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| 1 | Solvent additive-free ternary polymer solar cells with 16.27% efficiency显示文摘Ternary strategy has been commonly demonstrated as an efficient method to improve the performance of polymer solar cells(PSCs), which has great potential in application of PSCs due to the simple device fabrication. | Qiaoshi An Xiaoling Ma Jinhua Gao Fujun Zhang | 2019 | Science Bulletin2019，64，8： | 14 |
| 2 | Leukocyte-derived biomimetic nanoparticulate drug delivery systems for cancer therapy显示文摘Precise drug delivery to tumors with low system toxicity is one of the most important and challenging tasks for pharmaceutical researchers. Despite progress in the field of nanotherapeutics, the use of artificially synthesized nanocarriers still faces several challenges, including rapid clearance from blood circulation and limited capability of overcoming multiple physiological barriers, which hamper the clinical application of nanoparticle-based therapies. Since leukocytes(including monocytes/macrophages,neutrophils, dendritic cells and lymphocytes) target tumors and can migrate across physiological barriers,leukocytes are increasing utilized as carriers to transfer nanoparticles to tumors. In this review we specifically focus on the molecular and cellular mechanisms of leukocytes that can be exploited as a vehicle to deliver nanoparticles to tumors and summarize the latest research on how leukocytes can be harnessed to improve therapeutic end-points. We also discuss the challenges and opportunities of this leukocyte-derived nanoparticle drug delivery system. | Yukun Huang Xiaoling Gao Jun Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 10 |
| 3 | Xa7, a new executor R gene that confers durable and broad-spectrum resistance to bacterial blight disease in rice显示文摘Bacterial blight(BB)is a globally devastating rice disease caused by Xanthomonas oryzae pv.oryzae(Xoo).The use of disease resistance(R)genes in rice breeding is an effective and economical strategy for the control of this disease.Nevertheless,a majority of R genes lack durable resistance for long-term use under global warming conditions.Here,we report the isolation of a novel executor R gene,Xa7,that confers extremely durable,broad-spectrum,and heat-tolerant resistance to Xoo.The expression of Xa7 was induced by incompatible Xoo strains that secreted the transcription activator-like effector(TALE)AvrXa7 or PthXo3,which recognized effector binding elements(EBEs)in the Xa7 promoter.Furthermore,Xa7 induction was faster and stronger under high temperatures.Overexpression of Xa7 or co-transformation of Xa7 with avrXa7 triggered a hypersensitive response in plants.Constitutive expression of Xa7 activated a defense response in the absence of Xoo but inhibited the growth of transgenic rice plants.In addition,analysis of over 3000 rice varieties showed that the Xa7 locuswas found primarily in the indica and aus subgroups.A variation consisting of an 11-bp insertion and a base substitution(G to T)was found in EBEAvrXa7 in the tested varieties,resulting in a loss of Xa7 BB resistance.Through a decade of effort,we have identified an important BB resistance gene and characterized its distinctive interaction with Xoo strains;these findings will greatly facilitate research on the molecular mechanism of Xa7-mediated resistance and promote the use of this valuable gene in breeding. | Xifeng Chen Pengcheng Liu Le Mei Xiaoling He Long Chen Hui Liu Shurong Shen Zhandong Ji Xixi Zheng Yuchen Zhang Zhenyu Gao Dali Zeng Qian Qian Bojun Ma | 2021 | Plant Communications2021，2，3： | 9 |
