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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 3 | Characteristics of pressure fluctuations and fine coal preparation in gas-vibro fluidized bed显示文摘To improve the separation efficiency of air dense medium fluidized beds for dry coal preparation,a gasvibro fluidized bed has been proposed in which magnetic powder is used as the heavy medium.Pressure fluctuations in the gas-vibro fluidized bed were investigated using time-and frequency-domain analysis methods.The relationship between pressure fluctuations,bubble behavior,and separation efficiency was established.The low amplitude of the standard deviation,the power spectral density(PSD),the incoherent-output PSD,and the high amplitude of the coherent-output PSD,which corresponds to the bubble behavior in the bed,were improved for coal preparation.The coal ash content was reduced from 42.55% to 16.54% by using the gas-vibro fluidized bed. | Liang Dong Yuemin Zhao Liping Peng Jie Zhao Zhenfu Luo Qingxia Liu Chenlong Duan | 2015 | Particuology2015，13，4： | 4 |
| 4 | Optical visualization and polarized light absorption of the single-wall carbon nanotube to verify intrinsic thermal applications显示文摘The predicted extraordinary properties of carbon nanotubes(CNTs)from theoretical calculations have great potential for many applications.However,reliable experimental determination of intrinsic properties at the single-tube level is currently a matter of concern,and many challenges remain because of the unhandled and nanoscale size of individual nanotubes.Here,we demonstrated a prototype to detect the intrinsic thermal conductivity of the single-wall carbon nanotube(SWCNT)and verify the significant non-resonant optical absorption behavior on tiny nanotubes by integrating the nanotube and ice into a new core-shell design.In particular,a reversible optical visualization method based on the individual suspended ultra-long SWCNT was first developed by wrapping a nanotube with ice in the cryogenic air environment.The light-induced thermal effect on the hybrid core-shell structure was used tomelt the ice shell,which subsequently acted as a temperature sensor to verify the intrinsic thermal conductivity of the core-like nanotube.More interestingly,we successfully determined for the first time the thermal response phenomenon of the tiny absorption cross section in SWCNT in the vertical-polarization configuration and the significant non-resonant absorption behavior in the parallel-polarization configuration.These investigations will provide a better understanding for the unique optical behaviors of CNT and enable the detection of intrinsic properties of various one-dimensional nanostructures such as nanotubes,nanowires,and nanoribbons. | Xiao Zhang Li Song Le Cai Xuezeng Tian Qiang Zhang Xiaoying Qi Wenbin Zhou Nan Zhang Feng Yang Qingxia Fan Yanchun Wang Huaping Liu Xuedong Bai Weiya Zhou Sishen Xie | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 5 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 6 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 7 | Multiple structure graphite stabilized stearic acid as composite phase change materials for thermal energy storage显示文摘This paper used 3 types of graphite with different physical structures as the porous matrix to prepare composite phase change materials(PCMs),and investigated their photo-thermal conversion performance and application in battery thermal management.Multiple structure graphite minerals,including microcrystalline graphite(MG),scale graphite(SG),and expanded graphite(EG)were used as porous matrix,while stearic acid(SA)acts as the phase change material.The vacuum impregnation method was applied to prepare SA/MG,SA/SG,SA/EG,and