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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Multi-quasiparticle rotational bands in neutron-rich erbium isotopes显示文摘Multi-quasiparticle states and rotational bands in neutron-rich erbium isotopes have been investigated by the configuration-constrained pairing-deformation-frequency self-consistent total-Routhian-surface (TRS) method with particle-number-conserved pairing. Specifically, the recently observed Kn=4-bands in 168,170,172 Er have been found to experience a configuration change in our calculation. Some other multi-quasiparticle states with uncertain configuration assignments have been reinvestigated by calculating their collective rotations. The configuration-constrained TRS calculation can reproduce experimental data consistently. | FU XiMing JIAO ChangFeng XU FuRong ZHANG ZhenHua | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，8： | 8 |
| 3 | Investigation of octupole effects in superheavy nuclei with improved potential-energy-surface calculations显示文摘It has been found that high-order deformation (e.g.β6) can have important effects on the structures of superheavy nuclei. In the present work, we investigate octupole deformation effects on superheavy nuclei with an improved potential-energy-surface (PES) calculation by including reflection-asymmetric deformations in a space of (β2 ,β3 ,β4 , β5). The calculations give various deformations including highly deformed (β2 ≈ 0.4) and superdeformed (β2 ≈ 0.7) shapes. The octupole-deformation degree of freedom mainly affects the fission barrier beyond the second minimum of PES. | WANG HuaLei LIU HongLiang XU FuRong JIAO ChangFeng | 2012 | Chinese Science Bulletin2012，57，15： | 7 |
| 4 | Competition between collective oblate rotation and non-collective prolate K isomerism in neutron-rich tungsten isotopes显示文摘Recent experiments open up the possibility to investigate oblate rotation-aligned states and prolate high-K isomers in neutron-rich tungsten isotopes.In the present work,we perform the projected-shell-model calculations for A ~ 190 tungsten nuclei.The 190 W results are compared with experimental data.The observed 8 + isomer is assigned as a two-quasiproton K π = 8 + configuration.Low-lying high-K four-quasiparticle states are predicted.Of particular interest is the prediction of the K π = 20 + state in 190,192 W,which may form a long-lived spin trap.In competition with the prolate high-K states,rotational alignment leads to near-yrast collective oblate rotation. | JIAO ChangFeng SHI Yue XU FuRong SUN Yang WALKER P M | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，9： | 5 |
| 5 | Towards the drip lines of the nuclide landscape显示文摘In the paper we review the recent progress of studies in unstable nuclei,mainly affiliated with the facilities of radioactive ion beams in China,including both experimental and theoretical aspects of researches.Many experiments for reactions,decays and structures have been performed targeting better understandings of properties of unstable nuclei.Special experimental measurements related to nuclear astrophysics have been done to seek insights into the processes of syntheses of elements in the universe.Theoretical calculations have provided many useful predictions on the behaviors of unstable nuclei,with model developments.Studies covered many mass regions from light to superheavy nuclei,giving plenty of information about the structures of unstable nuclei,towards the limits of existence of atomic nuclei. | XU FuRong | 2012 | Chinese Science Bulletin2012，57，36： | 5 |
| 6 | Calculations of electric quadrupole moments and charge radii for high-K isomers显示文摘Configuration-constrained potential-energy-surface calculations are performed to investigate high-K isomers in97Y,130Ba,176Yb,177Lu,and178Hf that were observed to have increased electric quadrupole moments but decreased charge radii relative to the states on which they are built.Taking into account the efects of deformation change and unpaired protons,our calculations can reproduce the enhancement of electric quadrupole moments for the isomers in97Y,130Ba,176Yb,177Lu and the Kπ=8 isomer in178Hf,and can reproduce the reduction of charge radii for the Kπ=27/2 isomer in97Y and the Kπ=16+isomer in178Hf. | LIU HongLiang XU FuRong | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，11： | 5 |
| 7 | Shape change induced by g_(9/2) rotational alignment in ^(84,86)Mo显示文摘Neutron-deficient Z ≈ N nuclei84,86Mo have been investigated using pairing-deformation self-consistent cranked shell modelcalculations up to spin I > 20 . Our calculations are in good agreement with the experimental data, indicating γ-soft triaxial shapesat low rotational frequency and well-deformed triaxial-oblate shapes at high rotational frequency for both nuclei. The shape changeis due to the alignments of the g9/2protons and g9/2neutrons. | LIU XuDong SHI Yue XU FuRong | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 5 |
