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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 3 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 4 | Climate sensitivities of two versions of FGOALS model to idealized radiative forcing显示文摘Projections of future climate change by climate system models depend on the sensitivities of models to specified greenhouse gases.To reveal and understand the different climate sensitivities of two versions of LASG/IAP climate system model FGOALS-g2 and FGOALS-s2,we investigate the global mean surface air temperature responses to idealized CO2 forcing by using the output of abruptly quadrupling CO2 experiments.The Gregory-style regression method is used to estimate the'radiative forcing'of quadrupled CO2 and equilibrium sensitivity.The model response is separated into a fast-response stage associated with the CO2 forcing during the first 20 years,and a slow-response stage post the first 20 years.The results show that the radiative forcing of CO2 is overestimated due to the positive water-vapor feedback and underestimated due to the fast cloud processes.The rapid response of water vapor in FGOALS-s2 is responsible for the stronger radiative forcing of CO2.The climate sensitivity,defined as the equilibrium temperature change under doubled CO2 forcing,is about 3.7 K in FGOALS-g2 and4.5 K in FGOALS-s2.The larger sensitivity of FGOALS-s2 is due mainly to the weaker negative longwave clear-sky feedback and stronger positive shortwave clear-sky feedback at the fast-response stage,because of the more rapid response of water vapor increase and sea-ice decrease in FGOALS-s2 than in FGOALS-g2.At the slow-response stage,similar to the fast-response stage,net negative clear-sky feedback is weaker in FGOALS-s2.Nevertheless,the total negative feedback is larger in FGOALS-s2 due to a larger negative shortwave cloud feedback that involves a larger response of total cloud fraction and condensed water path increase.The uncertainties of estimated forcing and net feedback mainly come from the shortwave cloud processes. | CHEN XiaoLong ZHOU TianJun GUO Zhun | 2014 | Science China Earth Sciences2014，57，6： | 19 |
| 5 | Multi-scale HPC system for multi-scale discrete simulation—Development and application of a supercomputer with 1 Petaflops peak performance in single precision显示文摘A supercomputer with 1.0 Petaflops peak performance in single precision,designed and established by Institute of Process Engineering,Chinese Academy of Sciences,is introduced in this brief communication.A designing philosophy utilizing the similarity between hardware,software and the problems to be solved is embodied,based on the multi-scale method and discrete simulation approaches developed at Institute of Process Engineering(IPE)and implemented in a graphic processing unit(GPU)-based hybrid computing mode.The preliminary applications of this machine in areas of multi-phase flow,molecular dynamics and so on are reported,demonstrating the supercomputer as a paradigm of green computation in new architecture. | Feiguo Chen Wei Ge Li Guo Xianfeng He Bo Li Jinghai Li Xipeng Li Xiaowei Wang Xiaolong Yuan | 2009 | Particuology2009，7，4： | 19 |
| 6 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 7 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 8 | Uncertainty in crossing time of 2 °C warming threshold over China显示文摘The 2 °C warming target has been used widely in global and regional climate change research. Previous studies have shown large uncertainties in the time when surface air temperature(SAT) change over China will reach 2 °C relative to the pre-industrial era. To understand the uncertainties,we analyzed the projected SAT in the twenty-first century using 40 state-of-the-art climate models under two Representative Concentration Pathways(RCP4.5 and RCP8.5)from the Coupled Model Intercomparison Project Phase 5.The 2 °C threshold-crossing time(TCT) of SAT averaged across China was around 2033 and 2029 for RCP4.5 and RCP8.5, respectively. Considering a ±1r range of intermodel SAT change, the upper and lower bounds of the 2 °C TCT could differ by about 25 years or