| 4 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 5 | Reconstituted high-density lipoproteins: novel biomimetic nanocarriers for drug delivery显示文摘High-density lipoproteins(HDL) are naturally-occurring nanoparticles that are biocompatible,non-immunogenic and completely biodegradable. These endogenous particles can circulate for an extended period of time and transport lipids, proteins and micro RNA from donor cells to recipient cells.Based on their intrinsic targeting properties, HDL are regarded as promising drug delivery systems. In order to produce on a large scale and to avoid blood borne pollution, reconstituted high-density lipoproteins(rHDL) possessing the biological properties of HDL have been developed. This review summarizes the biological properties and biomedical applications of rHDL as drug delivery platforms. It focuses on the emerging approaches that have been developed for the generation of biomimetic nanoparticles rHDL to overcome the biological barriers to drug delivery, aiming to provide an alternative,promising avenue for efficient targeting transport of nanomedicine. | Xinyi Ma Qingxiang Song Xiaoling Gao | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 7 |
| 6 | Respective IL-17A production by γδ T and Th17 cells and its implication in host defense against chlamydial lung infection显示文摘The role of IL-17A is important in protection against lung infection with Chlamydiae,an obligate intracellular bacterial pathogen.In this study,we explored the producers of IL-17A in chlamydial lung infection and specifically tested the role of major IL-17A producers in protective immunity.We found thatγδT cells and Th17 cells are the major producers of IL-17A at the early and later stages of chlamydial infection,respectively.Depletion ofγδT cells in vivo at the early postinfection(p.i.)stage,when mostγδT cells produce IL-17A,failed to alter Th1 responses and bacterial clearance.In contrast,the blockade of IL-17A at the time when IL-17A was mainly produced by Th17(day 7 p.i.)markedly reduced the Th1 response and increased chlamydial growth.The data suggest that theγδT cell is the highest producer of IL-17A in the very early stages of infection,but the protection conferred by IL-17A is mainly mediated by Th17 cells.In addition,we found that depletion ofγδT cells reduced IL-1αproduction by dendritic cells,which was associated with a reduced Th17 response.This finding is helpful to understand the variable role of IL-17A in different infections and to develop preventive and therapeutic approaches against infectious diseases by targeting IL-17A. | Hong Bai Xiaoling Gao Lei Zhao Ying Peng Jie Yang Sai Qiao Huili Zhao Shuhe Wang YiJun Fan Antony George Joyee Zhi Yao Xi Yang | 2017 | Cellular & Molecular Immunology2017，14，10： | 7 |
| 7 | Spatial analysis of intra-site use at a Late Paleolithic site at Shuidonggou, Northwest China显示文摘Intra-site spatial analysis provides an alternative perspective for understanding the functions of a site, and the occupational organization of early human living and activities associated with it. We examined features and cultural remains recovered from Locality 2 at Shuidonggou, a Late Paleolithic site, focusing on early occupants' survival behaviors and settlement patterns, as indicated by evidence regarding the functional organization of the site. Three-dimensional data from unearthed remains (including lithic assemblages, faunal remains, ornaments, etc) were used to reconstruct intra-site use patterns of Cultural Layer 2, which yielded seven earth-pit hearths and tens of thousands of artifacts and bones. We discuss the population size and group composition, as well as the functions of the living spaces, based on the analysis of the hearth patterns and the ostrich eggshell ornaments surround the hearths. In conclusion, Cultural Layer 2 of SDG Locality 2 appears to have functioned as a base camp for ancient foragers, where occupants produced tools, as well as preparing and consuming food. | GUAN Ying GAO Xing WANG HuiMin CHEN FuYon PEI ShuWen ZHANG XiaoLing ZHOU ZhenYu | 2011 | Chinese Science Bulletin2011，56，32： | 6 |
