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| 1 | A long-term Global LAnd Surface Satellite(GLASS)data-set for environmental studies显示文摘Recently,five Global LAnd Surface Satellite(GLASS)products have been released:leaf area index(LAI),shortwave broadband albedo,longwave broadband emissivity,incident short radiation,and photosynthetically active radiation(PAR).The first three products cover the years 19822012(LAI)and 19812010(albedo and emissivity)at 15 km and 8-day resolutions,and the last two radiation products span the period 20082010 at 5 km and 3-h resolutions.These products have been evaluated and validated,and the preliminary results indicate that they are of higher quality and accuracy than the existing products.In particular,the first three products have much longer time series,and are therefore highly suitable for various environmental studies.This paper outlines the algorithms,product characteristics,preliminary validation results,potential applications and some examples of initial analysis of these products. | Shunlin Liang Xiang Zhao Suhong Liu Wenping Yuan Xiao Cheng Zhiqiang Xiao Xiaotong Zhang Qiang Liu Jie Cheng Hairong Tang Yonghua Qu Yancheng Bo Ying Qu Huazhong Ren Kai Yu John Townshend | 2013 | International Journal of Digital Earth2013，6，S01： | 16 |
| 2 | Chromosome-scale genome assembly of sweet cherry(Prunus avium L.)cv.Tieton obtained using long-read and Hi-C sequencing显示文摘Sweet cherry(Prunus avium)is an economically significant fruit species in the genus Prunus.However,in contrast to other important fruit trees in this genus,only one draft genome assembly is available for sweet cherry,which was assembled using only Illumina short-read sequences.The incompleteness and low quality of the current sweet cherry draft genome limit its use in genetic and genomic studies.A high-quality chromosome-scale sweet cherry reference genome assembly is therefore needed.A total of 65.05 Gb of Oxford Nanopore long reads and 46.24 Gb of Illumina short reads were generated,representing~190x and 136x coverage,respectively,of the sweet cherry genome.The final de novo assembly resulted in a phased haplotype assembly of 344.29 Mb with a contig N50 of 3.25 Mb.Hi-C scaffolding of the genome resulted in eight pseudochromosomes containing 99.59%of the bases in the assembled genome.Genome annotation revealed that more than half of the genome(59.40%)was composed of repetitive sequences,and 40,338 protein-coding genes were predicted,75.40%of which were functionally annotated.With the chromosomescale assembly,we revealed that gene duplication events contributed to the expansion of gene families for salicylic acid/jasmonic acid carboxyl methyltransferase and ankyrin repeat-containing proteins in the genome of sweet cherry.Four auxin-responsive genes(two GH3s and two SAURs)were induced in the late stage of fruit development,indicating that auxin is crucial for the sweet cherry ripening process.In addition,772 resistance genes were identified and functionally predicted in the sweet cherry genome.The high-quality genome assembly of sweet cherry obtained in this study will provide valuable genomic resources for sweet cherry improvement and molecular breeding. | Jiawei Wang Weizhen Liu Dongzi Zhu Po Hong Shizhong Zhang Shijun Xiao Yue Tan Xin Chen Li Xu Xiaojuan Zong Lisi Zhang Hairong Wei Xiaohui Yuan Qingzhong Liu | 2020 | Horticulture Research2020，7，1： | 4 |
