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| 1 | Orbit determination and time synchronization for a GEO/IGSO satellite navigation constellation with regional tracking network显示文摘Aiming at regional services,the space segment of COMPASS (Phase I) satellite navigation system is a constellation of Geostationary Earth Orbit (GEO),Inclined Geostationary Earth Orbit (IGSO) and Medium Earth Orbit (MEO) satellites.Precise orbit determination (POD) for the satellites is limited by the geographic distribution of regional tracking stations.Independent time synchronization (TS) system is developed to supplement the regional tracking network,and satellite clock errors and orbit data may be obtained by simultaneously processing both tracking data and TS data.Consequently,inconsistency between tracking system and TS system caused by remaining instrumental errors not calibrated may decrease navigation accuracy.On the other hand,POD for the mixed constellation of GEO/IGSO/MEO with the regional tracking network leads to parameter estimations that are highly correlated.Notorious example of correlation is found between GEO's orbital elements and its clock errors.We estimate orbital elements and clock errors for a 3GEO+2IGSO constellation in this study using a multi-satellite precise orbit determination (MPOD) strategy,with which clock error elimination algorithm is applied to separate orbital and clock estimates to improve numerical efficiency.Satellite Laser Ranging (SLR) data are used to evaluate User Ranging Error (URE),which is the orbital error projected on a receiver's line-of-sight direction.Two-way radio-wave time transfer measurements are used to evaluate clock errors.Experimenting with data from the regional tracking network,we conclude that the fitting of code data is better than 1 m in terms of Root-Mean-Square (RMS),and fitting of carrier phase is better than 1 cm.For orbital evaluation,difference between computed receiver-satellite ranging based on estimated orbits and SLR measurements is better than 1 m (RMS).For clock estimates evaluation,2-hour linear-fitting shows that the satellite clock rates are about 1.E-10 s/s,while receiver clock rates are about 1×10 13-1×10 12 s/s.For the 72-hour POD experiment,the average differences between POD satellite clock rates estimates and clock measurements based on TS system are about 1×10 13 s/s,and for receiver clock rates,the differences are about 1×10 15 s/s. | ZHOU ShanShi HU XiaoGong WU Bin LIU Li QU WeiJing GUO Rui HE Feng CAO YueLing Wu XiaoLi ZHU LingFeng SHI Xin TAN HongLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 44 |
| 2 | Urban expansion in China and its effect on cultivated land before and after initiating'Reform and Open Policy'显示文摘Urbanization in China has expanded at an unprecedented speed since the declaration of 'Reform and Open Policy'and presented many challenges. Unbalanced regional development, appearance of super megacities and concomitant problems,and conflicts between urbanization and cultivated land protection are three critical problems that Chinese urbanization has to face. To develop new plans for foreseeable future urbanization in China, it is critical to understand the evolving history of cities across China. This study maps urban expansion of 60 typical Chinese cities based on large amount of remote sensing data and the labor-intensive image interpretation method, in order to understand the history of urban expansion from the 1970 s to 2013.Results showed that area of cities expanded 5.23 times compared to their area in the 1970 s. Urban expansion in China accelerated three times(1988–1996, 1999–2006, and 2009–2011) and decelerated three times(1997–1998, 2007–2008, and 2012–2013) over the 40 years. The urban area of South China expanded most significantly 9.42 times, while the urban area in Northeast China expanded only 2.37 times. The disparity among different administrative ranks of cities was even greater than(3.81 times) the differences among different regions. Super megacities have been continuously