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| 1 | Developing land use scenario dynamics model by the integration of system dynamics model and cellular automata model显示文摘Modeling land use scenario changes and its potential impacts on the structure and function of the ecosystem in the typical regions are helpful to understanding the interactive mechanism between land use system and ecological system. A Land Use Scenario Dynamics (LUSD) model by the integration of System Dynamics (SD) model and Cellular Automata (CA) model is developed with land use scenario changes in northern China in the next 20 years simulated in this paper. The basic idea of LUSD model is to simulate the land use scenario de-mands by using SD model at first, then allocate the land use scenario patterns at the local scale with the considerations of land use suitability, inheritance ability and neighborhood effect by using CA model to satisfy the balance between land use scenario demands and supply. The application of LUSD model in northern China suggests that the model has the ability to reflect the complex behavior of land use system at different scales to some extent and is a useful tool for assessing the potential impacts of land use system on ecological system. In addition, the simulated results also indicate that obvious land use changes will take place in the farming-pastoral zone of northern China in the next 20 years with cultivated land and urban land being the most active land use types. | HE Chunyang, SHI Peijun, CHEN Jin, Li Xiaobing, PAN Yaozhong, LI Jing, LI Yuechen & LI Jinggang Key Laboratory of Environmental Change and Natural Disaster, Ministry of Education of China, Beijing Normal University College of Resources Science & Technology, Beijing Normal University, Beijing 100875, China | 2005 | Science China Earth Sciences2005，48，11： | 21 |
| 2 | YEATS2 是一个选择 histone crotonylation 读者显示文摘 | Dan Zhao Haipeng Guan Shuai Zhao Wenyi Mi Hong Wen Yuanyuan Li Yingming Zhao C David Allis Xiaobing Shi Haitao Li | 2016 | Cell Research2016，26，5： | 9 |
| 3 | Lysine methylation: beyond histones显示文摘histone 蛋白质的 Posttranslational 修正(PTM ) 例如 acetylation, methylation, phosphorylation,和 ubiquitylation,在调整染色质动力学起必要作用。histone 蛋白质上的不同修正的联合,在许多情况中的称为的 histone 代码,由在 epigenetic 水平调整 DNA 扩大遗传密码的信息潜力。许多 PTM 象 histones 一样发生在 non-histone 蛋白质上,调整涉及多样的细胞的过程的蛋白质的 proteinprotein 相互作用,稳定性,本地化,或酶的活动。尽管蛋白质 phosphorylation, ubiquitylation,和 acetylation 广泛地被学习了,仅仅除 histones 以外的一些蛋白质被报导了那能被离氨酸 methylation 修改。这评论在 non-histone 的离氨酸 methylation 上总结当前的进步蛋白质,和我们建议离氨酸 methylation 象 phosphorylation 和 acetylation 一样,是在多样的细胞的过程调整蛋白质的普通 PTM。 | Xi Zhang Hong Wen Xiaobing Shi | 2012 | Acta Biochimica et Biophysica Sinica2012，44，1： | 7 |
| 4 | Flexible artificial synapse based on single-crystalline BiFeO_(3) thin film显示文摘Realization of functional flexible artificial synapse is a significant step toward neuromorphic computing.Herein,a flexible artificial synapse based on ferroelectric tunnel junctions(FTJs)is demonstrated,using BiFeO_(3)(BFO)thin film as the functional layer.The inorganic single crystalline FTJs grown on rigid perovskite substrates at high temperatures are integrated with the flexible plastic substrates,by using the water-soluble Sr_(3)Al_(2)O_(6)(SAO)as the sacrificial layer and the following transfer.The transferred freestanding BFO thin film exhibits excellent ferroelectric properties.Moreover,the memristive properties and the brain-like synaptic learning performance of the flexible FTJs are investigated.The results show that multilevel resistance states were maintained well of the flexible artificial synapse,together with their stable synaptic learning properties.Our work indicates the promising opportunity of ferroelectric thin film based flexible synapse used in the future neuromorphic computing system. | Zhen Zhao Amr Abdelsamie Rui Guo Shu Shi Jianhui Zhao Weinan Lin Kaixuan Sun Jingjuan Wang Junling Wang Xiaobing Yan Jingsheng Chen | 2022 | Nano Research2022，15，3： | 2 |
