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| 1 | Two-dimensional heterostructure promoted infrared photodetection devices显示文摘It is a rapidly developed subject in expanding the fundamental properties and application of two-dimensional(2D)materials.The weak van der Waals interaction in 2D materials inspired researchers to explore 2D heterostructures(2DHs)based broadband photodetectors in the far-infrared(IR)and middle-IR regions with high response and high detectivity.This review focuses on the strategy and motivation of designing 2DHs based high-performance IR photodetectors,which provides a wide view of this field and new expectation for advanced photodetectors.First,the photocarriers'generation mechanism and frequently employed device structures are presented.Then,the 2DHs are divided into semimetal/semiconductor 2DHs,semiconductor/semiconductor 2DHs,and multidimensional semi-2DHs;the advantages,motivation,mechanism,recent progress,and outlook are discussed.Finally,the challenges for next-generation photodetectors are described for this rapidly developing field. | Gaofeng Rao Xuepeng Wang Yang Wang Peihua Wangyang Chaoyi Yan Junwei Chu Lanxin Xue Chuanhui Gong Jianwen Huang Jie Xiong Yanrong Li | 2019 | InfoMat2019，1，3： | 12 |
| 2 | Mountain tunnel under earthquake force:A review of possible causes of damages and restoration methods显示文摘Accurate seismic assessment and proper aseismic design of underground structures require a comprehensive understanding of seismic performance and response of underground structures under earthquake force.In order to understand the seismic behavior of tunnels during an earthquake,a wide collection of case histories has been reviewed from the available literature with respect to damage classification,to discuss the possible causes of damage,such as earthquake parameters,structural form and geological conditions.In addition,a case of Tawarayama tunnel subjected to the 2016 Kumamoto earthquake is studied.Discussion on the possible influence factors aims at improving the performancebased aseismic design of tunnels.Finally,restoration design criterion and methods are presented taking Tawarayama tunnel as an example. | Xuepeng Zhang Yujing Jiang Kazuhiko Maegawa | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，2： | 11 |
| 3 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 4 | The DEAD-Box RNA Helicase DDX1 Interacts with the Viral Protein 3D and Inhibits Foot-and-Mouth Disease Virus Replication显示文摘Foot-and-mouth disease virus(FMDV)can infect domestic and wild cloven-hoofed animals.The non-structural protein 3D plays an important role in FMDV replication and pathogenesis.However,the interaction partners of 3D,and the effects of those interactions on FMDV replication,remain incompletely elucidated.In the present study,using the yeast two-hybrid system,we identified a porcine cell protein,DEAD-box RNA helicase 1(DDX1),which interacted with FMDV 3D.The DDX1-3D interaction was further confirmed by co-immunoprecipitation experiments and an indirect immunofluorescence assay(IFA)in porcine kidney 15(PK-15)cells.DDX1 was reported to either inhibit or facilitate viral replication and regulate host innate immune responses.However,the roles of DDX1 during FMDV infection remain unclear.Our results revealed that DDX1 inhibited FMDV replication in an ATPase/helicase activity-dependent manner.In addition,DDX1 stimulated IFN-p activation in FMDV-infected cells.Together,our results expand the body of knowledge regarding the role of DDX1 in FMDV infection. | Qiao Xue Huisheng Liu Qiaoying Zeng Haixue Zheng Qinghong Xue Xuepeng Cai | 2019 | Virologica Sinica2019，34，6： | 9 |