even more. Uncertainty in the projected SAT and the warming rate around the TCT are the two main factors responsible for the TCT uncertainty. The former is determined by the climate sensitivity represented by the global mean surface temperature response. About 45 % of the intermodel variance of the projected 2 °C TCT for averaged SAT over China can be explained by climate sensitivity across the models, which is contributed mainly by central and southern China. In a climate more sensitive to CO2 forcing, stronger greenhouse effect, less stratus cloud over the East Asian monsoon region,and less snow cover on the Tibetan Plateau result in increased downward longwave radiation, increased shortwave radiation, and decreased shortwave radiation reflected by the surface, respectively, all of which may advance the TCT. | Xiaolong Chen Tianjun Zhou | 2016 | Science Bulletin2016，61，18： | 15 |
| 9 | Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway显示文摘Rheumatoid arthritis(RA)is a chronic inflammatory disease that eventually leads to disability.Inflammatory cell infiltration,severe joint breaking and systemic bone loss are the main clinical symptoms.In this study,we established a collagen-induced arthritis(CIA)model and found a large number of M1 macrophages and pyroptosis,which are important sources of proinflammatory cytokines.Punicalagin(PUN)is an active substance extracted from pomegranate peel.We found that it inhibited joint inflammation,cartilage damage and systemic bone destruction in CIA mice.PUN effectively alleviated the high expression of inflammatory cytokines in synovial tissue in vivo.PUN treatment shifted macrophages from the M1 phenotype to the M2 phenotype after stimulation with lipopolysaccharide(LPS)and interferon(IFN)-γ.The expression of inducible nitric oxide synthase(i NOS)and other proinflammatory cytokines released by M1 macrophages was decreased in the PUN treatment group.However,simultaneously,the expression of markers of anti-inflammatory M2 macrophages,such as arginase(Arg)-1 and interleukin(IL)-10,was increased.In addition,PUN treatment attenuated pyroptosis by downregulating the expression of NLRP3 and caspase-1,thereby preventing inflammatory cell death resulting from the release of IL-1βand IL-18.Mechanistically,PUN inhibited the activation of receptor activators of the nuclear factor-κB(NF-κB)signaling pathway,which contributes to M1 polarization and pyroptosis of macrophages.We concluded that PUN ameliorated pathological inflammation by inhibiting M1 phenotype polarization and pyroptosis and has great potential as a therapeutic treatment for human RA. | Gaoran Ge Jiaxiang Bai Qing Wang Xiaolong Liang Huaqiang Tao Hao Chen Minggang Wei Junjie Niu Huilin Yang Yaozeng Xu Yuefeng Hao Yi Xue Dechun Geng | 2022 | Science China(Life Sciences)2022，65，3： | 14 |
| 10 | The molecular mechanism of HOTAIR in tumorigenesis, metastasis, and drug resistance显示文摘长非编码的 RNA 被报导了在细胞的新陈代谢和开发起一个重要作用。Homeobox 抄本 antisense intergenic RNA (HOTAIR ) ,长非编码的 RNA,与非癌的邻近的纸巾相比在很人的癌症是弥漫地过去表示的。尽管许多文章报导了,那 HOTAIR 仔细与转移,上皮间充质的转变,先进病理学的阶段,药抵抗,和差的预后被联系,在基因规定和肿瘤开发的 HOTAIR 的角色大部分是未知的,并且潜在的分子的机制还不是完全清楚的。在这评论,我们在 HOTAIR 的主要功能的学习总结了最近的进步。miR-331-3p, miR-130a, miR-7, miR-141, HER2, c-MYC, WIF-1, RBM38, PTEN,和 Col-1 涉及 HOTAIR 规定网络。我们试着阐明在 tumorigenesis,转移,药抵抗,和规定的方面的 HOTAIR 的分子的机制。 | Xiaolong Zhou Jin Chen Wenru Tang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 12 |
| 11 | Sedimentary and OSL dating evidence for the development of the present Hobq desert landscape, northern China显示文摘The sedimentary sequence and landscape of the Hobq desert was observed through twelve profiles along five N-S sections extending through the entire desert.Aeolian sands were found to overlie the alluvial,diluvial,and lacustrine sediments in this desert.Optically stimulated luminescence(OSL)dating results were obtained from post-IR OSL signals of quartz fractions of sand samples at the bottom of sand dunes and hills by using the Double-SAR protocol.The OSL ages reveal that the latest sand accumulation began around 19 ka in the northwestern part and 9 ka in the eastern part of the Hobq Desert.Around 7 ka,the sand accumulation was strengthened and extended southward and northward 2 ka to develop the present desert landscape.Our study suggests that the aeolian sand accumulation around 19,9 and 7 ka resulted from the weakening of the Asian summer monsoon over this region.However,the rapid development of the present Hobq desert landscape since 2 ka was likely triggered by human activities in this desert. | FAN YuXin CHEN XiaoLong FAN TianLai JIN Ming LIU JianBao CHEN FaHu | 2013 | Science China Earth Sciences2013，56，12： | 11 |