expanding at a fast rate(8.60-fold), and have not shown obvious signs of slowing down. The proportion of cultivated land among the land sources for urban expansion decreased to a small extent in the 1990 s, but cultivated land continues to be the major land source for urban expansion. Effective future urbanization needs controlling the expansion scale of large cities and reasonably developing medium and small cities, as well as balancing regional development. | ZHANG ZengXiang WEN QingKe LIU Fang ZHAO XiaoLi LIU Bin XU JinYong YI Ling HU ShunGuang WANG Xiao ZUO LiJun LI Na LI MinMin SHI LiFeng ZENG Tian JU HongRun | 2016 | Science China Earth Sciences2016，59，10： | 12 |
| 3 | Modification of Costanza's model of valuing ecosystem services and its application in China显示文摘In the past,evaluations of ecosystem functions were mostly based on Costanza's model,whereas the spatial,quality and temporal characteristics of regional ecosystems were not considered in the model.Focusing on these issues,coefficients of regional difference,spatial heterogeneity and willingness-to-pay(WTP)were established to modify Costanza's model,and a new comprehensive valuation model of ecosystem functions is proposed.The analytical results indicate that the comprehensive model could evaluate regional ecosystem functions in China accurately and provide more helpful information for decision-making.The empirical study on Zhangbei County in Hebei Province shows that the intensive human activities could limit the provision of ecosystem functions while the planned ecological programs might promote the restoration of ecosystem functions. | Shi Xiaoli Wang Wei | 2009 | Ecological Economy2009，5，4： | 10 |
| 4 | Dipeptidyl peptidase Ⅳ(DPP Ⅳ):a novel emerging target for thetreatment of type 2 diabetes显示文摘The enzyme, dipeptidyl peptidase Ⅳ(DPP Ⅳ), is a novel target for the treatment of type 2 diabetes. Dipeptidyl peptidase Ⅳ inhibition improves the impaired insulin secretion and decrease postprandial concentrations of glucagon by enhancing the incretin hormone levels lucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide(GIP). Recently, DPP Ⅳ inhibitors have attracted more and more attention, several of which have entered pre-clinical and clinical trials, and one has received approval for use as an anti-diabetic agent. Among the DPP Ⅳ inhibitors, two leading agents(sitagliptin and vildagliptin) have been shown to be effective in reducing glycosylated hemoglobin(HbA1c) and fasting plasma glucose(FPG) in patients with type 2 diabetes. This review summarizes the evidence supporting DPP IV inhibitors as potential antidiabetic agents. | Jing Wu Yiding Chen Xiaoli Shi Wei Gu | 2009 | Journal of Nanjing Medical University2009，23，4： | 9 |
| 5 | Development of quantitative methods for detecting climate contributions to boundary shifts in farming-pastoral ecotone of northern China显示文摘易碎的区域上的气候变化的量的效果是对气候变化的回答的地里的一个热话题。以前的研究把品质上记录气候的影响在耕作牧剧交错群落(FPE ) 在边界移动上变化;然而,为检测气候贡献的量的方法仍然保持相对有限。自从 1970,基于气象学的车站的长期的数据和陆地使用的解释, 1970 年代, 1980 年代, 1990 年代和 2000 年代的气候和陆地使用边界被描出。为了检测气候贡献到 FPE 边界,变,我们开发了二个量的方法在东方西方探索气候和陆地使用边界的空间时间的模式(或南方北方)( 渔网方法) 并且横断方向(数字海岸线分析系统, DSAS 方法) 。结果显示重要差别在不同时期期间在不同区域在气候边界,陆地使用边界,以及气候贡献被展出。西北 FPE 有更小的变化,当东北 FPE 有更大的移动时。在更大的 Hinggan 山和内部蒙古的高原的东南穗的西北部分,气候边界的移动是显著地与陆地使用边界有关。在一个东方西方方向的气候贡献从 10.7% ~ 44.4%,并且那些从 4.7% ~ 55.9% 在一个南方北方方向变化了。从 DSAS 的结果的多数与从渔网的那些一致。DSAS 方法为在小规模的精确察觉更精确、合适,而渔网方法简单在大规模很快并且直接进行统计分析。我们的研究将是有用的适应气候变化,以开发生产潜力,以及在北中国保护 FPE 的环境。 | SHI Wenjiao LIU Yiting SHI Xiaoli | 2017 | Journal of Geographical Sciences2017，27，9： | 8 |
| 6 | An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel显示文摘金 nanoparticles (AuNPs ) 的 biodistribution 是仔细与毒物学的效果有关并且因为他们的潜在的申请,担心大。与为液体运输的新奇解剖、组织学的结构的发现,然而,内在的机制包含了在在里面 AuNPs 的 vivo 运输和 biodistribution 要求进一步深入的调查。在当前的学习,在腱,容器,和神经纤维的一个焦点的点可以最佳地与另外的遥远的结缔组织连接的地方,我们在跗骨的隧道在 intervaginal 空间注射(ISI ) 以后在老鼠调查了 10-nm AuNPs 的 biodistribution。AuNPs 的静脉内的注射(IVI ) 用作控制。血和机关与诱导地联合的血浆团 spectrometry (ICPMS ) 为 Au 分发的定量分析在注射以后在 5, 15,和 30 min 并且在 1, 4, 12,和 24 h 被收集。IVI 和 ISI 产出显著地不同的结果:在在 ISI 以后的血的 AuNP 内容在 IVI 以后是比那低得多的;在肺,心,和肠是类似的;并且在皮和肌肉是更高的。这些调查结果被 AuNP 内容和相对机关 AuNP 分发比例的比率支持。我们表明的结果一快,直接并且发行量无关的 AuNP 器官运输小径,它可以改进我们生理、病理学的 biodistribution 的理解在生物系统处理。而且,这些结果提供新奇卓见进在里面 vivo 运输和 AuNPs 的 biodistribution,它可以导致新奇、有效治疗学并且管理策略。 | Xiaoli Shi Yuting Zhu Wenda Hua Yinglu Ji Qing Ha Xinxiao Han Yang Liu Jingwei Gao Qiang Zhang Sidi Liu Keli Ren Xiaochun Wu Hongyi Li Dong Han | 2016 | Nano Research2016，9，7： | 7 |
