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| 1 | Episodic rifting of continental marginal basins and tectonic events since 10 Ma in the South China Sea显示文摘Integrated study on the tectonic, basin filling and thermal evolution of the Tertiary basins on the northern margin of the South China Sea has indicated that the rift continental margin on the northern South China Sea is not a passive margin and that the western margin is characteristic of the transformextension. Episodic rifting and the thermal events since 10 Ma in the area have been documented by the integrated analysis of dynamic process. It has been clarified that the tectono-thermal events have exerted a significant influence on basin features and hydrocarbon accumulation, and particularly, the westward collision of the Lusong Island Arc, the generation of densely spaced faults in the Pearl River Mouth Basin, the rapid subsidence, high heat flow and large-scale over pressure and thermal-fluid breakthrough in the Yinggehai and the Qiongdongnan basins have proved to be the important factors determining the formation of oil and gas in these basins. | Sitian Li Changsong Lin Qiming Zhang Shigong Yang Peikan Wu | 1999 | Chinese Science Bulletin1999，44，1： | 27 |
| 2 | Hydrocarbon Accumulation Conditions of Ordovician Carbonate in Tarim Basin显示文摘基于形成水库的条件,水库的差异和多级式的烃充电的差别的全面分析是为在 Tarim 盆的奥陶纪的碳酸盐烃累积的关键因素。经历四个主要免职构造的周期,奥陶纪碳酸盐形成了一个稳定的结构的框架与巨大高举,在哪个是礁石银行类型和不顺从类型的发达水库,并且在古苏格兰的、迟了的 Hercynian 期间导致多级式的烃充电和累积并且迟了喜玛拉雅。与低矩阵孔和奥陶纪碳酸盐的渗透,第二等的答案毛孔和大洞用作主要水库空间。多相的构造运动形成了广泛地在 paleo 高举附近散布的不顺从水库;并且礁石银行水库被二种沉积外形带控制,也就是陡峭的斜坡和轻轻的斜坡。异乎寻常的碳酸盐水池被水库控制的广泛的分发,没有明显的边水或底部水,复杂油 / 气体 / 水关系和严重异质描绘。和多时期烃累积的低孔和低渗透水库导致了油 / 气体 / 水的分发和生产的差别和建筑群。烃的分发被在来源岩石和 paleo 高举的革命之间的时间空间的关系控制。heterogenetic 碳酸盐水库和迟了阶段的煤气的充电是做 oil/ 气体阶段的主要因素复杂。形成在的 paleo 高举的斜坡区域古生代基于全面评估是主要碳酸盐探索方向。Tazhong 的北斜坡的奥陶纪高举, Lunnan 和它的圆周区域是实际探索域。Yengimahalla-Hanikatam 和 Markit 斜坡是为碳酸盐探索的重要代替目标。Gucheng, Tadong,在 Lunnan 和 Tazhong-Bachu 区域的寒武纪的白云石的深层是为研究和风险探索的有利方向。 | LI Qiming WU Guanghui PANG Xiongqi PAN Wenqin LUO Chunshu WANG Chenglin LI Xinsheng ZHOU Bo | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 10 |
| 3 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 4 | The City Intelligence Quotient (City IQ) Evaluation System" Conception and Evaluation显示文摘 | Zhiqiang Wu Yunhe Pan Qiming Ye Lingyu Kong | 2016 | Engineering2016，2，2： | 7 |
| 5 | UAV cooperative air combat maneuver decision based on multi-agent reinforcement learning显示文摘In order to improve the autonomous ability of unmanned aerial vehicles(UAV)to implement air combat mission,many artificial intelligence-based autonomous air combat maneuver decision-making studies have been carried out,but these studies are often aimed at individual decision-making in 1 v1 scenarios which rarely happen in actual air combat.Based on the research of the 1 v1 autonomous air combat maneuver decision,this paper builds a multi-UAV cooperative air combat maneuver decision model based on multi-agent reinforcement learning.Firstly,a bidirectional recurrent neural network(BRNN)is used to achieve communication between UAV individuals,and the multi-UAV cooperative air combat maneuver decision model under the actor-critic architecture is established.Secondly,through combining with target allocation and air combat situation assessment,the tactical goal of the formation is merged with the reinforcement learning goal of every UAV,and a cooperative tactical maneuver policy is generated.The simulation results prove that the multi-UAV cooperative air combat maneuver decision model established in this paper can obtain the cooperative maneuver policy through reinforcement learning,the cooperative maneuver policy can guide UAVs to obtain the overall situational advantage and defeat the opponents under tactical cooperation. | ZHANG Jiandong YANG Qiming SHI Guoqing LU Yi WU Yong | 2021 | Journal of Systems Engineering and Electronics2021，32，6： | 6 |