| 12 | Climate Sensitivity and Feedbacks of a New Coupled Model CAMS-CSM to Idealized CO_2 Forcing: A Comparison with CMIP5 Models显示文摘Climate sensitivity and feedbacks are basic and important metrics to a climate system. They determine how large surface air temperature will increase under CO_2 forcing ultimately, which is essential for carbon reduction policies to achieve a specific warming target. In this study, these metrics are analyzed in a climate system model newly developed by the Chinese Academy of Meteorological Sciences(CAMS-CSM) and compared with multi-model results from the Coupled Model Comparison Project phase 5(CMIP5). Based on two idealized CO_2 forcing scenarios, i.e.,abruptly quadrupled CO_2 and CO_2 increasing 1% per year, the equilibrium climate sensitivity(ECS) and transient climate response(TCR) in CAMS-CSM are estimated to be about 2.27 and 1.88 K, respectively. The ECS is near the lower bound of CMIP5 models whereas the TCR is closer to the multi-model ensemble mean(MME) of CMIP5 due to compensation of a relatively low ocean heat uptake(OHU) efficiency. The low ECS is caused by an unusually negative climate feedback in CAMS-CSM, which is attributed to cloud shortwave feedback(λSWCL) over the tropical Indo-Pacific Ocean.The CMIP5 ensemble shows that more negative λSWCL is related to larger increase in low-level(925–700 hPa)cloud over the tropical Indo-Pacific under warming, which can explain about 90% of λSWCL in CAMS-CSM. Static stability of planetary boundary layer in the pre-industrial simulation is a critical factor controlling the low-cloud response and λSWCL across the CMIP5 models and CAMS-CSM. Evidently, weak stability in CAMS-CSM favors lowcloud formation under warming due to increased low-level convergence and relative humidity, with the help of enhanced evaporation from the warming tropical Pacific. Consequently, cloud liquid water increases, amplifying cloud albedo, and eventually contributing to the unusually negative λSWCL and low ECS in CAMS-CSM. Moreover, the OHU may influence climate feedbacks and then the ECS by modulating regional sea surface temperature responses. | Xiaolong CHEN Zhun GUO Tianjun ZHOU Jian LI Xinyao RONG Yufei XIN Haoming CHEN Jingzhi SU | 2019 | Journal of Meteorological Research2019，33，1： | 11 |
| 13 | Artificial intelligence in drug design显示文摘Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to speed up the process of research and reduce the cost and risk related to preclinical and clinical trials.Owing to the development of machine learning theory and the accumulation of pharmacological data, the artificial intelligence(AI) technology, as a powerful data mining tool, has cut a figure in various fields of the drug design, such as virtual screening,activity scoring, quantitative structure-activity relationship(QSAR) analysis, de novo drug design, and in silico evaluation of absorption, distribution, metabolism, excretion and toxicity(ADME/T) properties. Although it is still challenging to provide a physical explanation of the AI-based models, it indeed has been acting as a great power to help manipulating the drug discovery through the versatile frameworks. Recently, due to the strong generalization ability and powerful feature extraction capability,deep learning methods have been employed in predicting the molecular properties as well as generating the desired molecules,which will further promote the application of AI technologies in the field of drug design. | Feisheng Zhong Jing Xing Xutong Li Xiaohong Liu Zunyun Fu Zhaoping Xiong Dong Lu Xiaolong Wu Jihui Zhao Xiaoqin Tan Fei Li Xiaomin Luo Zhaojun Li Kaixian Chen Mingyue Zheng Hualiang Jiang | 2018 | Science China(Life Sciences)2018，61，10： | 10 |
