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| 1 | 3D bioprinting: an emerging technology full of opportunities and challenges显示文摘 | Bin Zhang Yichen Luo Liang Ma Lei Gao Yuting Li Qian Xue Huayong Yang Zhanfeng Cui | 2018 | Bio-Design and Manufacturing2018，1，1： | 13 |
| 2 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 3 | Underground ground control monitoring and interpretation,and numerical modeling, and shield capacity design显示文摘Mine or longwall panel layout is a 3D structure with highly non-uniform stress distribution. Recognition of such fact will facilitate underground problem identification/investigation and solving by numerical modeling through proper model construction. Due to its versatility, numerical modeling is the most popular method for ground control design and problem solving. However numerical modeling results require highly experienced professionals to interpret its validity/applicability to actual mining operations due to complicated mining and geological conditions. Underground ground control monitoring is routinely performed to predict roof behavior such as weighting and weighting interval without matching observation of face mining condition while the mining pressures are being monitored, resulting in unrealistic interpretation of the obtained data on mining pressure. The importance of ground control pressure monitoring and simultaneous observation of mining and geological conditions is illustrated by an example of shield leg pressure monitoring and interpretation in an U.S. longwall coal mine: it was found that the roof strata act like a plate, not an individual block of the size of a shield dimension, as commonly assumed by all researchers and shield capacity is not a fixed property for a longwall panel or a mine or a coal seam. A new mechanism on the interaction between shield's hydraulic leg pressure and roof strata for shield loading is proposed. | Syd S.Peng Jingyi Cheng Feng Du Yuting Xue | 2019 | International Journal of Mining Science and Technology2019，29，1： | 7 |
| 4 | Quantitative evaluation of DNA damage caused by atmospheric and room-temperature plasma (ARTP) and other mutagenesis methods using a rapid umu-microplate test protocol for microbial mutation breeding显示文摘Mutagenesis is an important technique for microbial mutation breeding.As the source of mutations,DNA damage extent is a key indicator for the effectiveness of mutagenesis.Therefore,a rapid and easy DNA damage quantification method is required for the comparison of mutagenesis effects and development of mutagenesis tools.Here,we used the umu-microplate test system to quantitatively compare the DNA damage strength caused by atmospheric and room-temperature plasma(ARTP)and other traditional mutagenesis methods including:ultraviolet radiation(UV),diethyl sulfate(DES)and 4-nitroquinoline-1-oxide(4-NQO).The test strain of Salmonella typhimurium TA1535/pSK1002 was used to monitor the time-course profile of b-galactosidase activity induced by DNA damage caused by different mutagenesis methods using a microplate reader.The umu-microplate test results showed that ARTP caused higher extent of DNA damage than UV and chemical mutagens,which agrees well with the result obtained by SOS-FACS-based quantification method as reported previously.This umu-microplate test is accessible for broad researchers who are lack of the expensive FACS instruments and allows the quick quantitative evaluation of DNA damage among living cells for different mutagenesis methods in the study of the microbial mutation breeding. | Yuting Huang Liyang Wang Xue Zhang Nan Su Heping Li Yoshimitsu Oda Xinhui Xing | 2021 | Chinese Journal of Chemical Engineering2021，34，11： | 4 |
| 5 | Recent progress of nanotechnology-based theranostic systems in cancer treatments显示文摘Theranostics that integrates therapy and diagnosis in one system to achieve accurate cancer diagnosis and treatment has attracted tremendous interest,and has been recognized as a potential breakthrough in overcoming the challenges of conventional oncotherapy.Nanoparticles are ideal candidates as carriers for theranostic agents,which is attributed to their extraordinary physicochemical properties,including nanoscale sizes,functional properties,prolonged blood circulation,active or passive tumor targeting,specific cellular uptake,and in some cases,excellent optical properties that ideally meet the needs of phototherapy and imaging at the same time.Overall,with the development of nanotechnology,theranostics has become a reality,and is now in the transition stage of'bench to bedside.'In this review,we summarize recent progress on nanotechnology-based theranostics,i.e.,nanotheranostics,that has greatly assisted traditional therapies,and has provided therapeutic strategies emerging in recent decades,as well as'cocktail'theranostics mixing various treatment modalities. | Ying Xue Yuting Gao Fanling Meng Liang Luo | 2021 | Cancer Biology & Medicine2021，18，2： | 3 |
