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22篇 您的检索式:作者名="Xiangcheng Zhu"
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1Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity显示文摘The present study aims to investigate the therapeutic effect and mechanism of glycyrrhizic acid(GA)in diabetic peripheral neuropathy(DPN).GA significantly mitigated nerve conduction velocity(NCV)deficit and morphological abnormality and reduced high-mobility group box-1(HMGB1)expression in the sciatic nerves of diabetic rats independent of blood glucose and body weight.Notably,GA alleviated the increase of HMGB1 and the decrease of cell viability in high glucose-stimulated RSC96 cells.Furthermore,GA obviously reduced the concentration of inflammatory cytokines in the sciatic nerves of diabetic rats and supernatants of high glucose-exposed RSC96 cells,then restored the decreased expression levels of nerve growth factor(NGF)and neuritin-1,and the increased expression levels of cleaved caspase-3 and neuron-specific enolase.Additionally,GA markedly inhibited receptor for advanced glycation end products(RAGE)expression,p38MAPK phosphorylation,and the nuclear translocation of NF-κBp65 in diabetic rats and high glucose-exposed RSC96 cells.The promotional effect of high glucose in RSC96 cells was diminished following Hmgb1 siRNA treatment.Our findings indicate that GA may exert neuroprotection on DPN by suppressing HMGB1,which lead to extenuation of inflammation response,balance of NGF,neuritin-1 and caspase-3,as well as inactivation of RAGE/p38MAPK/NF-κBp65 signaling pathway.Min Shi Xiangcheng Zhang Ridong Zhang Hong Zhang Dalong Zhu Xiao Han 2022The Journal of Biomedical Research2022,36,3:5
2Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 2022Hepatobiliary Surgery and Nutrition2022,11,2:4
3Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events.Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO 2022Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022,23,11:4
4Mycotoxin fumonisins: Health impacts and biosynthetic mechanism显示文摘Fumonisins 是在农业和食物工业的 mycotoxins 的最重要的组之一。他们被玉米的几普遍真菌的病原体生产。在导出玉米的食物的 Fumonisin 污染并且喂原因在家畜和姿势的几致命的疾病重要癌症风险到人(组 2B 致癌物) 。在最近的年里, fumonisins 在 mycotoxin 研究成为了一个热区域。这评论试图为 fumonisin 生合成和行动的模式在分子的机制的研究加亮进步。在 fumonisins 导致的细胞的效果的分子的基础的当前的理解被讨论。在帐篷离子的专辑被付在涉及 fumonisions 的生合成的单个基因酶的描述介绍进步。WANG Qiaomei WANG Jiansheng YU Fengan ZHU Xiangcheng Zaleta-Rivera Kathia DU Liangcheng 2006Progress in Natural Science:Materials International2006,16,1:3
5Reducing nitrogen application with dense planting increases nitrogen use efficiency by maintaining root growth in a double-rice cropping system显示文摘Rational nitrogen(N) application can greatly increase rice(Oryza sativa L.) yield. However, excessive N input can lead not only to low N use efficiency(NUE) but also to severe environmental pollution.Reducing N application rate with a higher planting density(RNHD) is recommended to maintain rice yield and improve NUE. The effects of RNHD on fertilizer N fate and rice root growth traits remain unclear. We accordingly conducted a two-year field experiment to investigate the influence of RNHD on rice yield, fertilizer 15N fate, and root growth in a double-rice cropping system in China. In comparison with the conventional practice of high N application with sparse planting, RNHD resulted in similar yield and biomass production as well as plant N uptake. RNHD increased agronomic NUEs by 23.3%–31.9%(P < 0.05) and N recovery efficiency by 17.4%–24.1%(P < 0.05). RNHD increased fertilizer 15N recovery rate by 14.5%–34.7%(P < 0.05), but reduced15 N retention rate by 9.2%–12.0%(P < 0.05). Although a reduced N rate led to significantly reduced root length, surface area, volume, and biomass, these root traits were significantly increased by higher planting density. RNHD did not affect these root morphological traits and reduced activities of nitrate reductase(NR) and glutamine synthetase(GS) only at tillering stage. Plant N uptake was significantly positively correlated with these root traits, but not correlated with NR and GS activities. Together, these findings show that reducing N application with dense planting can lead to high plant N uptake by maintaining rice root growth and thus increase NUE.Jin Chen Xiangcheng Zhu Jiang Xie Guoqiang Deng Tianhua Tu Xianjiao Guan Zhen Yang Shan Huang Xianmao Chen Caifei Qiu Yinfei Qian Caihong Shao Minggang Xu Chunrui Peng 2021The Crop Journal2021,9,4:3