| 8 | Effects of Yishendaluo decoction on axonal degeneration,inflammatory reaction,and neurological function in a mouse model of experimental autoimmune encephalomyelitis显示文摘<正>BACKGROUND:Yishendaluo decoction reduces production of inflammatory mediators,relieves damage due to inflammatory reactions,and improves neural functions during experimental autoimmune encephalomyelitis. OBJECTIVE:To investigate the effects of Yishendaluo decoction on a mouse model of experimental autoimmune encephalomyelitis. DESIGN,TIME AND SETTING:The randomized,controlled,neuropathological,and molecular biological animal study was performed at the Key Laboratory of Chinese Internal Medicine,Ministry of Education,Dongzhimen Hospital of Beijing University of Chinese Medicine and Center for Neuroinformatics,General Hospital of Chinese PLA from 2005 to 2006. MATERIALS:Yishendaluo decoction pieces consisting of prepared rehmannia root,colla cornus cervi,cape jasmine fruit,and grassleaf sweetflag rhizome were purchased from the Dongzhimen Hospital of Beijing University of Chinese Medicine.Rabbit anti-mouseβ-amyloid precursor protein and p38 polyclonal antibody(Zhongshan Goldenbridge Biotechnology,China),as well interferon-γand interleukin-4 ELISA kit(Boster,China),were used in this study. METHODS:A total of 96 healthy,female,SJL/J mice,aged 8-12 weeks,were equally and randomly assigned to normal,model,hormone,and Chinese medicine groups.A total of 0.2 mL antigen preparation,supplemented with 150μg PLP139-151 and 400μg H37RA,was subcutaneously injected into the upper abdomen of mice from the model,hormone,and Chinese medicine groups. Mouse models of experimental autoimmune encephalomyelitis were established by intravenous injection of 0.1 mL Bordetella pertussis solution containing 0.6×10~6 Bordetella pertussis at days 1 and 3.Mice from the model,Chinese medicine,and hormone groups were respectively subjected to 0.2 mL saline,2 g/kg Yishendaluo decoction,and 0.078 mg/kg prednisone acetate,once daily for 14 consecutive days.Mice from the normal group were left intact. MAIN OUTCOME MEASURES:Pathological changes were observed using hematoxylin-eosin staining and Luxol fast blue staining.Expression ofβ-amyloid precursor protein and p38 protein was determined by immunohistochemistry.Levels of interferon-γand interleukin-4 were detected by ELISA.Behavioral changes were assessed in mice according to scores of neurological function. RESULTS:A few inflammatory cell infiltration,nerve fiber breakage and slight demyelination were detected in the central nervous system of mice from the Chinese medicine and hormone groups compared with the model group.Expression ofβ-amyloid precursor protein and p38 protein was significantly diminished in the central nervous system of mice from the Chinese medicine and hormone groups compared with the model group(P<0.05 or P<0.01),and the decrease was greatest in the Chinese medicine group.The decrease in mouse weight was not significant,and neurological function scores were less in the Chinese medicine and hormone groups compared with the model group(P<0.05 or P<0.01).Interferon-γlevels were significantly reduced(P<0.01),and interleukin-4 levels were significantly increased(P<0.01) in the brains of the Chinese medicine and hormone groups,compared with the model group. CONCLUSION:Yishendaluo decoction improved neurological function in mice with experimental autoimmune encephalomyelitis by downregulatingβ-amyloid precursor protein expression,resisting axonal degeneration,and relieving inflammatory reaction.The anti-inflammatory mechanism was regulated by inhibition of the p38 mitogen-activated protein kinase signal pathway. | Xiaoling Shang Ying Gao Ling Yin Jintao Zhang Shuoren Wang | 2009 | Neural Regeneration Research2009，4，11： | 6 |
