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| 1 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 2 | Bi Nanoparticles Anchored in N-Doped Porous Carbon as Anode of High Energy Density Lithium Ion Battery显示文摘A novel bismuth–carbon composite, in which bismuth nanoparticles were anchored in a nitrogen-doped carbon matrix(Bi@NC), is proposed as anode for high volumetric energy density lithium ion batteries(LIBs).Bi@NC composite was synthesized via carbonization of Zn-containing zeolitic imidazolate(ZIF-8) and replacement of Zn with Bi, resulting in the N-doped carbon that was hierarchically porous and anchored with Bi nanoparticles. The matrix provides a highly electronic conductive network that facilitates the lithiation/delithiation of Bi.Additionally, it restrains aggregation of Bi nanoparticles and serves as a buffer layer to alleviate the mechanical strain of Bi nanoparticles upon Li insertion/extraction.With these contributions, Bi@NC exhibits excellent cycling stability and rate capacity compared to bare Bi nanoparticles or their simple composites with carbon. This study provides a new approach for fabricating high volumetric energy density LIBs. | Yaotang Zhong Bin Li Shumin Li Shuyuan Xu Zhenghui Pan Qiming Huang Lidan Xing Chunsheng Wang Weishan Li | 2018 | Nano-Micro Letters2018，10，4： | 3 |
| 3 | A comparison of two different dosages of conjugated epuine estrogen in continue hormone replacement therapy with progestin显示文摘 | Xing Shumin Wu Yiyong Liu Jianli | 2003 | Chines medcal J2003，116，4： | 1 |
| 4 | Construction of a high-density mutant population of Chinese cabbage facilitates the genetic dissection of agronomic traits显示文摘Chinese cabbage(Brassica rapa ssp.pekinensis)is an economically important vegetable crop throughout the world,especially in Asia.High-quality genome sequences are available for Chinese cabbage,but gene functional studies remain challenging.To promote functional genomic studies of Chinese cabbage,we generated an ethyl methane sulfonate(EMS)mutant population of~8000 M_(2) plants using the double haploid inbred line A03 as the parent.The genome of A03 was sequenced and used as a reference for high-throughput functional characterization of gene mutations at the whole-genome level.A total of 300 M_(2) to M_(5) EMS mutants were phenotypically screened and then sequenced,revealing 750629 SNPs and 46272 InDel mutations that cover 98.27%of all predicted genes in the A03 genome.A forward-genetics approach was successfully used to identify two genes with chloroplast-related functions that are responsible for the yellow leaf mutant trait.A reverse-genetics approach was also used to identify associations between mutations in five genes of the glucosinolate biosynthetic pathway and variations in glucosinolate content of the mutant plants.In addition,we built the Chinese cabbage EMS mutation database(CCEMD,www.bioinformaticslab.cn/EMSmutation/home)to increase the usability of this mutant population resource.In summary,we performed large-scale screening of a heading Chinese cabbage EMS mutant collection at the phenotypic and genotypic levels,which will facilitate gene mining of Chinese cabbage and might also be useful for the study of other Brassica crops. | Xiaoxue Sun Xing Li Yin Lu Shan Wang Xiaomeng Zhang Kang Zhang Xiangjie Su Mengyang Liu Daling Feng Shuangxia Luo Aixia Gu Yu Fu Xueping Chen Shuxin Xuan Yanhua Wang Donghui Xu Shumin Chen Wei Ma Shuxing Shen Feng Cheng Jianjun Zhao | 2022 | Molecular Plant2022，15，5： | 1 |
| 5 | Short-Term Wind Power Prediction Based on ICEEMDAN-SE-LSTM Neural Network Model with Classifying Seasonal显示文摘Wind power prediction is very important for the economic dispatching of power systems containing wind power.In this work,a novel short-term wind power prediction method based on improved complete ensemble empirical mode decomposition with adaptive noise(ICEEMDAN)and(long short-term memory)LSTM neural network is proposed and studied.First,the original data is prepossessed including removing outliers and filling in the gaps.Then,the random forest algorithm is used to sort the importance of each meteorological factor and determine the input climate characteristics of the forecast model.In addition,this study conducts seasonal classification of the annual data where ICEEMDAN is adopted to divide the original wind power sequence into numerous modal components according to different seasons.On this basis,sample entropy is used to calculate the complexity of each component and reconstruct them into trend components,oscillation components,and random components.Then,these three components are input into the LSTM neural network,respectively.Combined with the predicted values of the three components,the overall power prediction results are obtained.The simulation shows that ICEEMDAN-SE-LSTM achieves higher prediction accuracy ranging from 1.57%to 9.46%than other traditional models,which indicates the reliability and effectiveness of the proposed method for power prediction. | Shumin Sun Peng Yu Jiawei Xing Yan Cheng Song Yang Qian Ai | 2023 | Energy Engineering2023，120，12： | 0 |
