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| 1 | Changes of p53 protein blood level in esophageal cancer patients and normal subjects from a high incidence area in Henan,China显示文摘Changesofp53proteinbloodlevelinesophagealcancerpatientsandnormalsubjectsfromahighincidenceareainHenan,ChinaYUGuoQiang1,ZHOU... | YU GuoQiang1, ZHOU Qi1, DING Ivan2, GAO ShanShan1, ZHENG ZuoYu1, ZOU JianXiang1, LI YongXin1 and WANG LiDong1 | 1998 | World Journal of Gastroenterology1998，4，4： | 12 |
| 2 | Effects of nano-HMX on the properties of RDX-CMDB propellant:Higher energy and lower sensitivity显示文摘Batch preparation of nano-HMX was achieved via a mechanical trituration method. The morphology and particle size of nano-HMX and raw RDX were characterized using SEM. Then nano-HMX was used in a formulation of composite modified double base propellant containing RDX. The method is to use nanoHMX to replace the RDX in the formulation by 10% gradually with the total mass content of RDX and HMX unchanged. The burning rate, mechanical sensitivity and mechanical property of propellant strands with different mass content of nano-HMX were tested. The results indicate that the 30% content of nanoHMX has the best comprehensive performance which can be used as an improvement of the existing formula. A possible mechanism of action was discussed. | Han GAO Xiao-ting HOU Xiang KE Jie LIU Gazi HAO Lei XIAO Teng CHEN Ying-ying ZUO Wei JIANG | 2017 | Defence Technology(防务技术)2017，13，5： | 10 |
| 3 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 4 | Tensile and Fracture Properties of 15 vol% SiC_p/2009Al Composites Fabricated by Hot Isostatic Pressing and Hot Extrusion Processes显示文摘15 vol% silicon carbide particle(Si Cp)-reinforced 2009 Al matrix(15 vol% Si Cp/2009Al) composites were fabricated by hot isostatic pressing(HIP) and hot extrusion processes. The tensile and fracture properties of 15 vol% Si Cp/2009 Al were studied. The results showed that hot extrusion increased the ultimate tensile strength(UTS), yield strength(YS), elongation(EL), reduction in area(RA), and fracture toughness of the composites. The heat treatment resulted in the increase in UTS, YS, and fracture toughness, but a decrease in EL and RA. Both hot extrusion and heat treatment had negligible effects on elastic modulus(E). With the increase of Si Cpsize, the UTS, YS, and E decreased, but the EL and RA increased. The fracture toughness increased first and then decreased with increasing Si Cpsize, and when the Si Cpsize was about 7 lm, the composites obtained the maximum fracture toughness value of 31.74 MPa m^(1/2). | Junhui Nie Jianzhong Fan Shaoming Zhang Shaohua Wei Tao Zuo Zili Ma Zhaobing Xiang | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，5： | 8 |
| 5 | Comparative studies on epithelial lesions at gastric cardia and pyloric antrum in subjects from a high incidence area for esophageal cancer in Henan,China显示文摘ComparativestudiesonepitheliallesionsatgastriccardiaandpyloricantruminsubjectsfromahighincidenceareaforesophagealcancerinHena... | GAO ShanShan1, ZHOU Qi1, LI YongXin1, BAI YongMin1, ZHENG ZuoYu1, ZOU JianXiang1, LIU Gang1, FAN ZongMin1, QI YiJun1, ZHAO Xin1 and WANG LiDong1,2Keywords esophageal neoplasms stomach neoplasms gastric ca | 1998 | World Journal of Gastroenterology1998，4，4： | 8 |
| 6 | Effects of External Electric Field on AlN Precipitation and Recrystallization Texture of Deep-drawing 08Al Killed Steel Sheet显示文摘AlN 降水和再结晶质地上的一个电场的效果被调查。滚动寒冷的 08Al 杀死了钢表根据二拍子的圆舞过程在 550 deg C 被退火,在各种各样的维持的时间,有或没有使用一个电场。电场支持第二个阶段(AINparticles ) 的降水,这被发现,加强 7 纤维并且削弱在 recrystallizedspecimens 的 cc 纤维质地部件。对由电场的 7 纤维质地的加强的可能的解释是第二个阶段艾因河粒子在损坏不同地面向的谷物的情况下支持 7 纤维的生长。 | Xiang ZHAO Zhuochao HU Liang ZUO | 2006 | Journal of Materials Science & Technology2006，22，6： | 7 |
| 7 | Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1显示文摘细胞内部的反应的氧种类(ROS ) 被知道调整 apoptosis。caspase-9 的激活,在 mitochondrial apoptotic 串联的起始的 caspase,仔细与被联系 ROS,而是它是不清楚的是否 ROS 经由直接氧化的修正调整 caspase-9。阐明的现在的学习目的由哪个 ROS 调停的分子的机制 caspase-9 激活。我们的结果证明细胞的氧化状态便于 caspase-9 激活。氢过氧化物治疗引起 caspase-9 和 apoptosis 的激活,并且支持在 caspase-9 和 apoptotic 之间的一个相互作用激活朊酶的因素 1 (Apaf-1 ) 经由二硫化物形成。另外,在里面一在里面 vitro 没有线粒体的系统, thiol 氧化剂 diamide 由便于连接二硫化物的建筑群的形成支持 caspase-9 和 caspase-9/Apaf-1 相互作用的汽车劈开。最后,在 caspase-9 的 C403 的一个点变化通过二硫化物形成的废除损害有 Apaf-1 的两支持 H2O2 的 caspase-9 激活和相互作用。在细胞色素 c 和 C403S 异种之间的协会在细胞色素 c 和野类型的 caspase-9 之间是比那显著地弱的,显示 caspase-9 的那氧化修正贡献在氧化应力下面的 apoptosome 形成。一起拿,由 ROS 的 caspase-9 的氧化修正能调停它和 Apaf-1 的相互作用,和罐头因此支持它的汽车劈开和激活。这机制可以在氧化应力下面便于 apoptosome 形成和 caspase-9 激活。 | Yong Zuo Binggang Xiang Jie Yang Xuxu Sun Yumei Wang Hui Cang Jing Yi | 2009 | Cell Research2009，19，4： | 6 |