| 14 | Comparison of survival outcomes between transthoracic and transabdominal surgical approaches in patients with Siewert-Ⅱ/Ⅲesophagogastric junction adenocarcinoma:a single-institution retrospective cohort study显示文摘Objective: To compare the survival outcomes of transabdominal(TA) and transthoracic(TT) surgical approaches in patients with Siewert-Ⅱ/Ⅲ esophagogastric junction adenocarcinoma.Methods: This retrospective study was conducted in patients with Siewert-Ⅱ/Ⅲ esophagogastric junction adenocarcinoma who underwent either TT or TA operations in the West China Hospital between January 2006 and December 2009.Results: A total of 308 patients(109 in the TT and 199 in the TA groups) were included in this study with a follow-up rate of 87.3%. The median(P25, P75) number of harvested perigastric lymph nodes was 8(5, 10) in the TT group and 23(16, 34) in the TA group(P<0.001), and the number of positive perigastric lymph nodes was 2(0, 5) in the TT group and 3(1, 8) in the TA group(P<0.004). The 5-year overall survival(OS) rate was 36% in the TT group and 51% in the TA group(P=0.005). Subgroup analysis by Siewert classification showed that 5-year OS rates for patients with Siewert Ⅱ tumors were 38% and 48% in TT and TA groups, respectively(P=0.134), whereas the 5-year OS rate for patients with Siewert Ⅲ tumors was significantly lower in the TT group than that in the TA group(33% vs. 53%; P=0.010). Multivariate analysis indicated that N2 and N3 stages, R1/R2 resection and a TT surgical approach were prognostic factors for poor OS.Conclusions: Improved perigastric lymph node dissection may be the main reason for better survival outcomes observed with a TA gastrectomy approach than with TT gastrectomy for Siewert Ⅲ tumor patients. | Weihan Zhang Xinzu Chen Kai Liu Kun Yang Xiaolong Chen Ying Zhao Yongfan Zhao Jiaping Chen Longqi Chen Jiankun Hu | 2016 | Chinese Journal of Cancer Research2016，28，4： | 10 |
| 15 | Recent progresses in the suppression method based on the growth mechanism of lithium dendrite显示文摘Lithium secondary batteries(LSBs) with high energy densities need to be further developed for future applications in portable electronic devices, electric vehicles, hybrid electric vehicles and smart grids. Lithium metal is the most promising electrode for next-generation rechargeable batteries. However, the formation of lithium dendrite on the anode surface leads to serious safety concerns and low coulombic efficiency.Recently, researchers have made great efforts and significant progresses to solve these problems. Here we review the growth mechanism and suppression method of lithium dendrite for LSBs' anode protection. We also establish the relationship between the growth mechanism and suppression method. The research direction for building better LSBs is given by comparing the advantages and disadvantages of these methods based on the growth mechanism. | Xiaolong Xu Suijun Wang Hao Wang Chen Hu Yi Jin Jingbing Liu Hui Yan | 2018 | Journal of Energy Chemistry2018，27，2： | 8 |
| 16 | Comparative Analysis of Leaf Trichomes, Epidermal Wax And Defense Enzymes Activities in Response to Puccinia horiana in Chrysanthemum and Ajania Species显示文摘White rust caused by Puccinia horiana is a destructive disease of chrysanthemum plants.To better understand the resistance mechanisms of composite species to this disease,the leaf cuticular traits,antioxidant and defensive enzymes activities of immune(Chrysanthemum makinoi var.wakasaense)and highly susceptible(Ajania shiwogiku var.kinokuniense)species were compared.Trichome density of two species was markedly different,negatively associated with plant resistance to P.horiana.Total wax load in C.makinoi var.wakasaense was two times more than that in A.shiwogiku var.kinokuniense.The wax composition in immune one was abundant in esters and primary alcohols.Superoxide dismutase(SOD,EC 1.15.1.1),peroxidase(POD,EC 1.11.1.7),polyphenoloxidase(PPO,EC 1.14.18.1 or EC 1.10.3.2)and phenylalanine ammonia lyase(PAL,EC 4.3.1.5)activitieswere