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| 1 | Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210显示文摘Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. | Xuelian Chen Lanying Ma Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu | 2019 | Cancer Biology & Medicine2019，16，1： | 53 |
| 2 | Study on the recovery of hydrogen from refinery (hydrogen+methane) gas mixtures using hydrate technology显示文摘A novel technique for separating hydrogen from (H2 + CH4) gas mixtures through hydrate formation/dissociation was proposed. In this work, a systematic experimental study was performed on the separation of hydrogen from (H2 + CH4) feed mixtures with various hydrogen contents (mole fraction x = 40%-90%). The experimental results showed that the hydrogen content could be enriched to as high as ~94% for various feed mixtures using the proposed hydrate technology under a temperature slightly above 0℃ and a pressure below 5.0 MPa. With the addition of a small amount of suitable additives, the rate of hydrate formation could be increased significantly. Anti-agglomeration was used to disperse hydrate particles into the condensate phase. Instead of preventing hydrate growth (as in the kinetic inhibitor tests), hydrates were allowed to form, but only as small dispersed particles. Anti-agglomeration could keep hydrate particles suspended in a range of condensate types at 1℃ and 5 MPa in the water-in-oil emulsion. | WANG XiuLin CHEN GuangJin YANG LanYing ZHANG LinWei | 2008 | Science China Chemistry2008，51，2： | 17 |
| 3 | A continuous and high-efficiency process to separate coal bed methane with porous ZIF-8 slurry:Experimental study and mathematical modelling显示文摘Coal bed methane has been considered as an important energy resource.One major difficulty of purifying coal bed methane comes from the similar physical properties of CH_4 and N_2.The ZIF-8/water-glycol slurry was used as a medium to separate coal bed methane by fluidifying the solid adsorbent material.The sorption equilibrium experiment of binary mixture(CH_4/N_2)and slurry was conducted.The selectivity of CH_4 to N_2 is within the range of 2-6,which proved the feasibility of the slurry separation method.The modified Langmuir equation was used to describe the gas-slurry phase equilibrium behavior,and the calculated results were in good agreement with the experimental data.A continuous absorption-adsorption and desorption process on the separation of CH_4/N_2 in slurry is proposed and its mathematical model is also developed.Sensitivity analysis is conducted to determine the operation conditions and the energy performance of the proposed process was also evaluated.Feed gas contains 30 mol%of methane and the methane concentration in product gas is 95.46 mol%with the methane recovery ratio of 90.74%.The total energy consumption for per unit volume of product gas is determined as 1.846 kWh Nm^(-3).Experimental results and process simulation provide basic data for the design and operation of pilot and industrial plant. | Wan Chen Xiaonan Guo Enbao Zou Mengling Luo Mengzijing Chen Mingke Yang Hai Li Chongzhi Jia Chun Deng Changyu Sun Bei Liu Lanying Yang Guangjin Chen | 2020 | Green Energy & Environment2020，5，3： | 5 |
| 4 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 5 | EFFECT OF LASER SCANNING SPEED ON PHASE CONSTITUTION AND WEAR RESISTANCE OF LASER CLADDING HARD FACING ALLOY STELLITE 12显示文摘Effect of laser scanning speed on phase constitution,microstructure,microhardness and wearresistance of laser-cladding hard facing alloy Stellite 12 has been investigated by means of across-flow-type CO2 laser of 1.5 kW.The laser-cladding layer on the alloy consists of ma-trix phase of suppersaturated solid solution γ(Co,Cr)and complex hexagonal carbideM7C3.Under certain condition,at higher laser scanning speed,the suppersaturated solubilityof elements increases in γ(Co,Cr),and the precipitation of the complex carbtde M7C3 de-creases,so the microhardness increases and the wear resistance decreases.But at slower laserscanning speed,more complex carbide M7C3 may precipitate,and the wear resistance may beimproved.Therefore,it is believed that the principal factor in improving wear resistance is theprecipitation of carbide M7C3,while increment of microhardness is the suppersaturated solu-bility of elements in matrix phase γ(Co,Cr). | XU Yourong ZHANG Henghua CHEN Darning XIE Fuchun XU Mingyu Shanghai University of Science and Technology,Shanghai,ChinaCHEN Lanying SU Baorong QIAN Hongbin Shanghai Optics and Fine Mechinery Research Institute,Academia Sinica,Shanghai,China XU Yourong,professor,Department of Materials Science and Engineering,Shanghai University of Science and Technology,Shanghai 201800,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，5： | 3 |