| 5 | Single titanium-oxide species implanted in 2D g-CsN4 matrix as a highly efficient visible-light CO2 reduction photocatalyst显示文摘A visible-light-response, efficie nt and robust photo-catalyst for CO2 reduction is highly desirable. Herein, we demonstrate that single titanium-oxide species impla nted in two-dime nsion al (2D) graphitic carb on n itride (g-C3N4) matrix (2D TiO-CN) can efficie ntly photo-catalyze the reduction of CO2 to CO under the irradiation of visible light. The synergistic interaction between single titanium oxide species and g-C3N4 in 2D TiO-CN not only enhances the separation of photo-excited charges, but also results in visible light response of single titanium-oxide species, realizing high activity of CO2 photo-reduction with extremely high CO generation rate of 283.9 pmol·h^-1·g^-1, 5.7, 6.8 and 292.2 times larger than those of TQ2/CN hybrid material, CN and commercial TiO2, respectively. Time-resolved fluoresce nee and electron spin resonance spectroscopy revealed the catalytic mechanism of the fabricated 2D TiO-CN photocatalysts for CO2 reduction. | Shangfeng Tang Xuepeng Yin Guanyu Wang Xiuli Lu Tongbu Lu | 2019 | Nano Research2019，12，2： | 8 |
| 6 | Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells显示文摘 | Yan Yuan Quan Zhou Haifeng Wan Bin Shen Xuepeng Wang Mei Wang Chunjing Feng Mingming Xie Tiantian Gu Tao Zhou Rui Fu Xingxu Huang Qi Zhou Jiahao Sha Xiao-Yang Zhao | 2015 | Cell Research2015，25，7： | 7 |
| 7 | Microscopic examination of intracellular organisms in bronchoalveolar lavage fluid for the diagnosis of ventilator-associated pneumonia:a prospective multi-center study显示文摘 | Liu Chang Du Zhaohui Zhou Qing Hu Bo Li Zhifeng Yu Li Xu Tao Fan Xuepeng Yang Junhui Li Jianguo | 2014 | Chinese Medical Journal2014，，10： | 6 |
| 8 | Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology显示文摘Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic development.However,it is unknown whether abnormal methylome reprogramming occurs and is associated with the failure of embryonic development.Here we analyzed the DNA methylomes of 57 blastocysts and 29 trophectoderm samples with different morphological grades during assisted reproductive technology(ART) practices.Our data reveal that the global methylation levels of high-quality blastocysts are similar(0.30 ± 0.02,mean ± SD).while the methylation levels of low-quality blastocysts are divergent and away from those of high-quality blastocysts.The proportion of blastocysts with a methylation level falling within the range of 0.30 ± 0.02 in different grades correlates with the live birth rate for that grade.Moreover,abnormal methylated regions are associated with the failure of embryonic development.Furthermore,we can use the methylation data of cells biopsied from trophectoderm to predict the blastocyst methylation level as well as to detect the aneuploidy of the blastocysts.Our data indicate that global abnormal methylome reprogramming often occurs in human embryos,and suggest that DNA methylome is a potential biomarker in blastocyst selection in ART. | Guoqiang Li Yang Yu Yong Fan Congru Li Xiaocui Xu Jialei Duan Rong Li Xiangjin Kang Xin Ma Xuepeng Chen Yuwen Ke Jie Yan Ying Lian Ping Liu Yue Zhao Hongcui Zhao Yaoyong Chen Xiaofang Sun Jianqiao Liu Jie Qiao Jiang Liu | 2017 | Journal of Genetics and Genomics2017，44，10： | 5 |
| 9 | Effects of Waxy Maize Relay Intercropping and Residue Retention on Rhizosphere Microbial Communities and Vegetable Yield in a Continuous Cropping System显示文摘Intercropping and residue retention contribute to high yield and quality of crops. However, their coupled effects on rhizospheric microbial communities under a continuous vegetable cropping system have not been adequately addressed. The objective of the present study was to assess the effects on soil microbial community and yields of waxy maize(Zea mays L.) intercropped with or without residue retention in a continuous broccoli(Brassica oleracea L.) cropping system, i.e., relay intercropping of broccoli and waxy maize(B/M-B), relay intercropping of broccoli and waxy maize with residue retention(B/MR-B), and broccoli monoculture(B-B). The biomass yields of spring and autumn vegetables in B/MR-B were 16.3%–32.5% and 30.1%–46.1% higher than those of B-B,respectively. Autumn vegetable economic yields of B/MR-B were 28.2%–40.3% higher