6Pore Size Distribution and Its Quantitative Relationship with Strength of Corundum Based Castables显示文摘A series of corundum based castables with 0,2%,4%,6%,and 8% α-Al2O3 micropowders were prepared using tabular alumina aggregates (6-3,3-1 and ≤1 mm) and fines (≤0.088 and ≤0.045 mm),calcium aluminate cement,and α-Al2O3 micropowders (d50=1.754 μm) as starting materials. Cold mechanical strength and pore size distribution of the castables specimens after heat treatment at 110,1 100 and 1 500 ℃ were tested,respectively. The quantitative relationship between strength and apparent porosity,and that between strength and median pore diameter were verified by Atzeni equation. The correlation between interval of pore size and mechanical strength of specimens was also studied by means of gray relational theory. The results show that:(1) the pore size distribution of castables is strongly influenced by both micropowders filling and matrix sintering; the addition of micropowders decreases median pore diameter while the sintering process increases it; (2) when adding a constant correction term,Atzeni equation can substantially describe the quantitative relationship between median pore diameter and strength of castables specimens after heat treatment at the same temperature; the significant differences of the gray relational degree between the interval of pore size and castables strength are characterized; it is also found that for the same interval of pore size,the gray relational degree isaffected by the heat treatment temperature; the pore size interval <0.5 μm has the highest gray relational degree with the strength at 110-1 500 ℃.FANG Binxiang ZHU Boquan LI Xiangcheng WAN Hongbo 2010China's Refractories2010,19,4:2
7Synthesis and hydra- tion kinetics of calcium aluminate cement with micro MgA12 04 spi- nels 显示文摘Zhu Boquan Song Yanan Li Xiangcheng 2015Mater Chem Phys2015,154,:1
8Effect of ceramic bonding phases on the thermo-mechanical properties of Al 2 O 3 –C refractories显示文摘Boquan Zhu Yuenan Zhu Xiangcheng Li Fei Zhao 2013Ceramics International2013,,6:1
9Biomass Homogeneity Reinforced Carbon Aerogels Derived Functional Phase-Change Materials for Solar–Thermal Energy Conversion and Storage显示文摘We deviseda functional form stable compositephase-change materials(PCMs)toachieve a three-dimensional(3D)interconnectedporous carbon aerogel structure for encapsulating polyethyleneglycol(PEG).Anovelhomogeneity reinforced carbonaerogel witha well-interconnected porous structure was constructed bycombining a flexible carbonresource from biomass guar gum with hard-brittle carbonfrom polyimide,to overcome severeshrinkage andpoor mechanical performance of traditionalcarbon aerogel.Thesupportingcarbon aerogel-encapsulated PEG produced thenovel composite PCMswithgood structure stability andcomprehensive energy storage performance.Theresults showed thatthecomposite PCMsdisplayed awell-defined 3Dinterconnected structure,and theirenergy storage capacities were 171.5 and169.5 J/g,which changed onlyslightlyafter 100 thermalcycles,andthe compositescould maintainthe equilibrium temperature at50.0−58.1℃ for about 760.3 s.The thermal conductivityofthe compositescould reach0.62 W m^(−1) K^(−1),which effectively enhanced the thermalresponse rate.And thecomposite PCMs exhibited good leakage-proof performance andexcellent light–thermal conversion.The compressive strengthof thecomposite PCMscan improveupto 1.602 MPa.Results indicatethatthisstrategy canbe efficiently usedtodevelop novel composite PCMswithimproved comprehensive thermalperformance and high light–thermal conversion.Qingfeng Zhang Tingfeng Xia Qihan Zhang Yucao Zhu Huanzhi Zhang Fen Xu Lixian Sun Xiaodong Wang Yongpeng Xia Xiangcheng Lin Hongliang Peng Pengru Huang Yongjin Zou Hailiang Chu Bin Li 2023Energy & Environmental Materials2023,6,1:1
