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| 1 | Study on the Application of UHVDC Hierarchical Connection Mode to Multi-infeed HVDC System显示文摘随着我国特高压交直流技术的广泛应用,多馈入直流集中落入受端负荷中心将是未来我国电网发展所面临的重要问题。为从电网结构上有效解决多馈入直流系统的问题,提出一种特高压直流分层接入交流电网的方式。研究分层接入方式直流多馈入短路比计算方法的适用性,从理论上对比特高压直流不同接入方式下多馈入直流电网的系统特性,证明特高压直流分层接入方式有助于提高多馈入直流系统的电压支撑能力,引导潮流在1000kV与500kV层级间合理分布。结合国家电网规划,仿真验证了特高压直流分层接入方式的优势。 | LIU Zhenya QIN Xiaohui ZHAO Liang ZHAO Qingbo | 2013 | 中国电机工程学报2013，33，10： | 80 |
| 2 | Research progress on silicon/carbon composite anode materials for lithium-ion battery显示文摘Silicon(Si) has been considered as one of the most promising anode material for the next generation lithium-ion batteries(LIBs) with high energy densities, due to its high theoretical capacity, abundant availability and environmental friendliness. However, silicon materials with low intrinsic electric and ionic conductivity suffer from huge volume variation during lithiation/delithiation processes leading to the pulverization of Si and subsequently resulting in severe capacity fading of the electrodes. Coupling of Si with carbon(C) realizes a favorable combination of the two materials properties, such as high lithiation capacity of Si and excellent mechanical and conductive properties of C, making silicon/carbon composite(Si/C) ideal candidates for LIBs anodes. In this review, recent progresses of Si/C materials utilized in LIBs are summarized in terms of structural design principles, material synthesis methods, morphological characteristics and electrochemical performances by highlighting the material structures. The mechanisms behind the performance enhancement are also discussed. Moreover, other factors that affect the performance of Si/C anodes, such as prelithiation, electrolyte additives, and binders, are also discussed. We aim to present a full scope of the Si/C-based anodes, and help understand and design future structures of Si/C anodes in LIBs. | Xiaohui Shen Zhanyuan Tian Ruijuan Fan Le Shao Dapeng Zhang Guolin Cao Liang Kou Yangzhi Bai | 2018 | Journal of Energy Chemistry2018，27，4： | 29 |
| 3 | Genome-wide comparative analysis of type-A Arabidopsis response regulator genes by overexpression studies reveals their diverse roles and regulatory mechanisms in cytokinin signaling显示文摘细胞激动素是为植物生长和开发的各种各样的方面的一个批评生长管理者。在 Arabidopsis,细胞激动素发信号被从受体播送一个信号的二部件的基于系统的 phosphorelay 调停,通过 histidine phosphotransfer 蛋白质,到下游的反应管理者(ARR ) 。这些 ARR,打字 -- A ARR 基因,其抄写能被细胞激动素很快导致,充当细胞激动素发信号的否定管理者。然而因为功能的冗余性,类型的功能 -- 在植物生长和开发的 A ARR 基因没被分析 loss-of-function 异种很好理解。在这研究,我们在所有十种类型上执行了比较功能的研究 -- 由分析这些 ARR 基因熔化了到 MYC epitope 的转基因的植物 overexpressing 的 A ARR 基因标注。ARR 基因的 Overexpression 导致许多联系细胞激动素的显型。尤其是,不同 ARR transgenes 的 overexpression 引起多样的显型,甚至在种系发生地密切相关的基因对之间,例如在 ARR3-ARR4 和 ARR5-ARR6 对以内。我们发现了 ARR 蛋白质的一个子集的累积(ARR3, ARR5, ARR7, ARR16 和 ARR17;可能 ARR8 和 ARR15 ) 被 MG132 增加,一个特定的 proteasomal 禁止者,显示这些蛋白质的那稳定性被 proteasomal 调整降级。而且,类似于的以前描绘的 ARR5, ARR6 和 ARR7, ARR16 和 ARR17 的稳定性,可能包括的 ARR8 和 ARR15,被细胞激动素调整。这些结果建议那种类型 -- A ARR 蛋白质被包含细胞激动素和 proteasome 小径的组合机制调整,从而在植物生长和开发执行特殊函数。 | Bo Ren Yan Liang Yan Deng Qingguo Chen Jian Zhang Xiaohui Yang Jianru Zuo | 2009 | Cell Research2009，19，10： | 23 |
| 4 | Safety Research in Traditional Chinese Medicine: Methods, Applications, and Outlook显示文摘Traditional Chinese medicine (TCM) is a medical system that has collected and summarized abundant clinical experience over its long history of more than 2000 years. However, the frequent occurrence of TCM-induced adverse reactions has hindered the modernization and internationalization of TCM, while attracting increasing attention from around the world. Unlike chemical drugs and biological agents, the difficulties involved in research on the toxicity and safety of TCM mainly include the complexity