| 5 | Numerical study on the deformation of soil stratum and vertical wells with gas hydrate dissociation显示文摘Gas hydrate(GH) dissociates owing to thermal injection or pressure reduction from the well in gas/oil or GH exploitation. GH dissociation leads to, for example, decreases in soil strength, engineering failures such as wellbore instabilities, and marine landslides. The FLAC3 D software was used to analyze the deformation of the soil stratum and vertical wells with GH dissociation. The effects of Young's modulus, internal friction angle, cohesion of the GH layer after dissociation, and the thickness of the GH layer on the deformation of soils were studied. It is shown that the maximum displacement in the whole soil stratum occurs at the interface between the GH layer and the overlayer. The deformation of the soil stratum and wells increases with decreases in the modulus, internal friction angle, and cohesion after GH dissociation. The increase in thickness of the GH layer enlarges the deformation of the soil stratum and wells with GH dissociation. The hydrostatic pressure increases the settlement of the soil stratum, while constraining horizontal displacement. The interaction between two wells becomes significant when the affected zone around each well exceeds half the length of the GH dissociation zone. | Xudong Chen Xuhui Zhang Xiaobing Lu Wei Wei Yaohong Shi | 2016 | Acta Mechanica Sinica2016，32，5： | 2 |
| 6 | High throughput sequencing analysis of biogeographical distribution of bacterial communities in the black soils of northeast China显示文摘 | Junjie Liu Yueyu Sui Zhenhua Yu Yu Shi Haiyan Chu Jian Jin Xiaobing Liu Guanghua Wang | 2013 | Soil Biology and Biochemistry2013，，： | 2 |
| 7 | Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy显示文摘Chimeric antigen receptor-based T-cell immunotherapy is a promising strategy for treatment of hematological malignant tumors;however,its efficacy towards solid cancer remains challenging.We therefore focused on developing nanobody-based CAR-T cells that treat the solid tumor.CD105 expression is upregulated on neoangiogenic endothelial and cancer cells.CD105 has been developed as a drug target.Here we show the generation of a CD105-specific nanobody,an anti-human CD105 CAR-T cells,by inserting the sequences for anti-CD105 nanobody-linked standard cassette genes into AAVS1 site using CRISPR/Cas9 technology.Co-culture with CD105+target cells led to the activation of anti-CD105 CAR-T cells that displayed the typically activated cytotoxic T-cell characters,ability to proliferate,the production of pro-inflammatory cytokines,and the specific killing efficacy against CD105+target cells in vitro.The in vivo treatment with anti-CD105 CAR-T cells significantly inhibited the growth of implanted CD105+tumors,reduced tumor weight,and prolonged the survival time of tumor-bearing NOD/SCID mice.Nanobody-based CAR-T cells can therefore function as an antitumor agent in human tumor xenograft models.Our findings determined that the strategy of nanobody-based CAR-T cells engineered by CRISPR/Cas9 system has a certain potential to treat solid tumor through targeting CD105 antigen. | Fengzhen Mo Siliang Duan Xiaobing Jiang Xiaomei Yang Xiaoqiong Hou Wei Shi Cueva Jumbo Juan Carlos Aiqun Liu Shihua Yin Wu Wang Hua Yao Zihang Yu Zhuoran Tang Shenxia Xie Ziqiang Ding Xinyue Zhao Bruce D.Hammock Xiaoling Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
| 8 | Microstructure and properties of nano-laminated Y_(3)Si_(2)C_(2) ceramics fabricated via in situ reaction by spark plasma sintering显示文摘A nano-laminated Y_(3)Si_(2)C_(2) ceramic material was successfully synthesized via an in situ reaction between YH_(2)and SiC using spark plasma sintering technology.A MAX phase-like ternary layered structure of Y_(3)Si_(2)C_(2) was observed at the atomic-scale by high resolution transmission electron microscopy.The lattice parameters calculated from both X-ray diffraction and selected area electron diffraction patterns are in good agreement with the reported theoretical results.The nano-laminated fracture of kink boundaries,delamination,and slipping were observed at the tip of the Vickers indents.The elastic modulus and Vickers hardness of Y_(3)Si_(2)C_(2) ceramics(with 5.5 wt%Y_(2)O_(3)) sintered at 1500℃were 156 and 6.4 GPa,respectively.The corresponding values of thermal and electrical conductivity were 13.7 W·m^(-1)·K^(-1) and 6.3×10^(5)S·m^(-1),respectively. | Lin-Kun SHI Xiaobing ZHOU Jian-Qing DAI Ke CHEN Zhengren HUANG Qing HUANG | 2021 | Journal of Advanced Ceramics2021，10，3： | 2 |