| 8 | A 5D simulation method on post-earthquake repair process of buildings based on BIM显示文摘The post-earthquake repair process of buildings is one of the key components of building seismic resilience.Understanding the details of the repair process in advance will benefit the evaluation and decision making for the seismic resilience of buildings.To this end,a five-dimensional(5 D)simulation method on the post-earthquake repair process of buildings is proposed based on building information modeling(BIM),by which the repair activities can be presented in the way associated with a 3 D model,time(denoted as the fourth dimension),and the related costs(denoted as the fifth dimension).First,a decision-making model of repair schemes based on the interval index of the possibility degree is created to determine the optimal post-earthquake repair schemes for a damaged building.Subsequently,an algorithm based on separate flowrepetitive process is designed to automatically make the repair schedule on a BIM platform according to the determined repair schemes.Finally,an algorithm of automatic mapping between the components in BIM and their repair schedules is developed,so that a 5 D simulation of a post-earthquake repair process can be implemented.A six-story office building is selected as a case study,and the details of the post-earthquake repair process(e.g.,the costs of labor,material and equipment over the repair time)are presented by the proposed 5 D simulation method.The outcome of this study can be used to evaluate the seismic resilience of buildings and also to facilitate the decision making for seismically resilient buildings by providing the detailed guidance of the repair process. | Xu Zhen Zhang Furong Jin Wei Wu Yingying Qi Mingzhu Yang Yajun | 2020 | Earthquake Engineering and Engineering Vibration2020，19，3： | 4 |
| 9 | Theoretical studies of proton capture reactions in A~25 proton-rich nuclei显示文摘The direct proton capture and resonance proton capture properties of stellar reactions 22Mg(p,γ)23Al and 26Si(p,γ)27P are studied by employing a mean-field potential obtained from the Skyrme-Hartree-Fock(SHF) model.Calculations with the SHF potential reproduce well the loosely-bound structure of the ground states as well as the widths of the resonant states in these nuclei.With the obtained potential we estimate the reaction rates of direct proton capture and resonance proton capture to nuclei 23Al and 27P.The effect of the 27P loosely-bound structure on the S factor of the direct proton capture is also discussed. | QI Chong DU RenZhong GAO Yang ZHU JianYu XU FuRong | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，10： | 4 |
| 10 | Effect of Quercetin on Breeding and Apoptosis of Cervical Cancer HeLa Cell and on Growth of Transplanted Tumor in Nude Mice显示文摘Effect of quercetin on HeLa cell system of cervical cancer was studied by methods of MTT and Annexin V-FITC/PI. The results show that quercetin has functions of inhibiting breeding of HeLa cells and inducing apoptosis of the cells. The total apoptosis rate is positively proportional to reaction duration and concentration of quercetin used. The maximum apoptosis rate being (88.76±2.35)% was obtained when the concentration was 50.0 μmol/L and the cells were treated with quercetin for 72 hours. Based on establishing a model of tumor of cervical cancer transplanted into nude mice,quercetin of different concentrations was injected into abdominal cavity of nude mice and situation of tumor growth was reviewed. The result showed that with quercetin concentration increasing from 0 to 100.0 μmol/L,the transplantation volume and weight of the tumors decreased from (279.59±70.58) mm3 and ( 0.145±0.019) g to (128.72±36.12) mm3 and (0.089± 0.019) g respectively,while apoptosis rate of the transplanted tumor increased from (9.63±1.85)% to (34.98±0.47)%,which proved that quercetin inhibited increment of volume and weight of transplanted tumor in nude mice bodies. | ZHANG Wei XU Xiaoxia CHEN Hong ZHANG Jie ZHANG Xiaobing LUO Ruoyu FANG Furong | 2007 | Wuhan University Journal of Natural Sciences2007，12，3： | 2 |
| 11 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 12 | Radiation reaction induced spiral attractors in ultra-intense colliding laser beams显示文摘The radiation reaction effects on electron dynamics in counter-propagating circularly polarized laser beams are investigated through the linearization theorem and the results are in great agreement with numeric solutions.For the first time,the properties of fixed points in electron phase-space were analyzed with linear stability theory,showing that center nodes will become attractors if the classical radiation reaction is considered.Electron dynamics are significantly affected by the properties of the fixed points and the electron phase-space densities are found to be increasing exponentially near the attractors.The density growth rates are derived theoretically and further verified by particle-in-cell sim-ulations,which can be detected in experiments to explore the effects of radiation reaction qualitatively.The attractor can also facilitate realizing a series of nanometer-scaled flying electron slices via adjusting the colliding laser frequencies. | Zheng Gong Ronghao Hu Yinren Shou Bin Qiao Chiaer Chen Furong Xu Xiantu He Xueqing Yan | 2016 | Matter and Radiation at Extremes2016，1，6： | 2 |