of its components and the unpredictability of drug–body interactions. Much of TCM, which has overall therapeutic effects, has the typical mechanisms of multiple components, multiple pathways, and multiple targets. While considering the gradualness and unpredictability of TCM toxicity, the ambiguity of toxicants and safe dosage, and individual differences during long-term TCM administration, we have systematically established key techniques for the toxicity assessment of TCM. These techniques mainly include TCM toxicity discovery in an early phase, based on a combination of drug toxicology genomics and metabolomics;methods to identify dose–toxicity relationships in TCM;and integrated techniques for the exploration of TCM interactions, such as fast-screening tests based on drug-metabolizing enzymes and receptor pathways. In particular, we have developed a new technical system for TCM safety evaluation using molecular toxicology, which has been validated well in research on TCM compatibility contraindication, quality control, and allergen discovery. The application of this key technical platform is introduced here in detail. This application includes model organisms, toxicant biomarkers, a magnetic suspension technique, and the application of network toxicology and computational toxicology in research on the toxicity of Fructus toosendan, Semen cassiae, Polygonum multiflorum, and Fructus psoraleae. | Yue Gao Aihua Liang Xiaohui Fan Limin Hu Feiran Hao Yubo Li | 2019 | Engineering2019，5，1： | 19 |
| 5 | The Arabidopsis PARAQUAT RESISTANT2 gene encodes an S-nitrosoglutathione reductase that is a key regulator of cell death显示文摘S-nitrosoglutathione (GSNO ) 的新陈代谢,主要生物学上活跃的氮的氧化物(没有) 种类,被进化地保存的 GSNO reductase (GSNOR ) 催化。以前的研究证明 Arabidopsis GSNOR1/HOT5 基因调整水杨酸酸由 modulating 发信号和 thermotolerance 细胞内部的 S-nitrosothiol 水平。这里,我们报导 Arabidopsis paraquat resistant2-1 (par2-1 ) 的描述显示出反房间死亡显型的异种。当由 paraquat (1,1'-dimethyl-4,4'-bipyridinium 二氯化物) 对待时,在 par2-1 的 superoxide 的生产比得上野类型的植物的,建议 PAR2 调整房间死亡的 superoxide 下游地行动。PAR2,由位置的克隆识别了,被显示与 GSNOR1/HOT5 相同。par2-1 异种在高度保存的 glycine 带一个错误感觉变化,它使变异的蛋白质变为不稳定。比作野类型, par2-1 异种有一不更高铺平,由与 4,5-diaminofluorescein diacetate 染色揭示了。与这结果一致,对待与的野类型的植物一没有施主显示抵抗到 paraquat。有趣地, GSNOR1/HOT5/PAR2 蛋白质水平除它的不变的 mRNA 水平以外,被 paraquat 导致,但是被没有施主减少。一起拿,这些结果建议 GSNOR1/HOT5/PAR2 在通过 modulating 在植物房间调整房间死亡起一个重要作用细胞内部没有水平。 | Ruiqiang Chen Shulan Sun Chun Wang Yansha Li Yan Liang Fengying An Chao Li Haili Dong Xiaohui Yang Jian Zhang Jianru Zuo | 2009 | Cell Research2009，19，12： | 14 |
| 6 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 7 | Environment-Stable CoxNiy Encapsulation in Stacked Porous Carbon Nanosheets for Enhanced Microwave Absorption显示文摘Magnetic/dielectric@porous carbon composites,derived from metal–organic frameworks(MOFs)with adjustable composition ratio,have attracted wide attention due to their unique magnetoelectric properties.In addition,MOFs-derived porous carbon-based materials can meet the needs of lightweight feature.This paper reports a simple process for synthesizing stacked CoxNiy@C nanosheets derived from CoxNiy-MOFs nanosheets with multiple interfaces,which is good to the microwave response.The CoxNiy@C with controllable composition can be obtained by adjusting the ratio of Co^2+ and Ni^2+.It is supposed that the increased Co content is benefit to the dielectric and magnetic loss.Additionally,the bandwidth of CoNi@C nanosheets can take up almost the whole Ku band.Moreover,this composite has better environmental stability in air,which characteristic provides a sustainable potential for the practical application. | Xiaohui Liang Zengming Man Bin Quan Jing Zheng Weihua Gu Zhu Zhang Guangbin Ji | 2020 | Nano-Micro Letters2020，12，8： | 11 |