| 9 | Integrated Analysis of Long Noncoding RNA and Coding RNA Expression in Esophageal Squamous Cell Carcinoma显示文摘 | Wei Cao Wei Wu Fachun Shi Xiaobing Chen Lihua Wu Ke Yang Fu Tian Minghui Zhu Guoyong Chen WeiWei Wang Fred G. Biddle Jianqin Gu Soraya E. Gutierrez | 2013 | International Journal of Genomics2013，，： | 1 |
| 10 | Characteristics of carbonyl compounds emission from a diesel - engine using biodiesel - ethanol - diesel as fuel 显示文摘 | Xiaobing Pang Xiaoyan Shi Yujing Mu | 2006 | Atmospheric Environment2006，40，： | 1 |
| 11 | Emission reduction potential of using ethanol - biodiesel - diesel fuel blend on a heavyduty diesel engine 显示文摘 | Xiaoyan Shi Xiaobing Pang Yujing Mu | 2006 | Atmospheric Environment2006，40，： | 1 |
| 12 | Emission reduction potential of using ethanol-biodiesel-diesel fuel blend on a heavy-duty diesel engine 显示文摘 | Shi Xiaoyan Pang Xiaobing Mu Yujing | 2006 | Atmospheric Environment2006，40，： | 1 |
| 13 | Characteristics of carbonyl compounds emission from a diesel-engine using biodiesel-ethanol-diesel as fuel 显示文摘 | Pang Xiaobing Shi Xiaoyan Mu Yujing | 2006 | Atmospheric Environment2006，40，36： | 1 |
| 14 | The fellowships of the INGs 显示文摘 | Shi Xiaobing Gozani O | 2005 | Journal of Cell Biochemistry2005，96，6： | 1 |
| 15 | Analysis of adverse events following the treatment of autologous cytokine-induced killer cells for adoptive immunotherapy in malignant tumour sufferers显示文摘 | Yajing Zhang Lei Xia Yan Zhang Yao Wang Xuechun Lu Fengxia Shi Yang Liu Meixia Chen Kaixhao Feng Wenying Zhang Xiaobing Fu Weidong Han | 2015 | Expert Opinion on Biological Therapy2015，，： | 1 |
| 16 | Determination of absolute gamma-ray emission probabilities for ^(88)Kr显示文摘In preparation of homogeneous Kr and Rb sources,the Kr activity was determined by the decay relationship between ^(88)Kr and ^(88)Rb using an HPGe detector.The peak efficiencies of ^(88)Kr and ^(88)Rbγ-rays were calibrated.The results show that the absolute probabilities of 196.3,834.8,1529.8,2195.8 and 2392.1 keVγ-rays of ^(88)Kr were 25.1(5)%,12.9(2)%,10.7(2)%,13.3(2)%and 34.9(5)%,respectively. | XIE Feng HE Xiaobing JIANG Wengang CHEN Zhanying SHI Quanlin CHANG Yongfu | 2011 | Nuclear Science and Techniques2011，22，5： | 1 |
| 17 | Land use pattern adjustment under ecological security: Look for secure land use pattern in China 显示文摘 | Shi Peijun Yuan Yi Li Xiaobing | 2004 | Geographical Review of Japan2004，77，12： | 1 |
| 18 | Government Investment in Disaster Risk Reduction Based on a Probabilistic Risk Model: A Case Study of Typhoon Disasters in Shenzhen, China显示文摘In recent years, cost-benefit analysis(CBA) has played an important role in disaster risk reduction(DRR)investment decisions, and now increasing attention is being paid to its application in developing countries. This article discusses government investment choices in DRR against typhoon disasters in Shenzhen, China. While the existing literature mainly focuses on disaster mitigation measures such as structural retrofitting, this study proposes a holistic framework of DRR investments in which structural(windproof retrofitting) and financial(insurance premium subsidies and post-disaster relief) are all taken into account.In particular, intermeasure spillover effects are measured and used in CBA. The results show that insurance premium subsidies yield the highest benefit-cost ratio and should be prioritized in investment. Windproof retrofitting comes in second place in terms of the benefit-cost ratio and can be considered when there is a sufficient budget. These results further confirm the need of a holistic review of government DRR investments to derive policy recommendations, while challenges remain in relation to the probabilistic modeling capacity to support CBA. | Tao Ye Yao Wang Binxia Wu Peijun Shi Ming Wang Xiaobing Hu | 2016 | International Journal of Disaster Risk Science2016，7，2： | 1 |
| 19 | Emission reduction potential of using ethanol-biodiesel-diesel fuel blend on a heavy-duty diesel engine显示文摘 | SHI Xiaoyan PANG Xiaobing MU Yujing | 2006 | Atmospheric Environment2006，40，14： | 1 |
| 20 | Asymmetric Alternating Copolymerization and Terpolymerization of Epoxides with Carbon Dioxide at Mild Conditions 显示文摘 | Shi Lei Lu Xiaobing Zhang Rong | 2006 | Macromole- cules2006，39，17： | 1 |
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