| 13 | Improved descriptions of collective and non-collective rotations in the superheavy nucleus ^(256)Rf显示文摘The superheavy nucleus256Rf,where rotational band and multi-quasiparticle isomer have been observed recently,has been investigated using total Routhian surface calculations and configuration-constrained calculations of potential energy surface,with the inclusion of b6deformation.The experimental moment of inertial is well reproduced,indicating that the alignment is delayed due to the b6deformation.A K p=5-or 8-state could form a two-quasiparticle isomer that is calculated to have higher fission barrier than the ground state. | Hongliang Liu Furong Xu | 2014 | Chinese Science Bulletin2014，59，1： | 2 |
| 14 | Collective rotations of fission isomers in actinide nuclei显示文摘Using the total-Routhian-surface(TRS)method,the rotational behaviors of fission isomers in the second well of actinide nuclei234 242U,236 244Pu and238 246Cm were investigated.The pairing-deformation-frequency self-consistent TRS calculations reproduced reasonably the experimental moments of inertia extracted from spectroscopic data.It is calculated that,in these largelyelongated(β2≈0.65 andβ4≈0.03)fission isomers,theν12[981]neutron andπ12+[651]proton align simultaneously at rotational frequencyω≈0.4 0.6 MeV(corresponding to spin I≈80),which leads to clear upbending in moments of inertia(MoI’s).Our calculations have indicated that the hexadecapole deformationβ4influenced significantly the frequency of the rotational alignment of the proton12+[651]orbit. | XIE KePing KE WeiYao LIANG WuYang FU XiMing JIAO ChangFeng PEI JunChen XU FuRong | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，2： | 2 |
| 15 | Collective properties of neon isotopes investigated by projected shell model显示文摘Collective phenomenon in neon isotopes is an interesting topic.However,even the ground-state deformations cannot be well described by theories.Recently,QJ Zhi and ZZ Ren[Phys Lett B 638:166(2006)]have suggested an improved Nilsson potential,which can give a suitable description of ground-state properties in magnesium isotopes.In order to test the description of neon isotopes located around the‘‘island of inversion’’,we have used this potential to provide the deformed basis for the projectedshell-model calculations.The low-lying spectra and transition properties of neon isotopes can be reproduced reasonably.The gyromagnetic factors of neon isotopes have also been investigated.The structures of excited states along the yrast line are studied in the language of band diagrams. | Guoxiang Dong Xiaobao Wang Furong Xu Shaoying Yu | 2014 | Chinese Science Bulletin2014，59，29： | 2 |
| 16 | β-delayed proton decays near the proton drip line显示文摘We briefly reviewed the experimental study on a-delayed proton decays near the proton drip line published by our group during the period of 1996―2004, namely the first observation of the a-delayed proton decays of 9 new nuclides in the rare-earth region and the new measurements of a-delayed proton decays of 5 nuclides in the mass ~90 region near the N = Z line with the aid of the “p-?” coincidence in combination with a He-jet tape transport system. In the meantime some important experimental technique details were supplemented. The experimental results, including the half -lives, spins, parities, deformations and production reaction cross sections for the 14 nuclei were summarized and compared with the current nuclear-model predictions, and then the following points were represented. (1) The experimental half-lives for 85Mo and 92Rh as well as the predicted “waiting point” nuclei 89Ru and 93Pd are 5―10 times longer than the theoretical predictions given by M?ller et al. using a macroscopic-microscopic model. It considerably influences the predictions of the abundances of the nuclides produced in the rp-process. (2) The current-model predictions are not consistent with the experimental assignments of the spins and parities for the proton drip-line nuclei 142Ho and 128Pm. However, the nuclear potential energy surface (PES) calculated by using a Woods- Saxon-Strutinsky method reproduced the experimental results. (3) The Alice code overestimated the production reaction cross sections of the studied 9 rare-earth nuclei by one order of magnitude or two, while HIVAP code overestimated them by one order of magnitude approximately. | XU Shuwei 1 , LI Zhankui 1 , XIE Yuanxiang 1 , HUANG Wenxue 1 , SHU Nengchuan 2 , CHEN Yongshou 2 , XU Furong 3 , WANG Kun 4 , PAN Qiangyan 1 , WANG Xudong 1 , YU Yong 1 & XING Yebing 1 1. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2. Nuclear Physics Department, China Institute of Atomic Energy, Beijing 102413, China 3. Department of Technical Physics, Peking University, Beijing 100871, China 4. Shanghai Institute for Nuclear Research, Shanghai 201800, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，3： | 2 |