| 6 | Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup analysis of a randomized phase 2 study (ALTER1202)显示文摘Patients with small-cell lung cancer (SCLC) relapse within months after completing previous therapies. This study aimed to investigate the efficacy and safety of anlotinib as third- or further-line therapy in patients with short-term relapsed SCLC from ALTER1202. Patients with short-term relapsed SCLC (disease progression within 3 months after completing ≥ two lines of chemotherapy) in the anlotinib (n = 67) and placebo (n = 34) groups were analyzed. The primary endpoint was progression-free survival (PFS). The secondary endpoints included overall survival, objective response rate (ORR), disease control rate, and safety. Anlotinib significantly improved median PFS/OS (4.0 vs. 0.7 months, P < 0.0001)/(7.3 vs. 4.4 months, P = 0.006) compared with placebo. The ORR was 4.5%/2.9% in the anlotinib/placebo group (P = 1.000). The DCR in the anlotinib group was higher than that in the placebo group (73.1% vs. 11.8%, P < 0.001). The most common adverse events (AEs) were hypertension (38.8%), loss of appetite (28.4%), and fatigue (22.4%) in the anlotinib group and gamma-glutamyl transpeptidase elevation (20.6%) in the placebo group. No grade 5 AEs occurred. For patients with short-term relapsed SCLC, third- or further-line anlotinib treatment was associated with improved survival benefit. Further studies are warranted in this regard. | Jianhua Shi Ying Cheng Qiming Wang Kai Li Lin Wu Baohui Han Gongyan Chen Jianxing He Jie Wang Haifeng Qin Xiaoling Li | 2022 | Frontiers of Medicine2022，16，5： | 5 |
| 7 | Filamin B:The next hotspot in skeletal research?显示文摘Filamin B(FLNB)is a large dimeric actin-binding protein which crosslinks actin cytoskeleton filaments into a dynamic structure.Up to present,pathogenic mutations in FLNB are solely found to cause skeleta deformities,indicating the important role of FLNB in skeletal development.FLNB-related disorders are classifiedasspondylocarpotarsalsynostosis(SCT),Larsensyndrome(LS),atelosteogenesis(AO)boomerang dysplasia(BD),and isolated congenital talipes equinovarus,presenting with scoliosis,shortlimbed dwarfism,clubfoot,joint dislocation and other unique skeletal abnormalities.Several mecha?nisms of FLNB mutations causing skeletal malformations have been proposed,including delay of ossification in long bone growth plate,reduction of bone mineral density(BMD),dysregulation of muscle differentiation,ossification of intervertebral disc(IVD),disturbance of proliferation,differentiation and apoptosis in chondrocytes,impairment of angiogenesis,and hypomotility of osteoblast,chondrocyte and fibroblast.Interventions on FLNB-related diseases require prenatal surveillance by sonography,gene testing in high-risk carriers,andproper orthosis or orthopedic surgeries to correct malformations including scoliosis,cervical spine instability,large joint dislocation,and clubfoot.Gene and cell therapies for FLNB-related diseases are also promising but require further studies. | Qiming xu Nan Wu Lijia Cui Zhihong Wu Guixing Qiu | 2017 | Journal of Genetics and Genomics2017，44，7： | 5 |
| 8 | Ductile and ultrahigh-strength eutectic high-entropy alloys by large-volume 3D printing显示文摘1.Introduction Additive manufacturing or 3D printing outweighs conventional casting methods in the aspect of complex parts fabrication,which can realize one-step formation without the need of complicated cast dies.3D printing significantly promotes industrial production for making near-net shaped components.However,this promising technique is not always ideally applicable for metals and alloys.For example,titanium alloys prepared by 3D printing often suf-fer from poor plasticity,and usually require further complex heat treatment or hot isostatic pressing treatment,in order to remove internal stress and regulate plasticity and strength[1,2],which de-feats the original intention of employing additive manufacturing.One of the fundamental causes for such issues is the low fluidity of the alloys upon melting,leading to great chemical heterogeneity,high porosity content and residual stresses.This limitation hinders further design and fabrication of high-performance printable alloys from large scale production and application. | Yiping Lu Xiaoxiang Wu Zhenghong Fu Qiankun Yang Yong Zhang Qiming Liu Tianxin Li Yanzhong Tian Hua Tan Zhiming Li Tongmin Wang Tingju Li | 2022 | Journal of Materials Science & Technology2022，，31： | 4 |
