|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Preliminary report on methane emissions from the Three Gorges Reservoir in the summer drainage period显示文摘Recently reported summertime methane (CH4) emissions (6.7 ± 13.3 mg CH4/(m2·hr)) from newly created marshes in the drawdown area of the Three Gorges Reservoir (TGR), China have triggered broad concern in academic circles and among the public. The CH4 emissions from TGR water surfaces and drawdown areas were monitored from 3rd June to 16th October 2010 with floating and static chambers and gas chromatography. The average CH4 emission flux from permanently flooded areas in Zigui, Wushan and Yunyang Counties was (0.33 ± 0.09) mg CH4/(m2·hr). In half of these hottest months of the year, the wilderness, cropland and deforested drawdown sites were aerobic and located above water level, and the CH4 emissions were very small, ranging from a sink at 0.12 mg CH4/(m2·hr) to a source at 0.08 mg CH4/(m2·hr) except for one mud-covered site after flood. Mean CH4 emission in flooded drawdown sites was 0.34 mg CH4/(m2·hr). The emissions from the rice paddy sites in the drawdown area were averaged at (4.86 ± 2.31) mg CH4/(m2·hr). Excepting the rice-paddy sites, these results show much lower emission levels than previously reported. Our results indicated considerable spatial and temporal variation in CH4 emissions from the TGR. Human activities and occasional events, such as flood, may also affect emission levels. Long-term CH4 measurements and modeling in a large region are necessary to accurately estimate greenhouse gas emissions from the TGR. | Fei Lu Le Yang Xiaoke Wang Xiaonan Duan Yujing Mu Wenzhi Song Feixiang Zheng Junfeng Niu Lei Tong Hua Zheng Yongjuan Zhou Jiangxiao Qiu Zhiyun Ouyang | 2011 | Journal of Environmental Sciences2011，23，12： | 13 |
| 2 | Thickness-dependent patterning of MoS2 sheets with well-oriented triangular pits by heating in air显示文摘自从 MoS2 表的性质对边结构敏感,有常规边或可控制的形状的 Patterning ultrathin MoS2 层正在呼吁。在这个工作,我们介绍了一种简单、有效、控制得好的技术由简单地在空中加热样品与面向井的等边的三角形的坑蚀刻分层的 MoS2 表。各向异性的氧化蚀刻被包围温度和 MoS2 层的数字极大地影响,坑由此随包围温度和 MoS2 层的数字的增加缩放增加。第一原则的计算被执行了解释三角形的坑的形成机制。这种技术把一条其他的大街提供给设计 MoS2 表的结构。 | Haiqing Zhou Fang Yu Yuanyue Liu Xiaolong Zou Chunxiao Cong Caiyu Qiu Ting Yu Zheng Yan Xiaonan Shen Lianfeng Sun Boris I. Yakobson James M. Tour | 2013 | Nano Research2013，6，10： | 9 |
| 3 | Silencing RhoA inhibits migration and invasion through Wnt/β-catenin pathway and growth through cell cycle regulation in human tongue cancer显示文摘地岬相当或相同的事物基因家庭成员 A (RhoA ) 作为肿瘤的一个批评管理者被识别了好攻击的行为。在 thisstudy,我们在位于有鳞的细胞 carcinomaof 舌头(TSCC ) 的生长,移植,和侵略下面的机制估计了 RhoA 的角色。TSCC 房间线 SCC-4 和 CAL27 击倒的稳定的 RhoA 用 Lentiviral transfection 被完成。房间移植,侵略,和房间增长上的 RhoA 弄空的 Theeffects 是坚定的。TSCC 房间线上的可能的位于决定 Galectin-3 (Gal-3 ) 的表示下面 mechanismof RhoA 弄空被也评估,在 vivo 的 -catenin, andmatrix metalloproteinase-9 (MMP-9 ) 。同时, TSCC 生长的内在的机制被 cyclin D1/2 的分析学习, p21 CIP1/WAF1 , 和 p27 Kip1 蛋白质层次。Immunohistochemical 评价被执行进一步证明 Gal-3 和 -catenin expression.We 的改变发现了那,在与在舌头的人的 TSCC 房间注射的老鼠, RhoA 层次与在正常纸巾的那些相比在主要肿瘤和 metastasizedlymph 节点是更高的。RhoA 的 Silencing 显著地减少了肿瘤生长, Gal-3 的 decreasedthe 层次, -catenin, MMP-9,和 cyclin D1/2,并且增加了 p21 CIP1/WAF1 和 p27 Kip1 。在 vitro, RhoA 击倒也导致了房间移植,侵略,和增长的抑制。我们的数据建议 RhoA 由通过分别地通过房间周期规定表明小径 andcell 增长的 Wnt/-catenin 调整房间移植和侵略在 TSCC 前进起 asignificant 作用。RhoA 可能是 TSCC 的一个新奇治疗学的目标。 | Guoxin Yan Ronghai Zou Zhenggang Chen Bing Fan Zhaoyan Wang Ying Wang Xiaonan Yin Dong Zhang Lei Tong Fang Yang Weina Jiang Wensheng Fu Jiwei Zheng Martin O. Bergo Martin Dalin Jiawei Zheng Shulan Chen Jianhua Zhou | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 7 |