| 8 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 9 | Investigation of College Students' Mental Health Status via Semantic Analysis of Sina Microblog显示文摘The objective of this study is to understand the current mental status of college students in China's Mainland. In this study, 60 thousand college students' microblog content from January 2014 to June 2014 was collected. An emotional energy level, which was developed by a psychologist David R Hawkins, was taken as a basis for ontology database to divide the student's emotion into three parts—positive, negative and neutral status. An ontology-based semantic analysis method was used to analyze the microblog data. The result shows that 46.38% of Sina microblog data reflects positive psychological status, and the ratios of neutral and negative psychological status are 19.77% and 33.85%, respectively. It means that almost one third microblog reflects some negative mentality. The semantic analysis of the big data suggests that most students have healthy mental status, and the negative status of the students should not be ignored. | LIANG Xiaohui GU Siqi DENG Jiayuan GAO Zhaixing ZHANG Zhonghua SHEN Dezhong | 2015 | Wuhan University Journal of Natural Sciences2015，20，2： | 7 |
| 10 | CoxP@NiCo-LDH heteronanosheet arrays as efficient bifunctional electrocatalysts for co-generation of value-added formate and hydrogen with less-energy consumption显示文摘The inefficiency of water splitting is mainly due to the sluggish anodic water oxidation reaction. Replacing water oxidation with thermodynamically more favorable selective methanol oxidation reaction and developing robust bifunctional electrocatalysts are of great significance. Herein, a hierarchical heteronanostructure with Ni–Co layered double hydroxide(LDH) ultrathin nanosheets coated on cobalt phosphide nanosheets arrays(CoxP@NiCo-LDH) are fabricated and used for co-electrolysis of methanol/water to co-produce value-added formate and hydrogen with saving energy. Benefiting from the fast charge transfer introduced by phosphide nanoarrays, the synergy in nanosheets catalysts with hetero-interface,CoxP@NiCo-LDH/Ni foam(NF) exhibits superior electrocatalytic performance(10 mA cm-2@ 1.24 V and-0.10 V for methanol selective oxidation and hydrogen evolution reaction, respectively). Furthermore,CoxP@NiCo-LDH/NF-based symmetric two-electrode electrolyzer drives a current density of 10 m A cm-2 with a low cell voltage of only 1.43 V and the Faradaic efficiency towards the generation of formate and H2 are close to 100% in the tested range of current density(from 40 to 200 m A cm-2). This work highlights the positive effect of hetero-interaction in the design of more efficient eletrocatalysts and might guide the way towards facile upgrading of alcohols and energy-saving electrolytic H2 co-generation. | Mei Li Xiaohui Deng Yue Liang Kun Xiang Dan Wu Bin Zhao Haipeng Yang Jing-Li Luo Xian-Zhu Fu | 2020 | Journal of Energy Chemistry2020，29，11： | 5 |
| 11 | Dataset of the plasma membrane proteome of nasopharyngeal carcinoma cell line HNE1 for uncovering protein function显示文摘鼻咽的癌(NPC ) 是在南部的中国和东南亚洲的一个通常发生的肿瘤。当前的学习集中了于为 NPC 房间线 HNE1 的外部、不可分的蛋白质开发一个广泛的分析方法。外部膜蛋白质被 biotinylated 丰富提取, 0.1 M Na 2 公司 3, 和 H 2 O。不可分或全部的血浆膜部分用 30% Percoll 密度等级 centrifugation 被准备与或没有 0.1 M Na 2 公司 3 处理并且由西方的污点分析评估了。蛋白质受到与双人脚踏车团 spectrometry,与双人脚踏车团 spectrometry 相结合的钠 dodecyl sulfate-polyacrylamide 胶化电气泳动,和猎枪分析相结合的二维的电气泳动。我们分别地从外部、不可分、全部的血浆膜部分识别了 371, 180,和 702 蛋白质。总共, 848 非冗余的蛋白质(534 个组) 被识别。有约束力、催化、结构的分子是主要的班。除了 NPC 房间的已知的房间表面标记,分析在癌症房间是特征的疾病小径揭示了涉及多重发信号房间的小径的 311 蛋白质和 25 蛋白质。由寻找,差别表示了蛋白质数据库(http://gffzze0f623e48f094866hcbk995ufuq0w6ucn.ffgz.tsg.suse.edu.cn/depd/index.jsp ) , 199 蛋白质被发现是在以前的癌症 proteome 研究表示的差别。671 蛋白质蛋白质相互作用网络被获得,包括在这个工作的 178 识别蛋白质。五蛋白质的血浆膜本地化被免疫学的技术证实,验证这 proteomic 策略。我们的学习能为理解 NPC 的分子的机制提供一些帮助。 | Lijun Zhang Xiaofang Jia Xiaohui Liu Tingting Sheng Rui Cao Quanyuan He Zhen Liu Xia Peng JixianXiong Pengfei Zhang Ni Shi Songping Liang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，1： | 5 |
