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| 1 | Geological and Geochemical Characteristics and Exploration Prospect of Coal-Derived Tight Sandstone Gas in China: Case Study of the Ordos, Sichuan, and Tarim Basins显示文摘This work extensively investigated global tight sandstone gas, and geologically and geochemically analyzed the tight sandstone gas in China's Ordos, Sichuan, and Tarim basins. We compared typical tight sandstone gas in China with that in North America. We proposed six conditions for the formation of China's tight sandstone gas, and illustrated the geological characteristics of tight sandstone gas. In China, gas-bearing tight sandstones were mainly deposited in continental lake deltas and marine-terrigenous facies basin environments, associated with coal-measure strata, and were mostly buried deeper than 2000 m under a formation pressure of 20–30 MPa, with pressure coefficients varying from overpressure to negative pressure. In other countries, tight gas bearing sandstones were dominantly deposited in marine to marine-terrigenous facies environments, occurred in coal-measure strata, and were mostly buried shallower than 2000 m in low-pressure systems. We systematically analyzed tight sandstone gas in the Ordos, Sichuan, and Tarim basins in terms of chemical compositions, geochemical characteristics of carbon isotopes, origins, and sources. Tight sandstone gas in China usually has a hydrocarbon content of >95%, with CH4 content >90%, and a generally higher dry coefficient. In the three above-mentioned large tight sandstone gas regions, δ13 C1 and δ13 C2 mainly ranges from-42‰ to-28‰ and from-28‰ to-21‰, respectively. Type III coal-measure source rocks that closely coexist with tight reservoirs are developed extensively in these gas regions. The organic petrology of source rocks and the carbon isotope compositions of gas indicate that tight sandstone gas in China is dominantly coal-derived gas generated by coal-measure strata. Our analysis of carbon isotope series shows that local isotope reversals are mainly caused by the mixing of gases of different maturities and that were generated at different stages. With increasing maturity, the reversal tendency becomes more apparent. Moreover, natural gas with medium-low maturity(e.g., Xujiahe Formation natural gas in the Sichuan Basin) presents an apparent reversal at a low-maturity stage, a normal series at a medium-maturity stage, and a reversal tendency again at a high-maturity stage. Finally, we proposed four conditions for preferred tight sandstone gas 'sweep spots,' and illustrated the recoverable reserves, proven reserves, production, and exploration prospects of tight sandstone gas. The geological and geochemical characteristics, origins, sources, and exploration potential of tight sandstone gas in China from our research will be instructive for the future evaluation, prediction, and exploration of tight sandstone gas in China and abroad. | ZOU Caineng TAO Shizhen HAN Wenxue ZHAO Zhenyu MA Weijiao LI Changwei BAI Bin GAO Xiaohui | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 11 |
| 2 | Analysis of the ore-controlling structure of the Shihu gold deposit, Hebei Province and deep-seated ore-prospecting prediction显示文摘Under the guidance of the theory of mantle-branch structure-associated metallogenesis and on the basis of the geological characteristics, analysis of the ore-forming and ore-controlling structures, the geochemical characteristics of metallogenesis, the source of ore-forming materials, changes in the physical and chemical conditions of metallogenesis, changes in the vertical width of ore veins, and changes in gold grade of the Shihu gold deposit, the mechanism of its metallogenesis was discussed and the rules of vertical variation of ore veins were summarized in this study. It is pointed out that the orebodies under exploitation at present time should be in the middle and upper portions of gold veins in the Shihu gold mining district. Particularly on the basis of the characteristics of mantle-branch structure-associated metallogenesis, it is indicated that metallogenesis is controlled mainly by such ore-forming conditions as temperature and pressure. Deep-seated ore-forming fluids are characterized mainly by injection and precipitation. So the vein bodies in the adjacent metallogenic structures are of obvious comparability, and there would be great prospects for ore search both at depth and in the periphery of the Shihu gold deposit. Therefore, ore prospecting should be strengthened both at depth and in the peripheries. | NIU Shuyin WANG Baode SUN Aiqun CHEN Chao WANG Zili MA Baojun WANG Wenxue JIANG Xiaoping ZHAO Yongli GAO Yincang LIU Huabin QIU Jianping | 2009 | Chinese Journal Of Geochemistry2009，28，4： | 6 |