SA/MG1,and SA/EG1was/were prepared by the ethyl alcohol method.Results show that the thermal conductivities of all composite phase change materials were 10.82 to 22.06 times higher than that of the pure SA.Thermogravimetric(TG)analysis showed that the loadages of SA were 43.61%,18.74%,and 92.66%for SA/MG,SA/SG,and SA/EG respectively.The load rates of SA were 18.98%and 18.88%for SA/MG1 and SA/EG1,respectively.For the 3 types of graphite materials of different dimensions,the BET(Brunauer,Emmett,and Teller)surface area determines the maximum load of SA.The Fourier-transform infrared(FTIR)and X-ray diffraction(XRD)results indicated that there was good compatibility between the SA and the supports.The SA/EG1 has better thermophysical properties in heat energy storage and release process.The thermal infrared images show that SA/EG1 has higher sensitivity to the temperature changes.SA/EG1 has better photo-heat conversion performance than SA/SG and SA/MG1 attributed to the multilayer structure of EG.SA/EG has better thermal management performance in the Li-ion batteries discharge process. | Xinbo Zhao Chuanchang Li Kaihao Bai Baoshan Xie Jian Chen Qingxia Liu | 2022 | International Journal of Mining Science and Technology2022，32，6： | 2 |
| 8 | Prevalence of transmitted drug resistance mutations among patients infected with human immunodeficiency virus type 1 (HIV-1) in Henan Province, China显示文摘To the Editor:Even with the emergence of highly active antiretroviral therapy,human immunodeficiency virus type 1(HIV-1)remains a serious public health problem worldwide.The widespread use of antiretroviral therapy(ART)has,on the one hand,significantly improved life expectancy in patients infected with HIV-1;on the other hand,it has inevitably brought along with it a difficult problem—viral resistance.Viral resistance is a common phenomenon evolutionarily,particularly in patients with poor adherence and suboptimal drug levels. | Jinjin Liu Xiaohua Zhang Mingjie Hou Shuguang Wei Jie Ma Lixia Xu Xuan Yang Yan Sun Chunli Liu Qingxia Zhao Yuqi Huo | 2022 | Chinese Medical Journal2022，135，22： | 2 |
| 9 | Effect of Reaction Temperature and Pressure on the Metathesis Reaction between Ethene and 2-Butene to Propene on the WO_3/Al_2O_3-HY Catalyst显示文摘在到丙烯的 ethene 和 2-butene 之间的换位反应上的反应温度和压力的效果在 WO3/| 上被学习 ?-Al2O3-HY 催化剂。这项活动被发现与提高的温度增加并且在 150 ¨ C 到达一个高原 240 ??6 号元素碳的化学符号。在那以后,这项活动经历显著减少在也高温。温度的效果被钨种类的氧化态阐明。评估结果也显示稳定性依赖于这个反应参数。中等压力(0.5 ¨ C 0.8 MPa ) 为稳定性是有利的,当时气压或也高压(> 1.0 MPa ) 败坏稳定性。为解释,紫外力,英尺红外, O2-TPO,和 TG,技术被用来描绘废催化剂。给词调音:换位;氧化钨催化剂;温度;压力;ethene;2-butene; | Shengjun Huang Shenglin Liu Wenjie Xin Sujuan Xie Qingxia Wang Longya Xu | 2006 | Journal of Natural Gas Chemistry2006，15，2： | 2 |
| 10 | Carboncapture and storage using alkaline industrial wastes显示文摘 | Bobicki Erin R Qingxia Liu Zhenghe Xu | 2012 | Progress in Energy and Combustion Science2012，，38： | 1 |
| 11 | Existence and stability for periodic boundary value problem of first order differential equations显示文摘 | Li Yanling Liu Anping Ma Qingxia | 2007 | Dynamics of Continuous Discrete and Impulsive Sysyems : A2007，14，： | 1 |
| 12 | Coke bunting behavior of a catalyst of ZSM - 5/ZSM - 11 co - crystallized zcolite in the alkylation benzene FCC off-gas toethylbenzene显示文摘 | Yi Song Sbenglin Liu Qingxia Wang | 2006 | Fule process technol2006，87，4： | 1 |
| 13 | Regeneration behaviors of Fe/Si‐2 and Fe–Mn/Si‐2 catalysts for C2H6 dehydrogenation with CO2 to C2H4显示文摘 | Longya Xu Jinxiang Liu Hong Yang Yide Xu Qingxia Wang Liwu Lin | 1999 | Catalysis Letters (-)1999，，2： | 1 |
| 14 | New progress in R&D; of lower olefin synthesis显示文摘 | Zhongmin Liu Chenglin Sun Gongwei Wang Qingxia Wang Guangyu Cai | 2000 | Fuel Processing Technology2000，，2： | 1 |
