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| 1 | Clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis显示文摘AIM To assess differences in clinical outcomes of isolated renal failure(RF) compared to other forms of organ failure(OF) in patients with severe acute pancreatitis(SAP).METHODS Using a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ(2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded. Differences in clinical outcomes after development of isolated RF in comparison to other forms of OF were determined using independent t and Mann-Whitney U tests for continues variables, and χ~2 test for discrete variables.RESULTS Among 500 patients with acute pancreatitis, 111 patients developed persistent OF: mean age was 54 years, and 75(67.6%) were male. Forty-three patients had isolated OF: 17(15.3%) renal, 25(21.6%) respiratory, and 1(0.9%) patient with cardiovascular failure. No differences in demographics, etiology of acute pancreatitis, systemic inflammatory response syndrome scores, or development of pancreatic necrosis were seen between patients with isolated RF vs isolated respiratory failure. Patients with isolated RF were less likely to require nutritional support(76.5% vs 96%, P = 0.001), ICU admission(58.8% vs 100%, P = 0.001), and had shorter mean ICU stay(2.4 d vs 15.7 d, P < 0.001), compared to isolated respiratory failure. None of the patients with isolated RF or isolated respiratory failure died.CONCLUSION Among patients with SAP per the Revised Atlanta Classification, approximately 15% develop isolated RF. This subgroup seems to have a less protracted clinical course compared to other forms of OF. Isolated RF might be weighed less than isolated respiratory failure in risk predictive modeling of acute pancreatitis. | Amir Gougol Mohannad Dugum Anwar Dudekula Phil Greer Adam Slivka David C Whitcomb Dhiraj Yadav Georgios I Papachristou | 2017 | World Journal of Gastroenterology2017，23，29： | 20 |
| 2 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 3 | Determinant-Based Classification of Acute Pancreatitis Severity: An International Multidisciplinary Consultation显示文摘 | E. Patchen Dellinger Christopher E. Forsmark Peter Layer Philippe Lévy Enrique Maraví-Poma Maxim S. Petrov Tooru Shimosegawa Ajith K. Siriwardena Generoso Uomo David C. Whitcomb John A. Windsor | 2012 | Annals of Surgery2012，，6： | 7 |
| 4 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 5 | Natural orifice surgery: initial clinical experience显示文摘 | Santiago Horgan John P. Cullen Mark A. Talamini Yoav Mintz Alberto Ferreres Garth R. Jacobsen Bryan Sandler Julie Bosia Thomas Savides David W. Easter Michelle K. Savu Sonia L. Ramamoorthy Emily Whitcomb Sanjay Agarwal Emily Lukacz Guillermo Dominguez Ped | 2009 | Surgical Endoscopy2009，，7： | 5 |
| 6 | Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice显示文摘 | Rui Kang Qiuhong Zhang Wen Hou Zhenwen Yan Ruochan Chen Jillian Bonaroti Preeti Bansal Timothy R. Billiar Allan Tsung Qingde Wang David L. Bartlett David C. Whitcomb Eugene B. Chang Xiaorong Zhu Haichao Wang Ben Lu Kevin J. Tracey Lizhi Cao Xue-Gong Fan M | 2013 | Gastroenterology2013，，： | 2 |
| 7 | Comparison of Existing Clinical Scoring Systems to Predict Persistent Organ Failure in Patients With Acute Pancreatitis显示文摘 | Rawad Mounzer Christopher J. Langmead Bechien U. Wu Anna C. Evans Faraz Bishehsari Venkata Muddana Vikesh K. Singh Adam Slivka David C. Whitcomb Dhiraj Yadav Peter A. Banks Georgios I. Papachristou | 2012 | Gastroenterology2012，，7： | 2 |