| 3 | The role of charged multivesicular body protein 5 in programmed cell death in leukemic cells显示文摘人(CHMP5 ) 现代人的控告的 multivesicular 身体蛋白质 5 是 multivesicular 身体的一个成员,它用作 anti-apoptotic 蛋白质并且被认为参予引起白血病。在这研究,一条短发卡的基于 RNA 的 RNA 干扰途径被用来在白血病的房间线 U937 禁止 CHMP5 的表示。在 CHMP5 被禁止以后,抗体 microarray 和西方的污点分析被用来在规划房间死亡(PCD ) 学习变化小径。PCD 能被分类进三种类型:apoptosis,坏死,和 autophagy。结果显示出那 caspase 3 在 CHMP5 缺乏的 U937 房间被激活,显示 apoptotic 小径被激活,尽管既不内在外来的 apoptotic 小径也没被激活。我们的结果也证明 Granzyme B/Perforin apoptotic 小径被 CHMP5 silencing 激活。坏死被 caspase 独立的刽子手激活。在这研究,我们证明导致 apoptosis 调停蛋白质的坏死的 PCD 小径在 CHMP5 抑制以后被激活。autophagic PCD 没发生在 CHMP5 缺乏的 U937 房间,这被发现。在结论,在 CHMP5 抑制,两条 Granzyme B/Perforin apoptotic 小径和导致 apoptosis 以后,调停因素的坏死的小径被激活,当 autophagic 小径没被激活时。 | Hairong Wang Jia Liu Feilong Wang Miao Chen Zhenyu Xiao Renrong OuYang Aihua Fei Yanlin Shen Shuming Pan | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 3 |
| 4 | Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway显示文摘Increasing brown and beige fat thermogenesis have an anti-obesity effect and thus great metabolic benefits.However,the molecular mechanisms regulating brown and beige fat thermogenesis remain to be further elucidated.We recently found that fat-specific knockout of Rheb promoted beige fat thermogenesis.In the current study,we show that Rheb has distinct effects on thermogenic gene expression in brown and beige fat.Fat-specific knockout of Rheb decreased protein kinase A(PKA)activity and thermogenic gene expression in brown adipose tissue of high-fat diet-fed mice.On the other hand,overexpression of Rheb activated PKA and increased uncoupling protein 1 expression in brown adipocytes.Mechanistically,Rheb overexpression in brown adipocytes increased Notch expression,leading to disassociation of the regulatory subunit from the catalytic subunit of PKA and subsequent PKA activation.Our study demonstrates that Rheb,by selectively modulating thermogenic gene expression in brown and beige adipose tissues,plays an important role in regulating energy homeostasis. | Wen Meng Xiuci Liang Ting Xiao Jing Wang Jie Wen Hairong Luo Jianhui Teng Yanquan Fei Qinghai Zhang Bilian Liu Fang Hu juli Bai Meilian Liu Zhiguang Zhou Feng Liu | 2019 | Journal of Molecular Cell Biology2019，11，9： | 2 |
| 5 | Plasma cell labeling index correlates with deletion of 13q14 in multiple myeloma显示文摘 | Chunming Li Lijuan Chen Xiao Gao Xiaoyan Qu Wenyi Shen Ruifang Yang Run Zhang Hairong Qiu Jiaren Xu Hua Lu Jianyong Li | 2011 | Leukemia & Lymphoma2011，，2： | 1 |
| 6 | Potent antifouling compounds produced by marine Streptomyces显示文摘 | Ying Xu Hongping He Stefan Schulz Xin Liu Nobushino Fusetani Hairong Xiong Xiang Xiao Pei-Yuan Qian | 2009 | Bioresource Technology2009，，4： | 1 |
| 7 | Self-Navigated 3D Acoustic Tweezers in Complex Media Based on Time Reversal显示文摘Acoustic tweezers have great application prospects because they allow noncontact and noninvasive manipulation of microparticles in a wide range of media.However,the nontransparency and heterogeneity of media in practical applications complicate particle trapping and manipulation.In this study,we designed a 1.04 MHz 256-element 2D matrix array for 3D acoustic tweezers to guide and monitor the entire process using real-time 3D ultrasonic images,thereby enabling acoustic manipulation in nontransparent media.Furthermore,we successfully performed dynamic 3D manipulations on multiple microparticles using multifoci and vortex traps.We achieved 3D particle manipulation in heterogeneous media(through resin baffle and ex vivo macaque and human skulls)by introducing a method based on the time reversal principle to correct the phase and amplitude distortions of the acoustic waves.Our results suggest cutting-edge applications of acoustic tweezers such as acoustical drug delivery,controlled micromachine transfer,and precise treatment. | Ye Yang Teng Ma Sinan Li Qi Zhang Jiqing Huang Yifei Liu Jianwei Zhuang Yongchuan Li Xuemin Du Lili Niu Yang Xiao Congzhi Wang Feiyan Cai Hairong Zheng | 2021 | Research2021，，1： | 1 |
