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| 1 | Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis显示文摘间充质的干细胞(MSC ) 试验性地被使用了对待煽动性的混乱,部分由于他们的抑制免疫力的性质。尽管 interleukin-1β(IL-1β) 是最重要的煽动性的调停人之一,成长证据显示那 IL-1β发信号得到 MSC 的抑制免疫力的性质。然而,它仍然保持不清楚怎么 IL-1β发信号完成这项活动。这里,我们集中于 IL-1β 的治疗学的功效;在葡聚糖硫酸盐钠(决策支持系统) 的告知的 MSC 劝诱了大肠炎模型,除了加重的机制。我们首先发现了那 IL-1β没有在 vitro 的任何看得见的显型变化,告知的 MSC 显著地稀释了导致决策支持系统的鼠科的大肠炎的发展。而且, IL-1β告知的 MSC 通过提高 cyclooxygenase-2 (COX-2 ) 在怒气和 mesenteric 淋巴节点(MLN ) 调制了有免疫力的房间的平衡, IL-6 和 IL-8 表示并且影响腹巨噬细胞的极化。重要地, IL-1β告知的 MSC 拥有了一个提高的能力经由 chemokine 受体类型 4 的 upregulation (CXCR4 ) 移居到内脏的煽动性的地点表示。在摘要, IL-1β告知的 MSC 在对待导致决策支持系统的大肠炎改进了功效,它部分至少取决于他们的增加的抑制免疫力的能力和提高的迁居能力。 | Hongye Fan Guangfeng Zhao Liu Liu Fei Liu Wei Gong Xianqin Liu Liu Yang Jianjun Wang Yayi Hou | 2012 | Cellular & Molecular Immunology2012，9，6： | 21 |
| 2 | Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?显示文摘Alcohol consumption is the principal factor in thepathogenesis of chronic liver diseases.Alcoholic liver disease(ALD)is defined by histological lesions on the liver that can range from simple hepatic steatosis to more advanced stages such as alcoholic steatohepatitis,cirrhosis,hepatocellular carcinoma and liver failure.As one of the oldest forms of liver injury known to humans,ALD is still a leading cause of liver-related morbidity and mortality and the burden is exerting on medical systems with hospitalization and management costs rising constantly worldwide.Although the biological mechanisms,including increasing of acetaldehyde,oxidative stress with induction of cytochrome p4502E1,inflammatory cytokine release,abnormal lipid metabolism and induction of hepatocyte apoptosis,by which chronic alcohol consumption triggers serious complex progression of ALD is well established,there is no universally accepted therapy to prevent or reverse.In this article,we have briefly reviewed the pathogenesis of ALD and the molecular targets for development of novel therapies.This review is focused on current therapeutic strategies for ALD,including lifestyle modification with nutrition supplements,available pharmacological drugs and new agents that are under development,liver transplantation,application of complementary medicines,and their combination.The relevant molecular mechanisms of each conventional medication and natural agent have been reviewed according to current available knowledge in the literature.We also summarized efficacy vs safety on conventional and herbal medicines which are specifically used for the prevention and treatment of ALD.Through a system review,this article highlighted that the combination of pharmaceutical drugs with naturally occurring agents may offer an optimal management for ALD and its complications.It is worthwhile to conduct large-scale,multiple centre clinical trials to further prove the safety and benefits for the integrative therapy on ALD. | Moon-Sun Kim Madeleine Ong Xianqin Qu | 2016 | World Journal of Gastroenterology2016，22，1： | 13 |
| 3 | Graft-accelerated virus-induced gene silencing facilitates functional genomics in rose flowers显示文摘Rose has emerged as a model ornamental plant for studies of flower development, senescence, and morphology, as well as the metabolism of floral fragrances and colors.Virus-induced gene silencing(VIGS) has long been used in functional genomics studies of rose by vacuum infiltration of cuttings or seedlings with an Agrobacterium suspension carrying TRV-derived vectors. However, VIGS in rose flowers remains a challenge because of its low efficiency and long time to establish silencing. Here we present a novel and rapid VIGS method that can be used to analyze gene function in rose,called ‘graft-accelerated VIGS', where axil ary sprouts are cut from the rose plant and vacuum infiltrated with Agrobacterium. The inoculated scions are then grafted back onto the plants to flower and silencing phenotypes can be observed within 5 weeks, post-infiltration. Using this new method, we successfully silenced expression of the RhDFR_1, RhA G, and RhNUDX_1 in rose flowers, and affected their color, petal number, as well as fragrance, respectively. This grafting method will facilitate high-throughput functional analysis of genes in rose flowers. Importantly, it may also be applied to other woody species that are not currently amenable to VIGS by conventional leaf or plantlet/seedling infiltration methods. | Huijun Yan Shaochuan Shi Nan Ma Xiaoqian Cao Hao Zhang Xianqin qiu Qigang Wang Hongying Jian Ningning Zhou Zhao Zhang Kaixue Tang | 2018 | Journal of Integrative Plant Biology2018，60，1： | 11 |
