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| 1 | A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs显示文摘African swine fever(ASF)is a devastating infectious disease in swine that is severely threatening the global pig industry.An efficacious vaccine is urgently required.Here,we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted viruses.The virulence,immunogenicity,safety,and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs,and pregnant sows indicated that one virus,namely HLJ/18-7GD,which has seven genes deleted,is fully attenuated in pigs,cannot convert to the virulent strain,and provides complete protection of pigs against lethal ASFV challenge.Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV,and as such is expected to play an important role in controlling the spread of ASFV. | Weiye Chen Dongming Zhao Xijun He Renqiang Liu Zilong Wang Xianfeng Zhang Fang Li Dan Shan Hefeng Chen Jiwen Zhang Lulu Wang Zhiyuan Wen Xijun Wang Yuntao Guan Jinxiong Liu Zhigao Bu | 2020 | Science China(Life Sciences)2020，63，5： | 72 |
| 2 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 3 | Source Separation of Diesel Engine Vibration Based on the Empirical Mode Decomposition and Independent Component Analysis显示文摘Vibration signals from diesel engine contain many different components mainly caused by combustion and mechanism operations,several blind source separation techniques are available for decomposing the signal into its components in the case of multichannel measurements,such as independent component analysis(ICA).However,the source separation of vibration signal from single-channel is impossible.In order to study the source separation from single-channel signal for the purpose of source extraction,the combination method of empirical mode decomposition(EMD) and ICA is proposed in diesel engine signal processing.The performance of the described methods of EMD-wavelet and EMD-ICA in vibration signal application is compared,and the results show that EMD-ICA method outperforms the other,and overcomes the drawback of ICA in the case of single-channel measurement.The independent source signal components can be separated and identified effectively from one-channel measurement by EMD-ICA.Hence,EMD-ICA improves the extraction and identification abilities of source signals from diesel engine vibration measurements. | DU Xianfeng LI Zhijun BI Fengrong ZHANG Junhong WANG Xia SHAO Kang | 2012 | Chinese Journal of Mechanical Engineering2012，25，3： | 21 |
| 4 | Multi-scale HPC system for multi-scale discrete simulation—Development and application of a supercomputer with 1 Petaflops peak performance in single precision显示文摘A supercomputer with 1.0 Petaflops peak performance in single precision,designed and established by Institute of Process Engineering,Chinese Academy of Sciences,is introduced in this brief communication.A designing philosophy utilizing the similarity between hardware,software and the problems to be solved is embodied,based on the multi-scale method and discrete simulation approaches developed at Institute of Process Engineering(IPE)and implemented in a graphic processing unit(GPU)-based hybrid computing mode.The preliminary applications of this machine in areas of multi-phase flow,molecular dynamics and so on are reported,demonstrating the supercomputer as a paradigm of green computation in new architecture. | Feiguo Chen Wei Ge Li Guo Xianfeng He Bo Li Jinghai Li Xipeng Li Xiaowei Wang Xiaolong Yuan | 2009 | Particuology2009，7，4： | 19 |
| 5 | Quasi-real-time simulation of rotating drum using discrete element method with parallel GPU computing显示文摘Real-time simulation of industrial equipment is a huge challenge nowadays. The high performance and fine-grained parallel computing provided by graphics processing units (GPUs) bring us closer to our goals. In this article, an industrial-scale rotating drum is simulated using simplified discrete element method (DEM) without consideration of the tangential components of contact force and particle rotation. A single GPU is used first to simulate a small model system with about 8000 particles in realtime, and the simulation is then scaled up to industrial scale using more than 200 GPUs in a 1D domain-decomposition parallelization mode. The overall speed is about 1/11 of the real-time. Optimization of the communication part of the parallel GPU codes can speed up the simulation further, indicating that such real-time simulations have not only methodological but also industrial implications in the near future. | Ji Xu Huabiao Oi Xiaojian Fang Liqiang Lu Wei Ge Xiaowei Wang Ming xu Feiguo Chen xianfeng He Jinghai Li | 2011 | Particuology2011，9，4： | 16 |