| 8 | Microstructural and textural evolutions in multilayered Ti/Cu composites processed by accumulative roll bonding显示文摘Ti/Cu multilayered composites were fabricated via accumulative roll bonding(ARB). During codeformation of the constituent metals, the hard Ti layers necked preferentially and then fragmented with the development of shear bands. Transmission electron microscopy showed that with increasing ARB cycles, grains in Ti were significantly refined even though dynamic recrystallization has occurred. For Cu the significant grain refinement was only found within the shear banded region when the composite was processed after five ARB cycles. Due to the diffusion of Cu atoms into Ti at the heterophase interfaces, amorphization with a width less than 10 nm was identified even in the composite processed by one cycle. At higher ARB cycles, the width of amorphous region increased and intermetallic compounds CuTi appeared from the region. The lattice defects introduced at the heterophase interfaces under roll bonding was responsible for the formation of the nano-scaled compounds. X-ray diffraction showed that an abnormal {1120} fiber texture was developed in Ti layers, while significant brass-type textures were developed in Cu layers. Some orientations along the {1120} fiber favored the prismatic < a> slip for Ti.Tensile tests revealed the elevated strength without a substantial sacrifice of ductility in the composites during ARB. The unique mechanical properties were attributed to the significantly refined grains in individual metals, the good bonding between the constituent metals, as well as the development of an abnormal {1120} fiber texture in Ti layers. | Shuang Jiang Ru Lin Peng Nan Jia Xiang Zhao Liang Zuo | 2019 | Journal of Materials Science & Technology2019，35，6： | 6 |
| 9 | Crystal orientation and morphology of a lamellae in wrought titanium alloys: On the role of microstructure evolution in b processing显示文摘To obtain high-quality aviation forgings of titanium alloys, b forging is an essential processing step which must be considered throughout a production process. In this work, the effect of b forging on the crystal orientation and morphology of lamellar a was experimentally investigated in a two-phase titanium alloy. Strong dynamic recovery during b working resulted in the formation of low-angle grain boundary(LAGBb) inside b grains. The lamellar a can penetrate through the LAGBb, leading to similar intra a LAGBs on subgrain boundaries. Deformation banding occurs at high strain rates, and both diffusive and sharp boundaries of deformation bands can be observed.A continuous change of the b orientation in diffusive boundaries results in the formation of fine and disordered a lamellae without intra-lamellar boundary to hold the Burgers orientation relationship(OR). On sharp boundaries, it is prone to producing continuous grain boundary a(aGB) with a highly similar orientation along the boundaries. Meanwhile, there may exist several lower-angle boundaries within the grain boundary a for a smoother orientation change on the b grain boundary. | Huojun ZHENG Xiaoguang FAN Xiang ZENG Rui ZUO | 2019 | Chinese Journal of Aeronautics2019，32，5： | 5 |
| 10 | CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development显示文摘学习必要基因的早功能是在发展生物学的一个重要、挑战性的问题。这里,我们为很快在二房间的阶段胚胎的一个分裂球导致 CRISPR-Cas9-mediated 变化建立了一个方法,称为的 2 房间 embryo-CRISPR-Cas9 注射(2CC ) ,学习在里面必需品的 vivo 功能(或未知) 在创始人的基因妄想的鼠标。由注射指向兴趣的基因进的 Cre mRNA 和 CRISPR-Cas9 荧光灯记者老鼠, 2CC 方法能在不同发展阶段跟踪野类型、变异的房间,为变异的房间的 phenotypic 分析的出现内部控制。用这个方法,我们在在发展中的鼠标调整有刺激性、禁止的 synaptic 传播识别了必要基因 Tet3 的新奇函数服的外皮。由产生妄想的变异的老鼠, 2CC 方法允许在多重纸巾和房间的基因功能的快速的屏蔽录入妄想的老鼠创始人,显著地扩展基因工具的当前的一套设备。 | Wang, Lingbo Li, Min-Yin Qu, Chao Miao, Wan-Ying Yin, Qi Liao, Jiaoyang Cao, Hua-Teng Huang, Min Wang, Kai Zuo, Erwei Peng, Guangdun Zhang, Shu-Xin Chen, Guodong Li, Qing Tang, Ke Yu, Qian Li, Zhoujie Wong, Catherine C. L. Xu, Guoliang Jing, Naihe Yu, Xiang Li, Jinsong | 2017 | Cell Research2017，27，6： | 5 |