| 4 | Inheritance of Perpetual Blooming in Rosa chinensis ‘Old Blush'显示文摘Perpetual blooming is one of the most important biological and economical traits in modern rose, while the genetic basis underlining the control of this trait is poorly investigated. With an aim in dissecting the genetic determinism of perpetual blooming, we developed six rose populations(OB, W, F1, F2, BC1 OB and BC1W) derived from a WOB population [interspecific diploid hybridization between Rosa chinensis ‘Old Blush'(OB) and R. wichuriana ‘Basye's Thornless'(W)]. Perpetual blooming is absent both in a F1 population with 296 individuals and a BC1 W population(W as the backcross parent) with 150 individuals. However, the perpetual blooming trait showed a typical 3︰1 segregation in a backcross population BC1 OB with OB as the backcross parent. In this population with 300 individuals, 83 plants had the perpetual blooming phenotype while the other 217 featured non-perpetual blooming, indicating that the perpetual blooming trait is very likely controlled by two recessive genes in R. chinensis(rpb1 and rpb2). These genetic data suggest that the inheritance of rose perpetual blooming may be controlled by a complex mechanism. | LI Shubin ZHOU Ningning ZHOU Qing YAN Huijun JIAN Hongying WANG Qigang CHEN Min QIU Xianqin ZHANG Hao WANG Shufang LI Shufa TANG Kaixue | 2015 | Horticultural Plant Journal2015，1，2： | 9 |
| 5 | Metal-free, carbon-based catalysts for oxygen reduction reactions显示文摘开发没有金属的、基于碳的催化剂为氧减小反应(ORR ) 代替基于铂的催化剂是研究的一个新兴的区域。在最近的年里,包括碳的不同的碳结构与 IIIA-VIIA heteroatoms 做了(厘米基于地点,在 M 代表做的 heteroatom 的地方) 并且在碳 nanotubes (CNT ) 包含的 polynitrogen (PN ) 混合物(NN 基于地点) 被综合了。比作金属性的催化剂,这些材料高度活跃、稳定、便宜、环境地友好。这评论讨论 heteroatoms 的加入怎么提高 ORR 活动的这些材料,他们的 ORR 表演和机制的发展。为定制碳底层的结构改进 ORR 性能的策略也被讨论。在这个区域的未来研究将需要包括优化合成策略控制合并 heteroatoms 的类型,数量和分发,以及更好在这些催化剂理解 ORR 机制。 | Zhiyi Wu Zafar Iqbal Xianqin Wang | 2015 | Frontiers of Chemical Science and Engineering2015，9，3： | 4 |
| 6 | Required catalytic properties for alkane production from carboxylic acids: Hydrodeoxygenation of acetic acid显示文摘The supported Pt catalysts(1 wt%)were prepared by the incipient impregnation method and analyzed using synchrotron-based X-ray diffraction,BET surface area,oxygen adsorption,CO pulse chemisorption,temperature-programmed desorption(TPD)of acetic acid,H2-TPD,NH3-TPD,O2-TPD,and H2-TPR.The reactivity of Pt-based catalysts was studied using a fixed bed reactor at 300 C and 4 MPa for hydrodeoxygenation of acetic acid,where Pt/TiO2 was very selective for ethane production.TPD experiments revealed that several conditions must be satisfied to achieve this high selectivity to ethane from acetic acid,such as Pt sites,moderate acidity,and medium metal-oxygen bond strength in the oxide support.This work provides insights in developing novel catalytic materials for hydrocarbon productions from various organics including bio-fuels. | Zhong He Xianqin Wang | 2013 | Journal of Energy Chemistry2013，22，6： | 3 |
| 7 | Preparation of aluminum borate whisker reinforced aluminum phosphate wave-transparent materials显示文摘Aluminum borate whisker/aluminum phosphates composites were prepared with normal pressure sintering. It was found that the aluminum borate whisker was effective to suppress the crystallization of aluminum phosphates in the aluminum borate whisker/aluminum phosphates composites and contributed to the improvement of the mechanical properties. After sintered at 1050℃ for 1 h, the flexural strength of the composites with 30 vol% aluminum borate whisker addition reached 215.3 MPa. The dielectric constant and loss tangent of the composites were 4.23 and 0.0024 at 10 GHz. | LU ZhenYu GENG HaoRan ZHANG MingXi HOU XianQin | 2008 | Chinese Science Bulletin2008，53，19： | 3 |
| 8 | Highly selective catalytic hydrodeoxygenation of guaiacol to cyclohexane over Pt/TiO2 and NiMo/Al2O3 catalysts显示文摘 | Zhong HE Xianqin WANG | 2014 | Frontiers of Chemical Science and Engineering2014，8，3： | 2 |