| 6 | Bioptical microcycles of laminated speleothems from China and their chronological significance显示文摘Interfaces of microlayers, in most stalagmites from China, consist of opaque and organic materials. Observed with microscope, the interfaces seem dark under transmitted light and luminiferous under reflected fluorescent light. Stalagmites in which the two optical characters are unified spatially would be most suitable for cross-dating use, and can play an important role in the study on speleochronology and speleoclimatology. | Ming Tan Xiaoguang Qin Linmei Shen Xianfeng Wang Yongjin Wang Tieying Li Linhua Song Laihong Wang Dongsheng Liu | 1999 | Chinese Science Bulletin1999，44，17： | 14 |
| 7 | The Interactions among DWARF10,Auxin and Cytokinin Underlie Lateral Bud Outgrowth in Rice显示文摘Previous studies have shown that DWARF10(D10) is a rice ortholog of MAX4/RMS1/DAD1,encoding a carotenoid cleavage dioxygenase and functioning in strigolactones/strigolactone-derivatives(SL) biosynthesis.Here we use D10-RNA interference(RNAi) transgenic plants similar to d10 mutant in phenotypes to investigate the interactions among D10,auxin and cytokinin in regulating rice shoot branching.Auxin levels in node 1 of both decapitated D10-RNAi and wild type plants decreased significantly,showing that decapitation does reduce endogenous auxin concentration,but decapitation has no clear effects on auxin levels in node 2 of the same plants.This implies that node 1 may be the location where a possible interaction between auxin and D10 gene would be detected.D10 expression in node 1 is inhibited by decapitation,and this inhibition can be restored by exogenous auxin application,indicating that D10 may play an important role in auxin regulation of SL.The decreased expression of most OsPINs in shoot nodes of D10-RNAi plants may cause a reduced auxin transport capacity.Furthermore,effects of auxin treatment of decapitated plants on the expression of cytokinin biosynthetic genes suggest that D10 promotes cytokinin biosynthesis by reducing auxin levels.Besides,in D10-RNAi plants,decreased storage cytokinin levels in the shoot node may partly account for the increased active cytokinin contents,resulting in more tillering phenotypes. | Shuying Zhang Gang Li Jun Fang Weiqi Chen Haipai Jiang Junhuang Zou Xue Liu Xianfeng Zhao Xiaobing Li Chengcai Chu Qi Xie Xiangning Jiang Lihuang Zhu | 2010 | Journal of Integrative Plant Biology2010，52，7： | 14 |
| 8 | Review of Hydrogen Embrittlement in Metals: Hydrogen Diffusion, Hydrogen Characterization, Hydrogen Embrittlement Mechanism and Prevention显示文摘Hydrogen dissolved in metals as a result of internal and external hydrogen can affect the mechanical properties of the metals, principally through the interactions between hydrogen and material defects. Multiple phenomena such as hydrogen dissolution, hydrogen diffusion, hydrogen redistribution and hydrogen interactions with vacancies, dislocations, grain boundaries and other phase interfaces are involved in this process. Consequently, several hydrogen embrittlement(HE) mechanisms have been successively proposed to explain the HE phenomena, with the hydrogen-enhanced decohesion mechanism, hydrogenenhanced localized plasticity mechanism and hydrogen-enhanced strain-induced vacancies being some of the most important. Additionally, to reduce the risk of HE for engineering structural materials in service, surface treatments and microstructural optimization of the alloys have been suggested. In this review, we report on the progress of the studies on HE in metals, with a particular focus on steels. It focuses on four aspects:(1) hydrogen diffusion behavior;(2) hydrogen characterization methods;(3) HE mechanisms;and(4) the prevention of HE. The strengths and weaknesses of the current HE mechanisms and HE prevention methods are discussed, and specific research directions for further investigation of fundamental HE mechanisms and methods for preventing HE failure are identified. | Xinfeng Li Xianfeng Ma Jin Zhang Eiji Akiyama Yanfei Wang Xiaolong Song | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，6： | 13 |