than B-B. The average well color development followed the order: B/MR-B > B/M-B > B-B. The Shannon index, Simpson index, and Mc Intosh index were higher in B/MR-B than under monoculture. A principal component analysis showed that microbial communities of B/MR-B soils differed from those of B/M-B and B-B soils. Carbon(C) sources utilized by the rhizosphere microorganisms were mainly carbohydrates, carboxylic acids, amino acids, and polymers; however, the C sources for the soil microbial community differed between intercropping and monoculture. The communities from B/MR-B preferred amino acids and polymers. Available nitrogen(N), potassium(K), and phosphorus(P) had an obvious impact on soil microbial community. Additionally, the C source utilization by microorganisms was significantly affected by p H and available K and P. Cropping system diversification through relay intercropping and residue retention effectively improved the functional diversity of the soil microbial communities and increased the yields of vegetables. | ZHANG Xuepeng NING Tangyuan HAN Huifang SUN Tao LI Geng LI Zengjia Rattan LAL | 2018 | Pedosphere2018，28，1： | 5 |
| 10 | Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs显示文摘Blastocyst complementation by pluripotent stem cell(PSC)injection is believed to be the most promising method to generate xenogeneic organs.However,ethical issues prevent the study of human chimeras in the late embryonic stage of development.Primate embryonic stem cells(ESCs),which have similar pluripotency to human ESCs,are a good model for studying interspecies chimerism and organ generation.However,whether primate ESCs can be used in xenogenous grafts remains unclear.In this study,we evaluated the chimeric ability of cynomolgus monkey(Macaca fascicularis)ESCs(cmESCs)in pigs,which are excellent hosts because of their many similarities to humans.We report an optimized culture medium that enhanced the anti-apoptotic ability of cmESCs and improved the development of chimeric embryos,in which domesticated cmESCs(D-ESCs)injected into pig blastocysts differentiated into cells of all three germ layers.In addition,we obtained two neonatal interspecies chimeras,in which we observed tissue-specific D-ESC differentiation.Taken together,the results demonstrate the capability of D-ESCs to integrate and differentiate into functional cells in a porcine model,with a chimeric ratio of 0.001-0.0001 in different neonate tissues.We believe this work will facilitate future developments in xenogeneic organogenesis,bringing us one step closer to producing tissue-specific functional cells and organs in a large animal model through interspecies blastocyst complementation. | Rui Fu Dawei Yu Jilong Ren Chongyang Li Jing Wang Guihai Feng Xuepeng Wang Haifeng Wan Tianda Li Libin Wang Ying Zhang Tang Hai Wei Li Qi Zhou | 2020 | Protein & Cell2020，11，2： | 4 |
| 11 | Effects of Pendular Waist on Gecko's Climbing: Dynamic Gait, Analytical Model and Bio-inspired Robot显示文摘当在水平或垂直的表面上爬时,大多数四足动物爬行动物例如蜥蜴,蝾螈和鳄鱼,转动他们的腰。由身体运动伴随了,矩心轨道也一条之字形路径而非一根直线成为更多。在垂直表面上由壁虎步法和姿势启发了,一只壁虎与一个钟摆运动的腰和腿,它被称为 GPL 建模的四活跃的腋鼓舞了模特儿,被建议。在支持脚上的腰位置,动态步法,和驱动力之间的关系被分析。至于腰轨道计划,在支持的脚之间的一根单个线被发现,它驱动力上的效果被讨论。基于 GPL 模型,它被发现那一条正弦曲线腰轨道,而非一根直线,在支持的腿上做驱动力更小。另外,到 pygal 的腰结束能在中间的脊椎之构成附近与那相比减少驱动力,它与壁虎身体在爬的过程弯曲一致。计划的配置设计和步法的原则基于理论分析被建议。最后,启发简历的机器人 DracoBot 被开发,两个都,驱动力,大小和爬的实验增强理论分析和壁虎的合理性动态步法。 | Wei Wang Xuepeng Li Shilin Wu Peihua Zhu Fei Zhao | 2017 | Journal of Bionic Engineering2017，14，2： | 4 |