| 8 | Plasma cell labeling index correlates with deletion of 13q14 in multiple myeloma显示文摘 | Chunming Li Lijuan Chen Xiao Gao Xiaoyan Qu Wenyi Shen Ruifang Yang Run Zhang Hairong Qiu Jiaren Xu Hua Lu Jianyong Li | 2011 | Leukemia & Lymphoma2011，，2： | 1 |
| 9 | Sliding backstepping control for ship course with nonlinear disturbance observer显示文摘 | LIU Wenjiang SUI Qingmei XIAO Hairong | 2011 | Journal of Infor- mation & Computational Science2011，，8： | 1 |
| 10 | A long-term Global LAnd Surface Satellite (GLASS) data-set for environmental studies显示文摘 | Shunlin Liang Xiang Zhao Suhong Liu Wenping Yuan Xiao Cheng Zhiqiang Xiao Xiaotong Zhang Qiang Liu Jie Cheng Hairong Tang Yonghua Qu Yancheng Bo Ying Qu Huazhong Ren Kai Yu John Townshend | 2013 | 2013 (sup1)2013，，1： | 1 |
| 11 | Research and Realization of Simulation Control System for Rudder and Ship with Autopilot显示文摘 | Hairong Xiao Yaozhen Han Changshun Wang | 2009 | Pro- ceedings of IEEE International Conference on Auto mation and Logistics2009，，： | 1 |
| 12 | Unraveling the Fundamental Mechanism of Interface Conductive Network Influence on the Fast‑Charging Performance of SiO‑Based Anode for Lithium‑Ion Batteries显示文摘Progress in the fast charging of high-capacity silicon monoxide(SiO)-based anode is currently hindered by insufficient conductivity and notable volume expansion.The construction of an interface conductive network effectively addresses the aforementioned problems;however,the impact of its quality on lithium-ion transfer and structure durability is yet to be explored.Herein,the influence of an interface conductive network on ionic transport and mechanical stability under fast charging is explored for the first time.2D modeling simulation and Cryo-transmission electron microscopy precisely reveal the mitigation of interface polarization owing to a higher fraction of conductive inorganic species formation in bilayer solid electrolyte interphase is mainly responsible for a linear decrease in ionic diffusion energy barrier.Furthermore,atomic force microscopy and Raman shift exhibit substantial stress dissipation generated by a complete conductive network,which is critical to the linear reduction of electrode residual stress.This study provides insights into the rational design of optimized interface SiO-based anodes with reinforced fast-charging performance. | Ruirui Zhang Zhexi Xiao Zhenkang Lin Xinghao Yan Ziying He Hairong Jiang Zhou Yang Xilai Jia Fei Wei | 2024 | Nano-Micro Letters2024，16，3： | 0 |
| 13 | Effects of seasonal changes on T-helper 1/T-helper 2 immune balance and eczema onset in rats显示文摘Objective: To explore the impact of seasonal changes on the T-helper 1(Th1)/T-helper 2(Th2) immune balance of the body in order to elucidate the internal immunological mechanisms underlying seasonal eczema.Methods: Eighty 4-week-old male Sprague-Dawley rats were divided into 5 season groups kept in corresponding season simulation environments, and subdivided into the model group and the control group. The Eczema Area and Severity Index(EASI) and scratching frequency were evaluated. The serum levels of immunoglobulin E(IgE), interleukin-2(IL-2), interleukin-12(IL-12), and interferon-gamma(IFN-γ), interleukin-4(IL-4), interleukin-25(IL-25), and interleukin-31(IL-31), and melatonin(MT), as well as the MT receptor(MTR) levels in the spleen, were detected by enzyme-linked immunosorbent assay analysis. The mRNA expression levels of T-bet and GATA3 were detected by quantitative real-time