| 9 | Stability analysis of liver cancer-related microRNAs显示文摘MicroRNAs (miRNAs ) 是非编码的, 22 nt 的搁浅单人赛的 RNA 并且组成在植物和动物被发现的基因管理者的一个新奇的班。几研究证明了浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。关于肝的稳定性的一些文件在浆液的癌症相关的 miRNAs 是可得到的。在浆液的 miRNA 的稳定性的全身的分析是相当必要的。这研究的目的是在不同试验性的条件下面从三不同来源,有教养的肝癌症 Huh-7 房间行,临床的肝癌症,和浆液评估 miRNAs 的稳定性,包括不同温度,时间持续时间, pH 价值, RNase A 消化, DNase 我消化,并且各种各样的 freezethaw 骑车。qRT-PCR 分析表明了癌症相关的 miRNAs 是的那个肝在每测试条件下面可检测,显示 miRNAs 在严厉环境条件下面对破坏和降级极其稳定、抵抗。然而, ribosomal RNA 由在非生理的测试条件下面表明相对表示的锋利的减少易碎、容易降级。我们也极大地为浆液 RNA 抽取建立了一个柔韧的过程,它是不仅为介绍研究的 miRNA 而且为疾病预后重要基于反常 miRNA 表示。 | Yan Li Zhenggang Jiang Lijian Xu Hu Yao Jiangfeng Guo Xianfeng Ding | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 12 |
| 10 | Enhanced debromination of 4-bromophenol by the UV/sulfite process:Efficiency and mechanism显示文摘Halogenated aromatic compounds have attracted increasing concerns due to their toxicity and persistency in the environment, and dehalogenation is one of the promising treatment and detoxification methods. Herein, we systematically studied the debromination efficiency and mechanism of para-bromophenol(4-BP) by a recently developed UV/sulfite process. 4-BP underwent rapid degradation with the kinetics accelerated with the increasing sulfite concentration, pH(6.1–10) and temperature, whereas inhibited by dissolved oxygen and organic solvents. The apparent activation energy was estimated to be 27.8 kJ/mol. The degradation mechanism and pathways of 4-BP were explored by employing N_2O and nitrate as the electron scavengers and liquid chromatography/mass spectrometry to identify the intermediates. 4-BP degradation proceeded via at least two pathways including direct photolysis and hydrated electron-induced debromination. The contributions of both pathways were distinguished by quantifying the quantum yields of 4-BP via direct photolysis and hydrated electron production in the system. 4-BP could be readily completely debrominated with all the substituted Br released as Br-, and the degradation pathways were also proposed. This study would shed new light on the efficient dehalogenation of brominated aromatics by using the UV/sulfite process. | Bihuang Xie Xuchun Li Xianfeng Huang Zhe Xu Weiming Zhang Bingcai Pan | 2017 | Journal of Environmental Sciences2017，29，4： | 12 |
| 11 | Synthesis of a novel triple-site diphosphinoamine (PNP) ligand and its applications in ethylene tetramerization显示文摘A novel triple-site diphosphinoamine (PNP) ligand was synthesized and characterized. In combination with Cr(III) and methylaluminoxane (MAO), it generated active catalytic systems for ethylene tetramerization toward 1-octene with high catalytic activity and long lifetime. The effects of reaction temperature, molar ratio of Al/Cr and molar ratio of ligand/Cr on catalytic activity and selectivity to 1-octene were studied with reaction kinetics of the catalytic system for ethylene tetramerization described. At the Al/Cr molar ratio of 100, the catalytic activity is up to 2.29×106 g·mol-1 (Cr)·h-1 and the selectivity to 1-octene is 49.65 wt%. | MAO GuoLiang NING YingNan HU WenBo LI ShanMing SONG XianFeng NIU Bo JIANG Tao | 2008 | Chinese Science Bulletin2008，53，22： | 11 |
| 12 | Spatiotemporal changes of cold surges in Inner Mongolia between 1960 and 2012显示文摘在这研究,我们在内部蒙古和包围区域从 121 个气象学的车站用每日的最小的温度数据在在 1960 和 2012 之间的内部蒙古和他们的可能的开车因素分析了冷巨浪的空间与时间的变化。这些数据被分析利用一个 piecewise 回归模型,一个 Sen+Mann-Kendall 模型,和关联分析。结果证明(1 ) 单个车站的冷巨浪的频率在学习时期期间在内部蒙古减少了,与 0.5 times/10a (2.4 ~ 1.2 times/10a ) 的一个线性趋势。在 1991 以前, 1.1 times/10a (3.3 ~ 2.5 times/10a ) 的一个重要减少趋势被检测,当 0.45 times/10a (4.4 ~ 4.2 times/10a ) 的一个增加的趋势在 1991 以后被发现时。在季节的规模上,在春天寒冷巨浪的趋势与年度价值一致,并且在冷巨浪的最明显的变化发生在春天期间。每月冷的巨浪频率显示了 bimodal 结构,并且 11 月见证冷巨浪的最高的发生。(2 ) 空间地,冷巨浪的高发生主要在内部蒙古的北、中央的部分被观察,与观察在的更高的出现比在中央部分北。内部十的特征也揭示了那高频率,分别地,低频率区域在 1960 和 1990 之间介绍了减少并且增加的趋势。在 1990 年代以后扩展的高频率区域,和展出高冷的巨浪频率的区域主要在 Tulihe, Xiaoergou,和 Xi Ujimqin 旗帜被散布。(3 ) 在年度规模上,冷巨浪被 AO, NAO, CA, APVII,和 CQ 统治。然而,在冷巨浪的驱动力的季节的差别被检测。冬季冷巨浪显著地与 AO, NAO,史, CA, TPI, APVII, CW,和 IZ 被相关,显示他们被多重因素引起。秋天冷巨浪被 CA 和 IM 主要影响,当春天寒冷巨浪显著地与 CA 和 APVII 被相关时。 | LIU Xianfeng | 2015 | Journal of Geographical Sciences2015，25，3： | 11 |