| 9 | Carbonaceous particles in Muztagh Ata ice core,West Kunlun Mountains,China显示文摘Carbonaceous particles concentrations of OC and EC are determined using a two-step gas chroma-tography system in Muztagh Ata ice core covering the time period of 1955―2000.Over the period rep-resented by the core,OC and EC concentrations appear to have changed significantly,varied in the range of 17.7―216.7 and 6.5―124.6,and averaged 61.8,32.9 ng·g-1,respectively.The average concen-tration of EC in Muztagh Ata ice core is much lower than that in an Alpine ice core record(100―300 ng·g-1) during the same period,but it is a factor of 14 in Greenland ice core(2.3 ng·g-1),this may induce a strong impact on the snow albedo in the last 46 years in our study area.Observations indicate two periods with obviously high deposition concentrations(1955―1965 and 1974―1989) and two periods with low concentrations(1966―1973 and 1990―1995),as well as a recent increasing trend.By com-paring EC and SO42- concentration variations and deciphering OC/EC ratios recorded in the same ice core,we can judge roughly that the carbonaceous particles deposited in Muztagh Ata ice core were attributed to fossil fuel combustion sources. | LIU XianQin XU BaiQing YAO TanDong WANG NingLian WU GuangJian | 2008 | Chinese Science Bulletin2008，53，21： | 2 |
| 10 | Isobaric vapor–liquid equilibrium for ternary system of ethanol, ethyl propionate and para-xylene at 101.3 kPa显示文摘Isobaric vapor–liquid equilibrium(VLE) data for the binary system ethyl propionate(2) + para-xylene(3) and ternary system ethanol(1) + ethyl propionate(2) + para-xylene(2) at atmospheric pressure(101.3 k Pa)were obtained by a VLE modified othmer still. All the experimental data passed a point to point consistency test of Van Ness method, which verified the data reliability. The Wilson and UNIQUAC activity coefficient models were employed to correlate the binary VLE data to obtain binary interaction parameters. Based on binary interaction parameters, ternary VLE data of ethanol(1) + ethyl propionate(2) + para-xylene(3) were predicted by Wilson and UNIQUAC models, which proved that predicted values are consistent with the experimental data.Furthermore, azeotropic phenomenon between ethanol and ethyl propionate disappears when the mole ratio of para-xylene and binary system of ethanol and ethyl propionate is 1:1. Therefore, this paper convinced that para-xylene is a proper extractive additive that could be used in extractive distillation to separate the binary azeotropic system of ethanol and ethyl propionate. | Zhongpeng Xing Yujie Gao Hui Ding Xianqin Wang Lujun Li Hang Zhou | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 1 |
| 11 | A novel DSPP mutation is associated with type dentinogenesis imperfecta in a chinese family 显示文摘 | Zhang Xianqin Chen Lanying Liu Jingyu | 2007 | BMC Medical Genetics2007，52，8： | 1 |
| 12 | Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease显示文摘 | VARMAN T SAMUEL ZHEN XIANG LIU XIANQIN QU | 2004 | J Biol Chem2004，279，32： | 1 |
| 13 | Intrinsic properties of active sites for hydrogen production from alcohols without coke formation显示文摘The detailed reaction pathway and coke formation mechanism over Pt/metal oxide nanoparticles during the steam reforming of ethanol(SRE) at 300℃were studied.The catalysts were prepared by incipient wetness impregnation method and were characterized with CO pulse chemisorption, BET surface measurement,oxygen adsorption,ethanol-TPD,NH3-TPD,and TPO.The SRE activity of the catalysts with steam/ethanol molar ratio of 3/1 was tested using a continuous fixed-bed reactor.Strong interaction between Pt and supports causes lower H2 production temperatures and no C2H4 formation,while weak interaction leads to C2H4 formation and strong bonded CO on Pt particles during ethanol-TPD. H2 production over Pt-based catalysts is mainly resulted from the decomposition and dehydrogenation of ethanol,and decarbonylation of acetaldehyde.Meanwhile,coke can be formed from acetaldehyde,acetone,C2H4 and CO.However,when the interaction between Pt and supports is weak,more coke is formed especially from acetone,C2H4 and CO.When the interaction is strong,no coke formation is observed due to high oxygen storage capacity of the catalyst. | Zhong He Xianqin Wang | 2013 | Journal of Energy Chemistry2013，22，3： | 1 |
| 14 | Heavy metalpollution of the world largest antimony mine-affected agriculturalsoils in Hunan province ( China) 显示文摘 | WANG Xianqin HE Mengchang XIE Jun | 2010 | Journal of Soils andSediments2010，10，5： | 1 |
| 15 | Antimonypollution in China显示文摘 | HE Mengchang WANG Xianqin WU Fengchang | 2012 | Sci Total Environ2012，42，： | 1 |