| 6 | Content analyses in GaMnAs by double-crystal X-ray diffraction显示文摘A model for analyzing point defects in com-pound crystals was improved. Based on this modified model, a method for measuring Mn content in GaMnAs was estab-lished. A technique for eliminating the zero-drift-error was also established in the experiments of X-ray diffraction. With these methods, the Mn content in GaMnAs single crystals fabricated by the ion-beam epitaxy system was analyzed. | CHEN Nuofu XIU Huixin YANG Junling WU Jinling ZHONG Xingru LIN Lanying | 2002 | Chinese Science Bulletin2002，47，4： | 2 |
| 7 | A core–shell amidoxime electrospun nanofiber affinity membrane for rapid recovery Au(Ⅲ) from water显示文摘An affinity membrane was prepared by coaxial electrospinning and amidoxime(AONFA),and it was applied to selectively recovery Au(Ⅲ)from an aqueous solution.The static adsorption results showed that,when p H at 5,the maximum adsorption capacity of AONFA membrane for Au(Ⅲ)was 509.3 mg·g^(-1).AONFA membrane exhibit much higher affinity and selectivity towards Au(Ⅲ)than other metal cations.The membrane could be regenerated effectively by mixture solution of thiourea and HCl,and the desorption ratio reached almost 100%after 4 hours desorption.The dead-end filtration results showed that,the membrane utilization efficiency and adsorption capacity can be improved by increasing the flow rate,while increasing the concentration shorted the breakthrough process and had little impact to adsorption capacity.We can flexibly adjust the flow rate and concentration according to the situation to obtain the maximum utilization efficiency of the membrane in filtration process.The dynamic adsorption capacity is higher than the static adsorption capacity.The adsorption mechanism for Au(Ⅲ)is electrostatic adsorption and reduction.Thus,AONFA membrane filtration was demonstrated to be a promising method for continuous recover Au(Ⅲ)from wastewater. | Yang Chen Lanying Jiang | 2022 | Chinese Journal of Chemical Engineering2022，35，2： | 2 |
| 8 | Carrier concentration profiling in magnetic GaMnSb/GaSb investigated by electrochemistry capacitance-voltage profiler显示文摘Depth profiles of carrier concentrations in Ga-MnSb/GaSb are investigated by electrochemistry capacitance-voltage profiler and electrolyte of Tiron. The carrier concentration in GaMnSb/GaSb measured by this method is coincident with the results of Hall and X-ray diffraction measurements. It is indicated that most of the Mn atoms in GaMnSb take the site of Ga, play a role of acceptors, and provide shallow acceptor level(s). | ZHANG Xiulan ZHANG Fuqiang SONG Shulin CHEN Nuofu WANG Zhanguo LIN Lanying | 2002 | Chinese Science Bulletin2002，47，21： | 1 |
| 9 | A novel DSPP mutation is associated with type dentinogenesis imperfecta in a chinese family 显示文摘 | Zhang Xianqin Chen Lanying Liu Jingyu | 2007 | BMC Medical Genetics2007，52，8： | 1 |
| 10 | Synthesis and structure of nanocrystal-assembled bulk GaN 显示文摘 | CHEN X L CAO Y G LANY C | 2000 | J Cryst Growth2000，209，1： | 1 |
| 11 | Research on laser welding of vehicle body显示文摘 | Qiang Wu Jinke Gong Genyu Chen Lanying Xu | 2007 | Optics and Laser Technology2007，，2： | 1 |
| 12 | Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system显示文摘 | Xiaoxuan Liu Cheng Liu Chao Chen Mélanie Bentobji Francine Azario Cheillan Jeanne Thomassin Piana Fanqi Qu Palma Rocchi Ling Peng | 2014 | Nanomedicine: Nanotechnology, Biology, and Medicine2014，，： | 1 |
| 13 | A novel DSPP mutation is associated with type lI dentinogenesis imperfecta in a chinese family 显示文摘 | Zhang Xianqin Chen Lanying Liu Jingyu | 2007 | BMC Medical Genetics2007，52，8： | 1 |
| 14 | Clinical and genetic characteristics of Chinese patients with hereditary haemorrhagic telangiectasia–associated pulmonary hypertension显示文摘 | Yan‐Jun Chen Qing‐Hui Yang Dong Liu Qian‐Qian Liu Mélanie Eyries Liang Wen Wen‐Hui Wu Xin Jiang Ping Yuan Rui Zhang Florent Soubrier Zhi‐Cheng Jing | 2013 | Eur J Clin Invest2013，，10： | 1 |
| 15 | Isolation, identification and antioxidative capacity of water-soluble phenylpropanoid compounds from Rhodiola crenulata显示文摘 | Danjun Chen Junting Fan Peng Wang Lanying Zhu Yang Jin Yan Peng Shuhu Du | 2012 | Food Chemistry2012，，4： | 1 |
| 16 | Structure, morphology and properties of Fe-doped ZnO films prepared by facing-target magnetron sputtering system显示文摘 | Changzheng Wang Zhong Chen Ying He Lanying Li Dong Zhang | 2009 | Applied Surface Science2009，，15： | 1 |
