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| 1 | Genome Warehouse: A Public Repository Housing Genome-scale Data显示文摘The Genome Warehouse(GWH)is a public repository housing genome assembly data for a wide range of species and delivering a series of web services for genome data submission,storage,release,and sharing.As one of the core resources in the National Genomics Data Center(NGDC),part of the China National Center for Bioinformation(CNCB;http://gffzz77e3413bc06540edswbx9vnqno0vq6cux.ffgz.tsg.suse.edu.cn),GWH accepts both full and partial(chloroplast,mitochondrion,and plasmid)genome sequences with different assembly levels,as well as an update of existing genome assemblies.For each assembly,GWH collects detailed genome-related metadata of biological project,biological sample,and genome assembly,in addition to genome sequence and annotation.To archive high-quality genome sequences and annotations,GWH is equipped with a uniform and standardized procedure for quality control.Besides basic browse and search functionalities,all released genome sequences and annotations can be visualized with JBrowse.By May 21,2021,GWH has received 19,124 direct submissions covering a diversity of 1108 species and has released 8772 of them.Collectively,GWH serves as an important resource for genomescale data management and provides free and publicly accessible data to support research activities throughout the world.GWH is publicly accessible at http://gffzz77e3413bc06540edswbx9vnqno0vq6cux.ffgz.tsg.suse.edu.cn/gwh. | Meili Chen Yingke Ma Song Wu Xinchang Zheng Hongen Kang Jian Sang Xingjian Xu Lili Hao Zhaohua Li Zheng Gong Jingfa Xiao Zhang Zhang Wenming Zhao Yiming Bao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 12 |
| 2 | A rapid reporter assay for recombinant human brain natriuretic peptide(rhBNP)by GloSensor technology显示文摘Accurate determination of biological activity is essential in quality control of recombinant human brain natriuretic peptide(rhBNP). In previous study, we successfully developed a genetically modified cell line 293GCAC3-based ELISA assay for rhBNP. But ELISA procedure is still tedious, so this study was aimed to develop a rapid and simple bioassay for rhBNP using GloSensor technology, which provides a platform of flexible luciferase-based biosensors for real-time detection of signaling events in live cells, including cGMP production. A reporter cell line 293GCAGlo-G1 was constructed by transfecting pGloSensor^(TM) 40 F plasmid into 293GCAC3. The reporter assay based on 293GCAGlo-G1 showed high precision with intraassay CV being 8.3% and inter-assay CV being 14.1%; high accuracy with 80%, 100% and 120% recovery rate being 99.2%, 102.4% and 99.0% respectively; and great linearity with R^2 of linear fitting equation being 0.99. Besides, no significant difference was found in test results of reporter assay and 293GCAC3-based ELISA assay(paired t test, p=0.630). All these results suggested that the reporter assay was a viable assay for biological determination of rhBNP. | Lei Yu Xinchang Shi Chunmei Han Chunming Rao Junzhi Wang | 2018 | Journal of Pharmaceutical Analysis2018，8，5： | 11 |
| 3 | Classifying rheumatoid arthritis by Traditional Chinese Medicine Zheng: a multi-center cross-sectional study显示文摘OBJECTIVE:To assess the relationship between disease symptoms and traditional Chinese medicine (TCM) syndrome (Zheng) in rheumatoid arthritis (RA) patients.METHODS:RA Patients were recruited in Guang'anmen Hospital,China Academy of Chinese Medical Sciences and in the Second Affiliated Hospital of Zhejiang Chinese Medical University,and diagnosed with a particular RA Zheng from their symptoms.Demographic characteristics,self-reported symptoms,and blood samples were collected from patients.All data were input into EpiData and analyzed using SPSS software.RESULTS:The study included 302 RA patients (age range:18-86 years).All patients were Chinese,and 85.1% were women.Cold and fatigue triggers were reported by 8.6% of patients,followed by triggers such as childbirth (4.3%),cold (3.0%),dampness (2.0%),menopause (1.3%),and psychentonia (0.7%).The most prevalent Zheng was dampness and heat blockage (Shire Yuzu in Chinese,SRYZ),diagnosed in 39.4% of patients (119),followed by phlegm and stagnation blockage (Tanyu Bizu,TYBZ) in 21.5%,liver and kidney deficiency (Ganshen