| 11 | Contributions of anthropogenic and external natural forcings to climate changes over China based on CMIP5 model simulations显示文摘Based on observations and historical simulations from the fifth phase of the Coupled Model Intercomparison Project(CMIP5) archive, the contributions of human activities(including greenhouse gases(GHGs), anthropogenic aerosols(AAs), and land use(LU)) and external natural forcings(Nat) to climate changes in China over the past 50 years were quantified. Both anthropogenic and external natural forcings account for 95%–99% of the observed temperature change from 1951–1975 to 1981–2005. In particular, the temperature changes induced by GHGs are approximately 2–3 times stronger than the observed changes, and AAs impose a significant cooling effect. The total external forcings can explain 65%–78% of the observed precipitation changes over the past 50 years, in which AAs and GHGs are the primary external forcings leading to the precipitation changes; in particular, AAs dominate the main spatial features of precipitation changes in eastern China. Human activities also dominate the long-term non-linear trends in observed temperature during the past several decades, and, in particular, GHGs, the primary warming contributor, have produced significant warming since the 1960 s. Compared to the long-term non-linear trends in observed precipitation, GHGs have largely caused the wetting changes in the arid-semiarid region since the 1970 s, whereas AAs have led to the drying changes in the humid-semihumid region; both LU and Nat can impose certain impacts on the long-term non-linear trends in precipitation. Using the optimal fingerprinting detection approach, the effects of human activities on the temperature changes can be detected and attributed in China, and the effect of GHGs can be clearly detected from the observations in humid-semihumid areas. However, the anthropogenic effects cannot be detected in the observed precipitation changes, which may be due to the uncertainties in the model simulations and to other issues. Although some results in this paper still need improvement due to uncertainties in the coupled models, this study is expected to provide the background and scientific basis for climate changes to conduct vulnerability and risk assessments of the ecological systems and water resources in the arid-semiarid region of China. | ZHAO Tian Bao LI Chun Xiang ZUO Zhi Yan | 2016 | Science China Earth Sciences2016，59，3： | 5 |
| 12 | Base editing-mediated splicing correction therapy for spinal muscular atrophy显示文摘Dear Editor,Spinal muscular atrophy(SMA)is a devastating autosomal recessive motor neuron disease.1,2 Infants with more severe forms of type I SMA die before the age of 2 if no intervention is provided.1,2 Spinraza and zolgensma have been approved by the FDA as SMA therapeutics for pediatric patients.1,2 However,as an antisense oligonucleotide(ASO)based therapy,spinraza requires four loading doses,followed by three annual maintenance doses.The patients would be subjected to repeated intrathecal injections in the procedure.Zolgensma is a single-dose gene-replacement therapy for SMA,but unfortunately is unreliable in maintaining a high,stable level of gene expression.These issues have limited the therapeutic effects of the two approved drugs for SMA. | Xiang Lin Haizhu Chen Ying-Qian Lu Shunyan Hong Xinde Hu Yanxia Gao Lu-Lu Lai Jin-Jing Li Zishuai Wang Wenqin Ying Lixiang Ma Ning Wang Erwei Zuo Hui Yang Wan-Jin Chen | 2020 | Cell Research2020，30，6： | 5 |
| 13 | Impairment of cognition and sleep after acute ischaemic stroke or transient ischaemic attack in Chinese patients: design, rationale and baseline patient characteristics of a nationwide multicentre prospective registry显示文摘background and aim Cognitive impairment and sleep disorder are both common poststroke conditions and are closely related to the prognosis of patients who had a stroke.The Impairment of CognitiON and Sleep after acute ischemic stroke or transient ischemic attack in Chinese patients(ICONS)study is a nationwide multicentre prospective registry to investigate the occurrence and associated factors of cognitive impairment and sleep disorder after acute ischaemic stroke(AIS)or transient ischaemic attack(TIA).Methods Consecutive AIS or TIA in-hospital patients within 7 