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| 1 | Synthesis and characterization of boron nitride sponges as a novel support for metal nanoparticles显示文摘This paper describes a simple synthetic route for the synthesis of hexagonal boron nitride (h-BN) powders with high specific surface area, in which BBr3, NH4Cl and Al powders are used as starting materials. The structure and composition of the powders were characterized by electron diffraction, Fourier transformation infrared spectroscopy and X-ray photoelectron spectroscopy in the selected area. X-ray diffraction shows wide peaks of crystalline h-BN with the particle size on the nanometer scale, and transmission electron microscopy reveals that the products have a novel spongy morphology. Silver nanoparticles loaded h-BN sponges were prepared via a one-step synthesis method. Different reaction conditions for the formation of h-BN sponges were also investigated. | ZHENG MingTao LIU YingLiang GU YunLe XU ZiLin | 2008 | Science China Chemistry2008，51，3： | 7 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | Sex disparity of lung cancer risk in non-smokers:a multicenter population-based prospective study based on China National Lung Cancer Screening Program显示文摘Background: Non-smokers account for a large proportion of lung cancer patients, especially in Asia, but the attention paid to them is limited compared with smokers. In non-smokers, males display a risk for lung cancer incidence distinct from the females-even after excluding the influence of smoking;but the knowledge regarding the factors causing the difference is sparse. Based on a large multicenter prospective cancer screening cohort in China, we aimed to elucidate the interpretable sex differences caused by known factors and provide clues for primary and secondary prevention.Methods: Risk factors including demographic characteristics, lifestyle factors, family history of cancer, and baseline comorbidity were obtained from 796,283 Chinese non-smoking participants by the baseline risk assessment completed in 2013 to 2018. Cox regression analysis was performed to assess the sex difference in the risk of lung cancer, and the hazard ratios (HRs) that were adjusted for different known factors were calculated and compared to determine the proportion of excess risk and to explain the existing risk factors.Results: With a median follow-up of 4.80 years, 3351 subjects who were diagnosed with lung cancer were selected in the analysis. The lung cancer risk of males was significantly higher than that of females;the HRs in all male non-smokers were 1.29 (95% confidence interval [CI]: 1.20-1.38) after adjusting for the age and 1.38 (95% CI: 1.28-1.50) after adjusting for all factors, which suggested that known factors could not explain the sex difference in the risk of lung cancer in non-smokers. Known factors were 7% (|1.29-1.38|/1.29) more harmful in women than in men. For adenocarcinoma, women showed excess risk higher than men, contrary to squamous cell carcinoma;after adjusting for all factors, 47% ([1.30-1.16]/[1.30-1]) and 4% ([7.02-6.75]/[7.02-1])) of the excess risk was explainable in adenocarcinoma and squamous cell carcinoma. The main causes of gender differences in lung cancer risk were lifestyle factors, baseline comorbidity, and family history.Conclusions: Significant gender differences in the risk of lung cancer were discovered in China non-smokers. Existing risk factors did not explain the excess lung cancer risk of all non-smoking men, and the internal causes for the excess risk still need to be explored;most known risk factors were more harmful to non-smoking women;further exploring the causes of the sex difference would help to improve the prevention and screening programs and protect the non-smoking males from lung cancers. | Zheng Wu Fengwei Tan Zhuoyu Yang Fei Wang Wei Cao Chao Qin Xuesi Dong Yadi Zheng Zilin Luo Liang Zhao Yiwen Yu Yongjie Xu Jiansong Ren Jufang Shi Hongda Chen Jiang Li Wei Tang Sipeng Shen Ning Wu Wanqing Chen Ni Li Jie He | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 4 | Reassessment of the Distribution of Mantle CO_(2) in the Bohai Sea,China:The Perspective from the Source and Pathway System显示文摘Research on the distribution of mantle CO_(2)should involve comprehensive analysis from CO_(2)source to accumulation.The crust-mantle pathway system is the key controlling factor of the distribution of mantle CO_(2),but has received little attention.The pathway system and controlling factors of CO_(2)distribution in the Bohai Sea are analyzed using data on fault styles and information on the mantle and lithosphere.The relation between volcanic rocks and the distribution of mantle CO_(2)is reassessed using age data for