| 6 | Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells显示文摘Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells(MSCs).However,the biological function of chaperone-mediated autophagy(CMA)in MSCs remains elusive.Here,we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α).In addition,suppression of CMA by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2(LAMP-2A)in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation,and as expected,LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation.This effect of CMA on the immunosuppressive function of MSCs was attributed to its negative regulation of the expression of chemokine C-X-C motif ligand 10(CXCL10),which recruits inflammatory cells,especially T cells,to MSCs,and inducible nitric oxide synthase(iNOS),which leads to the subsequent inhibition of T cell proliferation via nitric oxide(NO).Mechanistically,CMA inhibition dramatically promoted IFN-γplus TNF-α-induced activation of NF-κB and STAT1,leading to the enhanced expression of CXCL10 and iNOS in MSCs.Furthermore,we found that IFN-γplus TNF-α-induced AKT activation contributed to CMA inhibition in MSCs.More interestingly,CMA-deficient MSCs exhibited improved therapeutic efficacy in inflammatory liver injury.Taken together,our findings established CMA inhibition as a critical contributor to the immunosuppressive function of MSCs induced by inflammatory cytokines nd highlighted a previously unknown function of CMA. | Jie Zhang Jiefang Huang Yuting Gu Mingxing Xue Fengtao Qian Bei Wang Wanlin Yang Hongshuang Yu Qiwei Wang Xin Guo Xinyuan Ding Jina Wang Min Jin Yanyun Zhang | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 7 | 中国西南地区不同海拔高度在1961–2014年间极端高温趋势变化显示文摘本研究根据中国气象局最近发布的中国高分辨率气象站的日最高气温和平均气温观测数据,分析了中国西南地区在1961–2014年间极端高温的趋势。中国西南不同海拔地区的极端高温趋势在近50年间(1961–2014)呈现出阶段性变化。平均温度和最高温度的变化趋势也表现出相对应的变化。这些与温度有关的变量在1975–94年期间均缓慢增加,而在最近的1995–2014年期间则急剧增加,增幅约为1975–94年的2–10倍。这种加速的增加主要发生在中、高海拔地区,并且最高温度比平均温度上升得快得多。而这一时期正是众所周知的全球变暖间歇期。这一结果表明,我国内陆高海拔区域的气温变化趋势可能与全球平均气温变化有明显差异。 | XUE Yuting CHEN Quanliang ZHANG Jiayu HUANG Ping | 2020 | Atmospheric and Oceanic Science Letters2020，13，5： | 2 |
| 8 | Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: Involvement of its anti-inflammatory action显示文摘 | Huaning Wang Ruiguo Zhang Yuting Qiao Fen Xue Huang Nie Ying Wang Zhengwu Peng Qingrong Tan | 2014 | Behavioural Brain Research2014，，： | 2 |
| 9 | A coal-fired power plant integrated with biomass co-firing and CO_(2) capture for zero carbon emission显示文摘A promising scheme for coal-fired power plants in which biomass co-firing and carbon dioxide capture technologies are adopted and the low-temperature waste heat from the CO_(2) capture process is recycled to heat the condensed water to achieve zero carbon emission is proposed in this paper.Based on a 660 MW supercritical coal-fired power plant,the thermal performance,emission performance,and economic performance of the proposed scheme are evaluated.In addition,a sensitivity analysis is conducted to show the effects of several key parameters on the performance of the proposed system.The results show that when the biomass mass mixing ratio is 15.40%and the CO_(2) capture rate is 90%,the CO_(2) emission of the coal-fired power plant can reach zero,indicating that the technical route proposed in this paper can indeed achieve zero carbon emission in coal-fired power plants.The net thermal efficiency decreases by 10.31%,due to the huge energy consumption of the CO_(2) capture unit.Besides,the cost of electricity(COE)and the cost of CO_(2) avoided(COA)of the proposed system are 80.37/MWhand41.63/tCO_(2),respectively.The sensitivity analysis demonstrates that with the energy consumption of the reboiler decreasing from 3.22 GJ/tCO_(2) to 2.40 GJ/tCO_(2),the efficiency penalty is reduced to 8.67%.This paper may provide reference for promoting the early realization of carbon neutrality in the power generation industry. | Xiaojun XUE Yuting WANG Heng CHEN Gang XU | 2022 | Frontiers in Energy2022，16，2： | 2 |
| 10 | Suprapubic‐assisted laparoendoscopic single‐site surgery ( LESS ) in urology: our experience显示文摘 | Xiaofeng Zou Guoxi Zhang Yijun Xue Yuanhu Yuan Rihai Xiao Gengqing Wu Xiaoning Wang Yuting Wu Dazhi Long Jun Yang Hui Xu Folin Liu Xu Zhang | 2013 | BJU Int2013，，2： | 1 |