| 7 | Spatial Differences of Coastal Urban Expansion in China from 1970s to 2013显示文摘As the ′economic engines′ of China,coastal cities have developed and expanded considerably since the 1970 s.In this study,information on the urban expansion process of Chinese coastal cities from the 1970 s to 2013 was retrieved.Through the analysis of stage characteristics,spatial expansion modes,influences on land use,centroid shifts,and spatial morphological evolutions,the spatial differences of coastal urban expansion were revealed.Results indicate that 1) the expansion stages of southern coastal cities are more complex than those of northern coastal cities,and the expansion ranges and speeds of the former are far higher than those of the latter;2) the spatial expansion of southern coastal cities mostly adopt a single mode,whereas northern coastal cities mostly adopt a mixed mode;3) significant spatial differences in the occupations of different land sources exist between the south and the north along the coastline;4) the centroid of coastal cities tends to migrate toward the coastline,and the centroid shift distances of southern coastal cities are clearly higher than those of northern coastal cities;and 5) the spatial morphology of southern coastal cities tends to be compact,whereas that of northern coastal cities tends to be loose.Policies have a powerful significance in terms of guiding urban expansion and its spatial differences in coastal cities.Urban expansion in coastal cities will encounter new opportunities and challenges under the guidance of new types of urbanization strategies. | SHI Lifeng LIU Fang ZHANG Zengxiang ZHAO Xiaoli LIU Bin XU Jinyong WEN Qingke YI Ling HU Shunguang | 2015 | Chinese Geographical Science2015，25，4： | 7 |
| 8 | Health risk assessment of dietary exposure to polycyclic aromatic hydrocarbons in Taiyuan, China显示文摘Sixteen polycyclic aromatic hydrocarbons(PAHs) were determined in 24 duplicate-diet samples from people in Taiyuan during summer and winter in 2009. Dietary intake of PAHs for 2862 participants was subsequently estimated by a survey in Taiyuan. Results from these 24 samples were compared with a raw food study in Taiyuan in 2008. Three main sources of dietary PAHs are vegetables, wheat flour and fruits, the sum of which contributes 75.95% of PAHs in dietary food. Compared to the estimated value in raw food, much more B[a]Peq(benzo[a]pyrene equivalents) were detected in food samples collected in the duplicate-diet study in Taiyuan(60.75 ng/day). The cooking process may introduce more B[a]Peq into food, and the relative contribution of 16 PAHs in the diet would be changed during the cooking procedure. | Jing Nie Jing Shi Xiaoli Duan Beibei Wang Nan Huang Xiuge Zhao | 2014 | Journal of Environmental Sciences2014，26，2： | 6 |
| 9 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 10 | Urban Expansion in China Based on Remote Sensing Technology:A Review显示文摘Urban areas and its evolution are important anthropogenic indicators and human ecological footprints, and play decisive roles in environmental change analysis, global geo-conditional monitoring, and sustainable development. China has the highest rate of urban expansion and has emerged as an urban expansion hotspot worldwide. In this paper, the progress of studies on Chinese urban expansion based on remote sensing technology are summarized and analyzed from the aspects of urban area definition, remotely sensed imagery applied in urban expansion, monitoring methods of urban expansion, and urban expansion applications. Existing issues and future directions of Chinese urban expansion are discussed and proposed. Results indicate that: 1) The fusion of multi-source remotely sensed imagery is imperative to meet the needs of urban expansion with various monitoring terms and frequencies on different scales and dimensions. 