CO_(2)accumulations.The distribution of mantle CO_(2)is controlled by uplift of the asthenosphere and upper mantle,magma conduits in the mantle and fault systems in the crust.Uplifted regions of the asthenosphere are accumulation areas for CO_(2).The area with uplift of the Moho exhibits accumulation of mantle CO_(2)at depth.CO_(2)was mainly derived from vertical migration through the upper mantle and lower crust.The fault style in the upper crust controls the distance of horizontal migration and the locations of CO_(2)concentrations.The distribution of mantle CO_(2)and volcanic rocks are not the same,but both probably followed the same pathways sometimes.Mantle CO_(2)in the Bohai Sea is concentrated in the Bozhong sag and the surrounding area,particularly in a trap that formed before 5.1 Ma and is connected to crustal faults(the Bozhang faults)and lithospheric faults(the Tanlu faults). | TANG Huafeng GUO Tianchan WU Keqiang LIU Zilin XU Jianyong LU Baoliang WANG Pujun | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 2 |
| 5 | Interannual Variations of Phytoplankton, Zooplankton and Chlorophyll a in the Arctic Seas and Their Relations to ENSO and AO显示文摘To study effects of variations in climate-marine environment in the Arctic Ocean on ecology,based on the actual and reestablished data by biomarkers of algae in sediment in 1997,1999,2003,2008,and 2010,the interannual and spatial variations of phytoplankton,zooplankton and chlorophyll a concentration in the Chukchi Sea and the Bering Sea as well as their relations to El Nino-Southern Oscillation( ENSO) and Arctic Oscillation( AO) were analyzed. The results show that there were spatial and temporal anomalies in the phytoplankton community structure reestablished by biomarkers of algae in the Chukchi Sea and the Bering Sea in 1999 and 2010. The total content of biomarkers( brassicasterol,dinosterol,C37 alkenones and chlesterol) in sediment collected in 2010 was far lower than that in 1999,but brassicasterol was dominant in the two years,that is,diatom was dominant,which was consistent with the actual structure and distribution of phytoplankton community in 1999 and 2010; there were great changes in the dominant species of plankton in the two seas in 1999 and 2010,which could be regarded as the ecological response of the North Pole under the background of global warming. Chlorophyll a concentration in the water of the Bering Sea was 0. 720 μg/dm^3 at 0 m and 0. 765μg/dm^3 at 10 m in 1997 and 0. 723 μg/dm^3 at 0 m and 0. 731 μg/dm^3 at 10 m in 2003,and the concentration was very close to each other,which was affected by El Ni1 o and the negative phase of AO. It was 0. 395 μg/dm^3 at 0 m in 1999 and 0. 399 μg/dm^3 at 0 m and 0. 357 μg/dm^3 at 10 m in 2008,which was influenced by La Ni1 a and the positive phase of AO. The phases and intensity of AO and ENSO had various effects on the quantity and dominant species of phytoplankton and zooplankton in the Chukchi Sea and the Bering Sea. During the period of AO with positive or negative phase and El Ni1o( in 1997 and 2003),their combination was favorable to the growth of phytoplankton and zooplankton,while the combination of negative phase of AO and La Nina( in 2010) had adverse effects on the growth of phytoplankton. The combination of AO with positive phase and strong La Nina( in 1999 and 2008) had small effects on phytoplankton community. | Zhang Haisheng Chen Jianfang Han Zhengbing Ji Zhongqiang Xu Xudan Han Xibing Liu Zilin Peter, H.-U Vetter Walter | 2017 | Meteorological and Environmental Research2017，8，2： | 1 |
| 6 | Synthesis and characterization of boron nitride nanoropes 显示文摘 | Zheng Mingtao Gu Yunle Xu Zilin | 2007 | Materials Letters2007，61，： | 1 |
| 7 | Particle Kinematics Analysis of Droplet Drift in Spraying Operation of Plant Protection UAV显示文摘[Objectives]The paper was to study the effect of droplet drift on spray quality of plant protection UAV.[Methods]Based on the theory of multiphase flow and the method of particle kinematics,the force and motion trajectory of droplet sprayed by plant protection UAV were theoretically analyzed and mathematically modeled.On the basis of the assumption of wind speed in the ground layer and the laminar sublayer,that is,it is assumed that the wind speed in the area of wind measurement was approximately a linear distribution,the coupling iterative solution of the equations was carried out.The influence of droplet diameter,flight height,flight speed of plant protection UAV,course angle,wind speed,wind direction,initial droplet velocity and direction of initial velocity on droplet drift were analyzed.The influence of the coupling effect of each factor on droplet drift was further discussed and the distribution of droplet drift concentration was obtained.[Results]The wind speed and direction had much influence on the drift distance of droplets,and the drift distance and the initial velocity angle show a quadratic function distribution.Under the given conditions,the drift distance was the closest when the initial velocity angle was about 20°.The droplet drift was mainly distributed scatteredly around the nozzle.[Conclusions]The study provides a reference for improving the spraying quality of plant protection UAV. | Xiong ZOU Rangshu XU Jingchun LI Zilin LIU | 2022 | Plant Diseases and Pests2022，13，2： | 0 |