10High- level exogenous glutamie acid-independent production of poly-(-glutamic acid) with organic addition in a new iso- lated Bacillus subtilis CIO显示文摘Huili Zhang Jianzhong Zhu Xiangcheng Zhu 2012Bioresource Technology2012,116,:1
11Corrosion Mechanism of Ladle Furnace Refining Slag to Fired MgO-CaO Bricks显示文摘Corrosion effect of ladle furnace (LF) refining slag on fired MgO-CaO bricks with about 34% CaO was studied by static crucible method, and corrosion mechanism was analyzed by techniques of scan electron micrograph, energy dispersive spectrometer, and X-ray diffraction. The results show that: MgO-CaO bricks exhibit excellent corrosion resistance but poor penetration resistance to LF refining slag; oxidation of (Mg·Fe)O in reaction zone results in volume expansion forming cracks; penetration of 2CaO·Fe2O3 (C2F) from slag to MgO-CaO bricks increases liquid phases which accelerates corrosion of the bricks; a protective layer of 2CaO·SiO2 formed on reaction interface prevents penetration of C2F to the bricks.ZHU Boquan FANG Binxiang ZHANG Wenjie LI Xiangcheng WAN Hongbo 2010China's Refractories2010,19,3:1
12Efficient production of l -lactic acid from hydrolysate of Jerusalem artichoke with immobilized cells of Lactococcus lactis in fibrous bed bioreactors显示文摘Zhouming Shi Peilian Wei Xiangcheng Zhu Jin Cai Lei Huang Zhinan Xu 2012Enzyme and Microbial Technology2012,,5:1
13Influences of Al and Si Powders on Microstructure and Hot Mechanical Properties of Al_2O_3-C Slide Plates显示文摘The basic formulation of Al2O3- C slide plates was65%( in mass,the same hereinafter) white fused corundum particles,25% white fused corundum fines,6% active α-Al2O3 micropowder,4% carbon black and flake graphite, and additional 4% phenolic resin.Based on this formulation,3% Al powder,3% Si powder,and 3% Al + 3% Si powder were used to substitute equivalent white corundum fines to improve the hot mechanical properties of Al2O3- C slide plates. The specimens with dimensions of 140 mm × 25 mm × 25 mm were pressed at 150 MPa,dried at 200 ℃ for 24 h,and hot treated at 1 400 ℃ for 3 h in carbon embedded condition. Then hot modulus of rupture and thermal shock resistance of the specimens were tested and the phase compositions and microstructure were analyzed. The results show that specimen with 3% Al powder has the higher hot modulus of rupture but lower residual modulus of rupture after thermal shock than the specimen with3% Si powder; the specimen with 3% Al + 3% Si powders exhibits the highest hot modulus of rupture and the best thermal shock resistance; the change of mechanical property is closely related with the in-situ formed nonoxides: AlN in the form of bars is formed in specimens with Al powder; fibrous SiC whiskers are formed in specimens with Si powder; in the specimens with both Al and Sipowders,besides AlN and SiC whiskers,hexagonal tabular SiAlON is in-situ synthesized,which interlocks with each other.ZHAO Fei ZHU Boquan LI Xiangcheng ZHU Yuenan 2014China's Refractories2014,23,3:0
14Effects of Magnesia Fines Addition and Spinel with Different Compositions on Thermal Expansion Behavior of Alumina Magnesia Castables显示文摘Effects of magnesia fines addition ( 4% ,6% and 8% in mass) and spinel with different compositions ( alumina-rich,magnesia-rich and stoichiometric spinel) on thermal expansion behavior of alumina magnesia castables were researched using tabular corundum, magnesia fines,spinel fines,ρ-Al2O3,Secar-71 cement and SiO2 fume as main starting materials. The results show that: ( 1) thermal expansion coefficients of specimens with 4 mass% and 6 mass% magnesia fines have the similar change tendency,increasing slightly with temperature rising; when magnesia addition is 8 mass% ,the thermal expansion coefficient increases obviously at 1 050 ℃ and reaches the peak at 1 350 ℃ ; ( 2) when MgO content is the same,the specimen with magnesia-rich spinel has the lowest thermal expansion coefficient; ( 3) for the castables specimens with the same MgO content,the specimen with magnesia has higher thermal expansion coefficient than that with presynthesized spinel,which is related with the secondary spinelization during the heating process.ZHANG Qiaoyan ZHU Boquan LI Xiangcheng 2012China's Refractories2012,21,2:0
