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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | The Possibility and Molecular Mechanisms of Cell Pyroptosis After Cerebral Ischemia显示文摘Introduction Stroke is an important disease that is prevalent worldwide [1-3].Ischemic stroke accounts for 80%of stroke cases. Currently,evidence-based effective treatments for ischemic stroke are limited,and only intravenous throm- bolysis with Alteplase (a commercially available throm- bolytic agent)within 4.5 h of stroke onset and thrombectomy and arterial thrombolysis within 6-24h of onset are effective [4,5].However,because these two treatments have strict indications and certain risks (reper- fusion injury and bleeding)[5-8],there is an urgent need to develop new treatment methods.Thus,comprehensive elucidation of the molecular mechanisms underlying ischemic brain damage and the search for key signaling pathways and protein molecules are important for guiding the clinical treatment of ischemic stroke. | Zhaofei Dong Kuang Pan Jingrui Pan Qingxia Peng Yidong Wang | 2018 | Neuroscience Bulletin2018，34，6： | 17 |
| 3 | Prognostic Significance of Tumor-infiltrating CD8^+ or CD3^+ T Lymphocytes and Interleukin-2 Expression in Radically Resected Non-small Cell Lung Cancer显示文摘 | Chuntao Tian Shixin Lu Qingxia Fan Weijie Zhang Shunchang Jiao Xiao Zhao Zhiyong Wu Liang Sun Liuxing Wang | 2015 | Chinese Medical Journal2015，，1： | 11 |
| 4 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 5 | Review of Directly Producing Light Olefins via CO Hydrogenation显示文摘Directly making light olefins via CO hydrogenation is a promising process to obtain a non-petroleum based supply of alkenes. Limited by the ASF distribution function of Fischer-Tropsch synthesis,the yield of light olefins (C2-C4) can not reach the desired levels, which is a great challenge to overcome.Beginning with a brief introduction of F-T synthesis, this paper provides a review of current research,including thermodynamic analysis, the ASF distribution function, the reaction performance of CO hydro-genation and slurry reactor studies. The problems currently faced by this research area are presented atthe end of the article. | Chong Wang, Longya Xu, Qingxia WangDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China | 2003 | Journal of Natural Gas Chemistry2003，12，1： | 6 |
| 6 | The Impact of Aqueous Medium on Gas Yields and Kinetic Behaviors of Hydrogen Isotope Fractionation during Organic Matter Thermal Degradation显示文摘以便在有机物期间在煤气的收益和氢同位素分别的运动行为上认出水的媒介的影响热降级,金试管仪器被用来由与不同性质和比例的水混合 nC18 进行热模拟实验。天然气部件的收益,在每个部件和试验性的温度对加热的率的氢同位素作文之中的关系被获得了,并且结果显示在更高的温度条件下面,含水的实验在煤气的收益,更多什么时候流水上有明显的影响被增加,烃气体和 H2 的更高的数量被产出,并且水的存在显然与重烃气体的存在延长温度间隔。比由无水的实验产生了的,含水的实验产生的烃气体的氢同位素才显然轻,并且与增加的水的增加的数量,烃气体的 D 价值逐渐地减少。与煤气的收益相比, 5D 价值的变化对在热模拟实验的水的媒介更敏感。与增加的水的数量相比,然而,水的中等性质在煤气的收益上有更小的影响,它仍然在水的媒介的氢同位素作文上显示出 inherit 效果。通过模型模拟和同位素分别行为分析,氢同位素分别过程能被化学运动模型很好描述,这被验证。正常甲烷和包含 D 甲烷的反应部分的差别大,相应于一样的激活精力。正常甲烷的内容在有更低的激活精力的部分显然是更高的,当包含 D 甲烷的内容在有更高的激活精力的部分是更高的时。因此,它将导致更大的氢同位素分别振幅,和 D 价值将对成熟的变化更敏感。同时,从在含水的实验的 nC18 的甲烷产生的平均激活精力在无水的实验比那高,并且越增加的水的大数量,越 larger 甲烷产生反应的平均激活精力。这在形成历史和煤气来源的关联的煤气的水库的学习为它的探索申请打了基础,它在这取向显示研究和申请前景。 | LU Shuangfang WANG Min XUE Haitao LI Jijun CHEN Fangwen XU Qingxia | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 5 |
| 7 | Synthesis of ZSM-35 Zeolite and Its Application in Skeletal Isomerization of 1-Hexene显示文摘 | XIE Sujuan, WANG Qingxia, XU Longya, WU Zhihua (State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China) | 2000 | 催化学报2000，21，4： | 3 |