| 9 | Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells显示文摘Glioblastoma multiforme (GBM ) 是有有限治疗学的工具和差的预后的一个高度侵略的大脑肿瘤。最近的研究显示开始 glioma cells/glioma 干细胞(GICs/GSCs ) 可能为肿瘤开始,渗入,和复发负责。GIC 能异常地采用平衡胚胎的神经先锋的自强和区别的分子的机械。这里,我们发现那配对的相关 homeobox 1 (PRRX1 ) ,以前是的一个 homeodomain 抄写因素报导了控制骨胳的开发,在外皮的神经祖先被表示并且为他们的自强和合适的区别被要求。进一步, PRRX1 是在 glioma 样品和标签 GIC 的 overrepresented。Glioma 房间和 GIC 与 PRRX1 弄空不能在 vitro 宣传或在异种皮移植老鼠模型形成肿瘤。PRRX1 调整的 GIC 自强功能被多巴胺 D2 受体(DRD2 ) 调停。PRRX1 直接在 GIC 把它的表示绑在 DRD2 倡导者和 transactivates。发信号的 DRD2 的阻塞妨碍 GIC 自强,而它的 overexpression 恢复宣传和弄空 PRRX1 的 GIC 的 tumorigenic 潜力。最后, PRRX1 加强经由调停 DRD2 的细胞外的信号相关的 kinase (英皇家空军之阶级最低之兵) 和 AKT 的 GIC 激活。因此,我们的学习建议那治疗学的指向在 GIC 的 PRRX1DRD2ERK/AKT 轴是为对待 GBM 的有希望的策略。 | Yamu Li Wen Wang Fangyu Wang Qiushuang Wu Wei Li Xiaoling Zhong Kuan Tian Tao Zeng Liang Gao Ying Liu Shu Li Xiaobing Jiang Guangwei Du Yan Zhou | 2017 | Journal of Molecular Cell Biology2017，9，4： | 5 |
| 10 | White-light emitting single-phase phosphor La_3Si_6N_(11):Dy^(3+),Tb^(3+):Color tunable emission, thermal stability and energy transfer process显示文摘A novel white-light emitting single-phase phosphor La_3 Si_6 N_(11):Dy^(3+),exhibiting two emission peaks centering at 475 and 575 nm, was prepared via conventional solid-state reactions. The structure and morphology of La_3 Si_6 N_(11):Dy^(3+)/Tb^(3+) were investigated by X-ray diffraction(XRD) and scanning electron microscopy(SEM). The emission colors can be tuned from white to yellow-green through increasing the Tb^(3+) concentration in La_3 Si_6 N_(11):Dy^(3+),Tb^(3+), The mechanism of energy transfer(ET) from Dy^(3+) to Tb^(3+) is confirmed according to the excitation,emission spectra and decay lifetimes curve. The temperaturedependent luminescence measurements of La_(2.83)Si_6 N_(11):0.1 Dy^(3+),0.07 Tb^(3+) were also performed, and a good thermal stability is shown, suggesting superior properties for the application as white lightemitting diodes(w-LEDs) phosphor. | Yuanhong Liu Yuan Xue Ronghui Liu Mingyue Chen Guantong Chen Chunpei Yan Xia Zhang Yu'nan Zhou Wei Gao Xiaole Ma | 2019 | Journal of Rare Earths2019，37，4： | 5 |
| 11 | Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice显示文摘The novel coronavirus SARS-CoV-2 has infected more than 104 million individuals and resulted in more than 2.2 million deaths worldwide as of February 7,2021(http://gffzze7c39cdc9e894ca6snoxvxcuvvbcc6nkf.ffgz.tsg.suse.edu.cn).The COVID-19 pandemic highlights the need for safe and effective vaccines against SARS-CoV-2 infection. | Shihui Sun Lei He Zhongpeng Zhao Hongjing Gu Xin Fang Tiecheng Wang Xiaolan Yang Shaolong Chen Yongqiang Deng Jiangfan Li Jian Zhao Liang Li Xinwang Li Peng He Ge Li Hao Li Yuee Zhao Chunrun Gao Xiaoling Lang Xin Wang Guoqiang Fei Yan Li Shusheng Geng Yuwei Gao Wenjin Wei Zhongyu Hu Gencheng Han Yansong Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 12 | Primary Establishment of the Tissue Culture Technique and Regeneration System for Ornamental Lupinns polyphyllus显示文摘The purpose of this paper is to develop a system for tissue culture and rapid propagation of two ornamental lupins,Minaretie and Russell Prize. In view of screening out the better explant regeneration and suitable culture medium,through adding hormone 6-BA,NAA and 2,4-D into MS and B5 basic culture medium,a series of experiments were carried out with the shoot tips,leaves,leaf petioles and stems from the asepsis seedling. The results showed that the shoot tips had favorableness on the rapidly propagation;MS+6-BA 0.5 mg · L-1 for f irst generation,the induction rate of Minaretie and Russell Prize was 90.5% and 95.86% respectivdy;Minaretie had the highest propagation index(6.35) on MS+6-BA 0.5 mg · L-1+NAA 0 mg · L-1+GA 30.8 mg · L-1+AC 2 g · L-1,but Russell Prize had the highest propagation index(7.24) on MS+6-BA 0.5 mg · L-1+NAA 0.15 mg · L-1+GA3 1.0 mg · L-1+AC 0.5 g · L-1;1/2 MS+NAA 0.25 mg · L-1 was the best rooting medium. The ratios of getting roots of Minaretie and Russell Prize were 94.78% and 96.32%,respectively. | WANG Xiaoling GAO Zhu LIU Tengyun YU Faxin WANG Biqin | 2009 | Journal of Northeast Agricultural University(English Edition)2009，16，3： | 5 |