2) To guarantee the classification accuracy and efficiency and describe urban expansion and its influences on local land use simultaneously, the combination of visual interpretation and automatic classification is the tendency of future monitoring methods of urban areas. 3) Urban expansion data have become the prerequisite for recognizing the urban development process, excavating its driving forces, simulating and predicting the future development directions, and also is conducive to revealing and explaining urban ecological and environmental issues. 4) In the past decades, Chinese scholars have promoted the application of remote sensing technology in the urban expansion field, with data construction, methods and models developing from the quotation stage to improvement and innovation stage; however, an independent and consistent urban expansion data on the national scale with long-term and high-frequency(such as annual monitoring) monitoring is still lacking. | ZHANG Zengxiang LIU Fang ZHAO Xiaoli WANG Xiao SHI Lifeng XU Jinyong YU Sisi WEN Qingke ZUO Lijun YI Ling HU Shunguang LIU Bin | 2018 | Chinese Geographical Science2018，28，5： | 6 |
| 11 | Current advances in genome sequencing of common wheat and its ancestral species显示文摘Common wheat is an important and widely cultivated food crop throughout the world.Much progress has been made in regard to wheat genome sequencing in the last decade.Starting from the sequencing of single chromosomes/chromosome arms whole genome sequences of common wheat and its diploid and tetraploid ancestors have been decoded along with the development of sequencing and assembling technologies. In this review, we give a brief summary on international progress in wheat genome sequencing, and mainly focus on reviewing the effort and contributions made by Chinese scientists. | Xiaoli Shi Hong-Qing Ling | 2018 | The Crop Journal2018，6，1： | 5 |
| 12 | Quantification of microcystin-producing and non-microcystin producing Microcystis populations during the 2009 and 2010 blooms in Lake Taihu using quantitative real-time PCR显示文摘Lake Taihu,a large,shallow hypertrophic freshwater lake in eastern China,has experienced lake-wide toxic cyanobacterial blooms annually during summer season in the past decades.Spatial changes in the abundance of hepatotoxin microcystin-producing and nonmicrocystin producing Microcystis populations were investigated in the lake in August of 2009 and 2010.To monitor the densities of the total Microcystis population and the potential microcystin-producing subpopulation,we used a quantitative real-time PCR assay targeting the phycocyanin intergenic spacer(PC-IGS) and the microcystin synthetase gene(mcyD),respectively.On the basis of quantification by real-time PCR analysis,the abundance of potential toxic Microcystis genotypes and the ratio of the mcyD subpopulation to the total Microcystis varied significantly,from 4.08×104 to 5.22×107 copies/mL,from 5.7% to 65.8%,respectively.Correlation analysis showed a strong positive relationship between chlorophyll-a,toxic Microcystis and total Microcystis;the abundance of toxic Microcystis correlated positively with total phosphorus and ortho-phosphate concentrations,but negatively with TN:TP ratio and nitrate concentrations.Meanwhile the proportion of potential toxic genotypes within Microcystis population showed positive correlation with total phosphorus and ortho-phosphate concentrations.Our data suggest that increased phosphorus loading may be a significant factor promoting the occurrence of toxic Microcystis bloom in Lake Taihu. | Daming Li Fanxiang Kong Xiaoli Shi Linlin Ye Yang Yu Zhen Yang | 2012 | Journal of Environmental Sciences2012，24，2： | 5 |