polymerase chain reaction.Results: EASI scores and the scratching frequency of the model group were higher in the long summer than in the other 4 seasons. Meanwhile, the serum levels of IgE and the Th2 cytokines IL-4, IL-25, and IL-31, as well as GATA3 mRNA expression levels, were high during the long summer in both groups. However, the serum levels of the Th1 cytokines IL-2, IL-12, and IFN-γ, as well as MT, MTR, and T-bet mRNA levels, were lower during the long summer. In all 5 seasonal groups(spring, summer, long summer, autumn, and winter), the levels of all immune factors, especially IL-4 and IL-31, were higher in the model group than those in the control group,while the concentrations of MT and MTR were lower.Conclusion: Under long light, hot, and humid conditions in the long summer, the body is more likely to suffer from Th2-dominated immune imbalance. This is the internal mechanism behind the high incidence and severity of eczema during the long summer. MT and MTR play a key role in the seasonal onset of eczema. | Hairong Zhang Leilei Liu Yike Sun Wenna Li Ruochong Wang Xiao Sun Guangqin Zhu Shuran Ma | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，1： | 0 |
| 14 | An Industry Needing To Come of Age显示文摘New policy woos private investors to meet the need for elderly care services A hairy monkey stands on display in Zhou Yongning and Li Wen’s room.It’s not really a monkey but a tiny humanoid fi gure with its limbs fashioned from sloughed-off cicada shells while its torso is a dried magnolia bud.Both Zhou,80,and Li,his 78-year-old wife,are proud of this piece of traditional Beijing handicraft that Zhou has made. | Wang Hairong Liang Xiao | 2017 | Beijing Review2017，60，15： | 0 |
| 15 | The overexpression of Rps14 in Lgr5+progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea显示文摘Sensory hair cells(HCs)in the cochlea cannot regenerate spontaneously in adult mammals after being damaged by external or genetic factors.However,several genes and signaling pathways are reported to induce cochlear HC regeneration at the early neonatal stage.Rps14 encodes a ribosomal protein that is involved in the regulation of cell differentiation and proliferation in mammals.However,its roles in the cochlea have not been reported in vivo.Here,we specifically overexpressed Rps14 in Lgr5+progenitor cells in the newborn mouse cochlea and found that Rps14 conditional overexpression(cOE)mice had significantly increased the ectopic HCs,including inner and outer HCs.We further explored the source of these ectopic HCs and found no EdU+supporting cells observed in the Rps14 cOE mice.The lineage tracing results,on the other hand,revealed that Rps14 cOE mice had significantly more tdTomato+HCs in their cochleae than control mice.These results indicated that regenerated HCs by cOE of Rps14 are most likely derived from inducing the direct trans-differentiation of Lgr5+progenitor cells into HCs.Moreover,real-time qPCR results suggested that the transcription factor genes Atoh1 and Gfi1,which are important in regulating HC differentiation,were upregulated in the cochlear basilar membrane of Rps14 cOE mice.In summary,this study provides in vivo evidence that,in the postnatal mouse cochlea,Rps14 is a potential gene that can promote the spontaneous trans-differentiation of Lgr5+progenitor cells into HCs.This gene may one day be exploited as a therapeutic target for treating hearing loss. | Jingru Ai Pei Jiang Jingyuan Huang Hairong Xiao Yanqin Lin Mingchen Dai Yintao Wang Yuan Zhang Mengyao Tian Renjie Chai Shasha Zhang | 2023 | Engineered Regeneration2023，4，3： | 0 |
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