| 13 | Liensinine induces gallbladder cancer apoptosis and G2/M arrest by inhibiting ZFX-induced PI3K/AKT pathway显示文摘Gallbladder carcinoma (GBC) is the most comm on and aggressive can cer of the biliary tract. Liensinine has been proved to have hypotensive effect. However, the effect of liensinine on GBC is still unknown. The aim of this study is to investigate the effect and mechanism of liensinine in human GBC cells. Cell viability assay and colony formation assay were performed to assess cell growth and proliferation. Flow cytometry analysis was used to investigate cell cycle apoptosis in vitro. Hoechst 33342 staining was also used to evaluate cell apoptosis. Western blot analysis was used to determine the expression of proteins corresponding to the related cell cycle and apoptosis.The effect of liensinine treatment in vivo was experimented with xenografted tumors. We found that liensinine significantly inhibited the growth of GBC cells both in vivo and in vitro. In vitro, cell growth and proliferation were significantly suppressed by liensinine in a dose- and time-dependent manner. In vivo, liensinine inhibited tumor growth. Liensinine could induce GBC cells G2/M phase arrest by up-regulating the levels of Cyclin B1 and CDK1 proteins. Liensinine also affected GBC cell cycle progress!on and induced apoptosis by down-regulating phosphorylated protein kinase B (AKT), phosphorylated protein kinase B (p-AKT), phosphatidylinositol 3-kinase (PI3K), and Zinc finger X-chromosomal protein (ZFX) proteins. Liensinine induced G2/M arrest and apoptosis in gallbladder cancer, suggest!ng that liensinine might represent a novel and effective agent against gallbladder cancer. | Yitong Shen Rui Bian Yaxiong Li Yuan Gao Yingbin Liu Yuzhen Xu Xiaoling Song Yijian Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 4 |
| 14 | Carbon uptake and change in net primary productivity of oasis-desert ecosystem in arid western China with remote sensing technique显示文摘Arid and semi-arid ecosystems exhibit a spatially complex biogeophysical structure. According to arid western special climate-vegetation characters, the fractional cover of photosynthetic vegetation (PV), non-photosynthetic vegetation (NPV), bare soil and water are unmixed, using the remote sensing spectral mixture analysis. We try the method to unmix the canopy funation structure of arid land cover in order to avoid the differentiation of regional vegetation system and the disturbance of environmental background. We developed a modified production efficiency model NPP-PEM appropriate for the arid area at regional scale based on the concept of radiation use efficiency. This model refer to the GLO-PEM and CASA model was driven with remotely sensed observations, and calculates not just the conversion efficiency of absorbed photosynthetically active radiation but also the carbon fluxes that determine net primary productivity (NPP). We apply and validate the model in the Kaxger and Yarkant river basins in arid western China. The NPP of the study area in 1992 and 1998 was estimated based on the NPP-PEM model. The results show that the improved PEM model, considering the photosynthetical activation of heterogeneous functional vegetation, is in good agreement with field measurements and the existing literature. An accurate agreement (R2 = 0.85, P<0.001) between the estimates and the ground-based measurement was obtained. The spatial distribution of mountain-oasis-desert ecosystem shows an obvious heterogeneous carbon uptake. The results are applicable to arid ecosystem studies ranging from characterizing carbon cycle, carbon flux over arid areas to monitoring change in mountain-oasis-desert productivity, stress and management. | ZHANG Jie PAN Xiaoling GAO Zhiqiang SHI Qingdong LV Guanghui | 2006 | Journal of Geographical Sciences2006，16，3： | 4 |