days after onset were enrolled from 40 participating sites in China.Comprehensive baseline clinical and imaging data were collected prospectively.Blood and urine samples were also collected on admission and follow-up visits.Patients were interviewed face to face for cognition and sleep related outcomes at 2 weeks,3,6 and 12 months after AIS/TIA and followed up for clinical outcomes by telephone annually over 5 years.results Between August 2015 and January 2018,a total of 2625 patients were enrolled.92.65% patients had AIS and 7.35% patients had TIA.Overall,the average age was 61.04 years,and 72.38% patients were male.Median National Institutes of Health Stroke Scale score was 3 in AIS patients.Conclusions The ICONS study is a large-scale nationwide prospective registry to investigate occurrence and the longitudinal changes of cognitive impairment and sleep disorder after AIS or TIA.Data from this registry may also provide opportunity to evaluate associated factors of cognitive impairment or sleep disorder after AIS or TIA and their impact on clinical outcome. | Yongjun Wang Xiaoling Liao Chunxue Wang Ning Zhang Lijun Zuo Yang Yang Yuesong Pan Xianglong Xiang Jing Jing Xia Meng Xingquan Zhao Yilong Wang Jiong Shi Hao Li | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 14 | Isolation and characterization of rl_(t), a gene that controls leaf rolling in rice显示文摘Moderate leaf rolling is one of the most important morphological traits in rice breeding for plant ideotype.Previous studies have shown that the rl(t)gene has a high breeding potential for developing hybrid-rice varieties with an ideal ideotype,because it leads to an appropriate leaf rolling index(LRI)of about 30%in the heterozygous state,and had a positive effect on grain yield.In this study,we isolated rl(t)and performed a preliminary investigation of its function in regulating leaf rolling in rice.DNA sequencing identified a single base change(G to T)in the finely mapped region(11 kb)containing rl(t),and this is located in 30-untranslated region(30-UTR)of the only predicted gene,Roc5(Rice outermost cell-specific).The expression level of Roc5 is significantly higher in the rl(t)mutant than in the wild-type.Using RNAi and overexpression analysis,we found that the expression level of Roc5 correlated with LRI and leaf bulliform area,and wasalso associated with leaf abaxial or adaxial rolling.These results confirmed that Roc5 controls leaf rolling in a dosage-dependent manner.Bioinformatics analysis revealed a conserved 17-nt sequence(called the GU-rich element)in the 30-UTR of HD-GL2(Homeodomain-Glabra2)family genes including Roc5.Based on the model of this element in regulating mRNA stability in mammals,we speculate that the single nucleotide change in this element accounts for the higher expression level of Roc5 in the rl(t)mutant compared to the wild-type,which ultimately leads to adaxial rolling of the leaf.This discovery further enhances our knowledge of the molecular mechanisms underlying leaf rolling in rice. | Lei Li Xiang Xue Zongxiang Chen Yafang Zhang Yuyin Ma Cunhong Pan Junkai Zhu Xuebiao Pan Shimin Zuo | 2014 | Chinese Science Bulletin2014，59，25： | 4 |
| 15 | Loss of Wip1 aggravates brain injury after ischaemia/reperfusion by overactivating microglia显示文摘Background and purpose The inflammatory response mediated by microglia/macrophages is closely related to cerebral ischaemia/reperfusion injury.Wild-type p53-induced protein phosphatase 1(Wip1),a serine/threonine phosphatase,is expressed in various tissues.A growing number of reports have suggested that Wip1 is a negative regulator of inflammation in peripheral tissue;however,its role in the central nervous system(CNS)remains unclear.This study aimed to clarify whether Wip1 can inhibit CNS inflammation by regulating microglia/macrophage functions after ischaemic injury.Methods A model of middle cerebral artery occlusion and reperfusion was established in mice.CNS inflammation was simulated by lipopolysaccharide treatment of primary microglia.Laser speckle imaging was used to monitor regional cerebral blood flow.Behavioural outcomes were assessed with a TreadScan gait analysis system.TTC staining was used to evaluate the infarct volume,and western blotting and immunofluorescence staining were applied to detect the phenotypical