| 6 | Optimize the combination regimen of Trastuzumab and Nab-paclitaxel in HER2-positive tumors via modulating Caveolin-1 expression by lovastatin显示文摘The combination regimen of trastuzumab(Tras)plus Nab-paclitaxel(Nab)is recommended to treat HER2-positive(HER2+)cancers.However,they exert effects in different mechanisms:Tras need to stay on cell membranes,while Nab need to be endocytosed,therefore the concurrent combination regimen may not be the best one in HER2+tumors treatment.Caveolin-1(Cav-1)is a key player in mediating their endocytosis and is associated with their efficacy,but few researches noticed the opposite effect of Cav-1 expression on the combination efficacy.Herein,we systematically studied the Cav-1 expression level on the combination efficacy and proposed an optimized and clinically feasible combination regimen for HER2+Cav-1 High tumor treatment.In the regimen,lovastatin(Lova)was introduced to modulate the Cav-1 expression and the results indicated that Lova could downregulate Cav-1 expression,increase Tras retention on cell membrane and enhance the in vitro cytotoxicity of Tras in HER2+Cav-1 High cells but not in HER2+Cav-1 Low cells.Therefore,by exchanging the dosing sequence of Nab and Tras,and by adding Lova at appropriate time points,the precise three-drug-sequential regimen(PTDS,Nab(D1)-Lova(D2)-Lova&Tras(D2+12 h))was established.Compared with the concurrent regimen,the PTDS regimen exhibited a higher in vitro cytotoxicity and a stronger tumor growth inhibition in HER2+Cav-1 High tumors,which might be a promising combination regimen for these patients in clinics. | Canyu Yang Shumin Fan Xing Wang Wei Liu Long Yang Bing He Wenbing Dai Hua Zhang Xueqing Wang Qiang Zhang | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，5： | 0 |
| 7 | Visualizing Complex Anatomical Structure in Bamboo Nodes Based on X-ray Microtomography显示文摘In recent years,bamboo has been widely used in a broad range of applications,a thorough understanding of the structural characteristics of bamboo nodes is essential for better processing and manufacturing of biomimetic materials.This study investigated the complex anatomical structure for the nodes of two bamboo species,Indocalamus latifolius(Keng)McClure and Shibataea chinensis Nakai,using a high-resolution X-ray microtomography(μCT).The results show that the vascular bundle system in the nodal region of I.latifolius and S.chinensis is a net-like structure composed of horizontal and axial vascular bundles.Furthermore,the fiber sheath surrounding metaxylem vessels tended to be shorter in the tangential direction.This structure of bamboo nodes facilitates the tangential and axial transport of moisture and nutrients.The anatomical structure of I.latifolius and S.chinensis nodes has obvious differences,especially in the arrangement of vascular bundles.Vascular bundle frequency was significantly higher in S.chinensis nodes than in I.latifolius nodes.These findings indicate thatμCT is a nondestructive three-dimensional imaging method that can used to examine the anatomical structure of bamboo nodes. | Elin Xiang Shumin Yang Chunjie Cao Xinge Liu Guanyun Peng Lili Shang Genlin Tian Qianli Ma Jianfeng Ma | 2021 | Journal of Renewable Materials2021，9，9： | 0 |
| 8 | Main Anatomy Characteristics in Cell Wall and Lignin Distribution of Bamboo Culms(Pseudosasa amabilis)显示文摘The anatomy characteristics of cell wall and lignin distribution in different anatomical regions for 12-month-old bamboo species Pseudosasa amabilis was investigated.The lignin distribution was studied by means of optical microscope and confocal laser scanning microscope and the color reaction. In addition,the distribution of lignin in different tissues(fiber,parenchyma and vessel) was investigated by visible-light microspectrophotometry coupled with the Wiesner and Maule reaction.The cell walls of different tissues were all lignified and the lignin was widely distributed in different tissues, in which there was a difference between tissues and anatomical regions in lignin content.Guaiacyl lignin and syringyl lignin unit could be found in cell wall of fiber,parenchyma and vessel through Wiesner and Maule reaction and the absorbance peak of spectrum. There was no regular variation in lignin content with different radial location of culms and different location in fiber strands.The lamellation of the fiber cell wall was generally had as alternating broad and narrow layers with alternating low and high concentration of lignin. | Yang Shumin Liu Xing'e Fei Benhua Jiang Zehui Yang Xi Shan Haibin | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
| 9 | Engineering Janus gold nanorod–titania heterostructures with enhanced photocatalytic antibacterial activity against multidrugresistant bacterial infection显示文摘Photocatalytic antibacterial approach shows great potential in treating multidrug-resistant bacterial infections.However,the bactericidal efficiency heavily depends on the photocatalytic activity of semiconductor materials,which is limited by the fast recombination of photogenerated electron–hole pairs.Janus nano-heterostructures with spatial control growth of TiO_(2)nanoparticles(NPs)at one end of gold nanorods(Au NRs)are designed via surface ligand regulation for photocatalytic sterilization and infected wound healing.The asymmetric nanostructure of Janus gold nanorod-titanium dioxide nanoparticles(Janus AuNR-TiO_(2) NPs)promotes the