| 9 | LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells显示文摘LIN28 is an RNA binding protein with important roles in early embryo development,stem cell differentiation/re-programming,tumorigenesis and metabolism.Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs,and few have addressed LIN28's role within the nucleus.Here,we show that LIN28 displays dynamic temporal and spatial expression during murine embryo development.Maternal LIN28 expression drops upon exit from the 2-cell stage,and zygotic LIN28 protein is induced at the forming nucleolus during 4-cell to blas-tocyst stage development,to become dominantly expressed in the cytosol after implantation.In cultured pluripotent stem cells(PSCs),loss of LIN28 led to nucleolar stress and activation of a 2-cell/4-cell-like transcriptional program characterized by the expression of endogenous retrovirus genes.Mechanistically,LIN28 binds to small nucleolar RNAs and rRNA to maintain nucleolar integrity,and its loss leads to nucleolar phase separation defects,ribosomal stress and activation of P53 which in turn binds to and activates 2C transcription factor Dux.LIN28 also resides in a complex containing the nucleolar factor Nucleolin(NCL)and the transcrip-tional repressor TRIM28,and LIN28 loss leads to reduced occupancy of the NCL/TRIM28 complex on the Dux and rDNA loci,and thus de-repressed Dux and reduced rRNA expression.Lin28 knockout cells with nucleolar stress are more likely to assume a slowly cycling,translationally inert and anabolically inactive state,which is a part of previously unappreciated 2C-like transcriptional program.These findings elucidate novel roles for nucleolar LIN28 in PSCs,and a new mechanism linking 2C program and nucleolar functions in PSCs and early embryo development. | Zhen Sun Hua Yu Jing Zhao Tianyu Tan Hongru Pan Yuqing Zhu Lang Chen Cheng Zhang Li Zhang Anhua Lei Yuyan Xu Xianju Bi Xin Huang Bo Gao Longfei Wang Cristina Correia Ming Chen Qiming Sun Yu Feng Li Shen Hao Wu Jianlong Wang Xiaohua Shen George Q.Daley Hu Li Jin Zhang | 2022 | Protein & Cell2022，13，7： | 4 |
| 10 | Geology, Geochronology, and Hf Isotopic Composition of the Pha Lek Fe Deposit, Northern Laos: Implications for Early Permian Subduction-Related Skarn Fe Mineralization in the Truong Son Belt显示文摘The Truong Son metallogenic belt in central Laos and Vietnam is an important Fe-Cu-Sn-Au polymetallic ore district. The Pha Lek Fe deposit is closely related to Late Carboniferous– Early Permian I-type granitic magmatism, and contains >50 Mt @ 45% to 50% of Fe ore. Ore minerals occur mainly as magnetite and hematite in the skarn alteration zone between a granitic pluton and metamorphosed Middle–Upper Devonian carbonates. The granitic pluton comprises granodiorite and granite, with zircon U-Pb dating indicating synchronous emplacement at 288.2±1.3 and 284.9±1.2 Ma, respectively. Zircons from these granitoids have ε_(Hf)(t) values of 2.9–11.2 and relatively young TDM2 ages(<1.0 Ga), indicating an origin by partial melting of depleted mafic crust or magma mixing. Previous studies have shown that these granitoids have high Y, Yb, and K_2O contents, and low Sr and Na_2O contents, which are interpreted as the melting of mafic continental crust. Pyrite of the main mineralization stage yields an ^(187)Re/^(188)Os-^(187)Os/^(188)Os isochron age of 287±17 Ma, indicating that mineralization is associated with Pha Lek granitic magmatism. A Late Carboniferous–Early Permian subduction-related skarn-type Fe mineralization model is proposed for the Pha Lek deposit. More evidence is needed to verify a hypothesis of volcanic overprinting during Late Triassic post-collisional extension. | Lin Hou Shusheng Liu Linnan Guo Fuhao Xiong Chao Li Meifeng Shi Qiming Zhang Siwei Xu Songyang Wu | 2019 | Journal of Earth Science2019，30，1： | 2 |