| 17 | Differential protein expression in substantia nigra induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in a mouse model of chronic Parkinson’s disease显示文摘BACKGROUND: To date, a complete protein expression profile of the midbrain substantia nigra in a mouse model of chronic Parkinson’s disease, induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), does not exist. In addition, there are no reports of analysis of differential protein expression. OBJECTIVE: To separate and evaluate MPTP-induced differential protein expression through the use of proteomics in the substantia nigra of a mouse model of chronic Parkinson’s disease. DESIGN: Randomized controlled animal study. SETTING: Department of Neurology, the First Affiliated Hospital, Chongqing Medical University. MATERIALS: Sixteen 8–10-week old, healthy, male, C57BL mice, weighing 20–25 g, and of clean grade, were provided by the Experimental Animal Center of Chongqing Medical University. The experimental animals were disposed according to ethical criteria. MPTP was provided by Sigma Company, USA; Pdquest 2D image analysis software and gelatum/irradiance image analysis system (ChemiDoc XRS) by Bio-Rad, USA; and Voyager DE-PROMALDI-TOF-MS mass spectroscopy analyzer by ABI Company, USA. METHODS: This study was performed in Chongqing Neurological Laboratory between November 2006 and July 2007. Mice were randomly divided into model and control groups, with 8 mice in each group. Mice in the model group were received a subcutaneous injection of MPTP (25 mg/kg), twice a week, for five successive weeks, to establish a chronic Parkinson’s disease model. Mice in the control group received the same volume of a subcutaneous saline injection at the same time points. Mice were sacrificed by anesthesia to rapidly obtain the midbrain for protein separation of the substantia nigra. MAIN OUTCOME MEASURES: (1) 2-ED handbook (Bio-Rad Company) was referenced for two-dimensional electrophoresis. (2) PDQUEST8.0 analytical electrophoresis pattern was adopted to evaluate differential protein expression. (3) Peptide mass finger print map and data were retrieved on http://gffzzb861c23ee38d4d32h5u0xq0p0kovk69p9.ffgz.tsg.suse.edu.cn to compare differential substantia nigral protein expression in the two groups. RESULTS: Two-dimensional gel electrophoresis of substantia nigra tissue indicated that there were 33 differential protein expressions between the two groups. Three new proteins were evaluated, including α-enolase, which exhibited regulated expression, tumor necrosis factor ligand superfamily member 4, and cyclin-dependent kinase inhibitor 1B. CONCLUSION: There are three proteins that exhibit differential expression in the substantia nigra- α-enolase, tumor necrosis factor ligand superfamily member 4, and cyclin-dependent kinase inhibitor 1B. | Wenbin Tu Furong Xu Guoguang Peng | 2008 | Neural Regeneration Research2008，3，5： | 2 |
| 18 | Association of systemic inflammation with marked changes in particulate air pollution in Beijing in 2008显示文摘 | Xiaohua Xu Furong Deng Xinbiao Guo Peng Lv Mianhua Zhong Cuiqing Liu Aixia Wang Kevin Tzan Silis Y. Jiang Morton Lippmann Sanjay Rajagopalan Qingshan Qu Lung-Chi Chen Qinghua Sun | 2012 | Toxicology Letters2012，，2： | 1 |
| 19 | Preparation of copper nano-particle powder by γ-irradiation显示文摘Copper nano-particles were prepared by 100 kGy room temperature γ-ray irradiation of CuSO4 aqueous solution added with surfactant and inactive agent.Effects of the surfactants and pH value on particle size and morphology of the Cu powder,and the storage stability,were investigated.Structure,morphology,particle size and melting point of the copper nano-particles were characterized by X-ray diffraction(XRD),transmission electron microscopy(TEM),laser particle size analyzer and differential scanning calorimetry(DSC),respectively.The results show that the Cu nano-particles prepared with PCM as surfactant and N,N-bis-hydroxyethyl dodecyl amide as inactive agent,in pH=4.0-6.5 of the aqueous solution,can be stored in air for 140 days. | FU Junjie LIU Yajian TAN Yuanyuan ZHOU Xinyao XU Furong | 2012 | Nuclear Science and Techniques2012，23，3： | 1 |
| 20 | β-delayed proton decay of the proton drip-line nucleus142Ho in the rare-earth region显示文摘 | Xu Shuwei Li Zhankui Xie Yuanxiang Xu Furong Wang Xudong Guo Bin Leng Changgeng Yu Yong Wang Chunfang Xing Jianping Chen Hongyan | 2003 | Science in China Series G: Physics Mechanics and Astronomy2003，，2： | 1 |
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