| 3 | Fine mapping of the rice bacterial blight resistance gene Xa-4 and its co-segregation marker显示文摘An F2 population developed from the Xa-4 near isogenic lines, IR24 and IRBB4, was used for fine mapping of the rice bacterial blight resistance gene, Xa-4. Some restriction fragment length polymorphism (RFLP) markers on the high-density map constructed by Harushima et al. and the amplified DMA fragments homologous to the conserved domains of plant disease resistance (R) genes were used to construct the genetic linkage map around the gene Xa-4 by scoring susceptible individuals in the population. Xa-4 was mapped between the RFLP marker G181 and the polymerase chain reaction (PCR) marker M55. The R gene homologous fragment marker RS13 was found co-segregating with Xa-4 by analyzing all the plants in the population. This result opened an approach to map-based cloning of this gene, and marker RS13 can be applied to molecular marker-assisted selection of Xa-4 in rice breeding programs. | WANG Wenming ZHOU Yongli JIANG Guanhuai MA Bojun CHEN Xuewei ZHANG Qi ZHU Lihuang ZHAI Wenxue | 2000 | Chinese Science Bulletin2000，45，19： | 4 |
| 4 | Rice Interploidy Crosses Disrupt Epigenetic Regulation, Gene Expression, and Seed Development显示文摘在被子植物的种子开发在内乳要求 2:1 maternal-to-paternal 染色体比率(2m:1p ) 。当比率被破坏时,种子发展被损害。瑞斯 interploidy 十字导致内乳失败,但是内在的分子的机制仍然保持不清楚。这里,我们报导在米饭 interploidy 十字的有缺点的内乳与小 RNA 和编码蛋白质的基因的 nonadditive 表示被联系。有趣地, 24-nt 小介入 RNA 被充实在 5 和 3 ? flanking 序列 nonadditively 在 interploidy 十字表示了基因并且否定地与印的基因的表示被联系。而且,一些 PRC2 家庭基因和 DNA 包括 OsMET1b 和 OsCMT3a 的 methylation 相关的基因是在 2 湡散愠摮椠据敲獡摥礠敩摬鵸?鵸 的 upregulated?? | Limei Wang Jingya Yuan Yujie Ma Wu Jiao Wenxue Ye Dong-Lei Yang Chuandeng Yi Z. Jeffrey Chen | 2018 | Molecular Plant2018，11，2： | 3 |
| 5 | Comprehensive utilization of corn starch processing by-products:A review显示文摘Corn is a high starchy cereal crop with the highest production and provides over 85%of the starch produced worldwide.Various by-products,differentiated by technological process features such as steep liquor,corn germ,corn bran,gluten,are created largely during corn starch processing.They are inexpensive,nutrient-rich,and vary widely in chemical composition such as proteins,oils,carbohydrates,and minerals.In an increasingly resource-constrained modern world,the utilization approach of these by-products for non-starch industrial processing is attractive widely considering both nutritive value and economic aspects.In fact,at present,applications of these by-products can often be found in feed,fermentation,nutrient extraction and other industries.For example,protein-rich corn gluten can be used as a good animal feed,and corn germ can be used as a raw material for the high-quality edible oil industry.Undoubtedly,increasing utilization means that these by-products will no longer be treated as waste but will be transformed into high value-added products.In this work,the separation process and chemical composition of several main by-products of the corn starch industry is briefly described,and the application in many industrial fields of these by-products over the last ten years are discussed in particular.This review attempts to summarize all aspects of the application and research of these by-products.For the by-products of the corn starch industry,the most promising way is to be utilized in high value and used to produce high value-added products.According to the characteristics of their chemical composition,they have a better application prospect and research significance in the industries directly related to human beings,such as medicine,green food and health care products.In fact,in recent years,some researchers have recognized this and carried out the research.It is clear fromthese studies that the main issues to be faced nowand in the future are how to produce efficiently while maintaining the quality of the product and using it effectively.The retrospective discussions also provide some ideas for other grain and oilseed crops to be fully utilized. | Runyang Zhang Sen Ma Li Li Minghui Zhang Shuangqi Tian Dongying Wang Kunlun Liu Huamin Liu Wenxue Zhu Xuede Wang | 2021 | Grain & Oil Science and Technology2021，4，3： | 3 |