| 11 | Revealing the critical effect of solid electrolyte interphase on the deposition and detriment of Co(Ⅱ) ions to graphite anode显示文摘'Dissolution,migration,and deposition'of transition metal ions (TMIs) result in capacity degradation of lithium-ion batteries (LIBs).Understanding such detrimental mechanism of TMIs is critical to the development of LIBs with long cycle life.In most previous works,TMIs were directly introduced into the electrolyte to investigate such a detrimental mechanism.In these cases,the TMIs are deposited directly on the fresh anode surface.However,in the practical battery system,the TMIs are deposited on the anode covered with solid electrolyte interphase (SEI) film.Whether the pre-presence of SEI film on anode surface influences the deposition and detriment of TMIs is unclear.In this work,the deposition of Co element on graphite anode with and without SEI film were systematically studied.The results clearly show that,in comparison with that of fresh graphite (SEI-free),the presence of SEI film aggravates the deposition of Co ions due to the Li^(+)–Co^(2+) ion exchange between the SEI and Co^(2+)-containing electrolyte without the driving of the electric field,leading to faster capacity fading of graphite anode.Therefore,how to regulate electrolytes and film-forming additives to design the components of SEI and prevent its exchange with TMIs,is a crucial way to inhibit the deposition and detriment of TMIs on graphite anode. | Qiming Xie Jiawei Chen Lidan Xing Xianggui Zhou Zekai Ma Binhong Wu Yilong Lin Hebing Zhou Weishan Li | 2022 | Journal of Energy Chemistry2022，31，6： | 2 |
| 12 | Stable isotope geochemical characteristics of dissolved inorganic carbon in the Jiulong River Estuary, Fujian Province, China显示文摘The isotopic composition of dissolved inorganic carbon(DIC) in estuarine environments has been studied for its significant role in determining the isotopic composition of inorganic/organic matter and its applications to the study of various natural processes. In this paper, based on the stable isotope geochemical characteristics of dissolved inorganic carbon in the Jiulong River Estuary, the following conclusions are drawn:(1) δ13CDIC values are mainly controlled by the mixing ratio of fresh water and sea water;(2) δ13Cphytoplankton values are linearly related to the δ13CDIC values;(3) δ13CPOM values for the Jiulong River Estuary are affected by anthropogenic pollution significantly; and(4) the comprehensive analysis of δ13Cphytoplankton, δ13CPOM and δ13CDIC shows that along with increasing salinity, the proportion of POM derived from the degradation of phytoplanktons gradually increases. | LIU Qiming WU Qiong CAO Yinglan LIN Jinmei JIAO Yupei | 2014 | Chinese Journal Of Geochemistry2014，33，2： | 2 |
| 13 | Oxidation-strengthened disulfide-bridged prodrug nanoplatforms with cascade facilitated drug release for synergetic photochemotherapy显示文摘One of the major barriers in utilizing prodrug nanocarriers for cancer therapy is the slow release of parent drug in tumors.Tumor cells generally display the higher oxidative level than normal cells,and also displayed the heterogeneity in terms of redox homeostasis level.We previously found that the disulfide bond-linkage demonstrates surprising oxidationsensitivity to form the hydrophilic sulfoxide and sulphone groups.Herein,we develop oxidation-strengthened prodrug nanosystem loaded with pyropheophorbide a(PPa)to achieve light-activatable cascade drug release and enhance therapeutic efficacy.The disulfide bond-driven prodrug nanosystems not only respond to the redox-heterogeneity in tumor,but also respond to the exogenous oxidant(singlet oxygen)elicited by photosensitizers.Once the prodrug nanoparticles(NPs)are activated under irradiation,they would undergo an oxidative self-strengthened process,resulting in a facilitated drug cascade release.The IC50 value of the PPa@PTX-S-S NPs without irradiation was 2-fold higher than