| 12 | Histopathological Features and Viral Antigen Distribution in the Lung of Fatal Patients with Enterovirus 71 Infection显示文摘Dear Editor,Enterovirus 71(EV71)infection causes hand-foot-andmouth disease(HFMD)in infants and children.Patients with HFMD usually have good prognosis;however,in some extreme cases the infection can be accompanied by central nervous system diseases,eventually leading to cardiorespiratory failure,and even death.Currently。 | Zhenli Liang Hongbo Pan Xijing Wang Yinchuan Zhu Yiwu Dang Xiaohui Fan Lingxi Gao Zengfeng Zhang | 2018 | Virologica Sinica2018，33，3： | 4 |
| 13 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 14 | Joint Resource Allocation and Coordinated Computation Offloading for Fog Radio Access Networks显示文摘The cloud radio access network(C-RAN) and the fog computing have been recently proposed to tackle the dramatically increasing traffic demands and to provide better quality of service(QoS) to user equipment(UE).Considering the better computation capability of the cloud RAN(10 times larger than that of the fog RAN) and the lower transmission delay of the fog computing,we propose a joint resource allocation and coordinated computation offloading algorithm for the fog RAN(F-RAN),which takes the advantage of C-RAN and fog computing.Specifically,the F-RAN splits a computation task into the fog computing part and the cloud computing part.Based on the constraints of maximum transmission delay tolerance,fronthaul and backhaul capacity limits,we minimize the energy cost and obtain optimal computational resource allocation for multiple UE,transmission power allocation of each UE and the event splitting factor.Numerical results have been proposed with the comparison of existing methods. | Kai Liang Liqiang Zhao Xiaohui Zhao Yong Wang Shumao Ou | 2016 | China Communications2016，13，S2： | 4 |
| 15 | Multi-Stage Metamorphism of the UHP Pelitic Gneiss from the Southern Altyn Tagh HP/UHP Belt,Western China:Petrological and Geochronological Evidence显示文摘The kyanite-bearing garnet pelitic gneiss from the Jianggalesavi area in southern Altyn Tagh high pressure/ultra-high pressure belt was proved to have been experienced UHP metamorphism (>12 GPa) by the discovery of kyanite and spinel exsolution microstructure in quartz (precursor stishovite). In this study, three stages of retrograded metamorphism (M2-M4) after the UHP metamorphism (Ml) were identified for the UHP pelitic gneiss. The HP granulite-facies stage (M2) was characterized by the mineral assemblage of garnet+kyanite+K?feldspar+nitile+qiiartz±ilinenite, recording the P-T condition of >1.12 GPa and ?850-930℃. The granulite-facies stage (M3) was represented by the mineral assemblage of garnet rim+K-feldspar+sillimanite (SillJ+biotite (Bti)+plagioclase (Pli)+ilmenite+quartz, and confined under P-T conditions of 0.5-0.8 GPa and^770-795℃. The late cooling stage M4 was accompanied by the appearance of fine-grained Pl2, Sill2 and Bt2 in the matrix, and the P-T conditions were 0.4-0.6 GPa and <675℃. A clockvvised P-T path was obtained for the pelitic gneiss in the P-T pseudosection, which showed a deep subduction/collision processes with subsequent exhumation and cooling. Com? bined with the corresponding multistage metamorphic assemblages, the age dating results implied that the zircons from the gneiss have integrated the recording peak metamorphic (Ml,484±3 Ma) and retrograded metamorphic ages (M2 to M3, 450±2 Ma). There was about 32 Ma interval during the first exhumation from the upper mantle depth (>350 km) to the lower crust