15Effect of Spherical Ni Powder on Microstructure of Secondary Carbon in MgO-C Refractories Matrix显示文摘In order to tackle the shortcomings of high brittleness,hard graphitization,and poor oxidation resistance resulted from carbonization of phenolic resin of Mg O- C refractories, effects of 2 mass% spherical Ni, and2 mass% spherical Ni plus 7. 5 mass% Al composite powder on microstructure of the secondary carbon in Mg O- C refractories matrix were investigated. The results show that a large number of carbon whiskers form after the carbonization of phenolic resin with Ni powder;in the Mg O- C refractories matrix with only Ni powder,the carbon microspheres form at all treatment temperatures and change slightly with the temperature rising;the carbon whiskers begin to generate in the specimens with composite powder at 1 000 ℃,the diameter of the carbon whiskers is about 0. 4- 0. 5 μm,and the length is about 3- 4 μm,and the formed carbon whiskers increase gradually with the temperature rising.WANG Xian ZHU Boquan LI Xiangcheng MA Zheng WEI Ying 2015China's Refractories2015,24,2:0
16Sintering Densification of Boron Carbide Materials and Their Research Progress显示文摘Boron carbide(B_(4)C)has excellent high-temperature oxidation resistance,high hardness,low relative density,high melting point and excellent abrasive resistance,which is widely used in fields such as refractories,wear-resistant materials and lightweight protective materials.The research progress and application of B_(4)C materials in China and overseas in recent years were summarized.The influences of sintering processes(pressureless sintering,hot-pressing sintering,hot isostatic pressing sintering,spark plasma sintering and microwave sintering)and sintering additives(simple substances,oxides and carbides)on the B_(4)C densification were analyzed.The development of B_(4)C materials was prospected.ZOU Xin CHEN Ping'an XU Guangping LI Xiangcheng ZHU Yingli ZHU Boquan 2023China's Refractories2023,32,4:0
17Carbonization of Ni-doped Phenol Resin Under Various Conditions显示文摘Ni-doped phenol resin was prepared with 1∶100 mass ratio of Ni( NO_3)_2·6H_2O to thermosetting phenol resin to optimize the structure and properties of pyrolytic carbon derived from phenol resin and increase its carbon yield. The specimens were cured at 200 ℃ and carbonized under different atmospheres( carbon-embedded atmosphere and Ar atmosphere) and at different temperatures( 600,800,1000 and 1200 ℃) for3 h,respectively. The carbon yield was measured. Thermal decomposition characteristics of Ni-doped phenol resin,and the oxidation resistance,phase composition and microstructure of pyrolytic carbon were characterized by differential scanning calorimetry,X-ray diffraction,energy dispersive spectroscopy, scanning electron microscopy and transmission electron microscopy. The results show that the carbon yield of Ni-doped phenol resin carbonized at800 or 1 000 ℃ is increased significantly,compared with that without any dopants. The graphitization degree of pyrolytic carbon structure derived from Ni-doped phenol resin increases with the increase of carbonization temperature. The massive multi-wall carbon nanotubes of 50-100 nm in diameter and of micrometre scale in length are generated at 1000 ℃. Compared with the carbonembedded atmosphere,carbon nanotubes can be more easily generated in Ar atmosphere,resulting in higher carbon yield and degree of crystallinity of the pyrolyticcarbon derived from Ni-doped phenol resin. The oxidation resistance of the pyrolytic carbon derived from Ni-doped phenol resin at 1200 ℃ is improved significantly and its highest oxidation temperature is increased by about 84℃,compared with that from Ni free phenol resin.WEI Guoping ZHU Boquan LI Xiangcheng MA Zheng 2017China's Refractories2017,26,2:0