directional migration of charge carriers and is more conducive to the spatial separation of electron–hole pairs.Moreover,the injection of hot electrons and enhancement of plasmon near-fields from the surface plasmon resonance(SPR)effect further improve the photocatalytic efficiency of Janus AuNR-TiO_(2) NPs.Under simulated sunlight irradiation,large amounts of reactive oxygen species(ROS)are generated for photocatalytic antibacterial activity.Enhanced bactericidal efficiency up to 99.99%against methicillin-resistant Staphylococcus aureus(MRSA)is achieved in vitro.Furthermore,Janus AuNR-TiO_(2) NPs exhibit superior biocompatibility,structural stability,and also remarkably accelerate MRSA-infected wound healing.Taking the above all into consideration,Janus AuNR-TiO_(2) NPs,as an efficient antibacterial photocatalyst,offers a promising strategy for MRSA infectious therapy. | Shuqin Li Hongqi Huo Xing Gao Luntao Liu Shumin Wang Jiamin Ye Jing Mu Jibin Song | 2023 | Nano Research2023，16，2： | 0 |
| 10 | The effect of Bi composition on the electrical properties of InP1-xBix显示文摘Ⅲ-ⅤSemiconductors containing a small amount of Bi,known as dilute bismides,have attracted great interest in recent years,due to the large band-gap reduction and other unique properties[1,2].Previous studies have been primarily focused on the growth and optical properties of the GaAs-based bismuthides[3],while the properties of other dilute bismides are less well understood.Berding et al.[4]theoretically predicted that InPBi is expected to be | GuanNan Wei Xing Dai Qi Feng WenGang Luo YiYang Li Kai Wang LiYao Zhang WenWu Pan ShuMin Wang ShenYuan Yang KaiYou Wang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，4： | 0 |
| 11 | Physicochemical difference of coffee beans with different species,production areas and roasting degrees显示文摘In recent decades,the demand for coffee has seen a continuous increase,and the aroma and flavor of coffee has been widely studied.The current research chose coffee beans of two species(Coffea arabica and C.canephora)from five production areas(Brazil,India,Indonesia,Uganda and Vietnam)with four different roasting degrees(medium light,medium,medium dark and dark),to investigate the difference on physicochemical properties.The results showed that Arabica coffee beans had higher concentrations of fat and organic acids,and total amount of volatile compounds,whereas Robusta beans had higher concentrations of protein.With the increase of roasting degree,the concentrations of protein,fat,organic acids,and the total amount of volatile compounds of coffee beans increased,while the concentrations of chlorogenic acid compounds decreased.The discriminant analysis indicated that the tested coffee beans could be clearly discriminated by species and roasting degrees,but not by production area.The results of this research conclude the physicochemical difference of Arabica and Robusta beans with different roasting degrees.The results can provide a theoretical basis for coffee bean selection for the relevant industries. | Xinrong Liu Yanan Fei Weiqing Wang Shumin Lei Chao Cheng Zhiqiang Xing | 2022 | Beverage Plant Research2022，2，1： | 0 |
| 12 | Genome Assembly and Population Resequencing Reveal the Geographical Divergence of Shanmei(Rubus corchorifolius)显示文摘Rubus corchorifolius(Shanmei or mountain berry,2n=14)is widely distributed in China,and its fruits possess high nutritional and medicinal values.Here,we reported a highquality chromosome-scale genome assembly of Shanmei,with contig size of 215.69 Mb and 26,696 genes.Genome comparison among Rosaceae species showed that Shanmei and Fupenzi(Rubus chingii Hu)were most closely related,followed by blackberry(Rubus occidentalis),and that environmental adaptation-related genes were expanded in the Shanmei genome.Further resequencing of 101 samples of Shanmei collected from four regions in the provinces of Yunnan,Hunan,Jiangxi,and Sichuan in China revealed that among these samples,the Hunan population of Shanmei possessed the highest diversity and represented the more ancestral population.Moreover,the Yunnan population underwent strong selection based on the nucleotide diversity,linkage disequilibrium,and historical effective population size analyses.Furthermore,genes from candidate genomic regions that showed strong divergence were significantly enriched in the flavonoid biosynthesis and plant hormone signal transduction pathways,indicating the genetic basis of adaptation of Shanmei to the local environment.The high-quality assembled genome and the variome dataset of Shanmei provide valuable resources for breeding applications and for elucidating the genome evolution and ecological adaptation of Rubus species. | Yinqing Yang Kang Zhang Ya Xiao Lingkui Zhang Yile Huang Xing Li Shumin Chen Yansong Peng Shuhua Yang Yongbo Liu Feng Cheng | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 0 |
| 13 | Erratum to: The effect of Bi composition on the electrical properties of InP1-xBix [Sci. China-Phys. Mech. Astron. 60, 047022 (2017)]显示文摘 | GuanNan Wei Xing Dai Qi Feng WenGang Luo YiYang Li Kai Wang LiYao Zhang WenWu Pan ShuMin Wang ShenYuan Yang KaiYou Wang | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，5： | 0 |
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