| 15 | The Heuristic Algorithms for Selecting the Parameters of Support Vector Machine for Classification显示文摘 | LANG Rongling DENG Xiaole GAO Fei | 2012 | Chinese Journal of Electronics2012，21，3： | 4 |
| 16 | Thermochemical properties and thermokinetic behavior of energetic triazole ionic salts显示文摘The properties of dissolution in different solvents,the specific heat capacity and thermal decomposition process under the non-isothermal conditions for energetic triazole ionic salts 1,2,4-triazolium nitrate(1a),1,2,3-triazolium nitrate(1b),3,4,5triamino-1,2,4-triazolium nitrate(2a),3,4,5-triamino-1,2,4-triazolium dinitramide(2b)were precisely measured using a Calvet Microcalorimeter.The thermochemical equation,differential enthalpies of dissolution(△difH m ),standard molar enthalpies of dissolution(△difH m ),apparent activation energy(E),pre-exponential constant(A),kinetic equation,linear relationship of specific heat capacity with temperature over the temperature range from 283 to 353 K,standard molar heat capacity(C p,m)and enthalpy,entropy and Gibbs free energy at 283–353 K,taking 298.15 K as the benchmark for 1a,1b,2a and 2b were obtained with treating experimental data and theoretical calculation method.The kinetic and thermodynamic parameters of thermal decomposition reaction,critical temperature of thermal explosion(Tb),self-accelerating decomposition temperature(TSADT)and adiabatic time-to-explosion(t)of 1a,1b,2a and 2b were calculated.Their heat-resistance abilities were evaluated.Information was obtained on the relation between molecular structures and properties of 1a,1b,2a and 2b. | ZHAO FengQi XUE Liang XING XiaoLing HU RongZu ZHOU ZhiMing GAO HongXu YI JianHua XU SiYu PEI Qing | 2011 | Science China Chemistry2011，54，3： | 4 |
| 17 | Diversity of metabolite accumulation patterns in inner and outer seed coats of pomegranate:exploring their relationship with genetic mechanisms of seed coat development显示文摘The expanded outer seed coat and the rigid inner seed coat of pomegranate seeds,both affect the sensory qualities of the fruit and its acceptability to consumers.Pomegranate seeds are also an appealing model for the study of seed coat differentiation and development.We conducted nontarget metabolic profiling to detect metabolites that contribute to the morphological differentiation of the seed coats along with transcriptomic profiling to unravel the genetic mechanisms underlying this process.Comparisons of metabolites in the lignin biosynthetic pathway accumulating in seed coat layers at different developmental stages revealed that monolignols,including coniferyl alcohol and sinapyl alcohol,greatly accumulated in inner seed coats and monolignol glucosides greatly accumulated in outer seed coats.Strong expression of genes involved in monolignol biosynthesis and transport might explain the spatial patterns of biosynthesis and accumulation of these metabolites.Hemicellulose constituents and flavonoids in particular accumulated in the inner seed coat,and candidate genes that might be involved in their accumulation were also identified.Genes encoding transcription factors regulating monolignol,cellulose,and hemicellulose metabolism were chosen by coexpression analysis.These results provide insights into metabolic factors influencing seed coat differentiation and a reference for studying seed coat developmental biology and pomegranate genetic improvement. | Gaihua Qin Chunyan Liu Jiyu Li Yongjie Qi Zhenghui Gao Xiaoling Zhang Xingkai Yi Haifa Pan Ray Ming Yiliu Xu | 2020 | Horticulture Research2020，7，1： | 4 |