| 11 | Program managementorganization maturity integrated model for megaconstruction programs in China显示文摘 | Guangshe Jia Yuting Chen Xiangdong Xue JianguoChen Jiming Cao Kewei Tang | 2011 | International Journalof Project Management2011，29，7： | 1 |
| 12 | Dedifferentiated human umbilical cord mesenchymal stem cell reprogramming of endogenous hSDF-1a expression participates in neural restoration in hypoxic-ischemic brain damagerats显示文摘The transplantation of human umbilical cord mesenchymal stem cells(hUC-MSCs)can promote hypoxic-ischemic brain damage(HIBD)nerve repair,but finding suitable seed cells to optimize transplantation and improve treatment efficiency is an urgent problem to be solved.In this study,we induced hUC-MSCs into dedifferentiated hUC-MSCs(De-hUC-MSCs),and the morphology,stem cell surface markers,proliferation and tri-directional differentiation ability of the De-hUC-MSCs and hUC-MSCs were detected.A whole-gene chip was utilized for genome cluster,gene ontology and KEGG pathway analyses of differentially expressed genes.De-hUC-MSCs were transplanted into HIBD rats,and behavioral experiments and immunofluorescence assays were used to assess the therapeutic effect.A lentivirus vector for human stromal cell-derived factor-1(hSDF-1a)was constructed,and the role of hSDF-1a in the neuroprotective effect and mechanism of De-hUC-MSCs was verified.De-hUC-MSCs displayed similar cell morphology,stem cell surface marker expression,cell proliferation and even three-dimensional differentiation ability as hUC-MSCs but exhibited greater treatment potential in vivo.The reprogramming mechanism of hSDF-1a participated in the dedifferentiation process.By successfully constructing a stable hSDF-1a cell line,we found that De-hUC-MSCs might participate in nerve repair through the hSDF-1a/CXCR4/PI3K/Akt pathway.De-hUC-MSCs reprogramming of endogenous hSDF-1a expression may mediate the hSDF-1a/CXCR4/PI3K/Akt pathway involved in nerve repair in HIBD rats. | Zhou Xiaoqin Liu Jia Dai Mengjie Gu Jialu Bi Yang Wang Yuting Hu Huajian Liu Bo Zhang Xiaojun Li Zhongyue Chen Jie Li Tingyu Zhan Xue | 2021 | Genes & Diseases2021，8，3： | 1 |
| 13 | Program managementorganization maturity integrated model for megaconstruction programs in China显示文摘 | Guangshe Jia Yuting Chen Xiangdong Xue JianguoChen Jiming Cao Kewei Tang | 2011 | International Journalof Project Management2011，29，7： | 1 |
| 14 | 3D bioprinted hyaluronic acid‑based cell‑laden scaffold for brain microenvironment simulation显示文摘Treatments for lesions in central nervous system(CNS)are always faced with challenges due to the anatomical and physiological particularity of the CNS despite the fact that several achievements have been made in early diagnosis and precision medicine to improve the survival and quality of life of patients with brain tumors in recent years.Understanding the complexity as well as role of the microenvironment of brain tumors may suggest a better revealing of the molecular mechanism of brain tumors and new therapeutic directions,which requires an accurate recapitulation of the complex microenvironment of human brain in vitro.Here,a 3D bioprinted in vitro brain matrix-mimetic microenvironment model with hyaluronic acid(HA)and normal glial cells(HEBs)is developed which simulates both mechanical and biological properties of human brain microenvironment in vivo through the investigation of the formulation of bioinks and optimization of printing process and parameters to study the effects of different concentration of gelatin(GA)within the bioink and different printing structures of the scaffold on the performance of the brain matrix-mimetic microenvironment models.The study provides experimental models for the exploration of the multiple factors in the brain microenvironment and scaffolds for GBM invasion study. | Liang Ma Yuting Li Yutong Wu Mengfei Yu Abdellah Aazmi Lei Gao Qian Xue Yichen Luo Hongzhao Zhou Bin Zhang Huayong Yang | 2020 | Bio-Design and Manufacturing2020，3，3： | 1 |