| 13 | An Epigenetic Role for Disrupted Paternal Gene Expression in Postzygotic Seed Abortion in Arabidopsis Interspecific Hybrids显示文摘种间的混血儿经常增加杂合现象和混合活力的层次,而是一些种间的混合种子立即在授精以后被放弃。在这 postzygotic 种子流产后面的机制糟糕被理解。这里,我们在在在 Arabidopsis thaliana (关口, Ler,或 C24 ) 和 Arabidopsis arenosa 之间的三个 F1 种间的十字开发 siliques 和种子报导突变而产生之遗传的表示变化的染色体宽的分析。似母亲的多数表示了基因(MEG ) 而 272 父亲一般地表示的基因(木钉) 的 ∼90% 仅仅在一或二个 F1 十字被发现,在所有三个 F1 种间的十字之中被分享,在在不同十字变化的种子流产为破坏父亲的基因表示建议一个角色。与这个观点一致,在不肥沃的种间的混血儿的 12 个木钉在肥沃的 intraspecific 混血儿匹配 MEG。在种间的混血儿的木钉的这混乱与在在一位双母亲和一位 hexaploid 父亲之间的父亲过量的 interploidy 十字(2X6 ) 的基因的 upregulation 一致,导致种子流产。而且,在种间的十字的木钉的一个子集也是在 intraspecific 混血儿 met1XWT 或 meaXWT 的 upregulated,在哪个 MET1 (DNA METHYLTRANSFERASE1 ) 的异种或美狄亚, Polycomb 压抑的 Complex2gene,被用作母亲的父母。这些数据建议母亲的 epigenetic 因素和父亲的基因表示在种间的混血儿或 neo-allopolyploids 在 postzygotic 种子流产起重要作用。 | Ryan C. Kirkbride Helen Hong Yu Gyoungju Nah Changqing Zhang Xiaoli Shi Z. Jeffrey Chen | 2015 | Molecular Plant2015，8，12： | 5 |
| 14 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 15 | Hydrothermal Synthesis of Cs_xWO_3 and the Effects of N_2 Annealing on its Microstructure and Heat Shielding Properties显示文摘Cesium tungsten bronze(Cs_xWO_3) powders were synthesized by hydrothermal reaction at 190 ℃ by using sodium tungstate and cesium carbonate as raw materials,and the effects of N_2 annealing on the microstructure and near-infrared(NIR) shielding as well as heat insulation properties of Cs_xWO_3 were investigated.The results indicated that the synthesized Cs_xWO_3 powders exhibited hexagonal Cs_(0.32)WO_3crystal structure,and subsequent N_2 annealing could further improve the crystallinity of CsxW03 particles.Moreover,the NIR shielding and heat insulation properties of Cs_xWO_3 could be further improved after N_2annealing at appropriate temperature for a period of time.Particularly,the 500 ℃-annealed Cs_xWO_3 products in the N_2 atmosphere showed the best NIR shielding and heat insulation properties.When the N_2 annealing temperature was higher than 700 ℃,the NIR shielding properties decreased again.The 800 ℃-annealed samples in the N_2 atmosphere showed higher visible light transmittance,however,the NIR shielding properties were lower than that of the non-annealed samples. | Fei Shi Jingxiao Liu Xiaoli Dong Qiang Xu Jiayu Luo Hongchao Ma | 2014 | Journal of Materials Science & Technology2014，30，4： | 5 |
| 16 | Effects of elevated CO_2 on dynamics of microcystin-producing and non-microcystin-producing strains during Microcystis blooms显示文摘In an attempt to elucidate the effects of different CO2concentrations(270, 380, and 750 μL/L) on the competition of microcystin-producing(MC-producing) and non-MC-producing Microcystis strains during dense cyanobacteria blooms, an in situ simulation experiment was conducted in the Meiliang Bay of Lake Taihu in the summer of 2012. The abundance of total Microcystis and MC-producing Microcystis genotypes was quantified based on the 16 S r DNA and mcy D gene using real-time PCR. The results showed that atmospheric CO2 elevation would significantly decrease the p H value and increase the dissolved inorganic carbon(DIC) concentration.Changes in CO2 concentration did not show significant influence on the abundance of total Microcystis population. However, CO2 concentrations may be an important factor in determining the subpopulation structure of Microcystis. The enhancement of CO2 concentrations could largely increase the competitive ability of non-MC-producing over MC-producing Microcystis, resulting in a higher proportion of non-MC-producing subpopulation in treatments using high CO2 concentrations. Concurrently, MC concentration in water declined when CO2 concentrations were elevated. Therefore, we concluded that the increase of CO2 concentrations might decrease potential health risks of MC for human and animals in the future. | Li Yu Fanxiang Kong Xiaoli Shi Zhen Yang Min Zhang Yang Yu | 2015 | Journal of Environmental Sciences2015，27，1： | 4 |