depth (-40-20 km), resulting in an average exhumation rate of 9.11-9.70 mm/yr. In the southern Altyn Tagh region, the HP and UHP rocks from different areas had identical peak metamorphic ages. Therefore, contemporary UHP and HP rocks with different metamorphic evolutions were recognized coexisting in the same orogenic belt, which can be interpreted by the model of subduction channel. The continental crustal were subducted to different depths along the direction of the subduction channels at ~500 Ma, suffered different grade metamorphism, and then returned to the surface along the subduction channel. | Yuting Cao Liang Liu Chao Wang Cong Zhang Lei Kang Wenqiang Yang Xiaohui Zhu | 2019 | Journal of Earth Science2019，30，3： | 4 |
| 16 | Reconstruction the Process of Partial Melting of the Retrograde Eclogite from the North Qaidam,Western China: Constraints from Titanite U-Pb Dating and Mineral Chemistry显示文摘Retrograde eclogite and garnet amphibolite of the Lüliangshan unit of the Shenglikou area,North Qaidam,were studied with emphasis on rutile and titanite.A special focus is on the formation of rutile and its corona of titanite(Ttn1)in retrograde eclogite and on coarse-grained titanite(Ttn2)from the garnet amphibolite.Using zirconium(Zr)-in-rutile and Zr-in-titanite thermometers,the temperatures estimated for the formation of an early generation of rutile are 823–884℃at 2.5–2.8 GPa,while 812–894℃at 1.3–1.5 GPa are derived for the formation of coronitic Ttn1 in the retrograde eclogite.Therefore,isothermal decompression must have occurred during exhumation,which also has triggered the partial melting of the retrograde eclogite.Ttn2 of the garnet amphibolite has high REE contents and high Th/U ratios,indicating that it is newly grown from a Ti,Ca,and LREE enriched anatectic melt derived from the partial melting of retrograde eclogite.LA-ICP MS U-Pb dating yields a lower intercept age of 423±4 Ma for Ttn2,which is consistent with the granulite-facies metamorphic age of the retrograde eclogite.Moreover,a temperature of 781–823℃at 1.0–1.2 GPa is obtained for Ttn2,which fits the P-T conditions of the HP granulite-facies metamorphic stage(P=1.07–1.24 GPa and T=774–814℃),and documents that the crystallization of the melt occurred at the granulite-facies stage at 423 Ma.The high amount of REE of the garnet amphibolite is a consequence of the formation of Ttn2 from the melt.The contents and ratios of Zr and Hf in rutile and Ttn2 differ from those in the garnet amphibolite,and the whole rock Zr/Hf ratios of retrograde eclogite and garnet amphibolite are both higher than the respective ratios in rutile and Ttn2,suggesting that rutile and titanite cannot be the major carriers of Zr and Hf accounting for the high whole rock Zr/Hf ratios. | Yuting Cao Liang Liu Wenqiang Yang Yuan Gao Xiaohui Zhu | 2019 | Journal of Earth Science2019，30，6： | 4 |
| 17 | Natural and engineered bacterial outer membrane vesicles显示文摘Bacterial outer membrane vesicle(OMV)is a kind of spherical lipid bilayer nanostructure naturally secreted by bacteria,which has diverse functions such as intracellular and extracellular communication,horizontal gene transfei;transfer of contents to host cells,and eliciting an immune response in host cells.In this review,several methods including ultracentrifugation and precipNation for isolating OMVs were summarized.The latest progresses of OMVs in biomedical fields,especially in vaccine development,cancer treatment,infection control,and bioimaging and detection were also summarized in this review.We highlighted the importance of genetic engineering for the safe and effective application and in facilitating the rapid development of OMVs.Finally,we discussed the bottleneck problems about OMVs in preparation and application at present and put forward our own suggestions about them.Some perspectives of OMVs in biomedical field were also provided. | Guangchao Qing Ningqiang Gong Xiaohui Chen Jing Chen Hong Zhang Yongchao Wang Ruifang Wang Shouwen Zhang Zhen Zhang Xianxian Zhao Yang Luo Xing-Jie Liang | 2019 | Biophysics Reports2019，5，4： | 4 |