| 8 | Optical visualization and polarized light absorption of the single-wall carbon nanotube to verify intrinsic thermal applications显示文摘The predicted extraordinary properties of carbon nanotubes(CNTs)from theoretical calculations have great potential for many applications.However,reliable experimental determination of intrinsic properties at the single-tube level is currently a matter of concern,and many challenges remain because of the unhandled and nanoscale size of individual nanotubes.Here,we demonstrated a prototype to detect the intrinsic thermal conductivity of the single-wall carbon nanotube(SWCNT)and verify the significant non-resonant optical absorption behavior on tiny nanotubes by integrating the nanotube and ice into a new core-shell design.In particular,a reversible optical visualization method based on the individual suspended ultra-long SWCNT was first developed by wrapping a nanotube with ice in the cryogenic air environment.The light-induced thermal effect on the hybrid core-shell structure was used tomelt the ice shell,which subsequently acted as a temperature sensor to verify the intrinsic thermal conductivity of the core-like nanotube.More interestingly,we successfully determined for the first time the thermal response phenomenon of the tiny absorption cross section in SWCNT in the vertical-polarization configuration and the significant non-resonant absorption behavior in the parallel-polarization configuration.These investigations will provide a better understanding for the unique optical behaviors of CNT and enable the detection of intrinsic properties of various one-dimensional nanostructures such as nanotubes,nanowires,and nanoribbons. | Xiao Zhang Li Song Le Cai Xuezeng Tian Qiang Zhang Xiaoying Qi Wenbin Zhou Nan Zhang Feng Yang Qingxia Fan Yanchun Wang Huaping Liu Xuedong Bai Weiya Zhou Sishen Xie | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 9 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 10 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 11 | Shikonin alleviates collagen-induced arthritis mice by inhibiting M1 macrophage polarization显示文摘OBJECTIVE: To investigate the effects of shikonin(SKN) on M1 and M2 polarization of macrophages both in vitro and in vivo. METHODS: Collagen-induced arthritis(CIA) in male DBA/1 mice were treated with a dose of 4 mg/kg/day of SKN for 23 d(n = 6/group). The histopathology of inflamed joints in CIA mice was evaluated to test the antiarthritic effect of SKN. M1/M2 polarization of macrophages induced by lipopolysaccharide(LPS) and interferon(IFN)-γ or interleukin(IL)-4 and IL-13, were used to assess the effect of SKN(0.05, 0.1, and 0.2 μM). The effect of SKN on the protein expression of nitric oxide synthase, arginase, CD68, and CD206 was evaluated using western blot analysis. RESULTS: The results of this study revealed that SKN delayed the arthritis feet symptom score, reduced the incidence rate of arthritis, and relieved the inflammation of joints in CIA mice. SKN inhibited M1 macrophage polarization but did not affect M2 macrophage polarization in the joints of CIA mice. Moreover, SKN inhibited M1 polarization induced by LPS and IFN-γ, but did not affect M2 polarization induced by IL-4 and IL-13. CONCLUSION: These findings suggest that SKN alleviated CIA through inhibiting M1 macrophage polarization and has great potential as a new drug for RA treatment. | HE Lianhua LUAN Huijie QIN Qingxia HE Juan CHEN Jian HU Yiping CAI Yueming SUN Desheng SHI Yu WANG Qingwen | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 2 |