| 15 | Simulating effect of anthropogenic activities and climate variation on Liulin Springs discharge depletion by using the ARIMAX model显示文摘 | Yonghong Hao Jing Wu Qingxia Sun Yuen Zhu Yan Liu Zhongtang Li Tian‐Chyi J. Yeh | 2013 | Hydrol Process2013，，18： | 1 |
| 16 | A moonlighting function of choline kinase alpha 2 in the initiation of lipid droplet lipolysis in cancer cells显示文摘Cancer cells in the tumormicroenvironment,where nutrient availability is consistently changing during tumor progression,harness lipid metabolism to support their proliferation,survival,migration,invasion,and metastasis[1].When nutrients in the tumor microenvironment are sufficient,lipids such as triglycerides,steryl esters,and retinyl esters are stored in lipid droplets,which are dynamic lipid-rich cellular organelles surrounded by a single layer of polar and amphipathic phospholipids and structural proteins in the perilipin(PLIN)family. | Qingxia Ma Zhaoyuan Meng Ying Meng Rui Liu Zhimin Lu | 2021 | Cancer Communications2021，41，10： | 1 |
| 17 | The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma显示文摘Objective:In this post-hoc analysis,we evaluated anlotinib treatment-induced hypertension as a potential predictive factor of efficacy in esophageal squamous cell carcinoma(ESCC)patients.Methods:A total of 109 patients enrolled in the anlotinib group in a phase 2 trial were included.The tumor response was assessed by computed tomography at week 3,week 6,and then every 6 weeks until progressive disease was observed.The primary endpoint of the study was progression free survival(PFS).The secondary endpoints included overall survival(OS)and objective response rate(ORR).Results:In all patients,the median PFS was 3.02 months[95%confidence interval(CI):2.63–3.65 months]and the OS was 6.11 months(95%CI:4.40–7.79 months).The ORR was 7.34%(95%CI:3.22%–13.95%).A total of 59(54%)patients were diagnosed with treatment-induced hypertension(Group A),and the remaining patients(n=50,46%)were in Group B.Baseline prognostic factors were similar between the 2 groups.Patients in Group A had a longer PFS and OS and higher ORR.When stratifying patients using a previously known history of hypertension,treatment-induced hypertension was a predictor only for patients without previous hypertension,who had longer PFS[hazard ratio(HR):0.40,95%CI:0.24–0.68]and OS(HR:0.37,95%CI:0.21–0.67).Conclusions:We showed,for the first time,a correlation between treatment-induced hypertension and better prognoses in recurrent or metastatic ESCC patients treated with anlotinib,without a previously known history of hypertension.Treatment-induced hypertension may be a simple and low cost predictor for anlotinib antitumor efficacy in these patients,which may also reflect the intended target inhibition. | Yan Song Juxiang Xiao Wentao Fang Ping Lu Qingxia Fan Yongqian Shu Jifeng Feng Shu Zhang Yi Ba Yang Zhao Ying Liu Chunmei Bai Yuxian Bai Yong Tang Jie He Jing Huang | 2021 | Cancer Biology & Medicine2021，18，2： | 1 |
| 18 | Effect of polycarboxylate ether comb-type polymer on viscosity and interfacial properties of kaolinite clay suspensions显示文摘 | Ling Zhang Qingye Lu Zhenghe Xu Qingxia Liu Hongbo Zeng | 2012 | Journal of Colloid And Interface Science2012，，1： | 1 |
| 19 | Existence and stability for periodic boundary value problem of first order differential equations显示文摘 | Li YanLing Liu Anping Ma Qingxia Wang Xiaomei | 2007 | Dynamics of Continuous Discrete and Impulsive Sysyems-Series A-Mathematical Analysis2007，14，： | 1 |
| 20 | Impact of gypsum supersatura ted process water on the interactions between silica and zinc sulphide minerals 显示文摘 | Meijiao Deng Qingxia Liu | 2014 | Minerals Engineering2014，55，： | 1 |
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