investigated.In C.makinoi var.wakasaense,the activity of SOD and POD increased rapidly after inoculation,whichmight be non-host induced reactive oxygen species(ROS)activated antioxidant enzymes,however SOD and POD remained a low and steady level in the highly susceptible one after inoculation.Quick increase in PPO activities after inoculation was observed in both species,however it remained higher in C.makinoi var.wakasaense at the late period of inoculation.PAL in C.makinoi var.wakasaense was induced after pathogen inoculation,but not in A.shiwogiku var.kinokuniense,suggesting that these two enzymes might contribute to the resistance to P.horiana. | Yinjie Wang Jun Zeng Xiaolong Xia Yang Xu Jing Sun Jing Gu Hainan Sun Haini Lei Fadi Chen Jiafu Jiang Weiming Fang Sumei Chen | 2020 | Horticultural Plant Journal2020，6，3： | 8 |
| 17 | Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation显示文摘Gut inflammation is a challenging concern in humans and animals,which disturbs normal growth and leads to severe bowel diseases.Short chain fatty acids(SCFA)are the gut microbiota metabolites produced from fermentation of non-digestible carbohydrates,and have been reported to modulate gut inflammation.SCFA have been implicated as the potential therapeutic bioactive molecules for gut inflammatory diseases,and could be an alternative to antibiotic growth promoters(AGP).In this review,the existing knowledge about the types of SCFA,the related gut microbes producing SCFA,the roles of SCFA in maintaining gut homeostasis,and how SCFA modulate gut inflammation is summarized.The therapeutic application of SCFA in the treatment of inflammatory bowel disease(IBD)is also highlighted | Muhammad Akhtar Yan Chen Ziyu Ma Xiaolong Zhang Deshi Shi Jawaria AKhan Huazhen Liu | 2022 | Animal Nutrition2022，，1： | 8 |
| 18 | Climate Sensitivity and Feedbacks of BCC-CSM to Idealized CO2 Forcing from CMIP5 to CMIP6显示文摘Climate sensitivity represents the response of climate system to doubled CO2 concentration relative to the preindustrial level, which is one of the sources of uncertainty in climate projections. It is unclear how the climate sensitivity and feedbacks will change as a model system is upgraded from the Coupled Model Intercomparison Project Phase 5(CMIP5) to CMIP6. In this paper, we address this issue by comparing two versions of the Beijing Climate Center Climate System Model(BCC-CSM) participating in CMIP6 and CMIP5, i.e., BCC-CSM2-MR and BCC-CSM1.1 m,which have the same horizontal resolution but different physical parameterizations. The results show that the equilibrium climate sensitivity(ECS) of BCC-CSM slightly increases from CMIP5(2.94 K) to CMIP6(3.04 K). The small changes in the ECS result from compensation between decreased effective radiative forcing(ERF) and the increased net feedback. In contrast, the transient climate response(TCR) evidently decreases from 2.19 to 1.40 K, nearly the lower bound of the CMIP6 multimodel spread. The low TCR in BCC-CSM2-MR is mainly caused by the small ERF overly even though the ocean heat uptake(OHU) efficiency is substantially improved from that in BCC-CSM1.1 m.Cloud shortwave feedback(λSWCL) is found to be the major cause of the increased net feedback in BCC-CSM2-MR,mainly over the Southern Ocean. The strong positive λSWCL in BCC-CSM2-MR is coincidently related to the weakened sea ice-albedo feedback in the same region. This result is caused by reduced sea ice coverage simulated during the preindustrial cold season, which leads to reduced melting per 1-K global warming. As a result, in BCCCSM2-MR, reduced surface heat flux and strengthened static stability of the planetary boundary layer cause a decrease in low-level clouds and an increase in incident shortwave radiation. This study reveals the important compensation between λSWCL and sea ice-albedo feedback in the Southern Ocean. | Xueli SHI Xiaolong CHEN Yunwei DAI Guoquan HU | 2020 | Journal of Meteorological Research2020，34，4： | 8 |
| 19 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 20 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
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