu | 2020 | Journal of Bioresources and Bioproducts2020，5，1： | 1 |
| 19 | Expression levels and genetic polymorphisms of interleukin-2 and interleukin-10as biomarkers of Graves’ disease显示文摘 | Cuige Liang Wenhua Du Qingyu Dong Xiaomeng Liu Wenxia Li Yueli Wang Guanqi Gao | 2015 | Experimental and Therapeutic Medicine2015，，： | 1 |
| 20 | Slow- freezing cryopreservation of neural stem cell spheres with different diameters 显示文摘 | Ma Xuehu Shi Ying Hou Ying Liu Yang Zhang Lei Fan Wenxia Ge Dan Liu Tianqing Cui Zhanfeng | 2010 | Cryobiology2010，60，2： | 1 |
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