| 6 | SPL5, a cell death and defense-related gene, encodes a putative splicing factor 3b subunit 3 (SF3b3) in rice显示文摘 | Xifeng Chen Liang Hao Jianwei Pan Xixi Zheng Guanghuai Jiang Yang Jin Zhimin Gu Qian Qian Wenxue Zhai Bojun Ma | 2012 | Molecular Breeding2012，，2： | 2 |
| 7 | New β-delayed Proton Precursor ^(135)Gd显示文摘Newβ-delayedProtonPrecursor^(135)Gd￥XuShuwei;XieYuanxiang;LiZhankui;MaRuichang;GeYuanxiu;WangChunfang;GuoBing;XingJianping;Hu?.. | Xu Shuwei Xie Yuanxiang Li Zhankui Ma Ruichang Ge Yuanxiu Wang Chunfang Guo Bing Xing Jianping Huang Wenxue Zhang Tianmei Liu Zhong Zhu Shaofei Jin Genming and Luo Yixiao | 1996 | IMP & HIRFL Annual Report1996，，1： | 2 |
| 8 | Neaw β-delayed proton precursor121Ce near the proton drip-line显示文摘 | Shuwei Xu Zhankui Li Yuanxiang Xie Ruichang Ma Yuanxiu Ge Chunfang Wang Wenxue Huang Tianmei Zhang | 1998 | Science in China Series A: Mathematics1998，，11： | 1 |
| 9 | Neaw β-delayed proton precursor121Ce near the proton drip-line显示文摘 | Shuwei Xu Zhankui Li Yuanxiang Xie Ruichang Ma Yuanxiu Ge Chunfang Wang Wenxue Huang Tianmei Zhang | 1998 | Science in China Series A: Mathematics1998，，11： | 1 |
| 10 | Newβ-delayed proton precursor135Gd显示文摘 | Shuwei Xu Yuanxiang Xie Zhankui Li Ruichang Ma Yuanxiu Ge Chunfang Wang Bing Guo Jianping Xing Wenxue Huang Tianmei Zhang Zhong Liu Shaofei Zhu | 1996 | Zeitschrift für Physik A: Hadrons and Nuclei1996，，1： | 1 |
| 11 | Preparation of murine B7,1-glycosylphosphatidylinositol and transmembrane-anchored staphylococcal enterotoxin显示文摘 | Pingyong Yi Hai Yu Wenxue Ma | | 0，，07： | 1 |
| 12 | Flavonoid constituents and antioxidant capacity in flowers of different Zhongyuan tree penoy cultivars显示文摘 | Jinling Fan Wenxue Zhu Huaibin Kang Haile Ma Guanjun Tao | 2011 | Journal of Functional Foods2011，，1： | 1 |
| 13 | Newβ-delayed proton precursor135Gd显示文摘 | Shuwei Xu Yuanxiang Xie Zhankui Li Ruichang Ma Yuanxiu Ge Chunfang Wang Bing Guo Jianping Xing Wenxue Huang Tianmei Zhang Zhong Liu Shaofei Zhu | 1996 | Zeitschrift für Physik A: Hadrons and Nuclei1996，，1： | 1 |
| 14 | Rational design of a novel two-dimensional porous metal-organic framework material for efficient benzene sensor显示文摘As a common volatile organic compound,benzene(C_(6)H_(6)) exists in home decoration pollution gas widely,which causes great harm to the environment and human health.Therefore,it is necessary to rationally design advanced materials with high selectivity to detect and capture C_(6)H_(6).Herein,combined with the d-band center theory and cohesive energy,a new two-dimensional metal-organic framework material,Ni-doped hexaaminobenzene-based coordination polymer(Ni-HAB-CP)is designed,and its application potential as a C_(6)H_(6) sensor are systematically investigated by using first principles calculation.The result shows that Ni-HAB-CP has a strong adsorption for C_(6)H_(6) without any additional method.In addition,NiHAB-CP can maintain good conductivity before and after adsorption,and C_(6)H_(6) can be easily desorbed from the surface of Ni-HAB-CP by charge control.Moreover,the I-V curve calculated by Atomistix Toolkit(ATK)reveals that Ni-HAB-CP has high sensitivity and selectivity to C_(6)H_(6).Hence,Ni-HAB-CP is expected to be used as a potential material for a highly efficient and recyclable C_(6)H_(6) sensor in the future.The calculation and analysis methods used in this paper could provide a certain theoretical basis and reference for the future research of gas sensors. | Wenxue Zhang Huiyu Ma Tongtong Li Cheng He | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 15 | Efficient selection of homozy-gous lines of hybrid rice restorer with the transgene Xa21 using test cross and PCR显示文摘The homozygous restorer lines with a single copy of the transgene Xa21 have been obtained from the progenies of transgenic Minghui63 and Yanhui559 plants through PCR marker-assisted selection and test cross. These homozygoustransgenic restorer lines can be used to breed hybrid rice with high resistance to bacterial leaf blight. | MA Bojun WANG Wenming ZOU Junhuang LIU Guoqing FANG Jin ZHU Lihuang ZHAI Wenxue | 2001 | Chinese Science Bulletin2001，46，2： | 0 |