18Influence of α-Al_2O_3 Micropowder Addition on Properties of Corundum Dry Ramming Mix显示文摘In order to improve the service life of corundum lining for induction furnace,corundum dry ramming mix was prepared using brown corundum,fused magnesia,and α-Al2O3 micropowder as main starting materials,and the influence of α-Al2O3 micropowder additions(0,1%,2%,and 3%,in mass) on properties of corundum dry ramming mix was investigated. The results show that after heat treating at 1 600 ℃,with the increase of α-Al2O3 addition,the permanent change in dimensions on heating of the specimens decreases firstly and then increases,bulk density increases,apparent porosity decreases,and the crushing strength declines firstly and then enhances; when the addition of α-Al2O3 is 2 mass%,the permanent change in dimensions on heating of the specimens is relatively small and the crushing strength decreases to 22. 8 MPa. The XRD and SEM results show that after firing at 1 600 ℃ for 3 h small granular magnesium aluminate spinel forms and is welldistributed,which enhances the density.ZHANG Pinwei LI Xiangcheng ZHU Boquan 2013China's Refractories2013,22,3:0
19Differential impacts of adult trees on offspring and non-offspring recruits in a subtropical forest显示文摘An important mechanism promoting species coexistence is conspecific negative density dependence(CNDD),which inhibits conspecific neighbors by accumulating host-specific enemies near adult trees.Natural enemies may be genotype-specific and regulate offspring dynamics more strongly than non-offspring,which is often neglected due to the difficulty in ascertaining genetic relatedness.Here,we investigated whether offspring and non-offspring of a dominant species,Castanopsis eyrei,suffered from different strength of CNDD based on parentage assignment in a subtropical forest.We found decreased recruitment efficiency(proxy of survival probability)of offspring compared with non-offspring near adult trees during the seedling-sapling transition,suggesting genotype-dependent interactions drive tree demographic dynamics.Furthermore,the genetic similarity between individuals of same cohort decreased in late life history stages,indicating genetic-relatedness-dependent tree mortality throughout ontogeny.Our results demonstrate that within-species genetic relatedness significantly affects the strength of CNDD,implying genotype-specific natural enemies may contribute to population dynamics in natural forests.Fang Wang Xiangcheng Mi Lei Chen Wubing Xu Walter Durka Nathan GSwenson Daniel JJohnson Samantha JWorthy Jianhua Xue Yan Zhu Bernhard Schmid Yu Liang Keping Ma 2022Science China(Life Sciences)2022,65,10:0
20Strength and deformation characteristics of irregular columnar jointed rock mass: A combined experimental and theoretical study显示文摘The irregularity of jointed network poses a challenge to the determination of field mechanical param-eters of columnar jointed rock mass(CJRM),and a reasonable prediction of deformation and strength characteristics of CJRM is important for engineering construction.The Voronoi diagram and three-dimensional printing technology were used to make an irregular columnar jointed mold,and the irregular CJRM(ICJRM)specimens with different dip directions and dip angles were prepared.Uniaxial compression tests were performed,and the anisotropic strength and deformation characteristics of ICJRM were described.The failure modes and mechanisms were revealed in accordance with the final appearances of the ICJRM specimens.Based on the model test results,the empirical correlations for determining the field deformation and strength parameters of CJRM were derived using the dip angle and modified joint factor.The proposed empirical equations were used in the Baihetan Project,and the calculated mechanical parameters were compared with the field test results and those obtained from the tunneling quality index method.Results showed that the deformation parameters determined by the two proposed methods are all consistent with the field test results,and these two methods can also estimate the strength parameters effectively.Xiangcheng Que Zhende Zhu Yanxin He Zihao Niu Haonan Huang 2023Journal of Rock Mechanics and Geotechnical Engineering2023,15,2:0
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