| 12 | Effect of blocking Ras signaling pathway with K-Ras siRNA on apoptosis in esophageal squamous carcinoma cells显示文摘OBJECTIVE: To study the effect of RNAi silencing of the K-Ras gene on Ras signal pathway activity in EC9706 esophageal cancer cells. METHODS: EC9706 cells were treated in the following six groups: blank group (no transfection), negative control group (transfection no-carrier), transfection group (transfected with pSilencer-siK-ras), taxol chemotherapy group, taxol chemotherapy plus no-carrier group, taxol chemotherapy plus transfection group. Immunocytochemistry, Reverse transcription-polymerase chain reaction and western blotting were used to analyze the expression of MAPK1 (mitogen-activated protein kinases 1) and cyclin D1 in response to siRNA (small interfering RNA) transfection and taxol treatment. RESULTS: K-Ras (K-Ras gene) siRNA transfection of EC9706 esophageal squamous carcinoma cells decreased the expression of K-Ras, MAPK1 and cyclinD1 at the mRNA and protein level. Reverse transcription-polymerase chain reaction indicated that the expression levels of MAPK1 and cyclin D1 mRNAs were significantly lower in the transfection group than in the blank group (P<0.05). Western blotting showed that 72 h after EC9706 cell transfection, the expression levels of MAPK1 and cyclin D1 proteins had decreased in all groups, and the expression levels in the transfection group were significantly inhibited as compared with the blank group. Apoptosis increased significantly in the transfection group or after addition of taxol as compared with the blank group and the no-carrier group. The degree of apoptosis in the taxol plus transfection group was more severe. CONCLUSION: Apoptosis increased significantly in EC9706 esophageal carcinoma cells after siRNA-mediated inhibition of Ras signaling, with the most obvious increase observed in the transfection plus taxol chemotherapy group. Ras knockdown therefore increased cellular sensitivity to the chemotherapeutic agent, taxol. Ras knockdown also down-regulated the expression of the downstream genes, MAPK1 and cyclin D1, thus inhibiting the growth, proliferation and metabolism of esophageal cancer cells. | Xinjie Wang Yuling Zheng Qingxia Fan Xudong Zhang | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 2 |
| 13 | Effect of Reaction Temperature and Pressure on the Metathesis Reaction between Ethene and 2-Butene to Propene on the WO_3/Al_2O_3-HY Catalyst显示文摘在到丙烯的 ethene 和 2-butene 之间的换位反应上的反应温度和压力的效果在 WO3/| 上被学习 ?-Al2O3-HY 催化剂。这项活动被发现与提高的温度增加并且在 150 ¨ C 到达一个高原 240 ??6 号元素碳的化学符号。在那以后,这项活动经历显著减少在也高温。温度的效果被钨种类的氧化态阐明。评估结果也显示稳定性依赖于这个反应参数。中等压力(0.5 ¨ C 0.8 MPa ) 为稳定性是有利的,当时气压或也高压(> 1.0 MPa ) 败坏稳定性。为解释,紫外力,英尺红外, O2-TPO,和 TG,技术被用来描绘废催化剂。给词调音:换位;氧化钨催化剂;温度;压力;ethene;2-butene; | Shengjun Huang Shenglin Liu Wenjie Xin Sujuan Xie Qingxia Wang Longya Xu | 2006 | Journal of Natural Gas Chemistry2006，15，2： | 2 |
| 14 | Insulin-Enhanced Antitumor Effect of 5-Fluorouracil in vivo显示文摘OBJECTIVE To determine if insulin treatment can enhance the antitumor effect of 5-fluorouracil(5-FU),and to explore the mech- anism of the enhancement of insulin. METHODS S180 sarcoma,H22 liver cancer and human Eca-109 esophageal cancer cells were transplanted into nude mice to evaluate the inhibitory effect on tumor growth of insulin alone or in combination with 5-FU.The levels of serum insulin-like growth factor-I(IGF-I)and insulin-like growth factor binding protein-3 (IGFBP-3)were determined. RESULTS Compared with 5-FU treatment alone,the tumor weight of H22 liver cancer and S180 sarcoma was reduced further with high,medium and low-dose insulin(0.09,0.06,0.03 U/20 g) +5-FU treatment.When a high dosage of insulin+5-FU was ad- ministered,tumor weight was significantly reduced(P<0.05).The inhibitory rate of growth of S180 sarcoma and H22 liver cancer reached 50.2% and 51.4%,respectively,which was significantly higher than 24.9% and 27.9% in the group receiving 5-FU alone (P<0.05).High,medium and low-dose insulin combined with 5-FU significantly