transformation of microglia.ELISA was performed to detect the levels of inflammatory factors.Results Wip1 expression was increased after ischaemia/reperfusion.Wip1-knockout(KO)mice displayed more severe brain injury than wild-type mice,as indicated by aggravated motor dysfunction,greater brain infarct volumes and higher expression of inflammatory cytokines(interleukin-6 and tumour necrosis factor alpha)in the brain.We also found that Wip1 depletion increased microglial/macrophage activation in both in vitro and in vivo models,which all showed activation of microglia/macrophages.Lentivirus-Ppm1d reversed the injury induced by Wip1-KO.Conclusions Our results suggest that Wip1 may inhibit neuroinflammation by inhibiting microglial/macrophage activation after brain ischaemia/reperfusion injury. | Feng Yan Xiang Cheng Ming Zhao Shenghui Gong Ying Han Liping Ding Di Wu Yumin Luo Wei Zuo Lingling Zhu Ming Fan Xunming Ji | 2021 | Stroke & Vascular Neurology2021，6，3： | 4 |
| 16 | Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities显示文摘 | W. P. Jia C. Pang L. Chen Y. Q. Bao J. X. Lu H. J. Lu J. L. Tang Y. M. Wu Y. H. Zuo S. Y. Jiang K. S. Xiang | 2007 | Diabetologia2007，，2： | 4 |
| 17 | A compressed variance component mixed model for detecting QTNs and QTN-by-environment and QTN-by-QTN interactions in genome-wide association studies显示文摘Although genome-wide association studies are widely used to mine genes for quantitative traits,the effects to be estimated are confounded,and the methodologies for detecting interactions are imperfect.To address these issues,the mixed model proposed here first estimates the genotypic effects for AA,Aa,and aa,and the genotypic polygenic background replaces additive and dominance polygenic backgrounds.Then,the estimated genotypic effects are partitioned into additive and dominance effects using a one-way analysis of variance model.This strategy was further expanded to cover QTN-by-environment interactions(QEIs)and QTN-by-QTN interactions(QQIs)using the same mixed-model framework.Thus,a three-variance-component mixed model was integrated with our multi-locus random-SNP-effect mixed linear model(mrMLM)method to establish a new methodological framework,3VmrMLM,that detects all types of loci and estimates their effects.In Monte Carlo studies,3VmrMLM correctly detected all types of loci and almost unbiasedly estimated their effects,with high powers and accuracies and a low false positive rate.In re-analyses of 10 traits in 1439 rice hybrids,detection of 269 known genes,45 known gene-by-environment interactions,and 20 known gene-by-gene interactions strongly validated 3VmrMLM.Further analyses of known genes showed more small(67.49%),minor-allele-frequency(35.52%),and pleiotropic(30.54%)genes,with higher repeatability across datasets(54.36%)and more dominance loci.In addition,a heteroscedasticity mixed model in multiple environments and dimension reduction methods in quite a number of environments were developed to detect QEIs,and variable selection under a polygenic background was proposed for QQI detection.This study provides a new approach for revealing the genetic architecture of quantitative traits. | Mei Li Ya-Wen Zhang Ze-Chang Zhang Yu Xiang Ming-Hui Liu Ya-Hui Zhou Jian-Fang Zuo Han-Qing Zhang Ying Chen Yuan-Ming Zhang | 2022 | Molecular Plant2022，15，4： | 3 |
| 18 | Blast-induced rock damage control in Fangchenggang nuclear power station, China显示文摘In the process of blasting excavation, stress wave propagation and gas expansion can basically induce damage to surrounding rocks, which is detrimental to rock mass integrity and engineering safety. In this case, evaluation and control of blast-induced effects are essential to the safety of nearby buildings and integrity of bedrock in blasting field. In Fangchenggang nuclear power station of China, the drill-andblast method was employed for bedrock excavation. In order to reduce the blast-induced damage zone, the wave propagation and associated damage to rock mass should be carefully investigated. In this paper, the wave propagation regressively obtained from field monitoring data was presented based on empirical formula(e.g. Sadovsky formula). The relationship between the peak particle velocity(PPV) at a distance of 30 m away from the charge hole and charge per delay in blast design was derived. Meanwhile,the acoustic tests before and after blasting were conducted to determine the damage depth of rock mass.The charge per delay in blast design was then calibrated based on the blast-induced wave propagation regularity. The results showed that a satisfactory effect was achieved on blast-induced damage control of rock mass. This could be helpful to rock damage control in similar blasting projects. | Yongqing Zeng Haibo Li Xiang Xia Bo Liu Hong Zuo Jinlin Jiang | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，5： | 3 |