| 17 | A model to assess fundamental and realized carrying capacities of island ecosystem:A case study in the southern Miaodao Archipelago of China显示文摘Research on carrying capacity, aiming at maintaining the limited ability of the Earth's life supporting system to sustain human development, requires a comprehensive and ecosystem-based approach to monitor and assess the localized sustainability of coupled social and ecological systems. A definition termed the ecosystem-based carrying capacity of island(EBCCI) was developed in this paper of which the indices of fundamental and realized carrying capacities of island(FCCI and RCCI) were highlighted to emphasize the inter-dependencies between social systems and ecological systems. In order to avoid the difficulties and uncertainties of direct assessment, the related assessment model was established on the basis of synthetic evaluation of inherent and external factors affecting the EBCCI. The southern Miaodao Archipelago(SMA) located in the intersection of the Bohai Sea and the Yellow Sea, China, was taken as a typical example to acquire integrated recognition of the island ecosystem and its carrying capacity so as to discuss its sustainable development. The index scores of FCCI and RCCI in the SMA were 0.818 5 and 0.712 9 out of 1.0, respectively, with acceptable uncertainties. The results showed a relatively well capacity to sustain progress and relatively well realization of the carrying capacity of island ecosystem, owing to a well capacity of ecologically regulating, general performance of both ecologically supporting and resource provisioning, and a relatively high level of social supporting system. The study implied that it was critical to optimize the inter-dependencies and to sustain the relative balance between social systems and ecological systems so as to improve the RCCI and further facilitate the sustainability of SMA. The approach proposed in this paper provides a powerful tool which is well applicative to the regional level of an oceanic island or archipelago to study the sustainable development and can be further popularized to the coastal zone. | SHI Honghua SHEN Chengcheng ZHENG Wei LI Fen WANG Xiaoli CHI Yuan GUO Zhen QIAO Mingyang GAO Liyuan DING Dewen | 2016 | Acta Oceanologica Sinica2016，35，2： | 4 |
| 18 | Extraction of Basic Trends of Urban Expansion in China over Past 40 Years from Satellite Images显示文摘If urban sprawl is to be avoided in China in the next ten years, it is not only crucial to understand the overall history, current status, and future trends of urban expansion there, but also these differences, and this is presently lacking. In this study, remotely sensed images with approximately 30 m spatial resolution were used to quantitatively assess the spatial and temporal patterns of urban expansion of 60 Chinese cities(1973–2013). Urban-expansion-process curves of the cities studied were drawn using annual expansion area as an indicator. Curve similarity analysis generated four basic process modes of urban expansion in China. These included cities that: 1) peaked around 2004 and then decelerated; 2) peaked around 2010 and then decelerated; 3) showed sustained acceleration, and 4) showed continued deceleration. Four basic process modes represented cities under different levels of development stage. Geographic location was found to be the most related characteristic to urban expansion process. Regional development policies at the national level in each region also showed highly temporal consistency with fluctuation characteristics of urban expansion process. Urban characteristic such as population size and administrative level were not found to be significantly related to urban expansion-process modes. Understanding the basic process-mode categories well is extremely important for future regional-balance planning and development of macroeconomic policies. | WEN Qingke ZHANG Zengxiang SHI Lifeng ZHAO Xiaoli LIU Fang XU Jinyong YI Ling LIU Bin WANG Xiao ZUO Lijun HU Shunguang LI Na LI Minmin | 2016 | Chinese Geographical Science2016，26，2： | 4 |