| 15 | Quantum Dot Nanobeads-Labelled Lateral Flow Immunoassay Strip for Rapid and Sensitive Detection of Salmonella Typhimurium Based on Strand Displacement Loop-Mediated Isothermal Amplification显示文摘Rapid,sensitive,point-of-care detection of pathogenic bacteria is important for food safety.In this study,we developed a novel quantum dot nanobeads-labelled lateral flow immunoassay strip(QBs-labelled LFIAS)combined with strand displacement loop-mediated isothermal amplification(SD-LAMP)for quantitative Salmonella Typhimurium(ST)detection.Quantum dot nanobeads(QBs)served as fluorescence reporters,providing good detection efficiency.The customizable strand displacement(SD)probe was used in LAMP to improve the specificity of the method and prevent by-product capture.Detection was based on a sandwich immunoassay.A fluorescence strip reader measured the fluorescence intensity(FI)of the test(T)line and control(C)line.The linear detection range of the strip was 10^(2)–10^(8) colony forming units(CFU)·mL^(-1).The visual limit of detection was 10^(3) CFU·mL^(-1),indicating that the system was ten-fold more sensitive than AuNPs-labelled test strips.ST specificity was analyzed in accordance with agarose gel outputs of polymerase chain reaction(PCR)and SD-LAMP.We detected ST in foods with an acceptable recovery of 85%–110%.The method is rapid,simple,almost equipment-free,and suitable for bacterial detection in foods and for clinical diagnosis. | Yuting Shang Shuzhen Cai Qinghua Ye Qingping Wu Yanna Shao Xiaoying Qu Xinran Xiang Baoqing Zhou Yu Ding Moutong Chen Liang Xue Honghui Zhu Jumei Zhang | 2022 | Engineering2022，，12： | 0 |
| 16 | Counteracting lineage-specific transcription factor network finely tunes lung adeno-to-squamous transdifferentiation through remodeling tumor immune microenvironment显示文摘Human lung adenosquamous cell carcinoma(LUAS),containing both adenomatous and squamous pathologies,harbors strong plasticity and is significantly associated with poor prognosis.We established an up-to-date comprehensive genomic and transcriptomic landscape of LUAS in 109 Chinese specimens and demonstrated LUAS development via adeno-to-squamous transdifferentiation.Unsupervised transcriptomic clustering and dynamic network biomarker analysis identified an inflammatory subtype as the critical transition stage during LUAS development.Dynamic dysregulation of the counteracting lineage-specific transcription factors(TFs),containing adenomatous TFs NKX2-1 and FOXA2,and squamous TFs TP63 and SOX2,finely tuned the lineage transition via promoting CXCL3/5-mediated neutrophil infiltration.Genomic clustering identified the most malignant subtype featured with STK11-inactivation,and targeting LSD1 through genetic deletion or pharmacological inhibition almost eradicated STK11-deficient lung tumors.These data collectively uncover the comprehensive molecular landscape,oncogenic driver spectrum and therapeutic vulnerability of Chinese LUAS. | Shijie Tang Yun Xue Zhen Qin Zhaoyuan Fang Yihua Sun Chongzhe Yuan Yunjian Pan Yue Zhao Xinyuan Tong Jian Zhang Hsinyi Huang Yuting Chen Liang Hu Dasong Huang Ruiqi Wang Weiguo Zou Yuan Li Roman KThomas Andrea Ventura Kwok-Kin Wong Haiquan Chen Luonan Chen Hongbin Ji | 2023 | National Science Review2023，10，4： | 0 |
| 17 | Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S.aureus infection with osseointegration in murine models of implant-associated osteomyelitis显示文摘Eradication of MRSA osteomyelitis requires elimination of distinct biofilms.To overcome this,we developed bisphosphonateconjugated sitafloxacin(BCS,BV600072)and hydroxybisphosphonate-conjugate sitafloxacin(HBCS,BV63072),which achieve“target-and-release”drug delivery proximal to the bone infection and have prophylactic efficacy against MRSA static biofilm in vitro and in vivo.Here we evaluated their therapeutic efficacy in a murine 1-stage exchange femoral plate model with bioluminescent MRSA(USA300LAC::lux).Osteomyelitis was confirmed by CFU on the explants and longitudinal bioluminescent imaging(BLI)after debridement and implant exchange surgery on day 7,and mice were randomized into seven groups:1)Baseline(harvested at day7,no treatment);2)HPBP(bisphosphonate control for BCS)+vancomycin;3)HPHBP(hydroxybisphosphonate control for HBCS)+vancomycin;4)vancomycin;5)sitafloxacin;6)BCS+vancomycin;and 7)HBCS+vancomycin.BLI confirmed infection persisted in all groups except for mice treated with BCS or HBCS+vancomycin.Radiology revealed catastrophic femur fractures in all groups except mice treated with BCS or HBCS+vancomycin,which also displayed decreases in peri-implant bone loss,osteoclast numbers,and biofilm.To confirm this,we assessed the efficacy of vancomycin,sitafloxacin,and HBCS monotherapy in a transtibial implant model.The results showed complete lack of vancomycin efficacy while all mice treated with HBCS had evidence of infection control,and some had evidence of osseous integrated septic implants,suggestive of biofilm eradication.Taken together these studies demonstrate that HBCS adjuvant with standard of care debridement and vancomycin therapy has the potential to eradicate MRSA osteomyelitis. | Youliang Ren Jason Weeks Thomas Xue Joshua Rainbolt Karen L.de Mesy Bentley Ye Shu Yuting Liu Elysia Masters Philip Cherian Charles E.McKenna Jeffrey Neighbors Frank H.Ebetino Edward M.Schwarz Shuting Sun Chao Xie | 2023 | Bone Research2023，11，4： | 0 |