Buzu,GSBZ) in 18.5%,dual deficiency of Qi and blood (Qixue Liangxu,QXLX) in 9.6%,cold and dampness blockage (Hanshi Bizu,HSBZ) in 6%,and wind and dampness blockage (Fengshi Bizu,FSBZ) in 5%.Increased length of time since RA diagnosis was associated with the GSBZ group.Patients diagnosed with the SRYZ Zheng had the highest disease activity score.Patients diagnosed with the QXLX Zheng had the lowest blood platelet counts;patients diagnosed with the QXLX and HSBZ Zhengs had lower C-reactive protein levels and lower health assessment questionnaire scores.Patients diagnosed with the GSBZ and QXLX Zhengs had the highest health assessment questionnaire scores.CONCLUSION:The specific Zheng was related to RA characteristics.The findings suggest that eliminating dampness,cooling the patient,and promoting blood circulation may assist in treating severe RA. | Wang Weijie Tang Xiaopo Wang Xinchang Jiang Quan Fan Yongsheng | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 7 |
| 4 | A pH-and temperature-sensitive macrocyclic graft copolymer composed of PEO ring and multi-poly(2-(dimethylamino) ethyl methacrylate) lateral chains显示文摘A novel method for the synthesis of macrocyclic graft copolymers was developed through combination of anionic ring-opening polymerization (AROP) and atom transfer radical polymerization (ATRP).A linear α,ω-dihydroxyl poly(ethylene oxide) with pendant acetal protected hydroxyl groups (l-poly(EO-co-EEGE)) was prepared first by the anionic copolymerization of ethylene oxide (EO) and ethoxyethyl glycidyl ether (EEGE).Then l-poly(EO-co-EEGE) was cyclized.The crude cyclized product containing the linear byproduct was hydrolyzed and purified by being treated with α-CD.The pure cyclic copolymer [c-poly(EO-co-Gly)] was esterified by reaction with 2-bromoisobutyryl bromide,and then used as ATRP macroinitiators to initiate polymerization of 2-(dimethylamino) ethyl methacrylate (DMAEMA),and a series of pH-and temperature-sensitive macrocyclic graft copolymers composed of a hydrophilic PEO as the ring and PDMAEMA as side chains (c-PEO-g-PDMAEMA) were obtained.The behavior of pH-and temperature-sensitive macrocyclic copolymers was studied in aqueous solution by fluorescence and dynamic light scattering (DLS).The critical micellization pH values of macrocyclic graft copolymers and their corresponding linear graft copolymers (l-PEO-g-PDMAEMA) were measured.Under the same conditions,the cyclic graft copolymer with the shorter side chains gave the higher critical micellization pH value.The c-PEO-g-PDMAEMA showed the lower critical micellization pH value than the corresponding l-PEO-g-PDMAEMA.The average hydrodynamic diameters (Dh) of the micelles were measured by DLS with the variation of the aqueous solution pH value and temperature. | PANG XinChang,JING RongKuan,PAN MuGang & HUANG JunLian Key Laboratory of Molecular Engineering of Polymers,Ministry of Education Department of Macromolecular Science,Fudan University,Shanghai 200433,China | 2010 | Science China Chemistry2010，53，8： | 6 |
| 5 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 6 | Spatial calculating analysis model research of land-use change in urban fringe districts显示文摘The spatial calculating analysis model is based on GIS overlay. It compartmental-izes the research district land into three spatial parts: unchanged part,converted part and increased part. By this method we can evaluate the numerical model and dynamic degree model for existing calculating changing speed of land-use. Fur-thermore the paper raises reviving the calculating analysis model of spatial infor-mation in order to predict the dynamic changing level of all sorts of land. More concretely speaking,the model is mainly to know the changing area and changing speed (increased or decreased) of different land classifications from the micro-cosmic angle and to clearly show the spatial distribution and spatio-temporal law for changing urban lands. We discover why the situation has taken place by com-bining social and economic conditions. The result indicates that the calculating analysis model of spatial information can derive more accurate procedure of spatial transference and increase of all kinds of land from the microcosmic angle. By this model and technology,we can make the research of spatio-temporal structure evolution in land-use be more systematical and deeper. The result will benefit the planning management of urban land-use of developed districts in China in the fu-ture. | ZHANG XinChang,PAN Qiong,WANG ZhongYang & CHEN XinXiang Department of Remote Sensing and GIS Engineering,Sun Yat-sen University,Guangzhou 510275,China | 2008 | Science China(Technological Sciences)2008，51，S1： | 5 |