| 18 | Dynamic Programming Based Power Control Algorithm with Primary User QoS Guarantee for Cognitive Radio Networks显示文摘 | LIANG Hui ZHAO Xiaohui | 2013 | Chinese Journal of Electronics2013，22，2： | 3 |
| 19 | Enhancing rice grain production by manipulating the naturally evolved cis-regulatory element-containing inverted repeat sequence of OsREM20显示文摘Grain number per panicle(GNP)is an important agronomic trait that contributes to rice grain yield.Despite its importance in rice breeding,the molecular mechanism underlying GNP regulation remains largely unknown.In this study,we identified a previously unrecognized regulatory gene that controls GNP in rice,Oryza sativa REPRODUCTIVE MERISTEM 20(OsREM20),which encodes a B3 domain transcription factor.Through genetic analysis and transgenic validation we found that genetic variation in the CArG box-containing inverted repeat(IR)sequence of the OsREM20 promoter alters its expression level and contributes to GNP variation among rice varieties.Furthermore,we revealed that the IR sequence regulates OsREM20 expression by affecting the direct binding of OsMADS34 to the CArG box within the IR sequence.Interestingly,the divergent pOsREM20IR and pOsREM20ΔIR alleles were found to originate from different Oryza rufipogon accessions,and were independently inherited into the japonica and indica subspecies,respectively,during domestication.Importantly,we demonstrated that IR sequence variations in the OsREM20 promoter can be utilized for germplasm improvement through either genome editing or traditional breeding.Taken together,our study characterizes novel genetic variations responsible for GNP diversity in rice,reveals the underlying molecular mechanism in the regulation of agronomically important gene expression,and provides a promising strategy for improving rice production by manipulating the cis-regulatory element-containing IR sequence. | Xiaowei Wu Yan Liang Hengbin Gao Jiyao Wang Yan Zhao Lekai Hua Yundong Yuan Ahong Wang Xiaohui Zhang Jiafan Liu Jie Zhou Xiangbing Meng Dahan Zhang Shaoyang Lin Xuehui Huang Bin Han Jiayang Li Yonghong Wang | 2021 | Molecular Plant2021，14，6： | 3 |
| 20 | Generation and Analysis of Pathogenicity-related Gene Mutants of Colletotrichum gloeosporioides Using a Novel Promoter Trapping System显示文摘Agrobacterium tumefaciens-mediated transformation(ATMT) is an efficient tool for insertional mutagenesis and is used in a wide variety of plants. This paper reports a promoter trapping method to generate mutants in the filamentous fungus,Colletotrichum gloeosporioides,by ATMT insertion of a trapping vector(pCAHPH) that carries a promoterless hygromycin phosphotransferase(hph) gene. Transformants were selected on the media containing 200 μg/mL hygromycin B,and screened for pathogenicity-related gene mutants. Their pathogenicity-related mutants T-DNA flanking sequences were then cloned and analyzed. Hph genes were amplified from mutant genomic DNA but not from wild-type DNA,indicating that the phenotypic alternations of these mutants were the results of T-DNA insertion. T-DNA flanking sequences were obtained using modified thermal asymmetric interlaced PCR. Two right-sided flanking sequences were highly homologous to proteins from other species. | Zheng Xiaolan Liu Yan Wei Xiaohui He Chunping Wu Weihuai Liang Yanqiong Li Rui Zheng Fucong | 2013 | Plant Diseases and Pests2013，4，3： | 3 |
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