| 17 | The construction of the computer network system and network optimization 显示文摘 | Wang Lanying Chen Leiping | 2015 | Journal of hunan industrial vocational and technical coUege2015，，1： | 1 |
| 18 | Hydrate film growth at the interface between gaseous CO_2 and sodium chloride solution显示文摘Greenhouse gas CO2 has become a serious problem for human beings. The hydrate technology has been considered as a possible approach to sequester CO2. In this work, the lateral growth rates of a CO2 hydrate film in aqueous NaCl solutions of different concentrations were measured by means of suspending a single gas bubble in liquid. The results show that the film growth rates depended on not only the driving force, but also the NaCl concentration, and the film growth rates decreased with the increasing NaCl concentration. The simple relationship vf ∝ΔT5/2 could be used to correlate the hydrate film growth rate of a CO2 + NaCl + water system by introducing a NaCl concentration-dependent coefficient. The film thickness was investigated experimentally and evaluated theoretically; the results show that it became thicker at a higher NaCl concentration when the temperature and pressure were specified. In addition, a series of interesting phenomena, such as the occurrence of double hydrate films, were displayed and discussed. | PENG BaoZi, SUN ChangYu, CHEN GuangJin, YANG LanYing, ZHOU Wei & PANG WeiXin State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Beijing 102249, China | 2009 | Science China Chemistry2009，52，5： | 1 |
| 19 | Effects of Flowering Mode and Pollinator Sharing on Reproductive Success in Natural Hybrid of Two Epimedium(Berberidaceae)Species显示文摘Mediated by pollenflow,natural hybridization is deemed a crucial factor that propels speciation infloral plants.Despite the fact that the diversity of Epimedium species is concentrated mainly in Southwestern China,the poten-tial impact of interspecific pollination on natural hybridization has yet to be empirically scrutinized.To explore this,we studied theflowering period and the visitors offlowers in three frequently overlapping Epimedium species at Jinchengshan National Forest Park,located in Nanchong,Sichuan Province.Additionally,we performed a ser-ies of pollination experiments to examine breeding systems and hybrid compatibility.Morphologically,Epime-dium pubescens and Epimedium wushanense are clearly distinct and easily recognizable byflower morphology,while the putative hybrid is morphologically intermediate between them.Our observation revealed that E.pub-escens and E.wushanense had 15 days of overlapping anthesis.Both species are self-incompatible and require pol-linator services for successful reproduction.Although their pollinators differ in quantity and species,Lasioglossum sp.(Hymenoptera:Halictidae)visited all three species.Artificial pollination revealed no breeding barriers among the three species,and the resulting hybrid seeds exhibited fertility.The overlapping time offlowering,commonfloral visitors,and compatibility of hybrids may be important factors contributing to successful interspecific pol-lination and speciation for natural hybrid species of E.pubescens and E.wushanense.Consequently,the role of potential interspecific pollination is crucial for hybrid speciation and the evolutionary dynamics of Epimedium species. | Lanying Chen Qiumei Quan Yunxiang Li | 2024 | Phyton-International Journal of Experimental Botany2024，93，3： | 0 |
| 20 | The specific surface area of methane hydrate formed in different conditions and manners显示文摘The specific surface area of methane hydrates, formed both in the presence and absence of sodium dodecyl sulfate (SDS) and processed in different manners (stirring, compacting, holding the hydrates at the formation conditions for different periods of time, cooling the hydrates for different periods of time before depressurizing them), was measured under atmospheric pressure and temperatures below ice point. It was found that the specific surface area of hydrate increased with the decreasing temperature. The methane hydrate in the presence of SDS was shown to be of bigger specific surface areas than pure methane hydrates. The experimental results further demonstrated that the manners of forming and processing hydrates affected the specific surface area of hydrate samples. Stirring or compacting made the hydrate become finer and led to a bigger specific surface area. | WANG XiuLin SUN ChangYu CHEN GuangJin YANG LanYing MA QingLan CHEN Jun TANG XuLong LIU Peng | 2009 | Science China Chemistry2009，52，3： | 0 |
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