| 12 | Kinetostatics Analysis of a Novel 6-DOF Parallel Manipulator with Three Planar Limbs and Equipped with Three Fingers显示文摘It is significant to develop a robot hand with high rigidity by a 6-DOF parallel manipulator(PM).However,the existing6-DOF PMs include spherical joint which has less capability of pulling force bearing,less rotation range and lower precision under alternately heavy loads.A novel 6-DOF PM with three planar limbs and equipped with three fingers is proposed and its kinematics and statics are analyzed systematically.A 3-dimension simulation mechanism of the proposed manipulator is constructed and its structure characteristics is analyzed.The kinematics formulae for solving the displacement,velocity,acceleration of the platform,the active legs and the fingers are established.The statics formulae are derived for solving the active forces of PM and the finger mechanisms.An analytic example is given for solving the kinematics and statics of proposed manipulator and the analytic solved results are verified by the simulation mechanism.It is proved from the error analysis of analytic solutions and simulation solutions that the derived analytic formulae are correct and provide the theoretical and technical foundations for its manufacturing,control and application. | LU Yi LI Xuepeng | 2014 | Chinese Journal of Mechanical Engineering2014，27，5： | 4 |
| 13 | Derivation of Germline Competent Rat Embryonic Stem Cells from DA Rats显示文摘The laboratory rat was one of the earliest mammalian species for scientific research and used as animal disease models in physiology,toxicology,behavior,immunology,and tumor-biology for over 150 years(Jacob,1999).However,rat lags far behind mouse in generating human disease models and functional genomic studies because of the lack of authentic rat embryonic stem(ES) cells(Voigt and Serikawa, 2009),whereas the first mouse ES cell line was established in 1981(Evans and Kaufman,1981).By combining two or three kinase inhibitors which target GSK3,MEK and FGF signaling pathways in serum-free N2B27 medium,germline competent rat ES cells were first derived in 2008(Buehr et al.,2008; | Tianda Li Xiao-Yang Zhao Fei Teng Xin Li Minggui Jiang Wei Li Xuepeng Wang Jialiang Wang Lei Liu Zhonghua Liu Liu Wang Qi Zhou | 2012 | Journal of Genetics and Genomics2012，39，11： | 3 |
| 14 | QUALITATIVE ANALYSIS OF A PREDATOR-PREY SYSTEM WITH ALLEE EFFECT FOR PREY显示文摘In this paper,we study some predator-prey system with Allee effect for prey. In addition,we discuss the properties of equilibrium points and the existence and uniqueness of limit cycle. | Bai Zijun Yang Wensheng Li Xuepeng | 2007 | Annals of Differential Equations2007，23，4： | 3 |
| 15 | Effect of Draw Ratio on the Morphologies and Properties of BPDA/PMDA/ODA Polyimide Fibers显示文摘 | ZHANG Chunling ZHANG Qiong XUE Yanhu LI Guomin LIU Fangfang QIU Xuepeng JI Xiangling GAO Lianxun | 2014 | Chemical Research in Chinese Universities2014，30，1： | 3 |
| 16 | Cobalt porphyrins supported on carbon nanotubes as model catalysts of metal-N_(4)/C sites for oxygen electrocatalysis显示文摘Transition-metal based M-N_4/C catalysts are appealing for electrocatalytic oxygen reduction reaction(ORR) and oxygen evolution reaction(OER). Employing model catalysts, which have well-defined molecular structures and coordination environments, to investigate electrocatalytic performance of M-N_4/C sites for ORR and OER is of fundamental significance. Herein, we reported the use of Co tetra(phenyl)porphyrin 1 and Co tetra(pentafluorophenyl)porphyrin 2 as models to probe the role of Co-N_4/C sites for oxygen electrocatalysis. We showed that Co porphyrin 1 is more efficient than its structural analogue 2 for oxygen electrocatalysis in alkaline aqueous solutions, indicating that the electronrich Co-N_4/C site is more favored when noncovalently adsorbed on carbon supports. This work inspires rational design of reaction-oriented catalysts for sustainable energy storage and conversion technologies. | Haonan Qin Yanzhi Wang Bin Wang Xiaoguang Duan Haitao Lei Xuepeng Zhang Haoquan Zheng Wei Zhang Rui Cao | 2021 | Journal of Energy Chemistry2021，30，2： | 3 |