| 7 | Friction and Wear Performance of Boron Doped, Undoped Microcrystalline and Fine Grained Composite Diamond Films显示文摘Chemical vapor deposition(CVD) diamond films have attracted more attentions due to their excellent mechanical properties. Whereas as-fabricated traditional diamond films in the previous studies don't have enough adhesion or surface smoothness, which seriously impact their friction and wear performance, and thus limit their applications under extremely harsh conditions. A boron doped, undoped microcrystalline and fine grained composite diamond(BD-UM-FGCD) film is fabricated by a three-step method adopting hot filament CVD(HFCVD) method in the present study, presenting outstanding comprehensive performance, including the good adhesion between the substrate and the underlying boron doped diamond(BDD) layer, the extremely high hardness of the middle undoped microcrystalline diamond(UMCD) layer, as well as the low surface roughness and favorable polished convenience of the surface fine grained diamond(FGD) layer. The friction and wear behavior of this composite film sliding against low-carbon steel and silicon nitride balls are studied on a ball-on-plate rotational friction tester. Besides, its wear rate is further evaluated under a severer condition using an inner-hole polishing apparatus, with low-carbon steel wire as the counterpart. The test results show that the BD-UM-FGCD film performs very small friction coefficient and great friction behavior owing to its high surface smoothness, and meanwhile it also has excellent wear resistance because of the relatively high hardness of the surface FGD film and the extremely high hardness of the middle UMCD film. Moreover, under the industrial conditions for producing low-carbon steel wires, this composite film can sufficiently prolong the working lifetime of the drawing dies and improve their application effects. This research develops a novel composite diamond films owning great comprehensive properties, which have great potentials as protecting coatings on working surfaces of the wear-resistant and anti-frictional components. | WANG Xinchang WANG Liang SHEN Bin SUN Fanghong | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 5 |
| 8 | Logical and Innovative Construction of Digital Twin City显示文摘This paper first introduces the background and basic concept of digital twin city,then analyzes the relationship between digital twin city and smart city.Next,it introduces the primary supporting technologies for the construction of a digital twin city,and finally summarizes the current application status and development trends regarding digital twin city.The authors argue that digital twin technology will face challenges in regards to data,basic knowledge base,system integration,and talent issues if it is to be more widely applied in the construction of the smart city.Additionally,the authors propose institutional and technical suggestions for solving these problems at the macro and micro levels. | Xinchang ZHANG Shaoying LI Qiming ZHOU Ying SUN | 2021 | Journal of Geodesy and Geoinformation Science2021，4，4： | 5 |
| 9 | Assessment of the fused image of multispectral and panchromatic images of SPOT5 in the investigation of geological hazards显示文摘The investigated area in this paper is located on the northern mountain in Guangzhou City.It is characterized by high relief and inaccessibility.Multispectral and pan Images of SPOT5 were used as the remote sensing data source,and high-pass filtering(HPF),Brovery transform(BT),intensity-hue-saturation(IHS),principal component analysis(PCA) and the modified IHS(MIHS) methods were adopted for image fusion.Here,a comparison has been made between the entire fused images and the original multispectral images.Subjective evaluation and objective evaluation(entropy,average gradient,correlation coefficient,distribution of gray) have been adopted to assess the quality of the fused images.Also regional geological survey has been taken to find the interpretation veracity.Results show that the MIHS is the best image fusion method for geological hazards interpretation,and the fused image can provide abundant textural and spectral information for easy interpretation of such geological hazards as collapse,landslip,and debris flow. | KANG TingJun,ZHANG XinChang & WANG HaiYing Department of Remote Sensing and GIS Engineering,Sun Yat-sen University,Guangzhou 510275,China | 2008 | Science China(Technological Sciences)2008，51，S2： | 5 |