inhibited the growth of Eca-109 cancer cells (P<0.05).Compared with the control group,the level of serum IGF-1 decreased(P<0.05),whereas the level of serum IGFBP-3 slightly increased in the 5-FU±insulin groups(P>0.05).In mice with H22 liver cancer and S180 sarcoma the IGF-1 level with high- dose insulin+5-FU treatment was significantly lower compared to treatment with 5-FU alone(P<0.05),but the difference was not significant in mice transplanted with esophageal cancer cells. CONCLUSION Insulin can enhance the anti-tumor effect of 5-FU without significantly increasing 5-FU toxicity.Although changes in the serum IGF-1 or IGFBP-3 level do not explain the mechanism of the insulin-induced enhancement on 5-FU on growth,a decrease in the level of serum IGF-1 and an increase in serum IGFBP-3 may be important in the chemotherapeutic response. | Rui Wang Qingxia Fan Xiangjie Hu Liuxing Wang Peirong Zhao Ruilin Wang | 2008 | Chinese Journal of Clinical Oncology2008，5，4： | 1 |
| 15 | Effect of Citric Acid Solution Treatment on Textural Properties and Alkylation Activity of Zeolite Beta Catalyst显示文摘 | HE Shengbao, XIE Sujuan, SHENG Wulin, WANG Qingxia, XU Longya (Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, Liaoning, China) | 2003 | 催化学报2003，24，6： | 1 |
| 16 | 奥沙利铂联合替尼泊甙对胃癌BGC-823细胞的生长抑制和诱导凋亡的协同作用(英文)显示文摘Objective:The aim of this study was to investigate the synergistic effects of oxaliplatin and teniposide on proliferation and apoptosis of gastric cancer cell line BGC-823.Methods:MTT assay was carried to examine the inhibition rate of oxaliplatin and teniposide on gastric cancer cell line BGC-823 with various concentrations separately and associatively.The apoptosis rate of BGC-823 cells under the treatment of oxaliplatin or/and teniposide was examined by flow cytometry.The expression level of livin, an apoptosis-associated protein, was explored by western blot.Results:Oxaliplatin or teniposide could remarkably inhibit the BGC-823 gastric cancer cell growth with a dose-response manner, separately and associatively.The inhibition rate of oxaliplatin combined with teniposide on BGC-823 cells was higher than that of single oxaliplatin or single teniposide(P < 0.05), with 0.46 as combination index(CI) value.The apoptosis rates of cells treated by oxaliplatin for 12 h, 24 h and 48 h were 6.13%, 13.86% and 21.48%, respectively, while which of teniposide were 4.60%, 10.72%, 17.07%.But when the two medicines were carried associatively, the apoptosis rates for 12 h, 24 h and 48 h were 11.73%, 24.14% and 44.75%, respectively.Western blot showed that the expression level of livin was more down-regulated when cells were treated by oxaliplatin + teniposide than by oxaliplatin singly.Conclusion:The combination of oxaliplatin and teniposide can exert a synergistic effect on gastric cancer cell BGC-823. | Wang Ma Ming Gao Wei He Qingxia Fan | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，3： | 1 |
| 17 | 显示文摘 | Wang Qingxia Xu Yide | 1995 | Catal Lett1995，31，： | 1 |
| 18 | Coke bunting behavior of a catalyst of ZSM - 5/ZSM - 11 co - crystallized zcolite in the alkylation benzene FCC off-gas toethylbenzene显示文摘 | Yi Song Sbenglin Liu Qingxia Wang | 2006 | Fule process technol2006，87，4： | 1 |
| 19 | Regeneration behaviors of Fe/Si‐2 and Fe–Mn/Si‐2 catalysts for C2H6 dehydrogenation with CO2 to C2H4显示文摘 | Longya Xu Jinxiang Liu Hong Yang Yide Xu Qingxia Wang Liwu Lin | 1999 | Catalysis Letters (-)1999，，2： | 1 |
| 20 | Promotion Effect of K2O and MnO Additives on the Selective Production of Light Alkenes via Syngas over Fe/Silicalite-2 Catalysts 显示文摘 | Xu Longya Wang Qingxia Xu Yide | 1995 | Catal Lett1995，31，23： | 1 |
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