| 13 | The WRKY transcription factor PlWRKY65 enhances the resistance of Paeonia lactiflora(herbaceous peony)to Alternaria tenuissima显示文摘In this study,the disease resistance gene PlWRKY65 was isolated from the leaves of Paeonia lactiflora and analyzed by bioinformatics methods,and the localization of the encoded protein was explored.Quantitative real-time PCR(qRTPCR)was also used to explore the response of this gene to Alternaria tenuissima.The results showed that the gene sequence contained multiple cis-acting elements involved in the response to hormone signaling molecules belonging to the IIe subgroup of the WRKY family,and the encoded proteins were located in the nucleus.The PlWRKY65 gene has a positive regulatory effect on A.tenuissima infection.After silencing the PlWRKY65 gene via virus-induced gene silencing(VIGS),it was found that the gene-silenced plants were more sensitive to A.tenuissima infection than the wild plants,exhibiting more severe infection symptoms and different degrees of changes in the expression of the pathogenesis-related(PR)genes.In addition,we showed that the endogenous jasmonic acid(JA)content of P.lactiflora was increased in response to A.tenuissima infection,whereas the salicylic acid(SA)content decreased.After PlWRKY65 gene silencing,the levels of the two hormones changed accordingly,indicating that PlWRKY65,acting as a disease resistance-related transcriptional activator,exerts a regulatory effect on JA and SA signals.This study lays the foundation for functional research on WRKY genes in P.lactiflora and for the discovery of candidate disease resistance genes. | Xue Wang Junjie Li Jing Guo Qian Qiao Xianfeng Guo Yan Ma | 2020 | Horticulture Research2020，7，1： | 10 |
| 14 | Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions显示文摘Genotyping and phenotyping large natural populations provide opportunities for population genomic analysis and genome-wide association studies(GWAS). Several rice populations have been re-sequenced in the past decade;however, many major Chinese rice cultivars were not included in these studies. Here, we report large-scale genomic and phenotypic datasets for a collection mainly comprised of 1,275 rice accessions of widely planted cultivars and parental hybrid rice lines from China. The population was divided into three indica/Xian and three japonica/Geng phylogenetic subgroups that correlate strongly with their geographic or breeding origins. We acquired a total of 146 phenotypic datasets for 29 agronomic traits under multi-environments for different subpopulations. With GWAS, we identified a total of 143 significant association loci, including three newly identified candidate genes or alleles that control heading date or amylose content. Our genotypic analysis of agronomically important genes in the population revealed that many favorable alleles are underused in elite accessions, suggesting they may be used to provide improvements in future breeding efforts. Our study provides useful resources for rice genetics research and breeding. | Xiuxiu Li Zhuo Chen Guomin Zhang Hongwei Lu Peng Qin Ming Qi Ying Yu Bingke Jiao Xianfeng Zhao Qiang Gao Hao Wang Yunyu Wu Juntao Ma Liyan Zhang Yongli Wang Lingwei Deng Shanguo Yao Zhukuang Cheng Diqiu Yu Lihuang Zhu Yongbiao Xue Chengcai Chu Aihong Li Shigui Li Chengzhi Liang | 2020 | Science China(Life Sciences)2020，63，11： | 8 |