| 19 | Gene Expression Profile of Human Skeletal Muscle and Adipose Tissue of Chinese Han Patients with Type 2 Diabetes Mellitus显示文摘Objective To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus (T2DM) patients and healthy subjects using DNA microarray analysis. Methods T2DM patiens were divided into female group, young male group and old male group. DNA microarray analysis and quantitative real-time PCR were carried out to analyze the relation between gene expressions and T2DM. Results The mRNA expression of 298, 578, and 350 genes was changed in the skeletal muscle of diabetes mellitus patients compared with control subjects. The 1320, 1143, and 2847 genes were modified in adipose tissue of the three groups. Among the genes surveyed, the change of 25 and 39 gene transcripts in skeletal muscle and adipose tissue was ≥2 folds. These differentially expressed genes were classified into 15 categories according to their functions. Conclusion New genes are found and T2DM can be prevented or cured. | YAN-LI YANG RUO-LAN XIANG CHANG YANG XIAO-JUN LIU WEN-JUN SHEN JIN ZUO YONG-SHENG CHANG Fu-DE FANG | 2009 | Biomedical and Environmental Sciences2009，22，5： | 3 |
| 20 | Multi-proxy evidence of environmental change related to collapse of the Liangzhu Culture in the Yangtze Delta,China显示文摘The Liangzhu Culture(5300–4300 cal.a BP)has been regarded as the culmination of the Neolithic Age in the Yangtze Delta and as an archaic state.However,the reason behind the collapse of the Liangzhu Culture remains controversial.Some scholars attributed it to social conflicts or foreign invasions,while others suggested that environmental deterioration,such as cold episodes,inundation and palaeo-typhoon events,disrupted the civilization.Notably,the yellowish silty sediments widely overlying the Liangzhu group sites have been presumed to be one of the vital clues to resolving these issues.The process and cause of their formation are key to understanding the decline in the Liangzhu Culture.In this study,two typical profiles composed of the Liangzhu cultural layer and yellowish silty sediments were collected in Liangzhu Ancient City.Multiple proxies,including pollen,phytoliths and diatoms,along with radiocarbon and optically stimulated luminescence dating and synthesized geochemical evidence from different sediments,were applied to reconstruct ecological and hydrological changes and discuss their linkage to cultural collapse.The regional ecology was typical freshwater wetlands during 4800–4400 cal.a BP,which facilitated rice farming and large-scale architectural engineering in Liangzhu Ancient City.Evidence from microfossils and dating of the yellowish silty sediments indicated that Liangzhu Ancient City was significantly affected by seawater after abandonment during 4300–3400 cal.a BP.Furthermore,geochemical evidence,including trace element and Sr-Nd isotopic compositions,suggested that the primary provenance of the yellowish silt was a mixture of sediments from the Qiantang River,East China Sea,Yangtze River and Yellow River,which had been transported to Liangzhu Ancient City by the Yellow Sea Coastal Current and a marine transgression.Therefore,based on evidence from archaeological sites and numerical simulation in the Yangtze Delta,it was supposed that the short-term accelerated relative sea-level rise at approximately 4400 cal.a BP caused a marine transgression around Taihu Lake,formed a large range of yellowish silty sediments,destroyed rice farming production,and ultimately led to the collapse of the Liangzhu Culture. | Keyang HE Houyuan LU Guoping SUN Xiang JI Yonglei WANG Kaikai YAN Xinxin ZUO Jiangping ZHANG Bin LIU Ningyuan WANG | 2021 | Science China Earth Sciences2021，64，6： | 3 |
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