| 8 | Disparities in the global burden of tracheal,bronchus,and lung cancer from 1990 to 2019显示文摘Background:Tracheal,bronchus,and lung(TBL)cancer imposes a high disease burden globally,and its pattern varies greatly across regions and countries.This study aimed to explore the global burden and temporal trends of TBL cancer from 1990 to 2019.Methods:Data on incidence,mortality,and disability-adjusted life years(DALYs)metrics(number,crude rate,and age-standardized rates),and the attributable risk fraction of DALY of TBL cancer from 1990 to 2019 in 21 Global Burden of Disease(GBD)regions,four World Bank income regions,204 countries and territories,and the globe were obtained from the up-to-date GBD 2019 study.We applied estimated annual percentage changes(EAPCs)to the age-standardized incidence rate(ASIR),age-standardized mortality rate(ASMR),and age-standardized DALY rate(ASDR)to quantify the temporal trends of the TBL cancer burden from 1990-2019.Associations of EAPC of age-standardized rates with universal health coverage(UHC)index at the national level were evaluated with Pearson correlation analysis.Results:Globally,approximately 2,260,000 new TBL cancer cases,2,042,600 deaths,and 45,858,000 DALYs were reported in 2019.Combination of all modifiable risk factors,behavioral,environmental,and metabolic risk factors accounted for 79.1%,66.4%,33.3%,and 7.9%of global lung cancer DALYs,respectively.The overall ASIR(EAPC:-0.1[95%confidence interval[CI]:-0.2,-0.1]),ASMR(EAPC:-0.3[95%CI:-0.4,-0.3]),and ASDR(EAPC:-0.7[95%CI:-0.7,-0.6])decreased from 1990 to 2019.The highest mortality rate of TBL cancer occurred in the>85-year-old age group for both sexes among high-income countries(HICs)and upper-middle-income countries(UMCs),and in males aged 80-84 years and females aged>85 years in lower middle-income countries(LMCs).HICs experienced the largest declines in ASIR(-12.6%),ASMR(-20.3%),and ASDR(-27.8%)of TBL cancer between 1990 and 2019,while UMCs had the highest increases in ASIR(16.7%)and ASMR(8.0%)over the period.Eleven(52.4%),14(66.7%),and 15(71.4%)regions of the 21 GBD regions experienced descending trends in ASIR,ASMR,and ASDR of TBL cancer between 1990 and 2019,respectively,with the greatest mean decrease per year(EAPC:-1.7[95%CI:-2.0,-1.5]for ASIR,-1.9[95%CI:-2.2,-1.7]for ASMR,and-2.2[95%CI:-2.5,-2.0]for ASDR)being observed in eastern Europe.The ASIR,ASMR,and ASDR of TBL cancer were deemed to be in decreasing trends in 85,91,and 104 countries and territories,with the largest decrease in Bahrain(EAPC:-3.0[95%CI:-3.3,-2.7]for ASIR,-3.0[95%CI:-3.3,-2.6]for ASMR,and-3.4[95%CI:-3.8,-3.1]for ASDR).ASIR(r=0.524),ASMR(r=0.411),and ASDR(r=0.353)of TBL cancer were positively associated with UHC index at the national level in 2019.Conclusions:The TBL cancer burden shows a downward trend at the global level but varies greatly across regions and countries.A decreasing trend in the TBL cancer burden was observed in the most of the 21 GBD regions and 204 countries from 1990 to 2019.UMCs had the highest burden of TBL cancer and showed the largest increases in ASIR and ASMR. | Chenran Wang Zheng Wu Yongjie Xu Yadi Zheng Zilin Luo Wei Cao Fei Wang Xuesi Dong Chao Qin Liang Zhao Changfa Xia Fengwei Tan Wanqing Chen Ni Li Jie He | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，1： | 0 |
| 9 | Mutations in epigenetic regulator KMT2C detected by liquid biopsy are associated with worse survival in prostate cancer patients显示文摘Background:KMT2(lysine methyltransferase)family enzymes are epigenetic regulators that activate gene transcription.KMT2C is mainly involved in enhancer-associated H3K4me1,and is also one of the top mutated genes in cancer(6.6%in pan-cancer).Currently,the clinical significance of KMT2C mutations in prostate cancer is understudied.Methods:We included 221 prostate cancer patients diagnosed between 2014 and 2021 in West China Hospital of Sichuan University with cell-free DNA-based liquid biopsy test results in this study.We investigated the association between KMT2C mutations,other mutations,and pathways.Furthermore,we evaluated the prognostic value of KMT2C mutations,measured by overall survival(OS)and