| 17 | Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis显示文摘Major evolutionary transitions are enigmas,and the most notable enigma is between invertebrates and vertebrates,with numerous spectacular innovations.To search for the molecular connections involved,we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans.We focused on gametes and early embryos,where the methylomes are known to evolve divergently between fish and mammals.Here,we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects,but clearly presents in deuterostomes such as echinoderms and invertebrate chordates,and then becomes more evident in vertebrates.Functional association analysis suggests that DNA methylation reprogramming is associated with development,reproduction and adaptive immunity for vertebrates,but not for invertebrates.Interestingly,the single HOX cluster of invertebrates maintains unmethylated status in all stages examined.In contrast,the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate embryogenesis.Notably,the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals.Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution,especially after the evolutionary transitions from invertebrates to vertebrates,and then to mammals. | Xiaocui Xu Guoqiang Li Congru Li Jing Zhang Qiang Wang David KSimmons Xuepeng Chen Naveen Wijesena Wei Zhu Zhanyang Wang Zhenhua Wang Bao Ju Weimin Ci Xuemei Lu Daqi Yu Qian-fei Wang Neelakanteswar Aluru Paola Oliveri Yong EZhang Mark QMartindale Jiang Liu | 2019 | National Science Review2019，6，5： | 2 |
| 18 | Shelf-life extension of crucian carp ( Carassius auratus ) using natural preservatives during chilled storage显示文摘 | Tingting Li Jianrong Li Wenzhong Hu Xuguang Zhang Xuepeng Li Jin Zhao | 2012 | Food Chemistry2012，，1： | 2 |
| 19 | Flash memory based computing-in-memory system to solve partial differential equations显示文摘Dear editor,Many emerging non-volatile memories(NVM), such as resistive random access memory(RRAM) [1], phase-change memory(PCM) [2], and ferroelectric RAM(FeR AM) [3],together with the conventional flash memory [4, 5], have demonstrated their good capabilities in many artificial neural networks. | Yang FENG Fei WANG Xuepeng ZHAN Yuan LI Jiezhi CHEN | 2021 | Science China(Information Sciences)2021，64，6： | 2 |
| 20 | Effects of AlCoCrFeNiTi high-entropy alloy on microstructure and mechanical properties of pure aluminum显示文摘A new kind of AlCoCrFeNiTi high-entropy alloy(HEA)as a grain refiner was prepared by vacuum arc melting.In this work,the effects of HEA(1.0 wt.%,2.0 wt.%and 3.0 wt.%)on the microstructure and mechanical properties of pure aluminum were studied.The microstructure was characterized and examined by scanning electron microscope(SEM),energy dispersive X-ray spectroscopy(EDS),X-ray diffraction(XRD),electron probe micro-analyzer(EPMA)and transmission electron microscopy(TEM)to indicate the refining abilities and mechanism of HEA on pure aluminum.Results show that the addition of HEA refined both the macrostructure and microstructure of pure aluminum.When 1.0 wt.%HEA was added,most coarse columnar grains were refined into equiaxed crystals,and as the amount of HEA increased to 2.0 wt.%and3.0 wt.%,aluminum grains were further refined,and the grain boundaries were nearly indistinguishable.Moreover,the morphology ofα-Al transformed from coarse columnar crystals to equiaxed grains,and the mean size ofα-Al grains decreased from 374μm to 27μm.The Al3Ti,Al3Ni,and nano-phase precipitated from the aluminum alloy with HEA in the solidification.The typical rod-like nano-phases distributed interdendritic regions ofα-Al.The average length of nano-phases is 2568 nm,4372 nm,and 6907 nm and the average diameter is 112 nm,103 nm,and 92 nm when 1.0 wt.%,2.0 wt.%and 3.0 wt.%HEA were added to the pure aluminum,respectively.The ultimate tensile strength(UTS)and yield strength(YS)were improved in all samples,whereas the elongation(El)was decreased with increasing HEA concentration.When 3.0 wt.%HEA was added into the aluminum melt,the UTS was improved by 145.2%from62 MPa to 152 MPa,the YS was increased by 173.8%from 42 MPa to 115 MPa,and the El was decreased by 33.3%from 39%to 26%. | Qinglin Li Shang Zhao Xuepeng Bao Yushi Zhang Yuqian Zhu Chuangzao Wang Yefeng Lan Yuxin Zhang Tiandong Xia | 2020 | Journal of Materials Science & Technology2020，52，17： | 2 |
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