| 10 | Epidemiological characteristics and temporal-spatial analysis of overseas imported dengue fever cases in outbreak provinces of China, 2005–2019显示文摘Background Overseas imported dengue fever is an important factor in local outbreaks of this disease in the mainland of China.To better prevent and control such local outbreaks,the epidemiological characteristics and temporal-spatial distribution of overseas imported dengue fever cases in provincial-level administrative divisions(PLADs)where dengue fever is outbreak in the mainland of China were explored.Methods Using the Chinese National Notifiable Infectious Disease Reporting Information System(CNNDS),we identified overseas imported dengue fever cases in dengue fever outbreak areas in the mainland of China from 2005 to 2019 to draw the epidemic curve and population characteristic distribution of overseas imported cases in each PLAD.Based on spatial autocorrelation analysis of ArcGIS 10.5 and temporal-spatial scanning analysis of SaTScan 9.5,we analyzed the temporal-spatial distribution of overseas imported dengue fever in dengue fever outbreak areas in the mainland of China.Results A total of 11,407 imported cases,mainly from Southeast Asia,were recorded from 2005 to 2019 in these 13 PLADs.Of which 62.1%were imported into Yunnan and Guangdong Provinces.Among the imported cases,there were more males than females,mainly from the 21–50 age group.The hot spots were concentrated in parts of Yunnan,Guangdong and Fujian Provinces.We found the cluster of infected areas were expanding northward.Conclusions Based on the analysis of overseas imported dengue cases in 13 PLADs of the mainland of China from 2005 to 2019,we obtained the epidemiological characteristics and spatial distribution of imported dengue cases.Border controls need to pay attention to key population sectors,such as 21–50 years old men and education of key populations on dengue prevention.There is a need to improve the awareness of the prevention and control of imported cases in border areas.At the same time,northern regions cannot relax their vigilance. | Xinchang Lun Yiguan Wang Chunchun Zhao Haixia Wu Caiying Zhu Delong Ma Mingfang Xu Jun Wang Qiyong Liu Lei Xu Fengxia Meng | 2022 | Infectious Diseases of Poverty2022，11，1： | 3 |
| 11 | Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy显示文摘Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia(AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor(G-CSF)(low-dose chemotherapy(LDC)/G-CSF). Complete response(CR) after two induction courses was attained in 87.0%(40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy(SDC) for induction(80/94(85.1%) of the patients attained CR after induction Ⅱ, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free(67.4 vs. 70.7%;P = 0.99)and overall(70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell(WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC(11.5 vs. 18.5 d for WBCs(P < 0.001);15.5 vs. 22.0 d for platelets(P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF(n = 9) or SDC(n = 11), all of the mutations were below the reference value(variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML. | Yixin Hu Aili Chen Xinchang Zheng Jun Lu Hailong He Jin Yang Ya Zhang Pinpin Sui Jingyi Yang Fuhong He Yi Wang Peifang Xiao Xin Liu Yinmei Zhou Deqing Pei Cheng Cheng Raul C. Ribeiro Shaoyan Hu Qian-fei Wang | 2019 | National Science Review2019，6，3： | 3 |
| 12 | Recent developments in graphene-based optical modulators显示文摘Graphene 出现了在光活跃部件答应观点由于大它的介电常数变化活跃控制。这份报纸系统地考察基于 graphene 的光调节的人的最近的开发,包括材料性质,不同集成计划,单个层的基于 graphene 的调节的人,多层并且很少层基于 graphene 的调节的人,相应 figure-of-merits,波长 / 温度忍耐,和基于 graphene 的光纤的调节的人。为各向同性的 graphenes 和各向异性的性质的不同处理也被讨论。结果证明 graphene 是为提高硅的优秀材料弱调整能力在它集成于硅站台,并且为互补金属氧化物半导体(互补金属氧化物半导体) 有大潜力以后兼容光设备,对的出现重要影响光在未来相连综合 optoelectronic 电路。 | Ran HAO Jiamin JIN Xinchang WEI Xiaofeng JIN Xianmin ZHANG Erping LI | 2014 | Frontiers of Optoelectronics2014，7，3： | 3 |