castration resistance-free survival(CRFS).Also,we explored the prognostic value of KMT2C mutations in different patient subgroups.Lastly,we investigated the predictive value of KMT2C mutations in individuals receiving conventional combined anti-androgen blockade(CAB)and abiraterone(ABI)as measured by PSA progression-free survival(PSA-PFS).Results:The KMT2C mutation rate in this cohort is 7.24%(16/221).KMT2C-mutated patients showed worse survival than KMT2C-wild type(WT)patients regarding both CRFS and OS(CRFS:mutated:9.9 vs.WT:22.0 months,p=0.015;OS:mutated:71.9 vs.WT 137.4 months,p=0.012).KMT2C mutations were also an independent risk factor in OS[hazard ratio:3.815(1.461,9.96),p=0.006]in multivariate analyses.Additionally,we explored the association of KMT2C mutations with other genes.This showed that KMT2C mutations were associated with Serine/Threonine-Protein Kinase 11(STK11,p=0.004)and Catenin Beta 1(CTNNB1,p=0.008)mutations.In the CAB treatment,KMT2C-mutated patients had a significantly shorter PSA-PFS compared to KMT2C-WT patients.(PSA-PFS:mutated:9.9 vs.WT:17.6 months,p=0.014).Moreover,KMT2C mutations could effectively predict shorter PSA-PFS in 10 out of 23 subgroups and exhibited a strong trend in the remaining subgroups.Conclusions:KMT2C-mutated patients showed worse survival compared to KMT2C-WT patients in terms of both CRFS and OS,and KMT2C mutations were associated with STK11 and CTNNB1 mutations.Furthermore,KMT2C mutations indicated rapid progression during CAB therapy and could serve as a potential biomarker to predict therapeutic response in prostate cancer. | SHA ZHU NANWEI XU JIAYU LIANG FENGNIAN ZHAO ZILIN WANG YUCHAO NI JINDONG DAI JINGE ZHAO XINGMING ZHANG JUNRU CHEN GUANGXI SUN PENGFEI SHEN HAO ZENG | 2023 | Oncology Research2023，31，4： | 0 |
| 10 | Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury显示文摘Over the years,electroconductive hydrogels(ECHs)have been extensively applied for stimulating nerve regeneration and restoring locomotor function after peripheral nerve injury(PNI)with diabetes,given their favorable mechanical and electrical properties identical to endogenous nerve tissue.Nevertheless,PNI causes the loss of locomotor function and inflammatory pain,especially in diabetic patients.It has been established that bone marrow stem cells-derived exosomes(BMSCs-Exos)have analgesic,anti-inflammatory and tissue regeneration properties.Herein,we designed an ECH loaded with BMSCs-Exos(ECH-Exos)electroconductive nerve dressing to treat diabetic PNI to achieve functional recovery and pain relief.Given its potent adhesive and self-healing properties,this laminar dressing is convenient for the treatment of damaged nerve fibers by automatically wrapping around them to form a size-matched tube-like structure,avoiding the cumbersome implantation process.Our in vitro studies showed that ECH-Exos could facilitate the attachment and migration of Schwann cells.Meanwhile,Exos in this system could modulate M2 macrophage polarization via the NF-κB pathway,thereby attenuating inflammatory pain in diabetic PNI.Additionally,ECH-Exos enhanced myelinated axonal regeneration via the MEK/ERK pathway in vitro and in vivo,consequently ameliorating muscle denervation atrophy and further promoting functional restoration.Our findings suggest that the ECH-Exos system has huge prospects for nerve regeneration,functional restoration and pain relief in patients with diabetic PNI. | Qinfeng Yang Shenghui Su Shencai Liu Sheng Yang Jing Xu Yixiu Zhong Yusheng Yang Liangjie Tian Zilin Tan Jian Wang Zhiqiang Yu Zhanjun Shi Fangguo Liang | 2023 | Bioactive Materials2023，，8： | 0 |
| 11 | Fair hierarchical clustering of substations based on Gini coefficient显示文摘For the load modeling of a large power grid,the large number of substations covered by it must be segregated into several categories and,thereafter,a load model built for each type.To address the problem of skewed clustering tree in the classical hierarchical clustering method used for categorizing substations,a fair hierarchical clustering method is proposed in this paper.First,the fairness index is defined based on the Gini coefficient.Thereafter,a hierarchical clustering method is proposed based on the fairness index.Finally,the clustering results are evaluated using the contour coefficient and the t-SNE two-dimensional plane map.The substations clustering example of a real large power grid considered in this paper illustrates that the proposed fair hierarchical clustering method can effectively address the problem of the skewed clustering tree with high accuracy. | Dajun Si Wenyue Hu Zilin Deng Yanhui Xu | 2021 | Global Energy Interconnection2021，4，6： | 0 |
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