| 16 | Opportunities and challenges of CD47-targeted therapy in cancer immunotherapy显示文摘Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer,with the tumor microenvironment(TME)playing a pivotal role in modulating the immune response.CD47,a cell surface protein,has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer therapy.However,the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely understood.This comprehensive review aims to provide an overview of CD47’s multifaced role in TME regulation and immune evasion,elucidating its impact on various types of immunotherapy outcomes,including checkpoint inhibitors and CAR T-cell therapy.Notably,CD47-targeted therapies offer a promising avenue for improving cancer treatment outcomes,especially when combined with other immunotherapeutic approaches.The review also discusses current and potential CD47-targeted therapies being explored for cancer treatment and delves into the associated challenges and opportunities inherent in targeting CD47.Despite the demonstrated effectiveness of CD47-targeted therapies,there are potential problems,including unintended effects on healthy cells,hematological toxicities,and the development if resistance.Consequently,further research efforts are warranted to fully understand the underlying mechanisms of resistance and to optimize CD47-targeted therapies through innovative combination approaches,ultimately improving cancer treatment outcomes.Overall,this comprehensive review highlights the significance of CD47 as a promising target for cancer immunotherapy and provides valuable insight into the challenges and opportunities in developing effective CD47-targeted therapies for cancer treatment. | QIUQIANG CHEN XUEJUN GUO WENXUE MA | 2024 | Oncology Research2024，32，1： | 0 |
| 17 | Game-changing insights on vertebral skeletal stem cells in bone metastasis and therapeutic horizons显示文摘Greenblatt and his team have unveiled vertebral skeletal stem cells(vSSCs)as a critical player in the landscape of bone metastasis.This commentary delves into the transformative discoveries surrounding vSSCs,emphasizing their distinct role in bone metastasis compared to other stem cell lineages.We illuminate the unique properties and functions of vSSCs,which may account for the elevated susceptibility of vertebral bones to metastatic invasion.Furthermore,we explore the exciting therapeutic horizons opened by this newfound understanding.These include potential interventions targeting vSSCs,modulation of associated signaling pathways,and broader implications for the treatment and management of bone metastasis.By shedding light on these game-changing insights,we hope to pave the way for novel strategies that could revolutionize the prognosis and treatment landscape for cancer patients with metastatic bone disease. | QIUQIANG CHEN XIAOLEI ZHAO WENXUE MA | 2024 | Oncology Research2024，32，1： | 0 |
| 18 | Role of selenoprotein M knockdown in the melatonin antagonism of nickel-induced apoptosis and endoplasmic reticulum stress in mouse heart显示文摘The aim of this study was to investigate the role of selenoprotein M(SelM)in endoplasmic reticulum stress and apoptosis in nickel-exposed mouse hearts and to explore the detoxifying effects of melatonin.At 21 d after intraperitoneal injection of nickel chloride(NiCl_(2))and/or melatonin into male wild-type(WT)and SelM knockout(KO)C57BL/6J mice,NiCl_(2)was found to induce changes in the microstructure and ultrastructure of the hearts of both WT and SelM KO mice,which were caused by oxidative stress,endoplasmic reticulum stress,and apoptosis,as evidenced by decreases in malondialdehyde(MDA)content and total antioxidant capacity(T-AOC)activity.Changes in the messenger RNA(mRNA)and protein expression of genes related to endoplasmic reticulum stress(activating transcription factor 4(ATF4),inositol-requiring protein 1(IRE1),c-Jun N-terminal