| 4 | Performance of the Autism Spectrum Rating Scale and Social Responsiveness Scale in Identifying Autism Spectrum Disorder Among Cases of Intellectual Disability显示文摘The Autism Spectrum Rating Scale(ASRS) and the Social Responsiveness Scale(SRS) have been widely used for screening autism spectrum disorder(ASD) in the general population during epidemiological studies, but studies of individuals with intellectual disability(ID) are quite limited. Therefore, we recruited the parents/caregivers of 204 ASD cases, 71 ID cases aged 6–18 years from special education schools, and 402 typically developing(TD) children in the same age span from a communitybased population to complete the ASRS and SRS. The results showed that the ID group scored significantly lower on total and subscale scores than the ASD group on both scales(P \ 0.05) but higher than TD children(P \ 0.05).Receiver operating characteristic analyses demonstrated a similar fair performance in discriminating ASD from ID with the ASRS(area under the curve(AUC) = 0.709,sensitivity = 77.0%, specificity = 52.1%, positive predictive value(PPV) = 82.2%) and the SRS(AUC = 0.742,sensitivity = 59.8%, specificity = 77.5%, PPV = 88.4%).The results showed that individuals with ID had clear autistic traits and discriminating ASD from ID cases was quite challenging, while assessment tools such as ASRS and SRS, help to some degree. | Chunpei Li Hao Zhou Tianqi Wang Shasha Long Xiaonan Du Xiu Xu Weili Yan Yi Wang | 2018 | Neuroscience Bulletin2018，34，6： | 5 |
| 5 | An Investigation of the Potential Malignant Characteristics of Endometriosis显示文摘 | Chengxin Wang Hongyan Zhou Xiaonan You Xiji Shu Yan Li Xiaoling Zhao | 2005 | Chinese Journal of Clinical Oncology2005，2，6： | 4 |
| 6 | 在碳隐遁,土壤保留和水之间的交易在中国的 Guanzhong-Tianshui 经济区域让步显示文摘自然生态系统向人的社会提供很重要的产品和服务。随人口和自然资源的在利用上的快速的增加,人不断地在损坏其它的情况下正在提高一些服务的生产。这份报纸在中国的 Guanzhong-Tianshui 经济区域在生态系统服务,和在这些服务之间的关系估计变化。这些生态系统变化具有到这个经济区域的持续发展的大意义。生产可能性边疆(PPF ) 的概念被使用评估在碳隐遁,水收益和土壤保留之间的交易和协同作用。三陆地使用策略计划情形,使用评估潜力的利用和保护在生态系统服务变化。这研究表明在碳隐遁,土壤保留和水之间的显著交易让步,与在碳隐遁和土壤保留之间的协同作用。在在三种情形的碳隐遁,水收益和土壤保留之间有协同作用。保护情形是为调整生态系统服务能力的最赞成的陆地使用策略。这种情形导致最高的碳隐遁,水收益和土壤保留。结果能有含意因为计划的自然资本和生态系统服务,管理和土地使用决策。 | YANG Xiaonan ZHOU Zixiang LI Jing FU Xin MU Xingmin LI Ting | 2016 | Journal of Geographical Sciences2016，26，10： | 3 |
| 7 | The origin and evolution of the diosgenin biosynthetic pathway in yam显示文摘Diosgenin,mainly produced by Dioscorea species,is a traditional precursor of most hormonal drugs in the pharmaceutical industry.The mechanisms that underlie the origin and evolution of diosgenin biosynthesis in plants remain unclear.After sequencing the whole genome of Dioscorea zingiberensis,we revealed the evolutionary trajectory of the diosgenin biosynthetic pathway in Dioscorea and demonstrated the de novo biosynthesis of diosgenin in a yeast cell factory.First,we found that P450 gene duplication and neofunctionalization,driven by positive selection,played important roles in the origin of the diosgenin biosynthetic pathway.Subsequently,we found that the enrichment of diosgenin in the yam lineage was regulated by CpG islands,which evolved to regulate gene expression in the diosgenin pathway and balance the carbon flux between the biosynthesis of diosgenin and starch.Finally,by integrating genes fromplants,animals,and yeast,weheterologously synthesized diosgenin to 10mg/l in genetically-engineered yeast.Our study not only reveals the origin and evolutionary mechanisms of the diosgenin biosynthetic pathway in Dioscorea,but also introduces an alternative approach for the production of diosgenin through synthetic biology. | Jian Cheng Jing Chen Xiaonan Liu Xiangchen Li Weixiong Zhang Zhubo Dai Lina Lu Xiang Zhou Jing Cai Xueli Zhang Huifeng Jiang Yanhe Ma | 2021 | Plant Communications2021，2，1： | 2 |