| 8 | Chronic Pancreatitis: Diagnosis, Classification, and New Genetic Developments显示文摘 | Babak Etemad David C. Whitcomb | 2001 | Gastroenterology2001，，3： | 2 |
| 9 | Chronic Pancreatitis: Diagnosis, Classification, and New Genetic Developments显示文摘 | Babak Etemad David C. Whitcomb | 2001 | Gastroenterology2001，，3： | 2 |
| 10 | SPINK1 Is a Susceptibility Gene for Fibrocalculous Pancreatic Diabetes in Subjects from the Indian Subcontinent显示文摘 | Zahid Hassan Viswananthan Mohan Liaquat Ali Rebecca Allotey Khalid Barakat M. Omar Faruque Raj Deepa Michael F. McDermott Alan E. Jackson Paul Cassell David Curtis Susan V. Gelding Shanti Vijayaravaghan Niklaus Gyr David C. Whitcomb A.K. Azad Khan Graham | 2002 | The American Journal of Human Genetics2002，，4： | 1 |
| 11 | Genetic Aspects of Pancreatitis显示文摘 | David C. Whitcomb | 2010 | Annual Review of Medicine2010，，： | 1 |
| 12 | Chronic Pancreatitis: Diagnosis, Classification, and New Genetic Developments显示文摘 | Babak Etemad David C. Whitcomb | 2001 | Gastroenterology2001，，3： | 1 |
| 13 | Pain in Chronic Pancreatitis and Pancreatic Cancer显示文摘 | Kenneth E. Fasanella Brian Davis John Lyons Zongfu Chen Kenneth K. Lee Adam Slivka David C. Whitcomb | 2007 | Gastroenterology Clinics of North America2007，，2： | 1 |
| 14 | SPINK1/PSTI Polymorphisms Act as Disease Modifiers in Familial and Idiopathic Chronic Pancreatitis显示文摘 | Roland H. Pfützer* M.Michael Barmada? Andrew P.J. Brunskill§ ∥ Robert Finch* ? P.Suzanne Hart? ? John Neoptolemos# William F. Furey§ ∥ David C. Whitcomb* ?? ** ?? | 2000 | Gastroenterology2000，，3： | 1 |
| 15 | Is the Monocyte Chemotactic Protein-1 ?2518 G Allele a Risk Factor for Severe Acute Pancreatitis?显示文摘 | Georgios I. Papachristou David A. Sass Haritha Avula Janette Lamb Anna Lokshin M. Michael Barmada Adam Slivka David C. Whitcomb | 2005 | Clinical Gastroenterology and Hepatology2005，，5： | 1 |
| 16 | SPINK1/PSTI mutations are associated with tropical pancreatitis and type II diabetes mellitus in Bangladesh显示文摘 | Alexander Schneider Amitabh Suman Livio Rossi M.Michael Barmada Christoph Beglinger Shahana Parvin Soheli Sattar Liaquat Ali A.K.Azad Khan Niklaus Gyr David C. Whitcomb | 2002 | Gastroenterology2002，，4： | 1 |
| 17 | How to think about SPINK and pancreatitis显示文摘 | David C Whitcomb | 2002 | The American Journal of Gastroenterology2002，，5： | 1 |
| 18 | Chronic Pancreatitis: Diagnosis, Classification, and New Genetic Developments显示文摘 | Babak Etemad David C. Whitcomb | 2001 | Gastroenterology2001，，3： | 1 |
| 19 | SPINK1/PSTI Polymorphisms Act as Disease Modifiers in Familial and Idiopathic Chronic Pancreatitis显示文摘 | Roland H. Pfützer* M.Michael Barmada? Andrew P.J. Brunskill§ ∥ Robert Finch* ? P.Suzanne Hart? ? John Neoptolemos# William F. Furey§ ∥ David C. Whitcomb* ?? ** ?? | 2000 | Gastroenterology2000，，3： | 1 |
| 20 | Portosplenomesenteric Venous Thrombosis in Patients With Acute Pancreatitis Is Associated With Pancreatic Necrosis and Usually Has a Benign Course显示文摘 | Jeffrey Easler Venkata Muddana Alessandro Furlan Anil Dasyam Kishore Vipperla Adam Slivka David C. Whitcomb Georgios I. Papachristou Dhiraj Yadav | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 1 |
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