| 15 | Sedimentary fill history of the Huicheng Basin in the West Qinling Mountains and associated constraints on Mesozoic intracontinental tectonic evolution显示文摘The Qinling Orogenic Belt is divided commonly by the Fengxian-Taibai strike-slip shear zone and the Huicheng Basin into the East and West Qinling mountains,which show significant geological differences after the Indosinian orogeny.The Fengxian-Taibai fault zone and the Meso-Cenozoic Huicheng Basin,situated at the boundary of the East and West Qinling,provide a natural laboratory for tectonic analysis and sedimentological study of intracontinental tectonic evolution of the Qinling Orogenic Belt.In order to explain the dynamic development of the Huicheng Basin and elucidate its post-orogenic tectonic evolution at the junction of the East and West Qinling,we studied the geometry and kinematics of fault zones between the blocks of West Qinling,as well as the sedimentary fill history of the Huicheng Basin.First,we found that after the collisional orogeny in the Late Triassic,post-orogenic extensional collapse occurred in the Early and Middle Jurassic within the Qinling Orogenic Belt,resulting in a series of rift basins.Second,in the Late Jurassic and Early Cretaceous,a NE-SW compressive stress field caused large-scale sinistral strike-slip faults in the Qinling Orogenic Belt,causing intracontinental escape tectonics at the junction of the East and West Qinling,including eastward finite escape of the East Qinling micro-plate and southwest lateral escape of the Bikou Terrane.Meanwhile,the strike-slip-related Early Cretaceous sedimentary basin was formed with a right-order echelon arrangement in sinistral shear zones along the southern margin of the Huicheng fault.Overall during the Mesozoic,the Huicheng Basin and surrounding areas experienced four tectonic evolutionary stages,including extensional rift basin development in the Early and Middle Jurassic,intense compressive uplift in the Late Jurassic,formation of a strike-slip extensional basin in the Early Cretaceous,and compressive uplift in the Late Cretaceous. | LI Wei DONG YunPeng GUO AnLin LIU XiaoMing LIU YiQun ZHA XianFeng ZHANG KuaiLe | 2013 | Science China Earth Sciences2013，56，10： | 7 |
| 16 | Operative treatment of acromioclavicular joint dislocation:a new technique with suture anchors显示文摘ObjectiveTo 在在 acromioclavicular 关节 dislocationMethodsTwenty 的外科的治疗加强 acromioclavicular 和 coracoclavicular 系带评估缝术锚的临床的结果 -- 有尖锐创伤的 Rockwood III, IV 和 acromioclavicular 关节的 V 脱臼的八个病人通过手术在我们在 2010 年 10 月之间的研究所对待, 2012 年 1 月被招募。所有病人经历了与缝术锚相结合的开的减小。功能用 Constant-Murley 肩膀分数被评估。临床、 X 光线照相术的肩膀级别在 3, 6 和 12 用 Taft 标准被评估;有固定松开的 months.ResultsTwo 盒子没在最后的统计分析被包括。另外的病人获得了完整的关节在立即的手术后的拍上重新定位。后续与 15.6 的一般水准被执行;月(范围, 12-19 ) 。在运动锻练的早范围以后, 96.2% 病人(25/26 ) 能诱拐并且提高他们的肩膀在内的超过 90 度手术后 3 月。没有感染。平均 Constant-Murley 分数是 96.3 个点(范围, 94-100 )并且吝啬的 Taft 肩膀评价是 10.7 个点(范围, 8-12 )在 12 ; months.ConclusionThe 缝术锚是一种相对简单的技术并且能避免在重建有用的螺丝钉移动在尖锐创伤的 acromioclavicular 的 acromioclavicular 和 coracoclavicular 系带连接脱臼。 | Zhang Jingwei Li Min He Xianfeng Yu Yihui Zhu Limei | 2014 | Chinese Journal of Traumatology2014，17，4： | 7 |
| 17 | Progress and prospect for NASICON-type Na3V2(PO4)3 forelectrochemical energy storage显示文摘Sodium-ion batteries(SIBs) have attracted increasing attention in the past decades, because of high overall abundance of precursors, their even geographical distribution, and low cost. Na_3V_2(PO_4)_3(NVP), a typical sodium super ion conductor(NASICON)-based electrode material, exhibits pronounced structural stability, exceptionally high ion conductivity, rendering it a most promising electrode for sodium storage.However, the comparatively low electronic conductivity makes the theoretical capacity of NVP cannot be fully accessible even at comparatively low rates, presenting a major drawback for further practical applications, especially when high rate capability is especially important. Thus, many endeavors have been conformed to increase the surface and intrinsic electrical conductivity of NVP by coating the active materials with a conductive carbon layer, downsizing the NVP particles, combining the NVP particle with various carbon materials and ion doping strategy. In this review, to get a better understanding on the sodium storage in NVP, we firstly present 4 distinct crystal structures in the temperature range of -30°C^225°C namely α-NVP, β-NVP, β-NVP and γ-NVP. Moreover, we give an overview of recent approaches to enhance the surface electrical conductivity and intrinsic electrical conductivity of NVP. Finally, some potential applications of NVP such as in all-climate environment and PHEV, EV fields have been prospected. | Qiong Zheng Hongming Yi Xianfeng Li Huamin Zhang | 2018 | Journal of Energy Chemistry2018，27，6： | 7 |