| 19 | City Size Distribution and Its Spatiotemporal Evolution in China显示文摘Based on the National Land Use/Cover Database of China(NLUD-C) in the end of the 1980s(the 1980s,hereafter), 1995, 2000, 2005, and 2010, 665 cities were selected to study the size distribution and its changes of urban lands in China. In this study, the spatiotemporal evolutions of urban land size distribution as well as the influence of administrative-level on these cities were explored by combining urban spatial positions and administrative-levels. Results indicate that: 1) City size distribution using urban lands was more practical and reasonable than using non-agricultural population. 2) In the 1980s, cities with ascending urban land rank were centralized in Eastern China, specially the Changjiang(Yangtze) River Delta, the Zhujiang(Pearl) River Delta, and Beijing-Tianjin-Hebei region. Cities in Central, Western, and Northeast China mainly indicated descending urban land rank. 3) The transfer of national development focus resulted in cities with ascending urban land rank becoming evenly distributed nationwide; however, this trend was slightly centralized around Chengdu, Chongqing, and Wuhan in different periods. 4) During the 1980s to 2010, the proportion of cities with ascending urban land rank in provincial capitals, municipalities, and special administrative regions(high-level cities, hereafter) was consistently higher than those in prefecture- and county-level cities except for 2005–2010. The ranks of the majority of the prefecture- and county-level cities were mainly descending, supported by ascending; the proportion of cities with unchanged rank is small. This study breaks through the bottleneck of traditional research in the area of city size distribution by examining urban land replacing the non-agricultural population. The current study also provides scientific explanation for the healthy and reasonable development of urban land as well as the coordinated development of population urbanization and land urbanization. | SHI Lifeng ZHANG Zengxiang LIU Fang ZHAO Xiaoli WANG Xiao LIU Bin HU Shunguang WEN Qingke ZUO Lijun YI Ling XU Jinyong | 2016 | Chinese Geographical Science2016，26，6： | 4 |
| 20 | Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis:a TCGA pan-cancer analysis显示文摘Background:Cancer cells reprogram metabolism for proliferation.Phosphoglycerate kinase 1(PGK1),as a glycolytic enzyme and newly identified protein kinase,coordinates glycolysis and mitochondrial metabolism.However,the clini-cal significance of PGK1 expression and function in cancer progression is unclear.Here,we investigated the relation-ship between the progression and prognosis of multiple cancer types and PGK1 expression and its function in the mitochondrial metabolism regulation.Methods:We performed pan-cancer analyses of PGK1 mRNA level and DNA methylation in 11,908 tumor tissues and 1582 paired normal tissues across 34 cancer types in The Cancer Genome Atlas datasets.Using specific antibodies against PGK1 S203 and PDHK1 T338 phosphorylation,we performed immunohistochemistry with tissue microarray assay in additional 818 cancer cases with 619 paired normal tissues from five cancer types.Results:The PGK1 mRNA level was significantly elevated with hypomethylation in promotor regions and associated with advanced TNM stage in 15 and four cancer types,respectively.In breast carcinoma,elevated PGK1 mRNA level and promoter hypomethylation were associated with poor prognosis.Positively correlated PGK1 S203 and PDHK1 T338 phosphorylation levels were significantly associated with short overall survival(OS)in cancers of the breast,liver,lung,stomach,and esophagus and with advanced TNM stage in breast and esophageal cancers.PGK1 pS203 and PDHK1 pT338 were also independent predictors of short OS in liver,lung,and stomach cancer.Conclusions:The elevated expression,promoter hypomethylation,and phosphorylation of PGK1 and PDHK1 were related with disease progression and short OS in diverse types of cancer.PGK1 and PDHK1 phosphorylation may be potential prognostic biomarkers. | Fei Shao Xueying Yang Wei Wang Juhong Wang Wei Guo Xiaoli Feng Susheng Shi Qi Xue Shugeng Gao Yibo Gao Zhimin Lu Jie He | 2019 | Cancer Communications2019，39，1： | 4 |
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