| 8 | A time domain induced polarization relaxation time spectrum inversion method based on a damping factor and residual correction显示文摘Relaxation time spectra(RTS) derived from time domain induced polarization data(TDIP) are helpful to assess oil reservoir pore structures. However, due to the sensitivity to the signal-to-noise ratio(SNR), the inversion accuracy of the traditional singular value decomposition(SVD) inversion method reduces with a decrease of SNR. In order to enhance the inversion accuracy and improve robustness of the inversion method to the SNR, an improved inversion method, based on damping factor and spectrum component residual correction, is proposed in this study. The numerical inversion results show that the oscillation of the RTS derived from the SVD method increased with a decrease of SNR, which makes it impossible to get accurate inversion components. However, the SNR has little influence on inversion components of the improved method, and the RTS has high inversion accuracy and robustness. Moreover, RTS derived from core sample data is basically in accord with the pore-size distribution curve, and the RTS derived from the actual induced polarization logging data is smooth and continuous, which indicates that the improved method is practicable. | Liu Xiaonan Kong Li Zhou Kaibo Zhang Pu | 2014 | Petroleum Science2014，11，4： | 2 |
| 9 | Geometry dependent photoconductivity of In2S3 kinks synthesized by kinetically controlled thermal deposition显示文摘在 2 S 3 性变态经由一个运动地控制的热免职过程被综合,他们的 optoelectronic 特征系统地被探索。生长机制被归因于联合运动动态,水晶美容精力,和表面粗糙。二个陷井劝诱了排放乐队经由低温度阴极射线发光(CL ) 被证实学习。而且, nanowire 连接证明作为与直手臂相比,退化 photodetection 表演归因于从 kinked 区域测量的一个导致压力的额外的系列电阻。无机的 nanostructures 和他们的 optoelectronic 性质的详细探索的井可控制的形状为他们的进一步实际的应用是特别地珍贵的。 | Xing Xiong QiZhang Lin Gan Xing Zhou Xiaonan Xing Huiqiao Li Tianyou Zhai | 2016 | Nano Research2016，9，12： | 2 |
| 10 | Modulation of host signaling in the inflammatory response by enteropathogenic Escherichia coli virulence proteins显示文摘为了成功地感染,招待房间并且躲避主机免疫者反应,一个类型 III 分泌物系统(T3SS ) 被伤寒通常使用细菌的病原体象 enteropathogenic Escherichia coli (EPEC ) 那样。最近的调查结果表明了各种各样的受动器通过 T3SS 被注入主人房间并且在煽动性的发信号的小径上施加禁止的效果,破坏对这些病原体的有免疫力的回答。这里,我们考察针对探讨 EPEC 受动器蛋白质调制的几条重要煽动性的发信号小径的调整的最近的研究,例如原子 factor-B ( NF-B )和 激活mitogen 的蛋白质 kinase ( MAPK )小径,它在这块未经勘探的地和帮助里提供卓见进未完成的工作为 EPEC 受动器在煽动性的发信号的网络识别新奇位置。 | Xiaonan Zhuang Zijuan Chen Chenxi He Lin Wang Ruixue Zhou Dapeng Yan Baoxue Ge | 2017 | Cellular & Molecular Immunology2017，14，3： | 1 |
| 11 | The level of bile salt-stimulated lipase in the milk of Chinese women and its association with maternal BMI显示文摘This study aimed to investigate the bile salt-stimulated lipase(BSSL) concentration in the milk of Chinese women and its correlation with maternal body mass index(BMI), gestational diabetes mellitus(GDM) and gestational hypertensive disorder(GHD). The BSSL levels in the milk samples were measured by enzyme-linked immunosorbent assay(ELISA). BSSL level in colostrum milk of mothers with full-term infants was positively correlated with pregnancy week and negatively correlated with maternal pre-pregnancy BMI and BMI late in pregnancy. Moreover, the BSSL concentration in mature milk was positively correlated