| 18 | Efficient parallel implementation of the lattice Boltzmann method on large clusters of graphic processing units显示文摘Many-core processors, such as graphic processing units (GPUs), are promising platforms for intrinsic parallel algorithms such as the lattice Boltzmann method (LBM). Although tremendous speedup has been obtained on a single GPU compared with mainstream CPUs, the performance of the LBM for multiple GPUs has not been studied extensively and systematically. In this article, we carry out LBM simulation on a GPU cluster with many nodes, each having multiple Fermi GPUs. Asynchronous execution with CUDA stream functions, OpenMP and non-blocking MPI communication are incorporated to improve efficiency. The algorithm is tested for two-dimensional Couette flow and the results are in good agreement with the analytical solution. For both the oneand two-dimensional decomposition of space, the algorithm performs well as most of the communication time is hidden. Direct numerical simulation of a two-dimensional gas-solid suspension containing more than one million solid particles and one billion gas lattice cells demonstrates the potential of this algorithm in large-scale engineering applications. The algorithm can be directly extended to the three-dimensional decomposition of space and other modeling methods including explicit grid-based methods. | XIONG QinGang LI Bo XU Ji FANG XiaoJian WANG XiaoWei WANG LiMin HE XianFeng GE Wei | 2012 | Chinese Science Bulletin2012，57，7： | 6 |
| 19 | Novel constant-cladding tapered-core ytterbium-doped fiber for high-power fiber laser oscillator显示文摘Power scaling based on traditional ytterbium-doped fibers(YDFs)is limited by optical nonlinear effects and transverse mode instability(TMI)in high-power fiber lasers.Here,we propose a novel long tapered fiber with a constant cladding and tapered core(CCTC)along its axis direction.The tapered-core region of the fiber is designed to enhance the stimulated Raman scattering(SRS)threshold and suppress higher-order mode resonance in the laser cavity.The CCTC YDF was fabricated successfully with a modified chemical vapor deposition(MCVD)method combined with solution doping technology,which has a cladding diameter of 400µm and a varying core with a diameter of~24μm at both ends and~31μm in the middle.To test the performance of the CCTC fiber during high-power operation,an all-fiber laser oscillator based on a CCTC YDF was investigated experimentally.As a result,a maximum output power of 3.42 kW was achieved with an optical-to-optical efficiency of 55.2%,although the TMI effect was observed at an output power of~3.12 kW.The measured beam quality(M^(2)factor)was~1.7,and no sign of the Raman component was observed in the spectrum.We believe that CCTC YDF has great potential to simultaneously mitigate the SRS and TMI effects,and further power scaling is promising by optimizing the structure of the YDF. | Yun Ye Xianfeng Lin Xiaoming Xi Chen Shi Baolai Yang Hanwei Zhang Xiaolin Wang Jinyan Li Xiaojun Xu | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 20 | Application of the Mole-8.5 supercomputer:Probing the whole influenza virion at the atomic level显示文摘Discrete computer simulations are quite helpful in understanding dynamic structures in complex systems.Recently,using the Mole-8.5 supercomputer and molecular dynamics simulations as a'computational microscope',we simulated the dynamic structure of a whole H1N1 influenza virion in solution for the first time at the atomic level.In total,300 million atoms in a periodic cube with an edge length of 148.5 nm were simulated.Using 288 low level hybrids with 1728 C2050 GPUs and a software package developed specifically for the hardware,the simulation executed 770 ps/d with an integration time step of 1 fs,and analyzed the dynamic structure.With the tremendous computational power of GPUs,efficient software packages for various hardware designs,and consistent physical models,more challenging applications will be carried out in the near future. | XU Ji WANG XiaoWei HE XianFeng REN Ying GE Wei LI JingHai | 2011 | Chinese Science Bulletin2011，56，20： | 5 |
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