| 18 | Over 16.7% efficiency of ternary organic photovoltaics by employing extra PC71BM as morphology regulator显示文摘Ternary organic photovoltaics(OPVs)are fabricated with PBDB-T-2 Cl:Y6(1:1.2,wt/wt)as the host system and extra PC71BM as the third component.The PBDB-T-2 Cl:Y6 based binary OPVs exhibit a power conversion efficiency(PCE)of 15.49%with a short circuit current(JSC)of 24.98 mA cm^-2,an open circuit voltage(VOC)of 0.868 V and a fill factor(FF)of 71.42%.A 16.71%PCE is obtained in the optimized ternary OPVs with PBDB-T-2 Cl:Y6:PC71BM(1:1.2:0.2,wt/wt)active layer,resulting from the synchronously improved JSC of 25.44 mA cm^-2,FF of 75.66%and the constant VOCof 0.868 V.The incorporated PC71BM may prefer to mix with Y6 to finely adjust phase separation,domain size and molecular arrangement in ternary active layers,which can be confirmed from the characterization on morphology,2 D grazing incidence small and wide-angle X-ray scattering,as well as Raman mapping.In addition,PC71BM may prefer to mix with Y6 to form efficient electron transport channels,which should be conducive to charge transport and collection in the optimized ternary OPVs.This work provides more insight into the underlying reasons of the third component on performance improvement of ternary OPVs,indicating ternary strategy should be an efficient method to optimize active layers for synchronously improving photon harvesting,exciton dissociation and charge transport,while keeping the simple cell fabrication technology. | Jinhua Gao Jian Wang Qiaoshi An Xiaoling Ma Zhenghao Hu Chunyu Xu Xiaoli Zhang Fujun Zhang | 2020 | Science China Chemistry2020，63，1： | 4 |
| 19 | Distributed Packet-Aware Routing Scheme Based on Dynamic Network Coding显示文摘In this paper, we study transmission of packets with time constraints in cooperative 5G wireless networks. As we know, the packets which are transmitted with large delay become useless and have to be dropped. In order to minimize packet dropping probability, we consider multiple transmission methods and integrate packet scheduling with adaptive network coding method selection. Firstly we introduce queue length to obtain the gain of network. Based on this, we present the dynamic coding-aware routing metric, which can increase potential coding opportunities. Moreover, we propose a distributed packet-aware transmission routing scheme based on the above routing metric, which can discover the available paths timely and efficiently. Simulation results show that the proposed method can reduce average packet dropping probability with lower computational complexity. | Yao Yu Yuhuai Peng Xiaoling Li Jinfeng Gao Xiaozhu Cong | 2016 | China Communications2016，13，10： | 4 |
| 20 | Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model显示文摘Photobiomodulation,by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues,has been considered as a possible therapeutic strategy for Alzheimer’s disease(AD),while its specific mechanisms have remained elusive.Here,we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebralβ-amyloid(Aβ)burden,the hallmark of AD.The glial cells,including microglia and astrocytes,play important roles in Aβclearance.Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice.The 1070-nm lightinduced microglia responses with alteration in morphology and increased colocalization with Aβare sufficient to reduce Aβload in AD mice.Moreover,1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβclearance.Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD. | Lechan Tao Qi Liu Fuli Zhang Yuting Fu Xi Zhu Xiaofu Weng Hongbin Han Yong Huang Yuanzhen Suo Liang Chen Xiaoling Gao Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 4 |
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