with BMI gain during pregnancy. The BSSL concentration in colostrum milk was lower in GDM mothers than in normal mothers. The BSSL helps infants digest fat in early life and its level was associated with lactation. The changes in BSSL characteristics with maternal BMI and GDM in this study may have clinical implications regarding the effects of pregnancy weight and metabolism on the nutrition and health of the offspring. | Lijun Sha Shanshan Zhou Yangyang Xi Rong Li Xiaonan Li | 2020 | The Journal of Biomedical Research2020，34，2： | 1 |
| 12 | The Equilibrium Decisions in a Two-Echelon Supply Chain under Price and Service Competition显示文摘 | Xiaonan Han Xiaochen Sun Yancong Zhou | 2014 | Sustainability2014，，6： | 1 |
| 13 | Monte Carlo model ing of non-isothermal degradation of two cyanidin-based anthocyanins in aqueous system at high temperatures and its impact on antioxidant capacities显示文摘 | Xiaonan Sui Weibiao Zhou | | 0，，154： | 1 |
| 14 | Hepatitis B virus polymerase impairs interferon‐α–induced STA T activation through inhibition of importin‐α5 and protein kinase C‐δ显示文摘 | Jieliang Chen Min Wu Xiaonan Zhang Wen Zhang Zhanqing Zhang Lixiang Chen Jing He Ye Zheng Cuncun Chen Fan Wang Yunwen Hu Xiaohui Zhou Cong Wang Yang Xu Mengji Lu Zhenghong Yuan | 2013 | Hepatology2013，，2： | 1 |
| 15 | Extraction and antioxidant activities of intracellular polysaccharide from Pleurotus sp. mycelium显示文摘 | Xiaonan Liu Bo Zhou Rongshan Lin Le Jia Peng Deng Keming Fan Guoyi Wang Li Wang Jianjun Zhang | 2010 | International Journal of Biological Macromolecules2010，，2： | 1 |
| 16 | Anti-hypercalcemic effect of orally administered recombinant Saccharomyces cerevisiae expressing salmon calcitonin on hypercalcemic rats显示文摘 | Pingnan Sun Xuecheng Zhang Xiaonan Zang Xiaoling Zhou Yunsong Chen K. K. I. U. Arunakumara Bin Liang | 2007 | Biotechnology Letters2007，，7： | 1 |
| 17 | PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α-GLUT2 pathway显示文摘Drug-induced hyperglycemia/diabetes is a global issue. Some drugs induce hyperglycemia by activating the pregnane X receptor(PXR), but the mechanism is unclear. Here, we report that PXR activation induces hyperglycemia by impairing hepatic glucose metabolism due to inhibition of the hepatocyte nuclear factor 4-alpha(HNF4 a)-glucose transporter 2(GLUT2) pathway. The PXR agonists atorvastatin and rifampicin significantly downregulated GLUT2 and HNF4 a expression, and impaired glucose uptake and utilization in HepG2 cells. Overexpression of PXR downregulated GLUT2 and HNF4 a expression, while silencing PXR upregulated HNF4 a and GLUT2 expression.Silencing HNF4 a decreased GLUT2 expression, while overexpressing HNF4 a increased GLUT2 expression and glucose uptake. Silencing PXR or overexpressing HNF4 a reversed the atorvastatininduced decrease in GLUT2 expression and glucose uptake. In human primary hepatocytes, atorvastatin downregulated GLUT2 and HNF4 a mRNA expression, which could be attenuated by silencing PXR. Silencing HNF4 a downregulated GLUT2 mRNA expression. These findings were reproduced with mouse primary hepatocytes. Hnf4 a plasmid increased Slc2 a2 promoter activity. Hnf4 a silencing or pregnenolone-16 a-carbonitrile(PCN) suppressed the Slc2 a2 promoter activity by decreasing HNF4 a recruitment to the Slc2 a2 promoter. Liver-specific Hnf4 a deletion and PCN impaired glucose tolerance and hepatic glucose uptake, and decreased the expression of hepatic HNF4 a and GLUT2. In conclusion, PXR activation impaired hepatic glucose metabolism partly by inhibiting