| 16 | Formation of La-modified L1 2 –Al 3 Ti by mechanical alloying and annealing显示文摘 | ShouRen Wang Changchun Li Wang Yong Xianqin Hou Haoran Geng FuSong Xu | 2007 | Materials Characterization2007，，4： | 1 |
| 17 | Genomes of 12 fig wasps provide insights into the adaptation of pollinators to fig syconia显示文摘Figs and fig pollinators are one of the few classic textbook examples of obligate pollination mutualism.The specific dependence of fig pollinators on the relatively safe living environment with sufficient food sources in the enclosed fig syconia implies that they are vulnerable to habitat changes.However,there is still no extensive genomic evidence to reveal the evolutionary footprint of this long-term mutually beneficial symbiosis in fig pollinators.In fig syconia,there are also non-pollinator species.The non-pollinator species differ in their evolutionary and life histories from pollinators.We conducted comparative analyses on 11 newly sequenced fig wasp genomes and one previously published genome.The pollinators colonized the figs approximately 66.9 million years ago,consistent with the origin of host figs.Compared with nonpollinators,many more genes in pollinators were subject to relaxed selection.Seven genes were absent in pollinators in response to environmental stress and immune activation.Pollinators had more streamlined gene repertoires in the innate immune system,chemosensory toolbox,and detoxification system.Our results provide genomic evidence for the differentiation between pollinators and nonpollinators.The data suggest that owing to the long-term adaptation to the fig,some genes related to functions no longer required are absent in pollinators. | Jinhua Xiao Xianqin Wei Yi Zhou Zhaozhe Xin Yunheng Miao Hongxia Hou Jiaxing Li Dan Zhao Jing Liu Rui Chen Liming Niu Guangchang Ma Wenquan Zhen Shunmin He Jianxia Wang Xunfan Wei Weihao Dou Zhuoxiao Sui Haikuan Zhang Shilai Xing Miao Shi Dawei Huang | 2021 | Journal of Genetics and Genomics2021，48，3： | 1 |
| 18 | A novel DSPP mutation is associated with type lI dentinogenesis imperfecta in a chinese family 显示文摘 | Zhang Xianqin Chen Lanying Liu Jingyu | 2007 | BMC Medical Genetics2007，52，8： | 1 |
| 19 | Efficient degradation of atrazine through in-situ anchoring NiCo_(2)O_(4) nanosheets on biochar to activate sulfite under neutral condition显示文摘Sulfite (S(IV)) is a promising substitute for sulfate radical-based advanced oxidation processes.Here,a composite of in-situ anchoring Ni Co_(2)O_(4)nanosheets on biochar (BC) was firstly employed as a heterogeneous activator for sulfite (Ni Co_(2)O_(4)@BC-sulfite) to degrade atrazine (ATZ) in the neutral environment.The synergistic coupling of BC and Ni Co_(2)O_(4)endows the resulting composite excellent catalytic activity.82% of the degradation ratio of ATZ (1 mg/L) could be achieved within 10 min at initial concentrations of 0.6 g/L Ni Co_(2)O_(4)@BC,3.0 mmol/L sulfite in neutral environment.When further supplementing sulfite into the system at 20 min (considering the depletion of sulfite),outstanding degradation efficiency (100%) were achieved in the next 10 min without any other energy input by the Ni Co_(2)O_(4)@BC-sulfite system.The features of the prepared catalysts and the effects of some key parameters on ATZ degradation were systematically examined.A strong inner-sphere complexation (≡Co_(2)+/Ni^(2+)-SO_(3)^(2-)) was explored between sulfite and the metal sites on the Ni Co_(2)O_(4)@BC surface.The redox cycle of the surface metal efficiently mediated sulfite activation and triggered the series radical chain reactions.The generated radicals,in particular the surface-bound radicals were involved in ATZ degradation.High performance liquid chromatography-tandem mass spectrometry (LC-MS) technique was used to detect the degradation intermediates.Density functional theory (DFT) calculations were performed to illustrate the possible degradation pathways of ATZ.Finally,an underlying mechanism for ATZ removal was proposed.The present study offered a low-cost and sustainable catalyst for sulfite activation to remove ATZ in an environmentally friendly manner from wastewater. | Lizhen Feng Yijin Yuan Xianqin He Mengsi Wu Lizhi Zhang Jingming Gong | 2023 | Journal of Environmental Sciences2023，，4： | 1 |
| 20 | Fabrication of high-strength continuous zirconia fibers and their formation mechanism study显示文摘 | Liu Heyi Hou Xianqin Wang Xinqiang | 2004 | J Am Ceram Soc2004，87，12： | 1 |
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