kinase(JNK),and C/EBP homologous protein(CHOP))and apoptosis(B-cell lymphoma-2(Bcl-2),Bcl-2-associated X protein(Bax),Caspase-3,Caspase-9,and Caspase-12)were also observed.Notably,the observed damage was worse in SelM KO mice.Furthermore,melatonin alleviated the heart injury caused by NiCl_(2)in WT mice but could not exert a good protective effect in the heart of SelM KO mice.Overall,the findings suggested that the antioxidant capacity of SelM,as well as its modulation of endoplasmic reticulum stress and apoptosis,plays important roles in nickel-induced heart injury. | Xintong ZHANG Xiaoxue GAI Lihua XU Wenxue MA Qiaohan LIU Bendong SHI Cheng FANG Jingzeng CAI Ziwei ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，5： | 0 |
| 19 | Quantitative characterization of cell physiological state based on dynamical cell mechanics for drug efficacy indication显示文摘Cell mechanics is essential to cell development and function,and its dynamics evolution reflects the physiological state of cells.Here,we investigate the dynamical mechanical properties of single cells under various drug conditions,and present two mathematical approaches to quantitatively characterizing the cell physiological state.It is demonstrated that the cellular mechanical properties upon the drug action increase over time and tend to saturate,and can be mathematically characterized by a linear timeinvariant dynamical model.It is shown that the transition matrices of dynamical cell systems significantly improve the classification accuracies of the cells under different drug actions.Furthermore,it is revealed that there exists a positive linear correlation between the cytoskeleton density and the cellular mechanical properties,and the physiological state of a cell in terms of its cytoskeleton density can be predicted from its mechanical properties by a linear regression model.This study builds a relationship between the cellular mechanical properties and the cellular physiological state,adding information for evaluating drug efficacy. | Shuang Ma Junfeng Wu Zhihua Liu Rong He Yuechao Wang Lianqing Liu Tianlu Wang Wenxue Wang | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 0 |
| 20 | Population genomics reveals demographic history and selection signatures of hazelnut (Corylus)显示文摘Hazelnut(Corylus spp.)is known as one of the four famous tree nuts in the world due to its pleasant taste and nutritional benefits.However,hazelnut promotion worldwide is increasingly challenged by global climate change,limiting its production to a few regions.Focusing on the eurytopic Section Phyllochlamys,we conducted whole-genome resequencing of 125 diverse accessions from five geo-ecological zones in Eurasia to elucidate the genomic basis of adaptation and improvement.Population structure inference outlined five distinct genetic lineages corresponding to climate conditions and breeding background,and highlighted the differentiation between European and Asian lineages.Demographic dynamics and ecological niche modeling revealed that Pleistocene climatic oscillations dominantly shaped the extant genetic patterns,and multiple environmental factors have contributed to the lineage divergence.Whole-genome scans identified 279,111,and 164 selective sweeps that underlie local adaptation in Corylus heterophylla,Corylus kweichowensis,and Corylus yunnanensis,respectively.Relevant positively selected genes were mainly involved in regulating signaling pathways,growth and development,and stress resistance.The improvement signatures of hybrid hazelnut were concentrated in 312 and 316 selected genes,when compared to C.heterophylla and Corylus avellana,respectively,including those that regulate protein polymerization,photosynthesis,and response to water deprivation.Among these loci,22 candidate genes were highly associated with the regulation of biological quality.Our study provides insights into evolutionary processes and the molecular basis of how sibling species adapt to contrasting environments,and offers valuable resources for future climate-resilient breeding. | Zhen Yang Wenxu Ma Lujun Wang Xiaohong Yang Tiantian Zhao Lisong Liang Guixi Wang Qinghua Ma | 2023 | Horticulture Research2023，10，5： | 0 |
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