| 18 | Review of current coal rib control practices显示文摘The instability of coal ribs in underground mines continues to result in the injuries and fatalities of mine workers.The proper esti-mation and evaluation of primary and secondary support for coal ribs is still a challenging problem in the field of ground control science and requires further research and study.Although mining operations have various support design criteria and support methodologies for strata control,most rib support designs are still based on experience and local practices.This review study is intended to summarize the currently applied practices for rib support and control in various countries and mining conditions.Firstly,critical parameters that con-trol the amount and type of required rib support are considered and evaluated.The study revealed that among these parameters that control the stability of coal ribs,mining depth,rib height,cleat orientation/condition,and coal strength are the most significant param-eters.Secondly,current rib support application methods were also summarized.Similar to rock mass classification systems,some studies proposed a rib control rating system for practical estimation of the current rib condition and to estimate primary support requirements.These studies are classified and summarized into two groups(categorical and empirical)based on the required inputs and methodologies.Empirically based coal rib rating systems were closely examined,and the usefulness and intuitive aspects of each rating system were com-pared.This comprehensive literature review demonstrates that the Australian rating system,Analysis and Design of Rib Support(ADRS),and the new U.S.rating system,Coal Pillar Rib Rating(CPRR),are highly applicable for their regions. | Dogukan Guner Samuel Nowak Taghi Sherizadeh Maurice Sunkpal Khaled Mohamed Yuting Xue | 2023 | Underground Space2023，，2： | 0 |
| 19 | The successful treatment for cardiac tamponade during radiofrequency ablation of hepatocellular carcinoma显示文摘To the Editor:Hepatocellular carcinoma(HCC)is the second most common cause of cancer-related death worldwide[1].Repeated liver resection remains a valid and safe curative therapy option for recurrent HCC in a minority of patients,because of multifocal intrahepatic or extra-hepatic recurrence and tumors in unresectable locations[2].HCC nodules less than 3 cm located in the hepatic dome beneath the diaphragm may represent one of the most difficult sites for resection[3].Therefore,some local invasive therapies,such as radiofrequency ablation(RFA),microwave ablation,transarterial chemoembolization(TACE)and laser hyperthermia,have been developed and applied in clinical HCC treatment[4].RFA has high frequency energy which heats the surrounding tissues and causes severe complications such as acute massive hemorrhage,thermal injury to viscera,pneumothorax and cardiac tamponade[5]. | Chen Xue Zhigang Ren Xiaobo Hu Yuting He Ranran Sun Juan Li Guangying Cui Zujiang Yu | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 0 |
| 20 | Lung stem cells in regeneration and tumorigenesis显示文摘Adult lung is a highly quiescent organ,with extremely low cell turnover frequency.However,emerging evidences support the occurrence of repair and regeneration in pulmonary epithelia in response to various injuries.Lung regeneration mainly depends on the proliferation of regionally distributed pulmonary stem cells that re-enter the cell cycle.Genetic lineage-tracing approaches help to track the lung epithelial differentiation and/or de-differentiation path,and single-cell transcriptomic technique reveals the essential molecular signaling involved in lung regeneration.Dysregulation of the molecular signaling that balances quiescence and self-renewal leads to the transformation of lung stem cells,and thus promotes lung cancer development.Interestingly,different subtypes of lung cancer share common cells of origin and the pathological transition among various subtypes is responsible for drug resistance in the clinic.In this review,we summarize the recent understanding of lung stem cells in regeneration and tumorigenesis as well as related molecular mechanisms,with the hope to provide helpful insights for clinical treatments of respiratory diseases. | Yuting Chen Yun Xue Yujuan Jin Hongbin Ji | 2021 | Journal of Genetics and Genomics2021，48，4： | 0 |
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