| 13 | Competition Mechanism of Lightning Upward Leaders Issued from UHVDC Transmission Lines显示文摘 | SHI Wei LI Qingmin LU Xinchang ZOU Liang SUN Qiuqin | 2012 | 高电压技术2012，38，12： | 2 |
| 14 | Opportunities and challenges of strain engineering for advanced electrocatalyst design显示文摘Electrocatalysis is becoming more and more important in energy conversion and storage due to rising energy demands,increasing carbon dioxide emissions,and impending climate change.The design and synthesis of high-performance electrocatalysts are the spotlights of electrocatalysis.Among many design methodologies reported,strain engineering has gained growing attention because it can change the atomic arrangement and lattice structure of electrocatalysts.However,strain engineering remains to be problematic in regulating the properties of electrocatalysts.This review discusses the strain effect tactics to regulate metal and non-metal electrocatalysts,including three sections focusing on strain categorization,strain regulation mechanism,and applications in electrocatalysis,respectively.Finally,the current challenges and an outlook of strain engineering are discussed. | Qing-Man Liang Xinchang Wang Xin-Wang Wan Long-Xing Lin Bi-Jun Geng Zhong-Qun Tian Yang Yang | 2023 | Nano Research2023，16，7： | 2 |
| 15 | U-Pb Isotope Geochronology of Syntectonic Granites from Hainan Island,South China:Constraints on Tectonic Evolution of the Eastern Paleo-Tethys Ocean显示文摘Since the recognition of the Indosinian orogeny in northern Vietnam,Triassic orogens have been widely identified around the western and southwestern boundaries of the South China block.The paleo-Tethys sutures stretch from west to southeast,from Jinshajiang-Ailaoshan via NE Vietnam to Hainan Island;these sutures exhibit and develop voluminous Permian-early Triassic magmatism and numerous high-strain shear zones.As ophiolites related to the paleo-Tethys are lacking on Hainan Island,the eastward extension of the Indosinian orogeny and subduction and closure time of the paleo-Tethys Ocean on Hainan Island remain controversial.Here,an integrated kinematic and geochronological study has been conducted on two shear zones,called the Xiaomei and Mangsan shear zones.U-Pb zircon dating yields an age of early Triassic(252-251 Myr)for Xiaomei syntectonic granites which formed in the same tectonic setting and presented the similar nanoparticles to the Indosinian granites from Ailaoshan ductile shear zone,including the strawberry-like and flower-like nanoparticles.The NE-trending Mangsan shear zone represented by the gneissic granites with middle Permian ages(264-262 Myr)formed in the same tectonic setting as the Wuzhi-shan granites that were proposed as I-type granites.These middle Permian gneissic granites with arc affinity may represent an arc setting related to the NW subduction of the paleo-Tethys.The analyses reveal that granites with late Triassic ages(235-232 Myr)in the Xiaomei shear zone have the characteristics of A-type granites.The late Triassic extensional events on Hainan Island may be related to the subduction of the paleo-Pacific Plate beneath the East Asian continent. | ZHOU Yang YAN Yi LIU Hailing CAI Jianxin ZHOU Mengfei ZHANG Xinchang WANG Yin SHEN Baoyun | 2020 | Journal of Ocean University of China2020，19，6： | 1 |
| 16 | Investigations on the fabrication and erosion behavior of the composite diamond coated nozzles显示文摘 | XinChang Wang JianGuo Zhang FangHong Sun Tao Zhang Bin Shen | 2013 | 2013 (1-2)2013，，1： | 1 |
| 17 | Immunological detection of aflatoxin baicalin preparation of aflatoxin BI antigen显示文摘 | Chen Fusheng Luo Xinchang | 2006 | Mycosystema2006，18，3： | 1 |
| 18 | The effect of deposition parameters on the morphology of micron diamond powders synthesized by HFCVD method显示文摘 | Tao Zhang Xinchang Wang Bin Shen Fanghong Sun Zhiming Zhang | 2013 | Journal of Crystal Growth2013，，： | 1 |
| 19 | Immunological detection of aflatoxin baicalin preparation of aflatoxin B1 antigen 显示文摘 | Chen Fusheng Luo Xinchang | 2006 | Mycosys- tema2006，18，3： | 1 |
| 20 | Comparison of umami taste peptides in water-soluble extractions of Jinhua and Parma hams显示文摘 | DANG Yali GAG Xinchang MA Fumin | 2015 | LWT-Food Science and Technology2015，60，2： | 1 |
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