those of NPs plus irradiation.In vivo,the PPa@PTX prodrug NPs display prolonged systemic circulation and increased accumulation in tumor site.The PPa@PTXS-S NPs showed much higher efficiency than free PTX or the PPa@PTX-C-C NPs to suppress the growth of 4 T1 tumors.Therefore,this novel oxidation-strengthened disulfide-bridged prodrug-nanosystem has a great potential in the enhanced efficacy of cancer synergetic photochemotherapy. | Bin Yang Lin Wei Yuequan Wang Na Li Bin Ji Kaiyuan Wang Xuanbo Zhang Shenwu Zhang Shuang Zhou Xiaohui Yao Hang Song Yusheng Wu Haotian Zhang Qiming Kan Tao Jin Jin Sun | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，5： | 2 |
| 14 | First Synthesis and Characterization of Stereoisomers of Choleretic Drug Dihydroxydibutylether显示文摘Dihydroxydibutylether (DHBE ) 是由于它的 choleretic 活动和 hepatoprotective 行动为胆石和肝的混乱的处理使用的 choleretic 药。药是三 regioisomers 的混合物。主要 regioisomer 3-(3-hydroxylbutoxy )-1-butanol (III ) 包含四立体异构,包括(R)-3-((R)-3-hydroxylbutoxy)-1-butanol (IIIa ) ,(R)-3-((S)-3-hydroxylbutoxy)-1-butanol (IIIb ) ,(S)-3-((R)-3-hydroxylbutoxy)-1-butanol (IIIc ) 和(S)-3-((S)-3-hydroxylbutoxy)-1-butanol (标志) 。在这份报纸,四立体异构第一次独立被综合。 | Qiming Yue Yi Zhao Baohou Sun Li Hai Li Guo Yong Wu | 2015 | Chinese Journal of Chemistry2015，33，10： | 1 |
| 15 | A parallel multipole accelerated 3-D capacitance simulator based on an improved model显示文摘 | Zeyi Wang Yanhong Yuan Qiming Wu | 1996 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems1996，15，12： | 1 |
| 16 | Estimation of chlorophyll content in Brassica napus based on unmanned aerial vehicle images显示文摘The chlorophyll content has a direct effect on photosynthesis of crops.In order to explore a quick and convenient method for estimating the chlorophyll content of Brassica napus and facilitate efficient crop monitoring,we measured the actual value of chlorophyll with a SPAD-502 chlorophyll detector,and collected aerial images of B.napus with an unmanned aerial vehicle(UAV)carrying a RGB camera in this study.The total number of 270samples collected images were divided into regions according to the planting conditions of different B.napus varieties in the field.Then,according to the empirical formula,there were 36 colors’characteristic parameters calculated and combined.To estimate the chlorophyll content of rape,189 samples were included in the modeling set,while the other 81 samples were enrolled in the validation set for testing the accuracy of this model.After the combination of R(red),G(green)and B(blue)color channels,the results showed that the color characteristics B/(R+G),b,B/G,(G-B)/(G+B),g-b were highly connected with the measured value of chlorophyll SPAD,and the correlation coefficient between the combination based on B/(R+G)and SPAD value was 0.747.With R2=0.805,RMSE=3.343,and RE=6.84%,the regression model created using random forest had superior outcomes,according to the model comparison.This study offers a new method for quickly estimating the amount of chlorophyll in rapeseed and a workable reference for crop monitoring using the UAV platform. | Yayi Huang Qiming Ma Xiaoming Wu Hao Li Kun Xu Gaoxiang Ji Fang Qian Lixia Li Qian Huang Ying Long Xiaojun Zhang Biyun Chen Changhua Liu | 2022 | Oil Crop Science2022，7，3： | 1 |
| 17 | Dissolution of cellulose with ionic liquids and its application:a mini-review显示文摘 | Zhu Shengdong Wu Yuanxin Chen Qiming | 2006 | Green Chemistry2006，8，： | 1 |
| 18 | Dissolution of cellulose with ionic liquids and its application: a mini-review 显示文摘 | Zhu Shengdong Wu Yuanxin Chen Qiming | 2006 | Green Chemistry2006，8，4： | 1 |
| 19 | A two-dimensional resistance simulator using the boundary element method 显示文摘 | WANG Zeyi WU Qiming | 1992 | IEEE Trans on Computer-Aided Design of Integrated Circuits and Systems1992，11，49： | 1 |
| 20 | A parallel multipole accelerated 3-D capacitance simulator based on an improved model显示文摘 | Wang Zeyi Yuan Yanhong Wu Qiming | 1996 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems1996，15，12： | 1 |
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