the HNF4 aGLUT2 pathway. These results highlight the molecular mechanisms by which PXR activators induce hyperglycemia/diabetes. | Peihua Liu Ling Jiang Weimin Kong Qiushi Xie Ping Li Xiaonan Liu Jiayi Zhang Ming Liu Zhongjian Wang Liang Zhu Hanyu Yang Ying Zhou Jianjun Zou Xiaodong Liu Li Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 18 | Construction of concrete-faced rockfill dams with weak rocks 显示文摘 | XING Haofeng GONG Xiaonan ZHOU Xiaoguang | 2006 | Journal of Geotechnical and Geoenvironmental Engineering2006，132，6： | 1 |
| 19 | Prediction of chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma by SELDI-based serum decision tree classification显示文摘 | Jiefeng Cui Xiaonan Kang Zhi Dai Cheng Huang Haijun Zhou Kun Guo Yan Li Yu Zhang Ruixia Sun Jie Chen Yang Li Zhaoyou Tang Toshimasa Uemura Yinkun Liu | 2007 | Journal of Cancer Research and Clinical Oncology2007，，11： | 1 |
| 20 | Generation and expression analysis of BAC humanized mice carrying HLA-DP401 haplotype显示文摘Background:Human leukocyte antigen(HLA)-DP is much less studied than other HLA class Ⅱ antigens,that is,HLA-DR and HLA-DQ,etc.However,the accumulating data have suggested the important roles of DP-restricted responses in the context of cancer,allergy,and infectious disease.Lack of animal models expressing these genes as authentic cis-haplotypes blocks our understanding for the role of HLA-DP haplotypes in immunity.Methods:To explore the potential cis-acting control elements involved in the tran-scriptional regulation of the HLA-DPA1/DPB1 gene,we performed the expression analysis using bacterial artificial chromosome(BAC)-based transgenic humanized mice in the C57BL/6 background,which carried the entire HLA-DP401 gene locus.We further developed a mouse model of Staphylococcus aureus pneumonia in HLA-DP401 humanized transgenic mice,and performed the analysis on the expres-sion pattern of HLA-DP401 and immunological responses in the model.Results:In this study,we screened and identified a BAC clone spanning the entire HLA-DP gene locus.DNA from this clone was analyzed for integrity by pulsed-field gel electrophoresis and then microinjected into fertilized mouse oocytes to produce transgenic founder animals.Nine sets of PCR primers for regional markers with an average distance of 15 kb between each primer were used to confirm the integrity of the transgene in the five transgenic lines carrying the HLA-DPA1/DPB1 gene.Transgene copy numbers were determined by real-time PCR analysis.HLA-DP401 gene expression was analyzed at the mRNA and protein level.Although infection with S aureus Newman did not alter the percentage of immune cells in the spleen and thymus from the HLA-DP401-H2-Aβ1 humanized mice.Increased expression of HLA-DP401 was observed in the thymus of the humanized mice infected by S aureus.Conclusions:We generated several BAC transgenic mice,and analyzed the expres-sion of HLA-DPA1/DPB1 in those mice.A model of S aureus-induced pneumonia in the HLA-DP401-H2-Aβ1^(-/-)��humanized mice was further developed,and S aureus in-fection upregulated the HLA-DP401 expression in thymus of those humanized mice.These findings demonstrate the potential of those HLA-DPA1/DPB1 transgenic humanized mice for developing animal models of infectious diseases and MHC-associated immunological diseases. | Feng Li Meng-min Zhu Bo-wen Niu Ling-ling Liu Xiu-hua Peng Hua Yang Bo-yin Qin Meixiang Wang Xiaonan Ren Xiaohui Zhou | 2021 | Animal Models and Experimental Medicine2021，4，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员